Tomonobu Kado
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View article: <scp>TGFβ1</scp> and <scp>SMAD3</scp> Expression Are Associated With Survival After the Immune Checkpoint Inhibitor Therapy for Small Cell Lung Cancer
<span>TGFβ1</span> and <span>SMAD3</span> Expression Are Associated With Survival After the Immune Checkpoint Inhibitor Therapy for Small Cell Lung Cancer Open
Background Tumor immunity is involved in the progression of malignant tumors. However, there are few reports on the relationship between the immunological environment and the efficacy of immune checkpoint inhibitors in small cell lung canc…
View article: Tofogliflozin ameliorates cardiotoxin induced skeletal muscle injury and fibrosis in obesity
Tofogliflozin ameliorates cardiotoxin induced skeletal muscle injury and fibrosis in obesity Open
View article: IL-7Rα signaling in regulatory T cells of adipose tissue is essential for systemic glucose homeostasis
IL-7Rα signaling in regulatory T cells of adipose tissue is essential for systemic glucose homeostasis Open
Regulatory T cells (Tregs) mediate tissue homeostasis and repair. The function of the interleukin-7 receptor α (IL-7Rα) in nonlymphoid tissue Tregs is still unknown, although low expression of IL-7Rα is a widely accepted marker for Tregs. …
View article: Role of transforming growth factor-β1 in regulating adipocyte progenitors
Role of transforming growth factor-β1 in regulating adipocyte progenitors Open
View article: Role of transforming growth factor-β1 in regulating adipocyte progenitors
Role of transforming growth factor-β1 in regulating adipocyte progenitors Open
Adipose tissue (AT) metabolism involves coordinating various cells and cellular processes to regulate energy storage, release, and overall metabolic homeostasis. Therein, macrophage and its cytokine are important in controlling tissue home…
View article: History and future perspectives of adipose tissue macrophage biology
History and future perspectives of adipose tissue macrophage biology Open
Macrophages contribute to adipose tissue homeostasis; however, they are also thought to be responsible for insulin resistance in obesity. Macrophages, which were oversimplified in past methodologies, have become rather difficult to underst…
View article: Characterization of Diabetic Striatopathy With Repeated Follow-Up Using Multiple Imaging Studies
Characterization of Diabetic Striatopathy With Repeated Follow-Up Using Multiple Imaging Studies Open
View article: Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice
Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice Open
Our study demonstrated that IX prevents obesity and enhances glucose metabolism by inhibiting dietary fat absorption. This mechanism is linked to suppressing pancreatic lipase activity and shifts in microbial composition, notably an increa…
View article: Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of<i>Akkermansia muciniphila</i>in mice
Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of<i>Akkermansia muciniphila</i>in mice Open
Aims Dysbiosis is an important factor that leads to metabolic disorders by disrupting energy balance and insulin sensitivity. A decrease in Akkermansia muciniphila is a phenotype of obesity-induced dysbiosis. Although interventions to incr…
View article: Heterogeneity of adipose tissue-resident macrophages-beyond M1/M2 paradigm
Heterogeneity of adipose tissue-resident macrophages-beyond M1/M2 paradigm Open
View article: Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration Open
Muscle regeneration requires the coordination of muscle stem cells, mesenchymal fibro-adipogenic progenitors (FAPs), and macrophages. How macrophages regulate the paracrine secretion of FAPs during the recovery process remains elusive. Her…
View article: Astaxanthin, a Marine Carotenoid, Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to Its Healthy Functions
Astaxanthin, a Marine Carotenoid, Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to Its Healthy Functions Open
Recently, obesity-induced insulin resistance, type 2 diabetes, and cardiovascular disease have become major social problems. We have previously shown that Astaxanthin (AX), which is a natural antioxidant, significantly ameliorates obesity-…
View article: Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet
Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet Open
View article: Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance
Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance Open
The gut microbiota metabolizes the nutrients to produce various metabolites that play crucial roles in host metabolism. However, the links between the microbiota established by different nutrients and the microbiota-influenced changes in t…
View article: Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue
Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue Open
Meflin ( Islr ) expression has gained attention as a marker for mesenchymal stem cells, but its function remains largely unexplored. Here, we report the generation of Meflin - CreER T2 mice with CreER T2 inserted under the Meflin gene prom…
View article: Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway
Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway Open
Background Skeletal muscle is mainly responsible for insulin‐stimulated glucose disposal. Dysfunction in skeletal muscle metabolism especially during obesity contributes to the insulin resistance. Astaxanthin (AX), a natural antioxidant, h…
View article: Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis
Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis Open
View article: Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice
Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice Open
Aims/Introduction Chronic inflammation of the liver is often observed with obesity or type 2 diabetes. In these pathological conditions, the immunological cells, such as macrophages, play important roles in the development or growth of liv…
View article: Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation Open
View article: Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice
Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice Open
View article: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice
Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice Open
View article: CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors
CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors Open
View article: M2 macrophages in metabolism
M2 macrophages in metabolism Open