Explanipedia

Gut Microbiota Involved in the Immunopathogenesis of Autoimmune Pancreatitis Open

Kosuke Minaga, Tomohiro Watanabe, Ayako Hara, Tomoe Yoshikawa, Ken Kamata , et al. · 2025

Autoimmune pancreatitis (AIP), which is considered the pancreatic expression of a systemic immunoglobulin G4-related disease, is characterized by excessive infiltration of plasmacytes bearing immunoglobulin G4 and a unique form of fibrosis…

A positive cytokine/chemokine feedback loop establishes plasmacytoid DC–driven autoimmune pancreatitis in IgG4-related disease Open

Akane Hara, Tomohiro Watanabe, Kosuke Minaga, Tomoe Yoshikawa, Masayuki Kurimoto , et al. · 2024

The pathogenesis of the murine model of autoimmune pancreatitis associated with IgG4-related disease (AIP/IgG4-RD) induced by administration of polyinosinic-polycytidylic acid (poly[I:C]) is incompletely understood. While it is known that …

Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis Open

Yasuo Otsuka, Akane Hara, Kosuke Minaga, Ikue Sekai, Masayuki Kurimoto , et al. · 2023

Translocation of gut bacteria into the pancreas promotes the development of severe acute pancreatitis (SAP). Recent clinical studies have also highlighted the association between fungal infections and SAP. The sensing of gut bacteria by pa…

Low‐dose gemcitabine plus nab‐paclitaxel <i>versus</i> standard‐dose gemcitabine plus nab‐paclitaxel in elderly patients with metastatic pancreatic cancer: A randomized Phase <span>II</span> trial Open

Ken Kamata, Hajime Imai, Hisakazu Matsumoto, Yukitaka Yamashita, Takao Kato , et al. · 2023

Background and Aim A multicenter, open‐label randomized Phase II trial was conducted to determine whether low‐dose gemcitabine plus nab‐paclitaxel (GnP) could improve tolerability and show equivalent efficacy to the standard‐dose GnP for e…

Activation of the aryl hydrocarbon receptor inhibits the development of experimental autoimmune pancreatitis through IL-22-mediated signaling pathways Open

Ken Kamata, Akane Hara, Kosuke Minaga, Tomoe Yoshikawa, Masayuki Kurimoto , et al. · 2023

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor expressed in hematopoietic and non-hematopoietic cells. Activation of the AhR by xenobiotics, microbial metabolites, and natural substances induces immunoregula…

Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression Open

Yasuhiro Masuta, Kosuke Minaga, Masayuki Kurimoto, Ikue Sekai, Akane Hara , et al. · 2022

Mutations in nucleotide-binding oligomerization domain 2 (NOD2) are associated with Crohn’s disease (CD). Although NOD2 activation contributes to the maintenance of intestinal homeostasis through the negative regulation of pro-inflammatory…

Bispectral index-guided propofol sedation during endoscopic ultrasonography Open

Ayana Okamoto, Ken Kamata, Takeshi Miyata, Tomoe Yoshikawa, Rei Ishikawa , et al. · 2022

Background/Aims: Bispectral index (BIS) monitors process and display electroencephalographic data are used to assess the depth of anesthesia. This study retrospectively evaluated the usefulness of BIS monitoring during endoscopic ultrasono…

Utility of contrast-enhanced harmonic EUS for diagnosis of portal vein invasion by pancreatic cancer Open

Atsushi Nakai, Ken Kamata, Tomoko Hyodo, Takaaki Chikugo, Akane Hara , et al. · 2022

Background: The value of contrast.enhanced harmonic EUS (CH.EUS) for diagnosis of portal vein invasion in patients with pancreatic cancer was evaluated. Patients and Methods: This single-center, retrospective study included consecutive pat…

Case Report: New-Onset Rheumatoid Arthritis Following COVID-19 Vaccination Open

Tomohiro Watanabe, Kosuke Minaga, Akane Hara, Tomoe Yoshikawa, Ken Kamata , et al. · 2022

Efficient protection against coronavirus disease 2019 (COVID-19) has been achieved by immunization with mRNA-based vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, efficient immune responses against t…

Expression levels of cellular inhibitor of apoptosis proteins and colitogenic cytokines are inversely correlated with the activation of interferon regulatory factor 4 Open

Sho Masaki, Tomohiro Watanabe, Yasuyuki Arai, Ikue Sekai, Akane Hara , et al. · 2022

Cellular inhibitors of apoptosis proteins 1 (cIAP1) and 2 (cIAP2) are involved in signaling pathways mediated by Toll-like receptors (TLRs) and tumor necrosis factor (TNF)-α. Excessive activation of TLRs and TNF-α underlies the immunopatho…

Immunohistochemical characterization of granulomatosis with polyangiitis exhibiting spontaneous regression Open

Yasuhiro Masuta, Yoriaki Komeda, Ikue Sekai, Akane Hara, Masayuki Kurimoto , et al. · 2021

We characterized immune cell compositions of the lung lesions of a patient with GPA exhibiting spontaneous regression.

