Explanipedia

Efficacy of lateral lymph node dissection for local control of rectal cancer: A multicenter study Open

Yusuke Tanaka, Hitoshi Hino, Akio Shiomi, Keisuke Uehara, Jun Watanabe , et al. · 2024

Background This study aimed to evaluate the efficacy of lateral lymph node dissection (LLND) for rectal cancer by comparing the local control in patients with and without pathological lateral lymph node metastasis (LLNM). Methods We includ…

Sphingosine 1‐phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids Open

Baasanjav Uranbileg, Makoto Kurano, Kuniyuki Kano, Eri Sakai, Junichi Arita , et al. · 2022

Background In addition to potent agonist properties for sphingosine 1‐phosphate (S1P) receptors, intracellularly, S1P is an intermediate in metabolic conversion pathway from sphingolipids to glycerolysophospholipids (glyceroLPLs). We hypot…

Paraganglioma of the urinary bladder initially diagnosed as gastrointestinal stromal tumor requiring combined resection of the rectum: a case report Open

Natsumi Matsuzawa, Takeshi Nishikawa, Riki Ohno, Masaharu Inoue, Yu Nishimura , et al. · 2022

Background Paraganglioma of the urinary bladder (Pub) is rare and presents with clinical symptoms caused by catecholamine production and release. The typical symptoms of Pub are hypertension, macroscopic hematuria, and a hypertensive crisi…

Evaluation and diagnostic value of next‐generation sequencing analysis of residual liquid‐based cytology specimens of pancreatic masses Open

Yoko Sekita‐Hatakeyama, Tomomi Fujii, Takeshi Nishikawa, Akira Mitoro, Masayoshi Sawai , et al. · 2021

Background Liquid‐based cytology (LBC) is a widely used method for processing specimens obtained by endoscopic biopsy. This study evaluated next‐generation sequencing (NGS) analysis of LBC specimens to improve the diagnostic accuracy of pa…

Analysis of the Positional Relationship Among the Operator, Camera, and Monitor: Overcoming the Difficulties of Mirror-image Conditions During Laparoscopic Surgery Open

Yuriko Inagaki, Kazushige Kawai, Takeshi Nishikawa, Hiroaki Ishii, Shigenobu Emoto , et al. · 2021

Background: Although methods to overcome difficulties associated with mirror-image conditions have been investigated, the ideal spatial relationship among the operator line of sight, monitor location, and camera location remains unclear. M…

Risk factors for non-reaching of ileal pouch to the anus in laparoscopic restorative proctocolectomy with handsewn anastomosis for ulcerative colitis Open

Shigenobu Emoto, Keisuke Hata, Hiroaki Nozawa, Kazushige Kawai, Toshiaki Tanaka , et al. · 2021

Background/Aims: Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis and handsewn anastomosis for ulcerative colitis requires pulling down of the ileal pouch into the pelvis, which can be technically challenging. We examine…

Clinical significance of CD8<sup>+</sup> and FoxP3<sup>+</sup> tumor‑infiltrating lymphocytes and MFG‑E8 expression in lower rectal cancer with preoperative chemoradiotherapy Open

Yuzo Harada, Shinsuke Kazama, Teppei Morikawa, Hirofumi Sonoda, Hiroaki Ishi , et al. · 2021

Preoperative chemoradiotherapy (CRT) for rectal cancer contributes to tumor down-staging and decreases locoregional recurrence. However, each patient shows a significantly different response to CRT. Therefore, the identification of predict…

Actinomycosis of the Lower Lip; A Case of Report Open

S Fujii, Takeshi Nishikawa, Eiji Hirai, Tomotake Masuda, Toshihiro Kikuta , et al. · 2021

Actinomycosis is an uncommon chronic granulomatous infection. Typical symptoms of this infection are multiple abscess formation, plate-like induration and trismus. Recently, this infection has been difficult to diagnose because of the lack…

Surgical Outcomes of Robot-assisted Rectal Surgery for Highly Difficult Cases Open

Riki Ohno, Shinsuke Kazama, Yusuke Nishizawa, Takeshi Nishikawa, Takahide Shinagawa , et al. · 2021

