Explanipedia

Parallel Comparative Transcriptome Analyses of Bacterial–Fungal Interactions (BFI) Reveal the Determinants of BFI Directionality Open

Masahiro Toda, Tomonari Kasai, Takehito Sugasawa, Elaheh Seifollahi, Shingo Miyauchi , et al. · 2025

The current status and novel advances of boron neutron capture therapy clinical trials Open

T Zhou, Kazuyo Igawa, Tomonari Kasai, Takuya Sadahira, Wei Wang , et al. · 2024

Boron neutron capture therapy (BNCT) is a treatment method that focuses on improving the cure rate of patients with cancer who are difficult to treat using traditional clinical methods. By utilizing the high neutron absorption cross-sectio…

Deep Learning of Phase-Contrast Images of Cancer Stem Cells Using a Selected Dataset of High Accuracy Value Using Conditional Generative Adversarial Networks Open

Zaijun Zhang, Hiroaki Ishihata, Ryuto Maruyama, Tomonari Kasai, Hiroyuki Kameda , et al. · 2023

Artificial intelligence (AI) technology for image recognition has the potential to identify cancer stem cells (CSCs) in cultures and tissues. CSCs play an important role in the development and relapse of tumors. Although the characteristic…

Temporal and Locational Values of Images Affecting the Deep Learning of Cancer Stem Cell Morphology Open

Yumi Hanai, Hiroaki Ishihata, Zaijun Zhang, Ryuto Maruyama, Tomonari Kasai , et al. · 2022

Deep learning is being increasingly applied for obtaining digital microscopy image data of cells. Well-defined annotated cell images have contributed to the development of the technology. Cell morphology is an inherent characteristic of ea…

Self-assembling A6K peptide nanotubes as a mercaptoundecahydrododecaborate (BSH) delivery system for boron neutron capture therapy (BNCT) Open

Hiroyuki Michiue, Mizuki Kitamatsu, Asami Fukunaga, Nobushige Tsuboi, Atsushi Fujimura , et al. · 2020

Boron neutron capture therapy (BNCT) is a tumor selective therapy, the effectiveness of which depends on sufficient ¹⁰B delivery to and accumulation in tumors. In this study, we used self-assembling A6K peptide nanotubes as boro…

Deep Learning of Cancer Stem Cell Morphology Using Conditional Generative Adversarial Networks Open

Saori Aida, Junpei Okugawa, Serena Fujisaka, Tomonari Kasai, Hiroyuki Kameda , et al. · 2020

Deep-learning workflows of microscopic image analysis are sufficient for handling the contextual variations because they employ biological samples and have numerous tasks. The use of well-defined annotated images is important for the workf…

Conditional Generative Adversarial Networks to Model iPSC-Derived Cancer Stem Cells Open

Saori Aida, Hiroyuki Kameda, Sakae Nishisako, Tomonari Kasai, Atsushi Sato , et al. · 2020

The realization of effective and low-cost drug discovery is imperative to enable people to easily purchase and use medicines when necessary. This paper reports a smart system for detecting iPSC-derived cancer stem cells by using conditiona…

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness Open

Yuki Katsura, Toshiaki Ohara, Kazuhiro Noma, Takayuki Ninomiya, Hajime Kashima , et al. · 2019

Excess iron causes cancer and is thought to be related to carcinogenesis and cancer progression including stemness, but the details remain unclear. Here, we hypothesized that stemness in cancer is related to iron metabolism and that regula…

Suppression effect on IFN‑γ of adipose tissue‑derived mesenchymal stem cells isolated from β2‑microglobulin‑deficient mice Open

Junko Masuda, E. Takayama‐Muromachi, Tatsuo Ichinohe, Warren Strober, Masako Mizuno‐Kamiya , et al. · 2018

Administration of bone marrow-derived mesenchymal stem cells (MSCs) is a possible treatment for graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation and other inflammatory conditions. To address the…

Up-Regulation of PI 3-Kinases and the Activation of PI3K-Akt Signaling Pathway in Cancer Stem-Like Cells Through DNA Hypomethylation Mediated by the Cancer Microenvironment Open

Aung Ko Ko Oo, Anna Sanchez Calle, Neha Nair, Hafizah Mahmud, Arun Vaidyanath , et al. · 2018

Previously, we have succeeded in converting induced pluripotent stem cells (iPSCs) into cancer stem cells (CSCs) by treating the iPSCs with conditioned medium of Lewis lung carcinoma (LLC) cells. The converted CSCs, named miPS-LLCcm cells,…

