Tomoyoshi Shibuya
YOU?
Author Swipe
View article: Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial
Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial Open
Background/Objective: Dysbiosis is implicated in the pathogenesis of ulcerative colitis. Hydrogen has been reported to promote intestinal microbiota diversity and suppress ulcerative colitis progression in mice models. In this study, we in…
View article: Week 2 remission with vedolizumab as a predictor of long-term remission in patients with ulcerative colitis: a multicenter, retrospective, observational study
Week 2 remission with vedolizumab as a predictor of long-term remission in patients with ulcerative colitis: a multicenter, retrospective, observational study Open
Week 2 remission with VDZ is a predictor of week 54 remission in patients with UC. Week 2 may be used as an evaluation point for UC treatment decisions. (Japanese Registry of Clinical Trials: jRCT-1080225363).
View article: Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis Patients over and under 65 Years of Age: A Real-World Comparative Analysis
Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis Patients over and under 65 Years of Age: A Real-World Comparative Analysis Open
Introduction: It remains unclear whether Janus kinase (JAK) inhibitors differ in efficacy and safety between elderly and non-elderly patients with ulcerative colitis. Methods: We retrospectively compared outcomes between patients who start…
View article: Efficacy of Laser Lithotripsy with DBE-ERCP and Peroral Cholangioscopy in a Surgically Altered Anatomy for Intrahepatic Bile Duct Stones
Efficacy of Laser Lithotripsy with DBE-ERCP and Peroral Cholangioscopy in a Surgically Altered Anatomy for Intrahepatic Bile Duct Stones Open
View article: The duration of prior anti-tumor necrosis factor agents is associated with the effectiveness of vedolizumab in patients with ulcerative colitis: a real-world multicenter retrospective study
The duration of prior anti-tumor necrosis factor agents is associated with the effectiveness of vedolizumab in patients with ulcerative colitis: a real-world multicenter retrospective study Open
The effectiveness of vedolizumab in biologic-non-naïve patients was significantly influenced by duration of prior anti-TNFα therapy. (Japanese Registry of Clinical Trials: jRCT-1080225363).
View article: Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients
Small‐Bowel Capsule Endoscopy in Immune‐Mediated Enterocolitis: A Case Series of Four Patients Open
Immune checkpoint inhibitors (ICIs) have emerged as a cornerstone of cancer immunotherapy but are associated with immune‐mediated adverse events (imAEs), including gastrointestinal toxicities. Among these, enteritis is a less common but cl…
View article: Real‐World Effectiveness and Safety of Vedolizumab in Patients ≥ 70 Versus < 70 Years With Ulcerative Colitis: Multicenter Retrospective Study
Real‐World Effectiveness and Safety of Vedolizumab in Patients ≥ 70 Versus < 70 Years With Ulcerative Colitis: Multicenter Retrospective Study Open
Background and Aim Vedolizumab (VDZ) is often used in older patients with ulcerative colitis (UC) in clinical practice; however, real‐world evidence is still limited, including in those with late‐onset UC. Methods This post hoc analysis of…
View article: Primary aorto‐enteric fistula diagnosed by double‐balloon endoscopy
Primary aorto‐enteric fistula diagnosed by double‐balloon endoscopy Open
A primary aorto‐enteric fistula (PAEF), rarer than a secondary aorto‐enteric fistula, is a direct rupture of the bowel by an abdominal aortic aneurysm (AAA). More than 54% of cases were in the duodenum, while jejunum and ileum were affecte…
View article: Patient–donor similarity and donor-derived species contribute to the outcome of fecal microbiota transplantation for ulcerative colitis
Patient–donor similarity and donor-derived species contribute to the outcome of fecal microbiota transplantation for ulcerative colitis Open
Background and Aims Clinical applications of fecal microbiota transplantation (FMT) for treating ulcerative colitis (UC) have shown promising results. However, whether the beneficial effects of FMT are due to the transfer and colonization …
View article: Diagnosis of small bowel inflammation using small bowel capsule endoscopy combined with abdominal CT scan.
