Tomoki Kobayashi
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View article: Retrospective study on clinical value and optimal use of [18F] FDG PET/CT for inflammation of unknown origin in Japanese patients
Retrospective study on clinical value and optimal use of [18F] FDG PET/CT for inflammation of unknown origin in Japanese patients Open
Despite advancements in medical technology, the challenges of diagnosing fever of unknown origin (FUO) and inflammation of unknown origin (IUO) persist. Positron emission tomography/computed tomography (PET/CT) has been used to assess thes…
View article: Gout with Marked Ulnar Deviation Imitating Rheumatoid Arthritis
Gout with Marked Ulnar Deviation Imitating Rheumatoid Arthritis Open
View article: Supplementary Material for: Early phase partial Mayo score following golimumab treatment is associated with endoscopic improvement at 1-year in ulcerative colitis; A post hoc analysis of PURSUIT-J randomized controlled trial
Supplementary Material for: Early phase partial Mayo score following golimumab treatment is associated with endoscopic improvement at 1-year in ulcerative colitis; A post hoc analysis of PURSUIT-J randomized controlled trial Open
Objective: Golimumab (GLM) is an anti-tumor necrosis factor-alpha antibody therapy for moderately to severely active ulcerative colitis (UC). Endoscopic improvement is considered one of UC treatment's main goals, and earlier prediction of …
View article: Complete Pathological Response of Hepatocellular Carcinoma with Portal Vein Thrombosis Treated with Sorafenib—Report of a Case—
Complete Pathological Response of Hepatocellular Carcinoma with Portal Vein Thrombosis Treated with Sorafenib—Report of a Case— Open
症例は56歳，男性．右季肋部痛を主訴に受診し，ダイナミックCTにて肝右葉に動脈相での早期濃染される直径84mmの腫瘍，および門脈右枝まで進展する門脈腫瘍栓を認めた．AFP・PIVKA-IIも高値であり肝細胞癌と診断，Vp3の門脈腫瘍栓を伴うため，ソラフェニブの投与が開始された．ソラフェニブ投与5カ月後のCTでは，肝右葉の腫瘍は直径50mmに縮小し，動脈相での早期濃染を認めなくなっていた．また，門脈右枝の腫瘍栓も縮小していた．しかし，重度の下痢のためソラフェニブの継続が困難と…
View article: Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma
Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma Open
We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. C…
View article: Two Patients with Paget-Schroetter Syndrome That Were Successfully Diagnosed by Doppler Ultrasonography: Case Studies with a Literature Review
Two Patients with Paget-Schroetter Syndrome That Were Successfully Diagnosed by Doppler Ultrasonography: Case Studies with a Literature Review Open
We herein report on two male patients (age, 22 and 44 years) who were referred to our department with swelling of the upper right arm after attending other hospitals. Right subclavian vein thrombosis was demonstrated by ultrasonography and…
View article: Mesh Infection after Laparoscopic Inguinal Hernia Repair—A Report of Two Cases—
Mesh Infection after Laparoscopic Inguinal Hernia Repair—A Report of Two Cases— Open
症例1は75歳，男性．両側鼠径ヘルニアに対して腹腔鏡下鼠径ヘルニア修復術を施行し，術後1年10カ月目に右鼠径部の疼痛と発熱を主訴に来院．CTで右鼠径部に膿瘍を認め，メッシュ関連膿瘍と診断しメッシュ除去とドレナージ術を施行した．術中にタッカーが2個遺残したことが原因と思われる難治性の術後遺残膿瘍が生じたが，抗菌療法により約2カ月で保存的に改善した．症例2は幼少期に右鼠径ヘルニアの手術歴がある55歳の男性で，右鼠径部痛を主訴に来院．CTで鼠径ヘルニアの再発と小腸の嵌頓を認めた．…
View article: A case of giant cell arteritis simultaneously diagnosed with chronic subdural hematoma
A case of giant cell arteritis simultaneously diagnosed with chronic subdural hematoma Open
Here, we describe a case of giant cell arteritis (GCA) simultaneously diagnosed with chronic subdural hematoma. In this case, head to chest computed tomography angiography was useful for the diagnosis and treatment of GCA.
