Tomoki Miyoshi
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View article: Preventive Effects of Medium-Chain Fatty Acid Intake on Muscle Atrophy
Preventive Effects of Medium-Chain Fatty Acid Intake on Muscle Atrophy Open
Background/Objectives: Medium-chain fatty acids (MCFAs), abundant in coconut oil, have attracted considerable attention in recent years owing to their potential impact on muscle atrophy. However, the mechanisms underlying their effects rem…
View article: Investigation of factors associated with osteoporosis using metabolome analysis
Investigation of factors associated with osteoporosis using metabolome analysis Open
Osteoporosis is associated with low bone mineral density and poor bone quality in patients with type 2 diabetes mellitus (T2DM). Reports on the association between serum metabolome and osteoporosis in diabetes mellitus are rare. We aimed t…
View article: The effects of coconut oil intake on metabolic disorders and fatty liver disease in mice
The effects of coconut oil intake on metabolic disorders and fatty liver disease in mice Open
High-fat diets are closely implicated in the pathogenesis of chronic conditions, including obesity and hepatic steatosis. Recently, coconut oil, which is rich in medium-chain fatty acids, has attracted significant attention for its potenti…
View article: A multi‐omics approach to overeating and inactivity‐induced muscle atrophy in <i>db/db</i> mice
A multi‐omics approach to overeating and inactivity‐induced muscle atrophy in <i>db/db</i> mice Open
Background Overeating and inactivity are associated with type 2 diabetes. This study aimed to investigate its pathological basis using integrated omics and db/db/m ice, a model representing this condition. Methods The study involved housin…
View article: Association of Elevated Serum Branched-chain Amino Acid Levels With Longitudinal Skeletal Muscle Loss
Association of Elevated Serum Branched-chain Amino Acid Levels With Longitudinal Skeletal Muscle Loss Open
Context Branched-chain amino acids (BCAA) are substrates for protein synthesis. Although their intake may contribute to an increase in skeletal muscle mass, elevated serum BCAA levels have been reported to be associated with insulin resist…
View article: Changes in glycemic control and skeletal muscle mass indices after dapagliflozin treatment in individuals with type 1 diabetes mellitus
Changes in glycemic control and skeletal muscle mass indices after dapagliflozin treatment in individuals with type 1 diabetes mellitus Open
Aims/Introduction Dapagliflozin is used for individuals with type 1 diabetes, although the effect of this medication on skeletal muscle mass is not well established. In addition, there are few studies examining the effects of good glycemic…
View article: Gut Microbiota Changes by an SGLT2 Inhibitor, Luseogliflozin, Alters Metabolites Compared with Those in a Low Carbohydrate Diet in db/db Mice
Gut Microbiota Changes by an SGLT2 Inhibitor, Luseogliflozin, Alters Metabolites Compared with Those in a Low Carbohydrate Diet in db/db Mice Open
In recent years, sarcopenic obesity has been considered central pathological factors in diabetes. This study aimed to compare the effect of luseogliflozin, a sodium-glucose co-transporter-2 inhibitor (SGLT2i), on sarcopenic obesity in comp…
View article: Inulin reduces visceral adipose tissue mass and improves glucose tolerance through altering gut metabolites
Inulin reduces visceral adipose tissue mass and improves glucose tolerance through altering gut metabolites Open
View article: Effect of matcha consumption on gut microbiota in healthy Japanese individuals: study protocol for a double-blind crossover interventional study
Effect of matcha consumption on gut microbiota in healthy Japanese individuals: study protocol for a double-blind crossover interventional study Open
This study compares and clarifies the changes in intestinal flora resulting from the continuous consumption of two types of matcha. Healthy adults will consume two types of matcha tea for four weeks, and differences in the intestinal micro…
View article: Effects of probiotic <i>Bifidobacterium bifidum</i> G9‐1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open‐label, single‐arm, exploratory research trial
Effects of probiotic <i>Bifidobacterium bifidum</i> G9‐1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open‐label, single‐arm, exploratory research trial Open
Aims/Introduction Metformin is associated with the risk of gastrointestinal complications, and probiotic Bifidobacterium bifidum G9‐1 (BBG9‐1) can improve the symptoms of diarrhea. This study aimed to clarify the effects of probiotic BBG9‐…
View article: Correlation between Liver Stiffness by Two-Dimensional Shear Wave Elastography and Waist Circumference in Japanese Local Citizens with Abdominal Obesity
Correlation between Liver Stiffness by Two-Dimensional Shear Wave Elastography and Waist Circumference in Japanese Local Citizens with Abdominal Obesity Open
Background: Various factors other than fibrosis could affect liver stiffness (LS), measured by two-dimensional shear wave elastography (2D-SWE). We aimed to clarify the factors affecting LS in local citizens. Methods: We performed a cross-…
View article: Effect of matcha consumption on gut microbiota in healthy Japanese individuals: study protocol for a double-blind crossover interventional study
Effect of matcha consumption on gut microbiota in healthy Japanese individuals: study protocol for a double-blind crossover interventional study Open
Background : This study compares and clarifies the changes in intestinal flora resulting from the continuous consumption of two types of matcha. Methods : Healthy adults will consume two types of matcha tea for four weeks, and differences …
View article: Acute Bromide Intoxication in a Patient with Preserved Renal Function
Acute Bromide Intoxication in a Patient with Preserved Renal Function Open
BACKGROUND Electrolyte imbalance is frequent in many situations, but severe hyperchloremia is markedly rare in the absence of renal impairment. We report a patient with preserved renal function who exhibited severe hyperchloremia and negat…
View article: Effect of probiotics, <i>Bifidobacterium bifidum</i> G9-1, on gastrointestinal symptoms in patients with type 2 diabetes mellitus: study protocol for open-label, single-arm, exploratory research trial (Big STAR study)
Effect of probiotics, <i>Bifidobacterium bifidum</i> G9-1, on gastrointestinal symptoms in patients with type 2 diabetes mellitus: study protocol for open-label, single-arm, exploratory research trial (Big STAR study) Open
Metformin is associated with risks of gastrointestinal complications in patients with type 2 diabetes. In contrast, probiotic Bifidobacterium bifidum G9-1 (BBG9-1) could improve the symptoms of diarrhea caused by metformin in animal…
View article: Association between Body Weight Gain from 20 Years of Age and Diabetic Nephropathy in Japanese Patients with Type 2 Diabetes
Association between Body Weight Gain from 20 Years of Age and Diabetic Nephropathy in Japanese Patients with Type 2 Diabetes Open
Background/Aims: It has been reported that the body mass index shows a U-shaped association with death from cardiovascular disease (CVD) in the Asian population. The relationship between body weight (BW) gain from early adult…
View article: Peripheral Signs of Infective Endocarditis
Peripheral Signs of Infective Endocarditis Open