Diagnosis of small bowel inflammation using small bowel capsule endoscopy combined with abdominal CT scan. Open
Abdominal computed tomography (CT) scans are simple to perform and widely used in evaluating small bowel inflammation. However, detailed evaluation of small intestinal mucosa is difficult with CT. Conversely, small bowel capsule endoscopy …
View article: Endoscopic and Clinicopathological Features of a Colorectal Mucin-Rich Variant of Traditional Serrated Adenoma
Endoscopic and Clinicopathological Features of a Colorectal Mucin-Rich Variant of Traditional Serrated Adenoma Open
Introduction: The mucin-rich variant of traditional serrated adenoma (MR-TSA), pathologically defined by the presence of goblet cells comprising over 50% of the lesion compared to the absorptive epithelial eosinophilic cytoplasm, was recen…
View article: Factors affecting 1-year persistence with vedolizumab for ulcerative colitis: a multicenter, retrospective real-world study
Factors affecting 1-year persistence with vedolizumab for ulcerative colitis: a multicenter, retrospective real-world study Open
Persistence with vedolizumab was consistent with previous reports. Use of tacrolimus and shorter disease duration were the main predictors of decreased persistence.
View article: Antibiotic combination therapy for the induction and maintenance of remission in patients with ulcerative colitis
Antibiotic combination therapy for the induction and maintenance of remission in patients with ulcerative colitis Open
Dysbiosis of the gut microbiota has recently been identified as a therapeutic target for ulcerative colitis. We reported the effectiveness of antibiotic combination therapy (ATM therapy) for the induction and maintenance of ulcerative coli…
View article: Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence
Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence Open
Background and Aim: Colorectal carcinogenesis involves two distinct pathways, the serrated neoplasia pathway and adenoma (AD)–carcinoma sequence, whose precursors are sessile serrated lesion (SSL) and traditional AD, respectively. MicroRNA…
View article: Publisher Correction: Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study
Publisher Correction: Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study Open
View article: Treatment of Crohn’s Disease With Infliximab and Subsequent Development of Takayasu’s Arteritis
Treatment of Crohn’s Disease With Infliximab and Subsequent Development of Takayasu’s Arteritis Open
A 23-year-old man was diagnosed with Crohn's disease (CD) of the large intestine after colonoscopy revealed longitudinal ulcers, and pathology revealed non-caseating epithelioid cell granulomas and anal fistulas. The CD relapsed, and there…
View article: Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study
Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study Open
View article: Comparison of the Effectiveness of Vedolizumab and Ustekinumab in Patients with Ulcerative Colitis: A Real-World Retrospective Study
Comparison of the Effectiveness of Vedolizumab and Ustekinumab in Patients with Ulcerative Colitis: A Real-World Retrospective Study Open
Ulcerative colitis (UC) is a chronic inflammatory disorder of the large intestine. Data on the comparative effectiveness of biological therapies such as vedolizumab (VDZ) and ustekinumab (UST) remain limited. This retrospective study compa…
View article: Residual Recurrence of a Small Intestinal Capillary Hemangioma with Obscure Gastrointestinal Bleeding Treated by Double-Balloon Endoscopy: A Case Report and Literature Review
Residual Recurrence of a Small Intestinal Capillary Hemangioma with Obscure Gastrointestinal Bleeding Treated by Double-Balloon Endoscopy: A Case Report and Literature Review Open
An 86-year-old man presented with anemia. He underwent abdominal contrast-enhanced computed tomography, gastroscopy, and colonoscopy without any bleeding detected. Small bowel capsule endoscopy (SBCE) revealed a reddish polypoid lesion wit…
View article: Usefulness of magnifying endoscopy for diagnosis of sessile serrated lesion with dysplasia or carcinoma: Large retrospective study
Usefulness of magnifying endoscopy for diagnosis of sessile serrated lesion with dysplasia or carcinoma: Large retrospective study Open
