Tomoharu Wakugawa
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View article: Comparison of Spectrum Coverage Score-based Antimicrobial Consumption in Acute Care Hospitals Over Eight Years: A Multicentric Study
Comparison of Spectrum Coverage Score-based Antimicrobial Consumption in Acute Care Hospitals Over Eight Years: A Multicentric Study Open
Background Progress in antimicrobial stewardship programs has introduced new means of assessing antimicrobial use. Days of antibiotic spectrum coverage (DASC) incorporate spectrum data into traditional metrics, such as days of therapy (DOT…
View article: Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor
Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor Open
Previously, we have shown that pyrogallol alleviated nasal symptoms and suppressed IL-9 gene up-regulation in allergy model rats by inhibiting calcineurin/NFAT signaling. As pyrogallol has antioxidative activity, it may be responsible for …
View article: Role of Nuclear Factor of Activated T Cells Signaling in the Development of Allergic Rhinitis
Role of Nuclear Factor of Activated T Cells Signaling in the Development of Allergic Rhinitis Open
Histamine is a major chemical mediator that induces symptoms of allergic rhinitis through binding to the histamine H1 receptor (H1R). The H1R gene is upregulated in the nasal mucosa of patients with pollinosis, and the expression level of …
View article: Effects of Syo-seiryu-to and Its Constituent Crude Drugs on Phorbol Ester-Induced Up-Regulation of IL-33 and Histamine H1 Receptor mRNAs in Swiss 3T3 and HeLa Cells
Effects of Syo-seiryu-to and Its Constituent Crude Drugs on Phorbol Ester-Induced Up-Regulation of IL-33 and Histamine H1 Receptor mRNAs in Swiss 3T3 and HeLa Cells Open
Syo-seiryu-to (SST) is a traditional herbal medicine that has been used clinically to treat allergic rhinitis (AR) in Japan. SST improves acute symptoms, such as sneezing and rhinorrhea, as well as chronic symptoms, such as nasal obstructi…
View article: Effects of narrow‐band <scp>UVB</scp> on nasal symptom and upregulation of histamine <scp>H<sub>1</sub></scp> receptor <scp>mRNA</scp> in allergic rhinitis model rats
Effects of narrow‐band <span>UVB</span> on nasal symptom and upregulation of histamine <span>H<sub>1</sub></span> receptor <span>mRNA</span> in allergic rhinitis model rats Open
Background Phototherapy with narrow‐band ultraviolet B (narrow‐band UVB) is clinically effective treatment for atopic dermatitis. In the present study, we examined the effects of intranasal irradiation with narrow‐band UVB on nasal symptom…
View article: Elucidation of Inverse Agonist Activity of Bilastine
Elucidation of Inverse Agonist Activity of Bilastine Open
H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activi…
View article: Mechanism of action of pyrogallol on calcineurin-NFAT signaling
Mechanism of action of pyrogallol on calcineurin-NFAT signaling Open
Calcineurin-NFAT (CN/NFAT) signaling is one of the most well-known signaling pathways involving many biological functions. We have demonstrated that CN/NFAT signaling was responsible for the pathogenesis of allergic rhinitis and identified…
View article: Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression
Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression Open
As the expression level of allergic disease sensitive genes are correlated with the severity of allergic symptoms, suppression of these gene expressions could be promising therapeutics. We demonstrated that protein kinase Cδ / heat shock p…
View article: Isolation of anti-allergic compound from Lotus Root
Isolation of anti-allergic compound from Lotus Root Open
Histamine H1 Receptor (H1R) gene is upregulated in the nasal mucosa of pollinosis patients, and its expression level is strongly correlated with severity of allergic symptoms. In nasal hypersensitivity model rats sensitized with toluene-2,…