【目的】高難度症例に対するロボット支援下直腸切除術の有用性について検討する．

Classification of the colonic splenic flexure based on three-dimensional CT analysis Open

Kazushige Kawai, Hiroaki Nozawa, Keisuke Hata, Toshiaki Tanaka, Takeshi Nishikawa , et al. · 2021

Background Mobilization of the splenic flexure can be a challenging surgical step in colorectal surgery. This study aimed to classify the splenic flexure based on the three-dimensional (3D) coordinates of the splenic hilum and left renal h…

Upfront Surgery for Small Intestinal Non-Hodgkin's Lymphoma Open

TETSUHIRO IIDA, Hiroaki Nozawa, Hirofumi Sonoda, Kazuhiro Toyama, Kazushige Kawai , et al. · 2020

Surgical resection prior to chemotherapy is a feasible and safe therapeutic strategy for small intestinal NHL.

The Influence of Neoadjuvant Chemoradiation for Middle and Lower Rectal Cancer on Anorectal Function Open

Y. Hirata, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka , et al. · 2020

Preoperative chemoradiotherapy did not clearly impair postoperative anorectal function in patients who underwent low anterior resection and intersphincteric resection.

Rectocolic and colocolic fistulas accompanied by cytomegalovirus infection: Two case reports Open

Tatsuki Noguchi, Takeshi Nishikawa, Soichiro Ishihara · 2020

Anal canal adenocarcinoma with pagetoid spread and inguinal lymph node metastasis treated with preoperative chemoradiotherapy: A case report Open

Takeshi Nishikawa, Tetsuo Ushiku, Shigenobu Emoto, Koji Murono, Manabu Kaneko , et al. · 2020

Perianal Paget's disease is a rare condition, which is not usually accompanied by cancer. Here, a case of anal canal carcinoma with pagetoid spread and inguinal lymph node metastasis, which exhibited a significant response to preoperative …

Metastatic role of mammalian target of rapamycin signaling activation by chemoradiotherapy in advanced rectal cancer Open

Hiroshi Shiratori, Kazushige Kawai, Masamichí Okada, Hiroaki Nozawa, Keisuke Hata , et al. · 2020

Postoperative distant metastasis dramatically affects rectal cancer patients who have undergone neoadjuvant chemoradiotherapy (NACRT). Here, we clarified the association between NACRT‐mediated mammalian target of rapamycin (mTOR) signaling…

Assessment of the Changes in Mitochondrial Gene Polymorphism in Ulcerative Colitis and the Etiology of Ulcerative Colitis-associated Colorectal Cancer Open

Toshiaki Tanaka, Takashi Kobunai, Yoko Yamamoto, Koji Murono, SHIGENBU EMOTO , et al. · 2019

Significant mutations in mtDNA were observed in the non-neoplastic mucosa of patients with UC-associated cancer.

Risk factors and therapeutic significance for inguinal lymph node metastasis in advanced lower rectal cancer. Open

Hiroaki Nozawa, Hiroshi Shiratori, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka , et al. · 2019

120 Background: Which patients with lower rectal cancer are at risk of inguinal lymph node metastasis (ILNM) and how to treat ILNM remain unclear. This study aimed to clarify the predictors of ILNM and clinical significance of treatment fo…

Accelerated perineural invasion in colitis-associated cancer Open

Hiroaki Nozawa, Keisuke Hata, Tetsuo Ushiku, Kazushige Kawai, Toshiaki Tanaka , et al. · 2019

Perineural invasion (PNI) is a prognostic factor in patients with colorectal cancer. Neurotrophic factors, molecular determinants of PNI, are altered in their expression levels in patients with ulcerative colitis. In this study, we evaluat…

Cecal cancer with essential thrombocythemia treated by laparoscopic ileocecal resection: a case report Open

Masaya Hiyoshi, Hiroaki Nozawa, Kentaro Inada, T. Koseki, Keiichi Nasu , et al. · 2019

Clinical outcomes of preoperative chemoradiotherapy in octogenarian with locally advanced rectal cancer Open

Takeshi Nishikawa, Kazushige Kawai, Keisuke Hata, Shigenobu Emoto, Koji Murono , et al. · 2019