Targeting Glioblastoma Cells Expressing CD44 with Liposomes Encapsulating Doxorubicin and Displaying Chlorotoxin-IgG Fc Fusion Protein Open

Hafizah Mahmud, Tomonari Kasai, Apriliana Cahya Khayrani, Mami Asakura, Aung Ko Ko Oo , et al. · 2018

We recently have established a successful xenograft model of human glioblastoma cells by enriching hyaluronic acid-dependent spheroid-forming populations termed U251MG-P1 cells from U251MG cells. Since U251MG-P1 cells have been confirmed t…

Iron depletion is a novel therapeutic strategy to target cancer stem cells Open

Takayuki Ninomiya, Toshiaki Ohara, Kazuhiro Noma, Yuki Katsura, Ryoichi Katsube , et al. · 2017

Adequate iron levels are essential for human health. However, iron overload can act as catalyst for the formation of free radicals, which may cause cancer. Cancer stem cells (CSCs), which maintain the hallmark stem cell characteristics of …

Practical Liposomal Formulation for Taxanes with Polyethoxylated Castor Oil and Ethanol with Complete Encapsulation Efficiency and High Loading Efficiency Open

Tsukasa Shigehiro, Junko Masuda, Shoki Saito, Apriliana Cahya Khayrani, Kazumasa Jinno , et al. · 2017

Taxanes including paclitaxel and docetaxel are effective anticancer agents preferably sufficient for liposomal drug delivery. However, the encapsulation of these drugs with effective amounts into conventional liposomes is difficult due to …

A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment Open

Neha Nair, Anna Sanchez Calle, Maram H. Zahra, Marta Prieto‐Vila, Aung Ko Ko Oo , et al. · 2017

Cancer-associated fibroblasts (CAFs) are one of the most prominent cell types in the stromal compartment of the tumor microenvironment. CAFs support multiple aspects of cancer progression, including tumor initiation, invasion, and metastas…

A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment Open

Neha Nair, Anna Sanchez Calle, Maram H. Zahra, Marta Prieto‐Vila, Aung Ko Ko Oo , et al. · 2017

Cancer-associated fibroblasts (CAFs) are one of the most prominent cell types in the stromal compartment of the tumor microenvironment. CAFs support multiple aspects of cancer progression, including tumor initiation, invasion, and metastas…

Hyaluronic Acid Mediated Enrichment of CD44 Expressing Glioblastoma Stem Cells in U251MG Xenograft Mouse Model Open

Arun Vaidyanath, Hafizah Mahmud, Apriliana Cahya Khayrani, Aung Ko Ko Oo, Akimasa Seno , et al. · 2017

Background: Glioblastoma is one of the most aggressive cancer with high mortality rates and poses several hurdles in the efficient chemotherapeutic intervention.Similar to other cancers, glioma also harbors CSCs, that are self-renewable, m…

A Unique Procedure to Identify Cell Surface Markers through a Spherical Self-Organizing Map Applied to DNA Microarray Analysis Open

Yuh Sugli, Tomonari Kasai, Masashi Ikeda, Arun Vaidyanath, Kazuki Kumon , et al. · 2016

To identify cell-specific markers, we designed a DNA microarray platform with oligonucleotide probes for human membrane-anchored proteins. Human glioma cell lines were analyzed using microarray and compared with normal and fetal brain tiss…

Characterization of Gene Expression Patterns among Artificially Developed Cancer Stem Cells Using Spherical Self-Organizing Map Open

Akimasa Seno, Tomonari Kasai, Masashi Ikeda, Arun Vaidyanath, Junko Masuda , et al. · 2016

We performed gene expression microarray analysis coupled with spherical self-organizing map (sSOM) for artificially developed cancer stem cells (CSCs). The CSCs were developed from human induced pluripotent stem cells (hiPSCs) with the con…

iPSC-derived cancer stem cells provide a model of tumor vasculature. Open

Marta Prieto‐Vila, Ting Yan, Anna Sanchez Calle, Neha Nair, Laura Hurley , et al. · 2016

To grow beyond a size of approximately 1-2 mm³, tumor cells activate many processes to develop blood vasculature. Growing evidences indicate that the formation of the tumor vascular network is very complex, and is not restricted…

A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm). Open

Anna Sanchez Calle, Neha Nair, Aung Ko Ko Oo, Marta Prieto‐Vila, Megumi Koga , et al. · 2016

Pancreatic ductal adenocarcinoma (PDAC) is the most representative form of pancreatic cancers. PDAC solid tumours are constituted of heterogeneous populations of cells including cancer stem cells (CSCs), differentiated cancer cells, desmop…

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