Background and study aims Sessile serrated lesions (SSLs) are precursor lesions in the serrated neoplasia pathway that lead to invasive carcinoma from dysplasia arising from SSLs. This study aimed to elucidate the clinicopathological and e…
View article: Remission Factors for Ustekinumab Treatment of Ulcerative Colitis: A Multicenter Retrospective Study of Real-World Data in Japan
Remission Factors for Ustekinumab Treatment of Ulcerative Colitis: A Multicenter Retrospective Study of Real-World Data in Japan Open
Ustekinumab (UST) is an anti–IL-12/23p40 monoclonal antibody used to treat inflammatory bowel disease. The aim of this retrospective, multicenter study was to investigate the effectiveness of UST administration in achieving remission in pa…
View article: Novel physiological analysis using blood flow velocity for colonic polyps: Pilot study
Novel physiological analysis using blood flow velocity for colonic polyps: Pilot study Open
Real-time visualization of red blood cell flow inside subepithelial microvessels is performed with magnifying endoscopy. However, microvascular blood flow velocity in the colorectum has not been investigated. Here, we aimed to evaluate the…
View article: Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in Dextran Sulfate Sodium-Induced Murine Model of Ulcerative Colitis
Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in Dextran Sulfate Sodium-Induced Murine Model of Ulcerative Colitis Open
Oxidative stress is implicated in the pathogenesis of various acute disorders including ischemia/reperfusion injury, ultraviolet/radiation burn, as well as chronic disorders such as dyslipidemia, atherosclerosis, diabetes mellitus, chronic…
View article: P1225 The interplay of donor-derived gut microbiota correlates with the efficacy of combination therapy of fecal microbiota transplantation with antibiotics for ulcerative colitis
P1225 The interplay of donor-derived gut microbiota correlates with the efficacy of combination therapy of fecal microbiota transplantation with antibiotics for ulcerative colitis Open
Background Our previous reports suggest fecal microbiota transplantation (FMT) following bowel cleansing with amoxicillin, fosfomycin, and metronidazole (Antibiotic FMT: A-FMT) improved its efficacy and the recovery of the Bacteroidota spe…
View article: Small Intestinal Arteriovenous Malformation Treated by Double-balloon Endoscopy
Small Intestinal Arteriovenous Malformation Treated by Double-balloon Endoscopy Open
A 42-year-old man was referred to our hospital because of anemia. The patient underwent gastroscopy and colonoscopy, but no bleeding site was detected. Abdominal contrast-enhanced computed tomography (CT) showed vascular dilatation along t…
View article: Management of Chronic Constipation: A Comprehensive Review
Management of Chronic Constipation: A Comprehensive Review Open
Traditionally, the treatment of chronic constipation has focused on lifestyle modification, dietary guidance and therapy, and osmotic and stimulant laxatives. Recently, several drugs with new mechanisms of action have been introduced as tr…
View article: Anisakiasis in the Upper Esophagus: A Case Report
Anisakiasis in the Upper Esophagus: A Case Report Open
Anisakiasis is caused by consuming raw fish contaminated with Anisakis sp. larvae and is extremely rare, especially when originating in the esophagus. We present a case of esophageal anisakiasis in a 61-year-old male who experienced severe…
View article: Retrograde double-balloon endoscopy-assisted electrohydraulic lithotripsy: Effective treatment of a true-enterolith associated with Crohn’s disease
Retrograde double-balloon endoscopy-assisted electrohydraulic lithotripsy: Effective treatment of a true-enterolith associated with Crohn’s disease Open
A 42-year-old man with a history of Crohn’s disease was referred for treatment of an enterolith. The patient had no symptoms such as abdominal pain or nausea. Abdominal X-ray and computed tomography (CT) scan showed a 2.8-cm enterolith in …
View article: Comparison of Texture and Color Enhancement Imaging with White Light Imaging in 52 Patients with Short-Segment Barrett’s Esophagus
Comparison of Texture and Color Enhancement Imaging with White Light Imaging in 52 Patients with Short-Segment Barrett’s Esophagus Open
BACKGROUND Texture and color enhancement imaging (TXI), a new type of image-enhanced endoscopy, may improve the detection of gastrointestinal lesions. Barrett's esophagus (BE) requires an accurate diagnosis since it may undergo neoplastic …