Plasmacytoid Dendritic Cells as a New Therapeutic Target for Autoimmune Pancreatitis and IgG4-Related Disease Open

Kosuke Minaga, Tomohiro Watanabe, Akane Hara, Tomoe Yoshikawa, Ken Kamata , et al. · 2021

Although plasmacytoid dendritic cells (pDCs) able to produce large amounts of type 1 interferons (IFN-I) play beneficial roles in host defense against viral infections, excessive activation of pDCs, followed by robust production of IFN-I, …

Case Report: Regulatory T Cell-Independent Induction of Remission in a Patient With Collagenous Colitis Open

Hajime Honjo, Tomohiro Watanabe, Mizuki Tomooka, Takuya Matsubara, Masashi Kono , et al. · 2021

Collagenous colitis (CC), a prototypical microscopic colitis, is a chronic inflammatory disorder of the colon. The diagnosis of CC depends on the pathological examination. The colonic mucosa of patients with CC is characterized by the pres…

Case Report: Concurrent Occurrence of Abdominal Double Expressor Lymphoma and Jejunum Follicular Lymphoma Open

Ryutaro Takada, Tomohiro Watanabe, Ikue Sekai, Keisuke Yoshikawa, Akane Hara , et al. · 2021

Double expressor lymphoma (DEL), defined as overexpression of BCL2 and MYC, is an aggressive subtype of diffuse large B cell lymphoma (DLBCL). Here we report a case of a 64-year-old female diagnosed with abdominal DEL transformed from jeju…

Case Report: A Case of Intestinal Behçet's Disease Exhibiting Enhanced Expression of IL-6 and Forkhead Box P3 mRNA After Treatment With Infliximab Open

Keisuke Yoshikawa, Tomohiro Watanabe, Ikue Sekai, Ryutaro Takada, Akane Hara , et al. · 2021

Behçet's disease (BD) is a rare inflammatory condition characterized by oral and genital ulcers, skin lesions, as well as ophthalmological, neurological, and gastrointestinal manifestations. BD involving the gastrointestinal tract is known…

Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease Open

Akane Hara, Tomohiro Watanabe, Kosuke Minaga, Tomoe Yoshikawa, Ken Kamata , et al. · 2021

Solitary organ autoimmune disorders, formerly known as autoimmune pancreatitis (AIP), autoimmune sialadenitis, and autoimmune sclerosing cholangitis, are now considered organ-specific manifestations of systemic immunoglobulin G4-related di…

Should Contrast-Enhanced Harmonic Endoscopic Ultrasound Be Incorporated into the International Consensus Guidelines to Determine the Appropriate Treatment of Intraductal Papillary Mucinous Neoplasm? Open

Tomohiro Yamazaki, Mamoru Takenaka, Shunsuke Omoto, Tomoe Yoshikawa, Rei Ishikawa , et al. · 2021

This study aimed to investigate whether the incorporation of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) into the international consensus guidelines (ICG) for the management of intraductal papillary mucinous neoplasm (IPMN) c…

Intestinal Dysbiosis and Autoimmune Pancreatitis Open

Tomoe Yoshikawa, Tomohiro Watanabe, Ken Kamata, Akane Hara, Kosuke Minaga , et al. · 2021

Autoimmune pancreatitis (AIP) is a chronic fibro-inflammatory disorder of the pancreas. Recent clinicopathological analysis revealed that most cases of AIP are pancreatic manifestations of systemic IgG4-related disease (IgG4-RD), a newly e…

A unique profile of serum cytokines in type 1 autoimmune pancreatitis and chronic rhinosinusitis Open

Tomoe Yoshikawa, Kosuke Minaga, Akane Hara, Ikue Sekai, Yasuo Otsuka , et al. · 2021

Given that IL-33 is shared as one of pathogenic cytokines by type 1 AIP/IgG4-RD and CRS, enhanced IL33 responses may cause concurrent type 1 AIP/IgG4-RD and CRS.

