Tomi‐Pekka Tuomainen
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View article: Associations of Serum n–6 Polyunsaturated Fatty Acid Concentrations with Heart Rate-Corrected QT and JT Intervals in Middle-Aged Males
Associations of Serum n–6 Polyunsaturated Fatty Acid Concentrations with Heart Rate-Corrected QT and JT Intervals in Middle-Aged Males Open
Higher serum total n-6 PUFA and LA concentrations are associated with shorter QTc and JTc intervals, suggesting a potential protective effect on ventricular arrhythmias.
View article: Serum copper, zinc and selenium and their ratios as predictors of pneumonia death risk in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
Serum copper, zinc and selenium and their ratios as predictors of pneumonia death risk in men: the Kuopio Ischaemic Heart Disease Risk Factor Study Open
Purpose This study aimed to assess the associations between serum concentrations of copper, zinc and selenium, and pneumonia death risk. Methods Study included 2088 men from the Kuopio Ischaemic Heart Disease Risk Factor Study aged 42–60 y…
View article: Adherence to a healthy Nordic diet is associated with a lower prevalence of depressive symptoms
Adherence to a healthy Nordic diet is associated with a lower prevalence of depressive symptoms Open
There has been substantial research undertaken on the role of a health-promoting diet in depression. Yet, the evidence of the relationship between the Nordic diet and the risk of depression is scarce. This cross-sectional study aimed to as…
View article: Persistent Hyperglycemia and Insulin Resistance with the Risk of Worsening Cardiac Damage in Adolescents: A 7-Year Longitudinal Study of the ALSPAC Birth Cohort
Persistent Hyperglycemia and Insulin Resistance with the Risk of Worsening Cardiac Damage in Adolescents: A 7-Year Longitudinal Study of the ALSPAC Birth Cohort Open
Objective: Insulin resistance (IR) and dysglycemia can induce cardiac remodeling in adulthood but little evidence exists with respect to cardiac remodeling in youth with and without evidence of new-onset glucose metabolic alterations. This…
View article: Persistent Hyperglycemia and Insulin Resistance with the Risk of Worsening Cardiac Damage in Adolescents: A 7-Year Longitudinal Study of the ALSPAC Birth Cohort
Persistent Hyperglycemia and Insulin Resistance with the Risk of Worsening Cardiac Damage in Adolescents: A 7-Year Longitudinal Study of the ALSPAC Birth Cohort Open
Objective: Insulin resistance (IR) and dysglycemia can induce cardiac remodeling in adulthood but little evidence exists with respect to cardiac remodeling in youth with and without evidence of new-onset glucose metabolic alterations. This…
View article: Avocado consumption during pregnancy linked to lower child food allergy risk: prospective KuBiCo study
Avocado consumption during pregnancy linked to lower child food allergy risk: prospective KuBiCo study Open
Background Maternal exposures during pregnancy play a critical role in offspring’s health outcomes. This study aimed to investigate how maternal avocado consumption during pregnancy relates to offspring allergic health outcomes using the K…
View article: Associations of serum n-6 polyunsaturated fatty acid concentrations with heart rate at rest, during and after exercise in men
Associations of serum n-6 polyunsaturated fatty acid concentrations with heart rate at rest, during and after exercise in men Open
In conclusion, higher serum LA concentration was associated with lower resting HR, while GLA and DGLA were marginally associated with higher maximal exercise HR. No associations were found with AA.
