Explanipedia

Anti-viral and anti-commensal antibody repertoires differ across human tissues 3554 Open

Joshua I. Gray, Yosuke Sakamoto, Donna L. Färber, Tomer Hertz · 2025

Description Memory B cells (BRMs) are present in serum, lymphoid organs and non-lymphoid tissues, where they are strategically positioned to provide immediate protection at mucosal and barrier sites. We previously reported that in children…

Computational design of HLA class I superbinders for broad T cell immunogenicity Open

Els Van Peer, Liel Cohen-Lavi, Alessandro Sette, John Sidney, Tomer Hertz · 2025

Human leukocyte antigen (HLA) class I molecules are highly polymorphic, restricting peptide binding to narrow sequence subsets. Designing peptides that bind multiple HLA supertypes-termed superbinders-offers a promising strategy for broad-…

Neuraminidase-specific antibodies drive differential cross-protection between contemporary FLUBV lineages Open

Caroline Page, Justin D. Shepard, Sean D. Ray, James A. Ferguson, Alesandra J. Rodriguez , et al. · 2025

The two influenza B virus (FLUBV) lineages have continuously diverged from each other since the 1980s, with recent (post-2015) viruses exhibiting accelerated evolutionary rates. Emerging data from human studies and epidemiological models s…

Review 3: "Virus Testing Optimisation Using Hadamard Pooling" Open

Tomer Hertz · 2025

High capacity clinical SARS-CoV-2 molecular testing using combinatorial pooling Open

Shosh Zismanov, Bar Shalem, Yulia Margolin‐Miller, Dalia Rosin-Grunewald, Roy Adar , et al. · 2024

Mapping antibody footprints using binding profiles Open

A. Azulay, Liel Cohen-Lavi, Lilach M. Friedman, Maureen A. McGargill, Tomer Hertz · 2023

The increasing use of monoclonal antibodies (mAbs) in biology and medicine necessitates efficient methods for characterizing their binding epitopes. Here, we developed a high-throughput antibody footprinting method based on binding profile…

Correlates of protection for booster doses of the SARS-CoV-2 vaccine BNT162b2 Open

Tomer Hertz, Shlomia Levy, Daniel Ostrovsky, H. R. Oppenheimer, Shosh Zismanov , et al. · 2023

Vaccination, especially with multiple doses, provides substantial population-level protection against COVID-19, but emerging variants of concern (VOC) and waning immunity represent significant risks at the individual level. Here we identif…

Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity Open

Rei Matsumoto, Joshua I. Gray, Ksenia Rybkina, H. R. Oppenheimer, L Lévy , et al. · 2023

Peering into the future of SARS-CoV-2 evolution using a computational model of the SARS-CoV-2 serum antibody repertoire Open

Liel Cohen-Lavi, Eilay Koren, Yan Yegorov, Sinai Sacharen, Anat Burkovitz , et al. · 2023

The global emergence of SARS-CoV-2 has provided a wealth of immunological data, including more than 600 solved structures of SARS-CoV-2 Spike antibodies (Abs) available in the Protein Data Bank. We reasoned that this data could be used to …

Immune-history based correlates of protection for respiratory infections Open

Tomer Hertz, Shlomia Levy, H. R. Oppenheimer, Shosh Zismanov, Lilach M. Friedman , et al. · 2023

There is growing evidence that immune-history biases responses to vaccination and natural infections. We hypothesized that immune-history antibody profiles can be used to predict risk of infection from respiratory viruses. To study the pre…

Obesity is associated with impaired immune history to influenza Open

Marwa Abd Alhadi, Lilach M. Friedman, Erik A. Karlsson, Liel Cohen-Lavi, Anat Burkovitz , et al. · 2023

Obesity is a risk factor of severe disease and mortality for both influenza and SARS-CoV-2. While previous studies show that obese individuals generate antibody responses following influenza vaccination, infection rates within the obese gr…

Obesity Is Associated with an Impaired Baseline Repertoire of Anti-Influenza Virus Antibodies Open

Marwa Abd Alhadi, Lilach M. Friedman, Erik A. Karlsson, Liel Cohen-Lavi, Anat Burkovitz , et al. · 2023

Obesity is associated with increased morbidity and mortality from influenza and SARS-CoV-2 infection. While vaccination is the most effective strategy for preventing influenza virus infection, our previous studies showed that influenza vac…

US National Institutes of Health Prioritization of SARS-CoV-2 Variants Open

S. Richard Turner, Arghavan Alisoltani, Debbie Bratt, Liel Cohen-Lavi, Bethany L. Dearlove , et al. · 2023

Since late 2020, SARS-CoV-2 variants have regularly emerged with competitive and phenotypic differences from previously circulating strains, sometimes with the potential to escape from immunity produced by prior exposure and infection. The…

High capacity clinical SARS-CoV-2 molecular testing using combinatorial pooling Open

Shosh Zismanov, Bar Shalem, Yulia Margolin‐Miller, Dalia Rosin-Grunewald, Roy Adar , et al. · 2023

The SARS-CoV-2 pandemic led to unprecedented testing demands, causing significant testing delays globally. One strategy used for increasing testing capacity was pooled-testing, using a two-stage technique first introduced during WWII. Here…

