Tomohiko Ichikawa
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View article: Outcomes of sequential therapy for advanced upper tract urothelial cancer and bladder cancer
Outcomes of sequential therapy for advanced upper tract urothelial cancer and bladder cancer Open
This multicenter retrospective study compared clinical outcomes and sequential therapy patterns between upper urinary tract urothelial carcinoma (UTUC) and bladder cancer (BC). Data from 517 patients with locally advanced/metastatic urothe…
View article: Decisional conflicts of male patients undergoing Assisted Reproductive Technology: a qualitative study
Decisional conflicts of male patients undergoing Assisted Reproductive Technology: a qualitative study Open
View article: The Obesity–MASLD–Myopenia Cascade: A Dynamic Loop within Metabolic Metamorphosis in Liver Disease
The Obesity–MASLD–Myopenia Cascade: A Dynamic Loop within Metabolic Metamorphosis in Liver Disease Open
Summary Background & Aims The metabolic interplay between obesity and myopenia (MP) in chronic liver disease (CLD) remains poorly understood. We investigated whether progressive liver dysfunction mediates an obesity–MASLD (metabolic dysfun…
View article: Carbon-Ion Radiotherapy for Prostate Cancer in Patients with a History of Surgery for Benign Prostatic Hyperplasia
Carbon-Ion Radiotherapy for Prostate Cancer in Patients with a History of Surgery for Benign Prostatic Hyperplasia Open
Background/Objectives: Carbon-ion radiotherapy (CIRT) offers precise dose distribution and enhanced biological effectiveness in localized prostate cancer. However, the safety of CIRT in patients with a history of surgery for benign prostat…
View article: Initial report of prospective study of regional cooperation for imaging-based follow-up after curative renal cell carcinoma surgery
Initial report of prospective study of regional cooperation for imaging-based follow-up after curative renal cell carcinoma surgery Open
Late recurrence of renal cell carcinoma (RCC) is observed in some postoperative patients. In addition, some of these patients do not continue postoperative follow-up. Improving the regular follow-up process for the increased convenience of…
View article: Extracellular Vesicles From Prostate Cancer‐Corrupted Osteoclasts Drive a Chain Reaction of Inflammatory Osteolysis and Tumour Progression at the Bone Metastatic Site
Extracellular Vesicles From Prostate Cancer‐Corrupted Osteoclasts Drive a Chain Reaction of Inflammatory Osteolysis and Tumour Progression at the Bone Metastatic Site Open
Advanced‐stage prostate cancer (PCa) frequently causes bone metastases, resulting in a poor prognosis and a 5‐year survival rate of 30%. PCa bone metastasis is a highly complex and fluctuating process, comprising of osteolytic (bone‐degrad…
View article: The Role of Serum Testosterone in the Pathogenesis and Treatment of Prostate Cancer: A Review Based on the Clinical Evidence
The Role of Serum Testosterone in the Pathogenesis and Treatment of Prostate Cancer: A Review Based on the Clinical Evidence Open
Serum testosterone plays a pivotal role in the pathogenesis and treatment of prostate cancer, influencing tumor growth and progression. This review synthesizes current clinical evidence on the dual role of serum testosterone as both a biom…
View article: LHRH Antagonists Restore Serum Testosterone Faster Than LHRH Agonists in Prostate Cancer Patients After Radiotherapy
LHRH Antagonists Restore Serum Testosterone Faster Than LHRH Agonists in Prostate Cancer Patients After Radiotherapy Open
Introduction Maintaining a castration level of testosterone (TST) during radiation therapy combined with androgen deprivation therapy (ADT) is an essential strategy in the treatment of prostate cancer; however, hypogonadism can cause vario…
View article: Author Correction: The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2
Author Correction: The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2 Open
View article: Novel FBN1 intron variant causes isolated ectopia lentis via in-frame exon skipping
Novel FBN1 intron variant causes isolated ectopia lentis via in-frame exon skipping Open
