Tomohiro Ueda
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View article: Primary Neuroendocrine Carcinoma of the Anal Canal with Cancer Genome Profiling
Primary Neuroendocrine Carcinoma of the Anal Canal with Cancer Genome Profiling Open
Primary neuroendocrine carcinoma (NEC) of the anal canal is a rare, highly malignant tumor with a poor prognosis. Despite the standard first-line treatment with etoposide or irinotecan combined with cisplatin, effective second-line therapi…
View article: Feasibility of direct brain <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography attenuation and high-resolution correction methods using deep learning.
Feasibility of direct brain <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography attenuation and high-resolution correction methods using deep learning. Open
The direct+HRC method enables accurate attenuation without CT exposure and high-resolution correction without dedicated correction programs.
View article: OCCURRENCE OF HYPOXIC WATER MASSES CAUSED BY THE LARGE-SCALE FRESH WATER OUTFLOWS IN THE ARIAKE BAY IN 2020 AND 2021
OCCURRENCE OF HYPOXIC WATER MASSES CAUSED BY THE LARGE-SCALE FRESH WATER OUTFLOWS IN THE ARIAKE BAY IN 2020 AND 2021 Open
有明海における貧酸素水塊の空間分布を把握するために,2020年と2021年夏季に多機関が連携して一斉観測が行われた.2020年と2021年のいずれも有明海湾奥から諫早湾にかけて貧酸素水塊が形成されていた.また,2021年では出水前後で貧酸素水塊の分布を把握できており,大規模な出水により貧酸素水塊の分布面積が2倍程度になることが明らかになった.さらに,大規模な出水による密度成層の継続は1ヶ月程度と算出され,これは貧酸素化の時間スケールよりも長かった.大規模な出水によって長期間…
View article: Female pelvic organ‐preserving robot‐assisted simple cystectomy and intracorporeal ileal neobladder reconstruction on a young woman with Hunner‐type interstitial cystitis
Female pelvic organ‐preserving robot‐assisted simple cystectomy and intracorporeal ileal neobladder reconstruction on a young woman with Hunner‐type interstitial cystitis Open
Introduction Cystectomy is the last treatment option for Hunner‐type interstitial cystitis. However, consensus regarding optimal patient selection or treatment approaches is lacking. Case presentation A 27‐year‐old woman presented to a reg…
View article: Summary of the 2023 report of the international consultation on incontinence interstitial cystitis/bladder pain syndrome (IC/BPS) committee
Summary of the 2023 report of the international consultation on incontinence interstitial cystitis/bladder pain syndrome (IC/BPS) committee Open
Interstitial cystitis and bladder pain syndrome are essentially interchangeable as there is no accepted definition that clearly delineates the interstitial cystitis syndrome from bladder pain syndrome. IC/BPS is generally agreed to be defi…
View article: Effect of febuxostat on the level of malondialdehyde‐modified low‐density lipoprotein, an oxidative stress marker: A subanalysis of the PRIZE study
Effect of febuxostat on the level of malondialdehyde‐modified low‐density lipoprotein, an oxidative stress marker: A subanalysis of the PRIZE study Open
Background Febuxostat is a selective xanthine oxidase inhibitor that reportedly exhibits antioxidant properties. We previously performed a multicentre, randomized controlled (PRIZE) study for vascular evaluation under uric acid (UA) contro…
View article: Reply to “Interstitial Cystitis – A Consequence of Weakened Uterosacral Ligaments Failing to Support Visceral Plexuses and Bladder Stretch Receptors and Therefore Potentially Curable?”
Reply to “Interstitial Cystitis – A Consequence of Weakened Uterosacral Ligaments Failing to Support Visceral Plexuses and Bladder Stretch Receptors and Therefore Potentially Curable?” Open
See the letter "Interstitial Cystitis: A Consequence of Weakened Uterosacral Ligaments Failing to Support Visceral Plexuses and Bladder Stretch Receptors, and Therefore Potentially Curable?" on page 349.