View article: Associations of the serum <i>n</i>-6 PUFA concentrations with exercise-induced myocardial ischaemia in middle-aged and older men
Associations of the serum <i>n</i>-6 PUFA concentrations with exercise-induced myocardial ischaemia in middle-aged and older men Open
n -6 PUFA, especially linoleic acid (LA) but also arachidonic acid (AA), have been inversely associated with CHD. However, mechanisms underlying these associations are not fully known. We investigated the associations of the serum concentr…
View article: In vivo vitamin D targets reveal the upregulation of focal adhesion-related genes in primary immune cells of healthy individuals
In vivo vitamin D targets reveal the upregulation of focal adhesion-related genes in primary immune cells of healthy individuals Open
Vitamin D modulates innate and adaptive immunity, the molecular mechanisms of which we aim to understand under human in vivo conditions. Therefore, we designed the study VitDHiD (NCT03537027) as a human investigation, in which 25 healthy i…
View article: Renal Hyperfiltration as a New Mechanism of Smoking-Related Mortality
Renal Hyperfiltration as a New Mechanism of Smoking-Related Mortality Open
Introduction Renal hyperfiltration (RHF), an established risk factor for mortality, is prevalent among tobacco smokers. The aim of this study was to assess the mediating role of RHF in the association between smoking and mortality. Aims an…
View article: Accelerometer‐based sedentary time, light physical activity, and <scp>moderate‐to‐vigorous</scp> physical activity from childhood with arterial stiffness and carotid <scp>IMT</scp> progression: A <scp>13‐year</scp> longitudinal study of 1339 children
Accelerometer‐based sedentary time, light physical activity, and <span>moderate‐to‐vigorous</span> physical activity from childhood with arterial stiffness and carotid <span>IMT</span> progression: A <span>13‐year</span> longitudinal study of 1339 children Open
Aims We examined the longitudinal associations of sedentary time (ST), light physical activity (LPA), and moderate‐to‐vigorous PA (MVPA) from childhood with carotid‐femoral pulse wave velocity (cfPWV), a measure of arterial stiffness and c…
View article: Meaningfulness and mortality: exploring the sense of coherence in Eastern Finnish men
Meaningfulness and mortality: exploring the sense of coherence in Eastern Finnish men Open
Aims: The sense of coherence scale has been shown to have an epidemiological relationship with mortality. This study aimed to investigate how the three components of sense of coherence (meaningfulness, comprehensibility and manageability) …
View article: DXA-based Fat Mass With Risk of Worsening Insulin Resistance in Adolescents: A 9-Year Temporal and Mediation Study
DXA-based Fat Mass With Risk of Worsening Insulin Resistance in Adolescents: A 9-Year Temporal and Mediation Study Open
Context Surrogate measures of childhood and adolescent obesity have impaired the understanding of the relationship of body composition with insulin resistance in the young population. Objective We aim to examine the longitudinal associatio…
View article: Effects of accelerometer-based sedentary time and physical activity on DEXA-measured fat mass in 6059 children
Effects of accelerometer-based sedentary time and physical activity on DEXA-measured fat mass in 6059 children Open
Globally, childhood obesity is on the rise and the effect of objectively measured movement behaviour on body composition remains unclear. Longitudinal and causal mediation relationships of accelerometer-based sedentary time (ST), light phy…
View article: Serum N-6 polyunsaturated fatty acids and resting heart rate, exercise maximal heart and recovery heart rate
Serum N-6 polyunsaturated fatty acids and resting heart rate, exercise maximal heart and recovery heart rate Open
View article: Cumulative accelerometer-based sedentary time from childhood through young adulthood with increased arterial stiffness and carotid intima-media thickness in youth: a 13-year longitudinal study
Cumulative accelerometer-based sedentary time from childhood through young adulthood with increased arterial stiffness and carotid intima-media thickness in youth: a 13-year longitudinal study Open
Background Arterial stiffness and carotid intima-media thickness (cIMT) progression have been associated with cardiovascular morbidity and mortality in adulthood. Arterial stiffness is a strong risk factor for elevated blood pressure and h…
View article: Dietary fat quality and serum androgen concentrations in middle-aged men
Dietary fat quality and serum androgen concentrations in middle-aged men Open
View article: Arterial stiffness but not carotid intima-media thickness progression precedes premature structural and functional cardiac damage in youth: A 7-year temporal and mediation longitudinal study
Arterial stiffness but not carotid intima-media thickness progression precedes premature structural and functional cardiac damage in youth: A 7-year temporal and mediation longitudinal study Open
Arterial stiffness progression temporally preceded worsening structural and functional cardiac damage in youth with increased systolic blood pressure and insulin resistance partly mediating the relationships. Future interventions aimed at …