View article: Development of Novel Nomograms to Predict 5- and 7-Year Biochemical-Recurrence-Free Survival in High-Risk Prostate Cancer Patients After Carbon-Ion Radiotherapy and Androgen Deprivation Therapy
Development of Novel Nomograms to Predict 5- and 7-Year Biochemical-Recurrence-Free Survival in High-Risk Prostate Cancer Patients After Carbon-Ion Radiotherapy and Androgen Deprivation Therapy Open
Background: The aim of this study was to develop nomograms predicting 5- and 7-year biochemical-recurrence (BCR)-free survival in high-risk prostate cancer (PCa) patients treated with carbon-ion radiotherapy (CIRT) and androgen deprivation…
View article: A Phase I/II Study of Ultra-Hypofractionated Carbon-ion Radiation therapy for Low- and Intermediate-Risk Localized Prostate Cancer
A Phase I/II Study of Ultra-Hypofractionated Carbon-ion Radiation therapy for Low- and Intermediate-Risk Localized Prostate Cancer Open
View article: The Regulation and Function of the Amino Acid Transporters LAT1, ASCT2, xCT in Urological Cancers
The Regulation and Function of the Amino Acid Transporters LAT1, ASCT2, xCT in Urological Cancers Open
Amino acid transporters play pivotal roles in cancer biology, including in urological cancers. Among them, L-type amino acid transporter 1 (LAT1), alanine-serine-cysteine transporter 2 (ASCT2), and cystine-glutamate transporter (xCT) have …
View article: Genetic and Clinical Characteristics of Japanese Cystinuria with Exon and Exon-Intron Boundary Variants
Genetic and Clinical Characteristics of Japanese Cystinuria with Exon and Exon-Intron Boundary Variants Open
Cystinuria is the most common genetic cause of urinary stones. Defect in SLC3A1/SLC7A9 genes coding cystine transporter proteins rBAT/b0,+AT will cause Cystinuria. The current work analyzed the clinical and genetics characterist…
View article: Machine learning analysis for detecting late recurrence and loss to follow‐up after renal cell carcinoma surgery
Machine learning analysis for detecting late recurrence and loss to follow‐up after renal cell carcinoma surgery Open
Objectives Renal cell carcinoma (RCC) is shown to have a tendency for late recurrence, occurring 5 or more years after curative surgery. Imaging diagnosis is required for follow‐up, and there is no definitive answer as to how long this sho…
View article: TNFSF9 Is Associated with Favorable Tumor Immune Microenvironment in Patients with Renal Cell Carcinoma Who Are Treated with the Combination Therapy of Nivolumab and Ipilimumab
TNFSF9 Is Associated with Favorable Tumor Immune Microenvironment in Patients with Renal Cell Carcinoma Who Are Treated with the Combination Therapy of Nivolumab and Ipilimumab Open
Combination therapy of nivolumab and ipilimumab (NIVO + IPI) for metastatic renal cell carcinoma (mRCC) has shown efficacy, but approximately 20% of patients experience disease progression in the early stages of treatment. No useful biomar…
View article: PSA doubling time 4.65 months as an optimal cut-off of Japanese nonmetastatic castration-resistant prostate cancer
PSA doubling time 4.65 months as an optimal cut-off of Japanese nonmetastatic castration-resistant prostate cancer Open
View article: Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy
Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy Open
View article: A PHASE I/II STUDY OF ULTRA-HYPO-FRACTIONATED CARBON-ION RADIOTHERAPY FOR LOW- AND INTERMEDIATE-RISK LOCALIZED PROSTATE CANCER
A PHASE I/II STUDY OF ULTRA-HYPO-FRACTIONATED CARBON-ION RADIOTHERAPY FOR LOW- AND INTERMEDIATE-RISK LOCALIZED PROSTATE CANCER Open
View article: Association Between Residual Urine Volume and Recurrence Among Patients at High Risk of Non-Muscle-Invasive Bladder Carcinoma With Versus Without Bacillus Calmette-Guérin Treatment
Association Between Residual Urine Volume and Recurrence Among Patients at High Risk of Non-Muscle-Invasive Bladder Carcinoma With Versus Without Bacillus Calmette-Guérin Treatment Open
View article: The <scp>LAT1</scp> inhibitor <scp>JPH203</scp> suppresses the growth of castration‐resistant prostate cancer through a <scp>CD24</scp>‐mediated mechanism
The <span>LAT1</span> inhibitor <span>JPH203</span> suppresses the growth of castration‐resistant prostate cancer through a <span>CD24</span>‐mediated mechanism Open