View article: Role and Potential Mechanism of Heme Oxygenase-1 in Intestinal Ischemia-Reperfusion Injury
Role and Potential Mechanism of Heme Oxygenase-1 in Intestinal Ischemia-Reperfusion Injury Open
Intestinal ischemia-reperfusion (IR) injury is a complex, multifactorial, and pathophysiological condition with high morbidity and mortality, leading to serious difficulties in treatment, especially in humans. Heme oxygenase (HO) is the ra…
View article: Effect of Anagliptin versus Sitagliptin on Renal Function: Subanalyzes from the REASON Trial
Effect of Anagliptin versus Sitagliptin on Renal Function: Subanalyzes from the REASON Trial Open
Hiroki Teragawa,1 Takeshi Morimoto,2 Yuichi Fujii,1 Tomohiro Ueda,1 Mio Sakuma,2 Michio Shimabukuro,3 Osamu Arasaki,4 Koichi Node,5 Takashi Nomiyama,6 Shinichiro Ueda7 1Department of Cardiovascular Medicine, JR Hiroshima Hospital, Hiroshim…
View article: Time until onset of acute kidney injury by combination therapy with “Triple Whammy” drugs obtained from Japanese Adverse Drug Event Report database
Time until onset of acute kidney injury by combination therapy with “Triple Whammy” drugs obtained from Japanese Adverse Drug Event Report database Open
Acute kidney injury (AKI) associated with “Triple Whammy” drug therapy consisting of renin-angiotensin system inhibitors, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs) has been reported. There have been no reports investigat…
View article: The O'Leary‐Sant Interstitial Cystitis Symptom Index is a clinically useful indicator of treatment outcome in patients with interstitial cystitis/bladder pain syndrome with Hunner lesions: A post hoc analysis of the Japanese phase III trial of KRP‐116D, 50% dimethyl sulfoxide solution
The O'Leary‐Sant Interstitial Cystitis Symptom Index is a clinically useful indicator of treatment outcome in patients with interstitial cystitis/bladder pain syndrome with Hunner lesions: A post hoc analysis of the Japanese phase III trial of KRP‐116D, 50% dimethyl sulfoxide solution Open
Objectives To evaluate the efficacy of intravesical KRP‐116D, 50% dimethyl sulfoxide solution, in interstitial cystitis/bladder pain syndrome patients with Hunner lesions (Hunner‐type interstitial cystitis), and to evaluate the correlation…
View article: Current Understanding and Future Perspectives of Interstitial Cystitis/Bladder Pain Syndrome
Current Understanding and Future Perspectives of Interstitial Cystitis/Bladder Pain Syndrome Open
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic disease characterized by suprapubic pain and lower urinary tract symptoms. Perhaps because of the heterogeneous nature of this disease and its multifactorial etiology, clini…
View article: Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis
Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis Open
PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles.
View article: Efficacy and safety of intravesical instillation of KRP‐116D (50% dimethyl sulfoxide solution) for interstitial cystitis/bladder pain syndrome in Japanese patients: A multicenter, randomized, double‐blind, placebo‐controlled, clinical study
Efficacy and safety of intravesical instillation of KRP‐116D (50% dimethyl sulfoxide solution) for interstitial cystitis/bladder pain syndrome in Japanese patients: A multicenter, randomized, double‐blind, placebo‐controlled, clinical study Open
Objective To evaluate the efficacy and safety of intravesical KRP‐116D, 50% dimethyl sulfoxide solution compared with placebo, in interstitial cystitis/bladder pain syndrome patients. Methods Japanese interstitial cystitis/bladder pain syn…
View article: Usefulness of Cognitive Function Evaluation Using an Inhibition Task for Community-dwelling Elderly
Usefulness of Cognitive Function Evaluation Using an Inhibition Task for Community-dwelling Elderly Open
〔目的〕加齢に伴う認知機能の低下を早期から検出し得る可能性について検証するため，抑制機能課題を高齢者と健常若年者に実施して，脳神経活動や神経機能的連関性を比較した．〔対象と方法〕対象は若年者10名と高齢者6名とした．方法は，視覚性3刺激オドボール課題を用いてERP成分を算出し，eLORETAを用いて解析した．〔結果〕抑制機能実行時は，高齢者が右側頭極や右前頭極，若年者が左楔前部や左眼窩前頭皮質を中心とした脳神経活動性を認めた．また，神経機能的連関性は高齢者と若年者の間に差異…
View article: <p>Effect of Anagliptin versus Sitagliptin on Inflammatory Markers: Sub-Analysis from the REASON Trial</p>
Effect of Anagliptin versus Sitagliptin on Inflammatory Markers: Sub-Analysis from the REASON Trial Open
In this sub-analysis from the REASON Trial, taking a DPP-4 inhibitor, either ANA or SITA, for 52 weeks did not affect the levels of inflammatory markers.