View article: Hepatomesenteric-Type Variation of Hepatic Arterial Blood Flow Passing through the Pancreatic Head by Pancreaticoduodenectomy: Report of Two Cases
Hepatomesenteric-Type Variation of Hepatic Arterial Blood Flow Passing through the Pancreatic Head by Pancreaticoduodenectomy: Report of Two Cases Open
肝腸間膜動脈幹型かつ膵頭部実質内を肝動脈が貫通する膵頭部領域癌に対して血管を温存した膵頭十二指腸切除術を施行した2例を経験したので報告する．症例1は66歳の男性で，黄疸を主訴に来院し，精査で膵頭部癌の診断となった．肝腸間膜動脈幹から分岐する総肝動脈（common hepatic artery；以下，CHAと略記）が，膵頭部実質内を貫通していたが，腫瘍は離れていたため肝動脈を温存した根治術が可能と判断し，膵頭十二指腸切除を施行した．症例2は52歳の男性で，心窩部痛，黄疸を主訴…
View article: Pseudomyxoma Peritonei Arising from Mucinous Cystadenoma of the Urachus with Postoperative Disease-Free Survival over 15 Years
Pseudomyxoma Peritonei Arising from Mucinous Cystadenoma of the Urachus with Postoperative Disease-Free Survival over 15 Years Open
症例は58歳の男性で，腹部膨隆を主訴に当院を受診した．腹部CTにて多量の液体貯留と，膀胱頂部と連続する13 cm大の囊胞性腫瘤を認めた．腹腔穿刺でゼリー状の腹水が吸引され，尿膜管原発腫瘍に伴う腹膜偽粘液腫を疑い手術を施行した．手術所見では臍と膀胱に連続する囊胞性腫瘍と多量のゼリー状の粘液を認めた．腫瘍切除，広範囲腹膜切除で粘液物質の完全切除を施行し，その総重量は4.5 kgに達した．腹腔内注入用portを留置し術後にシスプラチン（CDDP）100 mgを2回注入した．病理組…
View article: Mo1499 – Deoxycholic Acid-Induced Senescent Hepatic Stellate Cells Promote Malignant Behaviors of Hepatocellular Carcinoma Cells: Implication to Underlying Mechanisms of Metabolic Syndrome-Based Fatty Liver and Carcinogenesis
Mo1499 – Deoxycholic Acid-Induced Senescent Hepatic Stellate Cells Promote Malignant Behaviors of Hepatocellular Carcinoma Cells: Implication to Underlying Mechanisms of Metabolic Syndrome-Based Fatty Liver and Carcinogenesis Open
View article: Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta<sup>+</sup>-thalassemia
Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta<sup>+</sup>-thalassemia Open
Acute chest syndrome (ACS), characterized by fever, respiratory symptoms, and new pulmonary infiltration, is a serious complication of sickle cell disease (SCD). Regardless of the etiology, the conventional treatment options for ACS includ…
View article: An Atypical Case of Non-asthmatic Eosinophilic Granulomatosis with Polyangiitis Finally Diagnosed by Tissue Biopsy
An Atypical Case of Non-asthmatic Eosinophilic Granulomatosis with Polyangiitis Finally Diagnosed by Tissue Biopsy Open
A 78-year-old woman with fever of unknown origin that had persisted for 3 months, systemic edema, and cervical lymphadenopathy was admitted to our hospital. Skin purpura and jaw claudication were subsequently observed. Histopathological ex…
View article: Evaluation of glycemic variability in chronic liver disease patients with type 2 diabetes mellitus using continuous glucose monitoring
Evaluation of glycemic variability in chronic liver disease patients with type 2 diabetes mellitus using continuous glucose monitoring Open
The CGM systems were useful in finding hidden abnormalities of blood glucose fluctuations in CLD patients with T2DM, especially in non-anemic CLD patients with HbA1c levels of < 7.0%.