L‐type amino acid transporter 1 (LAT1) is specifically expressed in many malignancies, contributes to the transport of essential amino acids, such as leucine, and regulates the mammalian target of rapamycin (mTOR) signaling pathway. We inv…
View article: PSA Doubling Time 4.65 months as an Optimal Cut-off of Japanese Nonmetastatic Castration-Resistant Prostate Cancer: Multi-institutional Study of Japanese Urological Oncology Group (JUOG)
PSA Doubling Time 4.65 months as an Optimal Cut-off of Japanese Nonmetastatic Castration-Resistant Prostate Cancer: Multi-institutional Study of Japanese Urological Oncology Group (JUOG) Open
A multicenter study of nonmetastatic castration-resistant prostate cancer (nmCRPC) was conducted to examine the prognostic to identify the optimal cut-off value of prostate-specific antigen (PSA) doubling time (PSADT) in Japanese nmCRPC. O…
View article: TNFSF9 is associated with favor tumor immune microenvironment in patients with renal cell carcinoma who are treated with the combination therapy of nivolumab and ipilimumab
TNFSF9 is associated with favor tumor immune microenvironment in patients with renal cell carcinoma who are treated with the combination therapy of nivolumab and ipilimumab Open
Combination therapy of nivolumab and ipilimumab (NIVO + IPI) for metastatic renal cell carcinoma (mRCC) has shown efficacy, but approximately 20% of patients experience disease progression in the early stages of treatment. No useful biomar…
View article: A phase 1/2 study of NS-87/CPX-351 (cytarabine and daunorubicin liposome) in Japanese patients with high-risk acute myeloid leukemia
A phase 1/2 study of NS-87/CPX-351 (cytarabine and daunorubicin liposome) in Japanese patients with high-risk acute myeloid leukemia Open
View article: Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy
Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy Open
The prognostic significance of unconventional histology (UH) subtypes including intraductal carcinoma of the prostate (IDC-P), ductal adenocarcinoma, and cribriform pattern has been investigated for prostate cancer (PCa). However, little i…
View article: Novel nerve-sparing robot-assisted radical prostatectomy with endopelvic fascia preservation and long-term outcomes for a single surgeon
Novel nerve-sparing robot-assisted radical prostatectomy with endopelvic fascia preservation and long-term outcomes for a single surgeon Open
View article: L‐type amino acid transporter 1 inhibitor <scp>JPH203</scp> prevents the growth of cabazitaxel‐resistant prostate cancer by inhibiting cyclin‐dependent kinase activity
L‐type amino acid transporter 1 inhibitor <span>JPH203</span> prevents the growth of cabazitaxel‐resistant prostate cancer by inhibiting cyclin‐dependent kinase activity Open
L‐type amino acid transporter 1 (LAT1, SLC7A5 ) is an amino acid transporter expressed in various carcinomas, and it is postulated to play an important role in the proliferation of cancer cells through the uptake of essential amino acids. …
View article: Beyond 2D: A scalable and highly sensitive method for a comprehensive 3D analysis of kidney biopsy tissue
Beyond 2D: A scalable and highly sensitive method for a comprehensive 3D analysis of kidney biopsy tissue Open
The spatial organization of various cell populations is critical for the major physiological and pathological processes in the kidneys. Most evaluation of these processes typically comes from a conventional 2D tissue cross-section, visuali…
View article: Summary of the Clinical Practice Guidelines for Upper Tract Urothelial Carcinoma 2023 by the Japanese Urological Association
Summary of the Clinical Practice Guidelines for Upper Tract Urothelial Carcinoma 2023 by the Japanese Urological Association Open
This article is an English translation of the Clinical Practice Guidelines for Upper Tract Urothelial Carcinoma (2nd edition) published in June 2023. The Japanese Urological Association's (JUA) Guidelines Committee on Upper Tract Urothelia…
View article: Challenges in the diagnosis of the enigmatic primary adrenal leiomyosarcoma: two case reports and review of the literature
Challenges in the diagnosis of the enigmatic primary adrenal leiomyosarcoma: two case reports and review of the literature Open