View article: Change in sense of coherence mediates the association between economic recession and mortality among middle-aged men: A population-based cohort study from Eastern Finland
Change in sense of coherence mediates the association between economic recession and mortality among middle-aged men: A population-based cohort study from Eastern Finland Open
A financial recession has been associated with a decrease in all-cause mortality, but little is known about how psychosocial fluctuations in stress tolerance or orientation to life affect this association. Sense of Coherence (SOC) is a cor…
View article: Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies
Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies Open
Background The association between common carotid artery intima‐media thickness (CCA‐IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA‐IMT and carotid p…
View article: The effect of vitamin D3 supplementation on atrial fibrillation in generally healthy men and women: The Finnish Vitamin D Trial
The effect of vitamin D3 supplementation on atrial fibrillation in generally healthy men and women: The Finnish Vitamin D Trial Open
Atrial fibrillation is a common cardiac arrhythmia with high morbidity risk. Observational studies suggest that vitamin D deficiency is associated with higher atrial fibrillation risk but there is limited evidence whether vitamin D supplem…
View article: Frailty alone and interactively with obesity predicts heart failure: Kuopio Ischaemic Heart Disease Risk Factor Study
Frailty alone and interactively with obesity predicts heart failure: Kuopio Ischaemic Heart Disease Risk Factor Study Open
Aims We aim to evaluate the association of frailty and high body mass index with risk of incident heart failure. Methods and results From the Kuopio Ischaemic Heart Disease Risk Factor Study, 408 women and 369 men, aged 61–74 years were in…
View article: What is the most appropriate follow-up time for detecting the epidemiological relationship between coronary artery disease and its main risk factors: novel findings from a 35-year follow-up study
What is the most appropriate follow-up time for detecting the epidemiological relationship between coronary artery disease and its main risk factors: novel findings from a 35-year follow-up study Open
Background The aim was to investigate the most appropriate follow-up time to detect the associations of coronary artery disease (CAD) with its traditional risk factors in a long-term prospective cohort study. Methods The Kuopio Ischaemic H…
View article: Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials
Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials Open
View article: The association between renal hyperfiltration and mortality is not mediated by diabetes mellitus
The association between renal hyperfiltration and mortality is not mediated by diabetes mellitus Open
View article: BJN volume 129 issue 8 Cover and Back matter
BJN volume 129 issue 8 Cover and Back matter Open
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View article: Cumulative insulin resistance and hyperglycemia with arterial stiffness and carotid IMT progression in 1,779 adolescents: a 9-yr longitudinal cohort study
Cumulative insulin resistance and hyperglycemia with arterial stiffness and carotid IMT progression in 1,779 adolescents: a 9-yr longitudinal cohort study Open
Fasting plasma glucose, insulin, and insulin resistance had a J- or U-shaped increase from 15 to 24 yr with the base of the curve at age 17 yr. Cumulative high insulin and high insulin resistance from 15 to 24 yr were negatively associated…
View article: Temporal longitudinal associations of carotid-femoral pulse wave velocity and carotid intima-media thickness with resting heart rate and inflammation in youth
Temporal longitudinal associations of carotid-femoral pulse wave velocity and carotid intima-media thickness with resting heart rate and inflammation in youth Open
Higher arterial stiffness but not carotid-intima media thickness in adolescence preceded higher resting heart rate in young adulthood, however, elevated high sensitivity C-reactive protein in adolescence preceded higher arterial stiffness …
View article: Frailty Predicts Incident Atrial Fibrillation in Women but Not in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study
Frailty Predicts Incident Atrial Fibrillation in Women but Not in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study Open
Introduction: Frailty and atrial fibrillation (AF) are common aging problems and increasing globally. The association(s) between frailty and AF has been inconclusive. The purpose of this prospective population-based cohort was to investiga…
View article: Cumulative dyslipidemia with arterial stiffness and carotid IMT progression in asymptomatic adolescents: A simulated intervention longitudinal study using temporal inverse allocation model
Cumulative dyslipidemia with arterial stiffness and carotid IMT progression in asymptomatic adolescents: A simulated intervention longitudinal study using temporal inverse allocation model Open
Late adolescence is key to preventing, halting, and reversing dyslipidemic-related preclinical atherosclerosis progression, warranting universal lipid screening in the general pediatric population.