Tomohiro Aoki
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View article: Mechanisms of Intracranial Aneurysm Rupture: An Integrative Review of Experimental and Clinical Evidence
Mechanisms of Intracranial Aneurysm Rupture: An Integrative Review of Experimental and Clinical Evidence Open
Background: Intracranial aneurysm (IA) rupture is a devastating event in neurosurgery and a leading cause of subarachnoid hemorrhage. Although aneurysm size has been traditionally emphasized, recent research has highlighted multifactorial …
View article: Correction: JNK2-MMP-9 axis facilitates the progression of intracranial aneurysms
Correction: JNK2-MMP-9 axis facilitates the progression of intracranial aneurysms Open
View article: Modified Intracranial Aneurysm Rupture Rat Model with Angiographic Imaging
Modified Intracranial Aneurysm Rupture Rat Model with Angiographic Imaging Open
Intracranial aneurysms (IAs) are a major cause of spontaneous subarachnoid hemorrhage (SAH) and are associated with high morbidity and mortality. Current IA rodent models often exhibit low rupture rates and limited imaging capabilities, re…
View article: Exploratory analyses of factors related to 5-aminolevulinic acid-induced intraoperative hypotension during malignant glioma surgery via literature review
Exploratory analyses of factors related to 5-aminolevulinic acid-induced intraoperative hypotension during malignant glioma surgery via literature review Open
View article: 311 | OUTCOMES OF PATIENTS WITH PRIMARY REFRACTORY AND EARLY RELAPSING LARGE B CELL LYMPHOMA ARE INFERIOR IN THE CD19 CAR T CELL THERAPY ERA
311 | OUTCOMES OF PATIENTS WITH PRIMARY REFRACTORY AND EARLY RELAPSING LARGE B CELL LYMPHOMA ARE INFERIOR IN THE CD19 CAR T CELL THERAPY ERA Open
View article: 761 | SURVIVAL OUTCOMES IN NODAL PERIPHERAL T‐CELL LYMPHOMA FOLLOWING PRIMARY AND SECOND‐LINE TREATMENT: AN AUSTRALASIAN‐CANADIAN COLLABORATIVE STUDY
761 | SURVIVAL OUTCOMES IN NODAL PERIPHERAL T‐CELL LYMPHOMA FOLLOWING PRIMARY AND SECOND‐LINE TREATMENT: AN AUSTRALASIAN‐CANADIAN COLLABORATIVE STUDY Open
View article: 390 | END‐OF‐TREATMENT PET/CT COMPLETE REMISSION IS HIGHLY PROGNOSTIC IN NODAL PERIPHERAL T‐CELL LYMPHOMA: AN AUSTRALASIAN‐CANADIAN COLLABORATIVE STUDY
390 | END‐OF‐TREATMENT PET/CT COMPLETE REMISSION IS HIGHLY PROGNOSTIC IN NODAL PERIPHERAL T‐CELL LYMPHOMA: AN AUSTRALASIAN‐CANADIAN COLLABORATIVE STUDY Open
View article: 309 | IMPACT OF AGE ON TREATMENT DECISIONS AND OUTCOMES IN RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA
309 | IMPACT OF AGE ON TREATMENT DECISIONS AND OUTCOMES IN RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA Open
View article: 328 | INTENTION‐TO‐TREATMENT ANALYSIS OF THIRD LINE CAR‐T FOR RELAPSE/REFRACTORY LARGE B CELL LYMPHOMA
328 | INTENTION‐TO‐TREATMENT ANALYSIS OF THIRD LINE CAR‐T FOR RELAPSE/REFRACTORY LARGE B CELL LYMPHOMA Open
View article: 454 | ASSOCIATION OF BRIDGING THERAPY WITH RESPONSE AND OUTCOMES IN PATIENTS WITH RELAPSED/REFRACTORY LARGE B CELL LYMPHOMA RECEIVING THIRD LINE CAR‐T
454 | ASSOCIATION OF BRIDGING THERAPY WITH RESPONSE AND OUTCOMES IN PATIENTS WITH RELAPSED/REFRACTORY LARGE B CELL LYMPHOMA RECEIVING THIRD LINE CAR‐T Open
View article: 735 | OUTCOMES IN DOUBLE‐EXPOSED CLASSICAL HODGKIN LYMPHOMA: IMPACT OF TREATMENT SEQUENCE AND SALVAGE STRATEGIES AFTER BRENTUXIMAB VEDOTIN AND CHECKPOINT INHIBITOR FAILURE
735 | OUTCOMES IN DOUBLE‐EXPOSED CLASSICAL HODGKIN LYMPHOMA: IMPACT OF TREATMENT SEQUENCE AND SALVAGE STRATEGIES AFTER BRENTUXIMAB VEDOTIN AND CHECKPOINT INHIBITOR FAILURE Open
View article: Distinct characteristics and social determinants in adult T‐cell leukaemia/lymphoma patients at a tertiary cancer centre in Canada
Distinct characteristics and social determinants in adult T‐cell leukaemia/lymphoma patients at a tertiary cancer centre in Canada Open
Summary Adult T‐cell leukaemia/lymphoma (ATLL) is a rare, aggressive haematological malignancy linked to human T‐cell leukaemia virus type I (HTLV‐1) and associated with poor outcomes. Despite its higher prevalence in HTLV‐1‐endemic region…
View article: Enhanced intracranial aneurysm development in a rat model of polycystic kidney disease
Enhanced intracranial aneurysm development in a rat model of polycystic kidney disease Open
Aims Polycystic kidney disease (PKD) patients have a high intracranial aneurysms (IAs) incidence and risk of rupture. The mechanisms that make PKD patients more vulnerable to IA disease are still not completely understood. The PCK rat is a…
View article: JNK2-MMP-9 axis facilitates the progression of intracranial aneurysms
JNK2-MMP-9 axis facilitates the progression of intracranial aneurysms Open
View article: Enhanced intracranial aneurysm development in a rat model of polycystic kidney disease
