Explanipedia

Pre‐Treatment Liver Stiffness Is a Stronger Predictor of Hepatocellular Carcinoma Development Than Post‐Treatment Liver Stiffness After Hepatitis C Virus Eradication Open

T. Nakatsuka, Ryo Nakagomi, Keisuke Mabuchi, Yuki Matsushita, Tomoharu Yamada , et al. · 2025

Introduction Liver stiffness measurement (LSM) values decrease after hepatitis C virus eradication. However, whether this reduction translates into a reduced risk of hepatocellular carcinoma (HCC) development in patients who achieve sustai…

The Significance of Ultrasonography in the Evaluation of Fontan-Associated Liver Disease (FALD) Open

T. Nakatsuka, Keisuke Mabuchi, Yuki Matsushita, Tomoharu Yamada, Kazuya Okushin , et al. · 2025

Impact of nucleos(t)ide analogues on the risk of hepatocellular carcinoma in chronic hepatitis B patients: a time-dependent Cox regression analysis Open

Makoto Moriyama, Ryosuke Tateishi, Mizuki Nishibatake Kinoshita, Tsuyoshi Fukumoto, Tomoharu Yamada , et al. · 2025

Background and aims The preventive effect of nucleos(t)ide analog (NA) use on HCC development in patients with chronic hepatitis B (CHB) is controversial due to the difficulty of conducting randomized controlled trials. Approach and result…

The Risk of Decompensation in Steatotic Liver Disease Related Hepatocellular Carcinoma: A Comparison with Viral-controlled Cases Open

Yuki Matsushita, Tatsuya Minami, Yoshikuni Kawaguchi, Akihiko Ichida, Ryo Oikawa , et al. · 2025

Background and Aims: Treatment options for steatotic liver disease (SLD) are limited compared to those for viral hepatitis, which may affect the prognosis of patients with hepatocellular carcinoma (HCC). Methods: This retrospective cohort …

Characteristics of Clinically Significant Hyperplastic Polyps: Distinctions Between Microvesicular and Goblet Cell‐Rich Types Open

Osamu Toyoshima, Toshihiro Nishizawa, Shuntaro Yoshida, Toru Arano, Hidenobu Watanabe , et al. · 2025

Background Clinically significant serrated polyps (CSSPs) are defined as sessile serrated lesions (SSLs), SSLs with dysplasia, traditional serrated adenomas (TSAs), hyperplastic polyps (HPs) ≥ 10 mm, and HPs ≥ 6 mm in the proximal colon. H…

Impact of nucleos(t)ide analogues on the risk of hepatocellular carcinoma in chronic hepatitis B patients: A time-dependent Cox regression analysis Open

Makoto Moriyama, Ryosuke Tateishi, Mizuki Nishibatake Kinoshita, Tsuyoshi Fukumoto, Tomoharu Yamada , et al. · 2024

Background and Aims: The preventive effect of nucleos(t)ide analog (NA) use on HCC development in patients with chronic hepatitis B (CHB) is controversial due to the difficulty of conducting randomized controlled trials. Approach and Resul…

Predictors for emergency hemostasis in patients with colonoscopic delayed post-polypectomy bleeding Open

Gota Fujisawa, Toshihiro Nishizawa, Tatsuya Matsuno, Shuntaro Yoshida, Takuma Hiramatsu , et al. · 2023

【背景】遅発性ポリペクトミー後出血(delayed post-polypectomy bleeding:DPPB)は大腸内視鏡ポリペクトミーの偶発症の一つであり,緊急内視鏡的止血術を含む迅速な対応を要する.しかし,DPPBを呈した症例の中で,どのような症例が緊急内視鏡的止血術となるかは明らかではない.本研究はDPPB症例において緊急内視鏡的止血術と関連する因子を特定することを目的とした.【方法】本研究はとよしま内視鏡クリニック単施設で行われた後向き・症例対象研究である.DP…

