Tomoko Dai
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View article: High expression of eukaryotic elongation factor 1‐alpha‐2 in lung adenocarcinoma is associated with poor prognosis
High expression of eukaryotic elongation factor 1‐alpha‐2 in lung adenocarcinoma is associated with poor prognosis Open
Eukaryotic elongation factor 1 alpha 2 (eEF1A2) encodes an isoform of the alpha subunit of the elongation factor 1 complex and is responsible for the enzymatic delivery of aminoacyl tRNA to the ribosome. Our proteomic analysis has identifi…
View article: In‐depth proteomics reveals the characteristic developmental profiles of early lung adenocarcinoma with epidermal growth factor receptor mutation
In‐depth proteomics reveals the characteristic developmental profiles of early lung adenocarcinoma with epidermal growth factor receptor mutation Open
Introduction Lung adenocarcinoma progresses stepwise from atypical adenomatous hyperplasia to adenocarcinoma in situ (AIS), followed by minimally invasive adenocarcinoma (MIA), and then obvious invasive adenocarcinoma. In this study, we ex…
View article: DNA hypomethylation-related overexpression of SFN, GORASP2 and ZYG11A is a novel prognostic biomarker for early stage lung adenocarcinoma
DNA hypomethylation-related overexpression of SFN, GORASP2 and ZYG11A is a novel prognostic biomarker for early stage lung adenocarcinoma Open
Although alteration of DNA methylation in advanced cancer has been extensively investigated, few data for early-stage lung adenocarcinoma are available. Here, we compared DNA methylation profiles between adenocarcinoma in situ (AIS) and ea…
View article: miR‐3941: A novel microRNA that controls <scp>IGBP</scp>1 expression and is associated with malignant progression of lung adenocarcinoma
miR‐3941: A novel microRNA that controls <span>IGBP</span>1 expression and is associated with malignant progression of lung adenocarcinoma Open
Immunoglobulin ( CD 79a) binding protein 1 ( IGBP 1) is universally overexpressed in lung adenocarcinoma and exerts an anti‐apoptotic effect by binding to PP 2Ac. However, the molecular mechanism of IGBP 1 overexpression is still unclear. …
View article: Methylation of<i>MGMT</i>and<i>ADAMTS14</i>in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans
Methylation of<i>MGMT</i>and<i>ADAMTS14</i>in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans Open
Somatic hypermethylation of the O6-methylguanine-DNA methyltransferase gene (MGMT) was previously associated with G > A transition mutations in KRAS and TP53 in colorectal cancer (CRC). We tested the association of MGMT methylation with G …