Enhanced intracranial aneurysm development in a rat model of polycystic kidney disease Open
Background Polycystic kidney disease (PKD) patients have a high intracranial aneurysms (IAs) incidence and risk of rupture. The mechanisms that make PKD patients more vulnerable to IA disease are still not completely understood. The PCK ra…
View article: C5a–C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms
C5a–C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms Open
View article: Time-of-flight and black-blood MRI to study intracranial arteries in rats
Time-of-flight and black-blood MRI to study intracranial arteries in rats Open
Intracranial aneurysms (IAs) are usually incidentally discovered by magnetic resonance imaging (MRI). Once discovered, the risk associated with their treatment must be balanced with the risk of an unexpected rupture. Although clinical obse…
View article: Application of deep neural survival networks to the development of risk prediction models for diabetes mellitus, hypertension, and dyslipidemia
Application of deep neural survival networks to the development of risk prediction models for diabetes mellitus, hypertension, and dyslipidemia Open
Objectives : Although numerous risk prediction models have been proposed, few such models have been developed using neural network-based survival analysis. We developed risk prediction models for three cardiovascular disease risk factors (…
View article: Hemodynamic force as a potential regulator of inflammation-mediated focal growth of saccular aneurysms in a rat model
Hemodynamic force as a potential regulator of inflammation-mediated focal growth of saccular aneurysms in a rat model Open
【背景】過去の研究より,脳動脈瘤増大機序において,マクロファージ依存的な慢性炎症が,重大な役割を果たしていることが明らかにされてきた.血行力学応力もまた,脳動脈瘤増大のトリガーであることが考えられてきたが,その機序は明らかにされていない.
View article: Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm
Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm Open
Subarachnoid hemorrhage being the rupture of intracranial aneurysm (IA) as a major cause has quite poor prognosis, despite the modern technical advances. Thereby, the mechanisms underlying the rupture of lesions should be clarified. Recent…
View article: Supplementary Figure S3 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Supplementary Figure S3 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Supplementary Figure S3. TLR2 specific response by LTA.
View article: Supplementary Figure S1 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Supplementary Figure S1 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Supplementary Figure S1. Fecal bacterial analysis.
View article: Supplementary Figure S7 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Supplementary Figure S7 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Supplementary Figure S7. Lipidomics analysis revealed that PGs accumulate in the liver tumor areas.
View article: Supplementary Figure S5 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Supplementary Figure S5 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Supplementary Figure S5. DCA and LTA promote obesity-associated HCC.
View article: Supplementary Figure S9 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Supplementary Figure S9 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Supplementary Figure S9. EP4 antagonist inhibit the growth of HFD-induced liver cancer.
View article: Supplementary Figure S6 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Supplementary Figure S6 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Supplementary Figure S6. Histopathology analysis of liver cancer.
View article: Supplementary Figure S8 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Supplementary Figure S8 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Supplementary Figure S8. The analysis of cells in the liver of DMBA-treated, HFD-fed mice.
View article: Data from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Data from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Obesity increases the risk of cancers, including hepatocellular carcinomas (HCC). However, the precise molecular mechanisms through which obesity promotes HCC development are still unclear. Recent studies have shown that gut microbiota may…
View article: Supplementary Figure S10 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Supplementary Figure S10 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Supplementary Figure S10. The representative H&E staining photographs of human NASH-associated HCC.
View article: Supplementary Figure S4 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity
Supplementary Figure S4 from Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE<sub>2</sub>-Mediated Suppression of Antitumor Immunity Open
Supplementary Figure S4. DCA and LTA promote obesity-associated HCC.