Identification of serum IFN-α and IL-33 as novel biomarkers for type 1 autoimmune pancreatitis and IgG4-related disease Open

Kosuke Minaga, Tomohiro Watanabe, Akane Hara, Ken Kamata, Shunsuke Omoto , et al. · 2020

IgG4-related disease (IgG4-RD) is a multi-organ autoimmune disease characterized by elevated serum IgG4 concentration. Although serum IgG4 concentration is widely used as a biomarker for IgG4-RD and type 1 autoimmune pancreatitis (AIP), a …

Gut microbiome alterations in type 1 autoimmune pancreatitis after induction of remission by prednisolone Open

Ken Kamata, Tomohiro Watanabe, Kosuke Minaga, Akane Hara, Ikue Sekai , et al. · 2020

Summary Although increasing evidence demonstrates the association between intestinal dysbiosis and pancreatic diseases such as chronic pancreatitis and pancreatic cancer, it remains largely unknown whether intestinal dysbiosis is involved …

A novel teaching tool for visualizing the invisible bile duct axis in 3 dimensions during biliary cannulation (Compact Disc method) Open

Mamoru Takenaka, Tomoe Yoshikawa, Kosuke Minaga, Kentaro Yamao, Masatoshi Kudo · 2020

Selective biliary cannulation is difficult to master, even in cases with normal papillae.1Jorgensen J. Kubiliun N. Law J.K. et al.ASGE Training CommitteeEndoscopic retrograde cholangiopancreatography (ERCP): core curriculum.Gastrointest En…

Clinical utility of treatment method conversion during single-session endoscopic ultrasound-guided biliary drainage Open

Kosuke Minaga, Mamoru Takenaka, Kentaro Yamao, Ken Kamata, Shunsuke Omoto , et al. · 2020

Among multi-step procedures in EUS-BD, guidewire manipulation appeared to be the most technically challenging. When initially planned EUS-BD is technically difficult, treatment method conversion in a single endoscopic session may result in…

Do Endoscopic Ultrasound-Guided Transluminal Procedures Involve High Radiation Exposure? Open

Mamoru Takenaka, Makoto Hosono, Madan M. Rehani, Yasutaka Chiba, Yasuo Otsuka , et al. · 2020

Novel concept using a plastic stent for endoscopic ultrasound-guided hepaticogastrostomy adjusting the length according to the patient’s anatomy Open

Mamoru Takenaka, Kosuke Minaga, Tomoe Yoshikawa, Ayana Okamoto, Atsushi Nakai , et al. · 2019

Recently, the usefulness of plastic stents for creation of an endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) was reported [1] [2] [3]. Re-intervention using a plastic stent is easy owing to the ability to remove it, which may b…

A novel technique for stent dysfunction after endoscopic ultrasound-guided hepaticogastrostomy with antegrade stenting Open

Ayana Okamoto, Kosuke Minaga, Mamoru Takenaka, Tomoe Yoshikawa, Ken Kamata , et al. · 2019

Recently, endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) has been developed as a new drainage technique for malignant biliary obstruction; however, a high adverse event rate has been reported [1]. Stent migration is a serious a…

Clinical Safety and Efficacy of Secondary Prophylactic Pegylated G-CSF in Advanced Pancreatic Cancer Patients Treated with mFOLFIRINOX: A Single-center Retrospective Study Open

Kentaro Yamao, Mamoru Takenaka, Tomoe Yoshikawa, Rei Ishikawa, Ayana Okamoto , et al. · 2019

Objective Although modified FOLFIRINOX (mFOLFIRINOX, mFFX) is widely used for patients with advanced pancreatic ductal adenocarcinoma (PDAC), maintenance of the standard dose intensity is often difficult due to the high incidence of neutro…

Novel sphincterotomy device that orientates blade along the axis of the bile duct in patients with Roux-en-Y anastomosis Open

Mamoru Takenaka, Tomoe Yoshikawa, Ayana Okamoto, Atsushi Nakai, Kosuke Minaga , et al. · 2019

Endoscopic papillary large balloon dilation (EPLBD) following endoscopic sphincterotomy (EST) is an effective and safe treatment for common bile duct (CBD) stones in patients with Roux-en-Y anastomosis [1] [2]. However, performing EST usin…

Rendezvous within biloma technique combining percutaneous and endoscopic approaches: a novel biliary recanalization method Open

Ayana Okamoto, Kosuke Minaga, Mamoru Takenaka, Tomoe Yoshikawa, Toshimitsu Iwasaki , et al. · 2018

Biliary injury and biloma are complications that can occur with hepatobiliary surgery [1]. Endoscopic or percutaneous recanalization for postoperative biliary injury have been reported as minimally invasive treatments [2], but remains chal…

Cytokines produced by innate immune cells in IgG4-related disease Open

Tomoe Yoshikawa, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Masatoshi Kudo · 2018

IgG4-related disease (IgG4-RD) is a newly defined multi-organ disease proposed by Japanese physicians. IgG4-RD is characterized by elevated serum levels of IgG4 and massive infiltration of IgG4-expressing plasma cells in the affected organ…

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