View article: Comments to Editorial by J. Curtis Nickel. It is premature to categorize Hunner lesion interstitial cystitis as a distinct disease entity. <i>Scandinavian Journal of Urology</i> 2020, Vol. 54, No. 2, 99–100; https://doi.org/10.1080/21681805.2020.1744714
Comments to Editorial by J. Curtis Nickel. It is premature to categorize Hunner lesion interstitial cystitis as a distinct disease entity. <i>Scandinavian Journal of Urology</i> 2020, Vol. 54, No. 2, 99–100; https://doi.org/10.1080/21681805.2020.1744714 Open
"Comments to Editorial by J. Curtis Nickel. It is premature to categorize Hunner lesion interstitial cystitis as a distinct disease entity. Scandinavian Journal of Urology 2020, Vol. 54, No. 2, 99–100; https://doi.org/10.1080/21681805.2020…
View article: Hunner lesion disease differs in diagnosis, treatment and outcome from bladder pain syndrome: an ESSIC working group report
Hunner lesion disease differs in diagnosis, treatment and outcome from bladder pain syndrome: an ESSIC working group report Open
Objectives: There is confusion about the terms of bladder pain syndrome (BPS) and Interstitial Cystitis (IC). The European Society for the Study of IC (ESSIC) classified these according to objective findings [9]. One phenotype, Hunner lesi…
View article: Supplementary Material for: Efficacy and Feasibility of Magnifying Blue Laser Imaging without Biopsy Confirmation for the Diagnosis of the Demarcation of Gastric Tumors: A Randomized Controlled Study
Supplementary Material for: Efficacy and Feasibility of Magnifying Blue Laser Imaging without Biopsy Confirmation for the Diagnosis of the Demarcation of Gastric Tumors: A Randomized Controlled Study Open
Background: Accurate diagnosis of the demarcation line (DL) of gastric tumors is essential for curative complete resection by endoscopic submucosal dissection (ESD). It is controversial to perform only magnifying endoscopy for diagnosing t…
View article: A case of inhaled nitric oxide (NO) effect on the hemodynamics and oxygenation decrease in endotracheal hemorrhage during extracorporeal circulatory surgery
A case of inhaled nitric oxide (NO) effect on the hemodynamics and oxygenation decrease in endotracheal hemorrhage during extracorporeal circulatory surgery Open
体外循環を行う手術における気管内出血は致命的となることがある。Nitric oxide（NO）吸入は，健常な肺胞の血管を選択的に拡張し，肺血管抵抗低下・換気血流比を改善し，酸素化の改善が期待される。症例は66歳の男性。胸部大動脈瘤に対し全弓部大動脈置換術を行った。人工心肺離脱直後に気管内チューブより多量の出血を認めた。右気管支からの出血であり，肺動脈カテーテルによる肺動脈損傷が疑われた。酸素化不良，血圧低下が持続したため，extracorporeal membrane ox…
View article: Development of a “Knot Tying Test”, a new method to evaluate the upper-extremity function
Development of a “Knot Tying Test”, a new method to evaluate the upper-extremity function Open
本研究は，新たに考案した上肢機能評価法「ひも結びテスト」について，再現性のある測定結果を得るための試行回数および既存の上肢機能評価法との関連を検討した。対象は女性大学生20名（20．5±1．1歳）とし，ひも結びテスト（5回測定），ペグテスト，握力の測定を行った。その結果，ひも結びテストの測定値は2回目以降に安定し，2回目と3回目の測定値から算出した級内相関係数は0．78と良好な再現性を示した。また，ひも結びテストは上肢巧緻性の指標であるペグテストと有意な相関関係を認めた（r…
View article: Quantitative evaluation using single-photon emission computed tomography with acetazolamide is reliable for preoperative evaluation before cardiac surgery in severe carotid intracranial artery stenotic and/or occlusive disease: a case report
Quantitative evaluation using single-photon emission computed tomography with acetazolamide is reliable for preoperative evaluation before cardiac surgery in severe carotid intracranial artery stenotic and/or occlusive disease: a case report Open
Preoperative quantitative evaluation using brain perfusion SPECT with acetazolamide is useful in assessing hemodynamic cerebrovascular risk in patients with severe obstructive CIAD. Off pump coronary artery bypass grafting with intra aorti…