The number of elderly patients who receive surgical treatment for rectal cancer has gradually increased with aging of the population. In recent years, preoperative chemoradiotherapy, followed by surgical treatment, has been widely used for…

The component changes of lysophospholipid mediators in colorectal cancer Open

Chieko Kitamura, Hirofumi Sonoda, Hiroaki Nozawa, Kuniyuki Kano, Shigenobu Emoto , et al. · 2019

Although lysophospholipids are known to play an important role in the development and progression of several kinds of cancers, their role in human colorectal cancer is as yet unclear. In this study, we aim to investigate lysophospholipid l…

The combination of temsirolimus and chloroquine increases radiosensitivity in colorectal cancer cells Open

Hiroshi Shiratori, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Takeshi Nishikawa , et al. · 2019

The PI3K/AKT/mTOR pathway and autophagy are known to play important roles in cancer radioresistance. The aim of the present study was to investigate whether the combination of temsirolimus (TEM), an mTOR inhibitor, and chloroquine (CQ), an…

Molecular Subtypes Are Frequently Discordant Between Lesions in Patients With Synchronous Colorectal Cancer: Molecular Analysis of 59 Patients Open

K Arakawa, Keisuke Hata, Hiroaki Nozawa, Kazushige Kawai, Toshiaki Tanaka , et al. · 2019

The present study on synchronous CRC demonstrated a low concordance of molecular subtypes between lesions in the same patient. A molecular analysis of metastatic lesions is warranted for molecular targeted therapy of metastatic synchronous…

Association between KRAS G13D mutations and anastomotic recurrence in colorectal cancer Open

Satoshi Okada, Keisuke Hata, Kazushige Kawai, Yoko Yamamoto, Toshiaki Tanaka , et al. · 2019

Rationale: The prevalence of anastomotic recurrence (AR) in colorectal cancer (CRC) after resection of the primary tumor (PT) is 5% to 14%. However, no association has been observed between specific somatic genetic alterations and AR. Such…

Venous thromboembolism in colorectal surgery: Incidence, risk factors, and prophylaxis Open

Shigenobu Emoto, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka , et al. · 2019

The influence of neoadjuvant chemoradiation for lower rectal cancer on urinary function Open

Y. Hirata, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka , et al. · 2019

Adjuvant chemotherapy improves prognosis of resectable stage IV colorectal cancer: a comparative study using inverse probability of treatment weighting Open

Hiroaki Nozawa, Hirotoshi Takiyama, Kiyoshi Hasegawa, Kazushige Kawai, Keisuke Hata , et al. · 2019

Background: Adjuvant chemotherapy (AC) is known to be beneficial for stage III colorectal cancer (CRC). In contrast, only a few studies have reported the survival benefits of AC for stage IV CRC after curative surgery. Methods: We identifi…

Prognostic Significance and Clinicopathological Features of Synchronous Colorectal Cancer Open

K Arakawa, Keisuke Hata, Hiroaki Nozawa, Kazushige Kawai, Toshiaki Tanaka , et al. · 2018

Aim: This study aimed to clarify the difference in the clinicopathological and prognostic features between synchronous colorectal cancer (CRC) and solitary CRC. Materials and Methods: A retrospective analysis was conducted in patients with…

Efficacy of 18-fluoro deoxy glucose-positron emission tomography computed tomography for the detection of colonic neoplasia proximal to obstructing colorectal cancer Open

Daisuke Hojo, Toshiaki Tanaka, M. Takahashi, Koji Murono, Shigenobu Emoto , et al. · 2018

Identification of secondary colonic neoplasia proximal to obstructing colorectal cancer is essential for determining the range of colorectal resection.We examined the accuracy of 18-fluoro deoxy glucose-positron emission tomography (FDG-PE…

Predictors for High Microsatellite Instability in Patients with Colorectal Cancer Fulfilling the Revised Bethesda Guidelines Open

K Arakawa, Keisuke Hata, Kazushige Kawai, Toshiaki Tanaka, Takeshi Nishikawa , et al. · 2018

Item 5 of the rBG and right-sided tumour location are significant predictors of MSI-H.

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