Impact of nucleos(t)ide analogues on the risk of hepatocellular carcinoma in chronic hepatitis B patients: A time-dependent Cox regression analysis Open

Makoto Moriyama, Ryosuke Tateishi, Mizuki Nishibatake Kinoshita, Tsuyoshi Fukumoto, Tomoharu Yamada , et al. · 2023

Background and Aims The preventive effect of nucleos(t)ide analog (NA) use on HCC development in patients with chronic hepatitis B (CHB) is controversial due to the difficulty of conducting randomized controlled trials. Approach and Result…

Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma Open

Tomoharu Yamada, Naoto Fujiwara, Naoto Kubota, Yuki Matsushita, T. Nakatsuka , et al. · 2023

Background: Lenvatinib was expected to enhance the effect of immune checkpoint inhibitors (ICIs) for unresectable HCC; however, their combination therapy failed to show the synergy in the phase III clinical trial. Methods: To elucidate len…

Steroid administration for ischemic complications after radiofrequency ablation: A retrospective study Open

Taijiro Wake, Ryosuke Tateishi, Makoto Moriyama, Tsuyoshi Fukumoto, Tomoharu Yamada , et al. · 2023

Aim The aim of this study was to evaluate the effects of steroids on ischemic complications after radiofrequency ablation. Methods A total of 58 patients with ischemic complications were divided into two groups according to corticosteroid …

Improved prognosis of hepatitis C‐related hepatocellular carcinoma in the era of direct‐acting antivirals Open

Tsuyoshi Fukumoto, Tatsuya Minami, Makoto Moriyama, Tomoharu Yamada, Taijiro Wake , et al. · 2022

The prognostic impact of direct‐acting antivirals (DAAs) on patients with hepatitis C‐related hepatocellular carcinoma (C‐HCC) is still unclear. This study aimed to evaluate the prognosis of C‐HCC in the DAA era. We enrolled 1237 consecuti…

Texture and color enhancement imaging in magnifying endoscopic evaluation of colorectal adenomas Open

Osamu Toyoshima, Toshihiro Nishizawa, Shuntaro Yoshida, Tomoharu Yamada, Nariaki Odawara , et al. · 2022

TXI provided higher visibility than WLI, lower than NBI, and comparable to or higher than CE in the magnified observation of colorectal adenomas.

TXI (Texture and Color Enhancement Imaging) for Serrated Colorectal Lesions Open

Toshihiro Nishizawa, Osamu Toyoshima, Shuntaro Yoshida, Chie Uekura, Ken Kurokawa , et al. · 2021

Background and aim: Olympus Corporation released the texture and color enhancement imaging (TXI) technology as a novel image-enhancing endoscopic technique. We investigated the effectiveness of TXI in the imaging of serrated colorectal pol…

Present Status of Transplant Hepatologist in Japan Open

Kaori Kuramitsu, Tomomi Kogiso, Reiko Itoh, Atsushi Takai, Yoko Yoshimaru , et al. · 2021

2017年1年間で10例以上の肝移植を実施した14施設の外科医と内科医を対象に，国内における肝移植内科医の現状について明らかにすることを目的にアンケートを実施した．回収率は100％であった．施設に対する移植患者は外科に直接紹介されるケースが多く，ドナーの術前評価はほぼ外科が，術後ICU管理は集中治療部が，移植後の胆管狭窄に対する内視鏡的逆行性胆管膵管造影は内科が実施していた．術前評価やレシピエント管理，術後肝生検や外来診察は内科医も行なっていたが，外科医にはあまり認識されて…

Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers Open

Osamu Toyoshima, Shuntaro Yoshida, Toshihiro Nishizawa, Akira Toyoshima, Kosuke Sakitani , et al. · 2021

Enlarged folds of gastritis were associated with submucosal invasion. Endoscopic observation of background gastritis as well as the lesion itself may help diagnose the depth of cancer invasion.

Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis Open

Shigeyuki Kurosaki, Hayato Nakagawa, Yuki Hayata, Satoshi Kawamura, Yuki Matsushita , et al. · 2021

Priority stratification for colonoscopy based on two-sample faecal immunochemical test screening: results from a cross-sectional study at an endoscopy clinic in Japan Open

Osamu Toyoshima, Yutaka Yamaji, Toshihiro Nishizawa, Shuntaro Yoshida, Tomoharu Yamada , et al. · 2021

Objectives Little has been reported on the yield and characteristics of colorectal neoplasia detected by the two-sample faecal immunochemical test (FIT), particularly the difference between subjects with two-positive results on the two-sam…

Endoscopic diagnosis for colorectal sessile serrated lesions Open

Toshihiro Nishizawa, Shuntaro Yoshida, Akira Toyoshima, Tomoharu Yamada, Yoshiki Sakaguchi , et al. · 2021

Size > 5 mm, mucus cap, and indistinct borders were significant endoscopic features for the diagnosis of SSLs. Serrated polyps with these three features should be removed during colonoscopy.

Kyoto classification in patients who developed multiple gastric carcinomas after <i>Helicobacter pylori</i> eradication Open

Kosuke Sakitani, Toshihiro Nishizawa, Akira Toyoshima, Shuntaro Yoshida, Tatsuya Matsuno , et al. · 2020

Patients diagnosed with gastric cancer after H. pylori eradication tended to have advanced gastritis. In particular, in cases of multiple gastric cancers developed after H. pylori eradication, the endoscopic Kyoto classificat…

Neoadjuvant Use of Oncolytic Herpes Virus G47Δ Enhances the Antitumor Efficacy of Radiofrequency Ablation Open

Tomoharu Yamada, Ryosuke Tateishi, Miwako Iwai, Kazuhiko Koike, Tomoki Todo · 2020

Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment Open

Makoto Sano, Hideaki Ijichi, Ryota Takahashi, Koji Miyabayashi, Hiroaki Fujiwara , et al. · 2019

Lipid Metabolic Reprogramming in Hepatocellular Carcinoma Open

Hayato Nakagawa, Yuki Hayata, Satoshi Kawamura, Tomoharu Yamada, Naoto Fujiwara , et al. · 2018

Metabolic reprogramming for adaptation to the local environment has been recognized as a hallmark of cancer. Although alterations in fatty acid (FA) metabolism in cancer cells have received less attention compared to other metabolic altera…

Peribiliary Glands as the Cellular Origin of Biliary Tract Cancer Open

Hayato Nakagawa, Yuki Hayata, Tomoharu Yamada, Satoshi Kawamura, Nobumi Suzuki , et al. · 2018

The identification of the cellular origin of cancer is important for our understanding of the mechanisms regulating carcinogenesis, thus the cellular origin of cholangiocarcinoma (CCA) is a current topic of interest. Although CCA has been …

Erratum to: Efficacy of Transcatheter Arterial Chemoembolization Followed by Sorafenib for Intermediate/Advanced Hepatocellular Carcinoma in Patients in Japan: A Retrospective Analysis Open

Takamasa Ohki, Koki Sato, Mari Yamagami, Daisaku Ito, Tomoharu Yamada , et al. · 2016

Efficacy of Transcatheter Arterial Chemoembolization Followed by Sorafenib for Intermediate/Advanced Hepatocellular Carcinoma in Patients in Japan: A Retrospective Analysis Open

Takamasa Ohki, Koki Sato, Mari Yamagami, Daisaku Ito, Tomoharu Yamada , et al. · 2015

Sa1097 Analysis of Weekend Admission on Upper Gastrointestinal Bleeding; Is Weekend Effect Demonstrated in Japan? Open

Koki Kawanishi, Nobuo Toda, Satoshi Kawamura, Yuki Hayata, Yuki Karasawa , et al. · 2015

Tomoharu Yamada YOU? Author Swipe