View article: Suplatast tosilate in patients with interstitial cystitis: Efficacy and treatment possibilities, with suggestions for future assessments
Suplatast tosilate in patients with interstitial cystitis: Efficacy and treatment possibilities, with suggestions for future assessments Open
Objective Suplatast tosilate, a Th2 cytokine inhibitor, was predicted to relieve interstitial cystitis symptoms. Four studies with suplatast tosilate in Japanese interstitial cystitis patients have been conducted: a single‐arm clinical stu…
View article: Low bladder capacity is an important predictor for comorbidity of interstitial cystitis with Hunner's lesion in patients with refractory chronic prostatitis/chronic pelvic pain syndrome
Low bladder capacity is an important predictor for comorbidity of interstitial cystitis with Hunner's lesion in patients with refractory chronic prostatitis/chronic pelvic pain syndrome Open
Objective To evaluate the predictive factors for comorbidity of Hunner‐type interstitial cystitis in patients with chronic prostatitis/chronic pelvic pain syndrome using urethrocystoscopy. Methods Thirty‐two male patients were included in …
View article: Administration of live, but not inactivated, Faecalibacterium�prausnitzii has a preventive effect on dextran sodium sulfate‑induced colitis in mice
Administration of live, but not inactivated, Faecalibacterium�prausnitzii has a preventive effect on dextran sodium sulfate‑induced colitis in mice Open
Faecalibacterium prausnitzii is one of the most abundant bacteria in the human gut microbiota. This bacterium is reported to serve an important role in inflammatory bowel diseases. In the present study, the preventive effects of F. prausni…
View article: Effect of Hand and Foot Massage Therapy on Psychological Factors and EEG Activity in Elderly People Requiring Long-Term Care: A Randomized Cross-Over Study
Effect of Hand and Foot Massage Therapy on Psychological Factors and EEG Activity in Elderly People Requiring Long-Term Care: A Randomized Cross-Over Study Open
Massage therapy is widely used as a complementary therapy in the elderly. Here, we investigate the effect of hand and foot massage therapy on psychological factors and electroencephalographic (EEG) activity in elderly people requiring long…
View article: Influence of Inhibition Tasks on Brain Activities in Cognitive Function Assessed Using a Stop Signal Task
Influence of Inhibition Tasks on Brain Activities in Cognitive Function Assessed Using a Stop Signal Task Open
〔目的〕健常者における抑制課題実行時の脳神経活動を，脳内情報処理過程が反映される脳波解析により時間的，空間的な側面から脳神経活動部位および神経機能的連関性の両者について検討した．〔対象と方法〕対象は健常男子学生20名とした．方法は視覚性3刺激オドボール課題を用いて，脳波ERP成分をLORETAにて解析した．〔結果〕抑制課題実行時は左楔前部，左眼窩前頭皮質に有意に高い神経活動を認めた．さらに，左前頭極，左運動前野および左下頭頂小葉の三領域に抑制課題実行時に有意に強い神経機能的…
View article: The Effects of Foot Massage on Mental and Physical Functions
The Effects of Foot Massage on Mental and Physical Functions Open
We examined the effects of foot massage on healthy adult females’ mental and physical functions by electroencephalography as an emotional assessment method. We randomized 20 healthy adult females into 2 groups receiving a massage by a ther…
View article: Effects of Odor of Hair Color Products on Psycho-physiological Index
Effects of Odor of Hair Color Products on Psycho-physiological Index Open
The objective of this study was to investigate and understand brain activities and mental state of humans in response to odors. On the 10 healthy adults with no neurological abnormalities electroencephalography was performed to analyze the…