Antibody Fingerprinting Using Binding Profiles Open

A. Azulay, Liel Cohen-Lavi, Lilach M. Friedman, Maureen A. McGargill, Tomer Hertz · 2023

<span>FLU‐LISA (</span>fluorescence‐linked immunosorbent assay<span>)</span>: high‐throughput antibody profiling using antigen microarrays Open

Shlomia Levy, Marwa Abd Alhadi, A. Azulay, Amit Kahana, Nir Bujanover , et al. · 2022

Vaccination and natural infection both elicit potent humoral responses that provide protection from subsequent infections. The immune history of an individual following such exposures is in part encoded by antibodies. While there are multi…

Correlates of protection for booster doses of the BNT162b2 vaccine Open

Tomer Hertz, Shlomia Levy, Daniel Ostrovsky, Hannah Oppenheimer, Shosh Zismanov , et al. · 2022

Variants of concern (VOC) of SARS-CoV2 and waning immunity pose a serious global problem. Overall, vaccination and prior infection provide significant protection, but some individuals remain susceptible to infection and severe disease. Rig…

Correlates of protection for booster doses of the BNT162b2 vaccine Open

Tomer Hertz, Shlomia Levy, Daniel Ostrovsky, Hannah Oppenheimer, Shosh Zismanov , et al. · 2022

Variants of concern (VOC) of SARS-CoV2 and waning immunity pose a serious global problem. Overall, vaccination and prior infection appear to provide significant protection to the majority of individuals, but some remain susceptible to infe…

ELISA–on-Chip: High throughput antibody profiling using antigen microarrays Open

Shlomia Levy, Marwa Abd Alhadi, A. Azulay, Amit Kahana, Nir Bujanover , et al. · 2022

Vaccination and natural infection both elicit potent humoral responses that provide protection from subsequent infections. The immune-history of an individual following such exposures is in part encoded by antibodies. While there are multi…

Obesity is Associated with Impaired Immune History to Influenza Open

Marwa Abd Alhadi, Lilach M. Friedman, Erik A. Karlsson, Liel Cohen-Lavi, Anat Burkovitz , et al. · 2022

Brain-immune axis regulation is responsive to cognitive behavioral therapy and mindfulness intervention: Observations from a randomized controlled trial in patients with Crohn's disease Open

Anna Nemirovsky, Karny Ilan, Livnat Lerner, Liel Cohen-Lavi, Doron Schwartz , et al. · 2021

Author response: TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs Open

Koshlan Mayer-Blackwell, Stefan Schattgen, Liel Cohen-Lavi, Jeremy Chase Crawford, Aisha Souquette , et al. · 2021

Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract T-cell receptors (TCRs…

P055 Brain-Immune Axis Regulation is Responsive to Cognitive Behavioral and Mindfulness-Based Stress Reduction in Crohn’s Disease Open

Anna Nemirovsky, Karny Ilan, Alexis Hope Lerner, Liel Cohen-Lavi, Doron Schwartz , et al. · 2021

Background Crohn’s disease (CD) is a chronic inflammatory bowel disease associated with psychological stress that is regulated primarily by the pituitary-hypophysis-adrenal (HPA) axis. Here, we determined whether the psychological characte…

Obesity is associated with an altered baseline and post-vaccination influenza antibody repertoire Open

Marwa Abd Alhadi, Lilach M. Friedman, Erik A. Karlsson, Liel Cohen-Lavi, Anat Burkovitz , et al. · 2021

As highlighted by the ongoing COVID-19 pandemic, vaccination is critical for infectious disease prevention and control. Obesity is associated with increased morbidity and mortality from respiratory virus infections. While obese individuals…

Obesity is Associated with an Altered Baseline and Post-Vaccination Influenza Antibody Repertoire Open

Marwa Abd Alhadi, Lilach M. Friedman, Erik A. Karlsson, Liel Cohen-Lavi, Anat Burkovitz , et al. · 2021

Efficient high-throughput SARS-CoV-2 testing to detect asymptomatic carriers Open

Noam Shental, Shlomia Levy, Vered Wuvshet, Shosh Skorniakov, Bar Shalem , et al. · 2020

Single-stage group testing uses compressed sensing for efficient high-throughput SARS-CoV-2 testing.

Stochasticity constrained by deterministic effects of diet and age drive rumen microbiome assembly dynamics Open

Ori Furman, Liat Shenhav, Goor Sasson, Fotini Kokou, Hen Honig , et al. · 2020

Efficient high throughput SARS-CoV-2 testing to detect asymptomatic carriers Open

Noam Shental, Shlomia Levy, Vered Wuvshet, Shosh Skorniakov, Yonat Shemer‐Avni , et al. · 2020

The COVID-19 pandemic is rapidly spreading throughout the world. Recent reports suggest that 10-30% of SARS-CoV-2 infected patients are asymptomatic. Other studies report that some subjects have significant viral shedding prior to symptom …

Validity of machine learning in biology and medicine increased through collaborations across fields of expertise Open

Maria Littmann, Katharina Selig, Liel Cohen-Lavi, Yotam Frank, Peter Hönigschmid , et al. · 2020

A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls Open

Liel Cohen-Lavi, Andrew Fiore-Gartland, Adrienne G. Randolph, Angela Panoskaltsis‐Mortari, Sook‐San Wong , et al. · 2019

Cytokines and chemokines are key signaling molecules of the immune system. Recent technological advances enable measurement of multiplexed cytokine profiles in biological samples. These profiles can then be used to identify potential bioma…

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