View article: Five Cases of Familial Mediterranean Fever in Japan: The Relationship with <i>MEFV</i> Mutations
Five Cases of Familial Mediterranean Fever in Japan: The Relationship with <i>MEFV</i> Mutations Open
Familial Mediterranean fever (FMF) is the most common genetic autoinflammatory disease, but it has been considered a rare disease in Japan. We herein describe five patients with FMF who were diagnosed both clinically and genetically at a s…
View article: Primary Signet Ring Cell Carcinoma of Rectum Diagnosed by Boring Biopsy in Combination with Endoscopic Mucosal Resection
Primary Signet Ring Cell Carcinoma of Rectum Diagnosed by Boring Biopsy in Combination with Endoscopic Mucosal Resection Open
A 46-year-old man with severe back pain visited our hospital. Magnetic resonance imaging revealed extensive bone metastasis and rectal wall thickness. Colonoscopy revealed circumferential stenosis with edematous mucosa, suggesting colon ca…
View article: Issue Information
Issue Information Open
View article: Periostin promotes malignant potential by induction of epithelial‐mesenchymal transition in intrahepatic cholangiocarcinoma
Periostin promotes malignant potential by induction of epithelial‐mesenchymal transition in intrahepatic cholangiocarcinoma Open
Periostin, a secreted matricellular protein, has been reported to induce epithelial‐mesenchymal transition (EMT), which increases motility and invasiveness in various epithelial cancer cells. Periostin is also overexpressed in intrahepatic…
View article: The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy
The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy Open
The risk of hepatocellular carcinoma (HCC) development is reduced following viral elimination by interferon therapy in chronic hepatitis C patients. However, the risk in patients treated with interferon-free direct-acting antivirals (DAAs)…
View article: Erratum to: Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy
Erratum to: Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy Open
View article: Key diagnostic features of fever of unknown origin: Medical history and physical findings
Key diagnostic features of fever of unknown origin: Medical history and physical findings Open
Background Fever of unknown origin ( FUO ) has many possible causes, so detailed history taking and physical examination are required. We identified key diagnostic features of medical history and physical findings for an efficient diagnosi…
View article: Enhanced ultrasonography detection of mucosa-associated lymphoid tissue of the liver with penetrating vessels in a tumor -case report
Enhanced ultrasonography detection of mucosa-associated lymphoid tissue of the liver with penetrating vessels in a tumor -case report Open
72歳，男性．肝機能異常を指摘され，腹部CTで肝に腫瘍性病変を認めた．腹部超音波検査では肝S6に47×36 mm大の境界不明瞭，内部均一，低エコー腫瘤を認めた．造影CT検査では肝S6に47×36 mm大の病変は共に単純CTで低吸収，造影早期相で濃染，後期相で低吸収となった．
View article: Systemic Inflammatory Syndrome Associated with a Case of Jugular Paraganglioma
Systemic Inflammatory Syndrome Associated with a Case of Jugular Paraganglioma Open
Jugular paraganlioma is a benign, slow-growing tumor originating from the paraganglion cells and it is associated with catecholamine secretion. Paragangliomas can secrete Interleukin-6 (IL-6) and present as a systemic inflammatory syndrome…
View article: Primary Gastric Choriocarcinoma with Long Term Postoperative Survival
Primary Gastric Choriocarcinoma with Long Term Postoperative Survival Open
症例は83歳の男性で,2008年4月より労作時息切れがあり当院を受診した.Hb 4.9 g/dlと貧血があり,上部消化管内視鏡検査で胃角部に潰瘍浸潤型の腫瘍を認めた.生検で低分化型腺癌と診断され,幽門側胃切除を施行した.腫瘍は90×80 mmで壊死と深い潰瘍を伴っていた.病理組織学的に腫瘍の浅層には低分化型腺癌,浸潤部には合胞体栄養細胞に類似した大型好酸性多核細胞を認め,免疫染色検査でヒト絨毛性ゴナドトロピン陽性であったため絨毛癌と診断した.H0,P0,CY0,M0,pT3…
View article: Efficacy of radiofrequency ablation for initial recurrent hepatocellular carcinoma after curative treatment: Comparison with primary cases
Efficacy of radiofrequency ablation for initial recurrent hepatocellular carcinoma after curative treatment: Comparison with primary cases Open
View article: Analysis of the HindIII-catalyzed reaction by time-resolved crystallography
Analysis of the HindIII-catalyzed reaction by time-resolved crystallography Open
In order to investigate the mechanism of the reaction catalyzed by HindIII, structures of HindIII–DNA complexes with varying durations of soaking time in cryoprotectant buffer containing manganese ions were determined by the freeze-trap me…