Tomoyoshi Yamano
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View article: Induction of antigen-specific regulatory T cells by engineered extracellular vesicles
Induction of antigen-specific regulatory T cells by engineered extracellular vesicles Open
Extracellular vesicles (EVs) are emerging as versatile nanocarriers for targeted drug delivery and immune modulation. However, strategies that can induce antigen-specific immune tolerance remain limited, highlighting an unmet need for more…
View article: Immune regulation by mRNA: inducing antigen-specific Tregs for therapeutic applications 2211
Immune regulation by mRNA: inducing antigen-specific Tregs for therapeutic applications 2211 Open
Description We aimed to develop a safer approach to induce antigen-specific regulatory T cells (Tregs) in vivo for treating autoimmune diseases and allergies. Existing therapies, like immunosuppressive drugs, lack specificity and cause ser…
View article: Selective expansion and differentiation of antigen-specific CD4 <sup>+</sup> T-helper cells by engineered extracellular vesicles
Selective expansion and differentiation of antigen-specific CD4 <sup>+</sup> T-helper cells by engineered extracellular vesicles Open
Extracellular vesicles (EVs), particularly small EVs (sEVs), are lipid bilayer vesicles secreted by various cell types and play a key role in intercellular communication. These vesicles are promising tools for cancer immunotherapy owing to…
View article: Direct delivery of immune modulators to tumour‐infiltrating lymphocytes using engineered extracellular vesicles
Direct delivery of immune modulators to tumour‐infiltrating lymphocytes using engineered extracellular vesicles Open
Extracellular vesicles (EVs) are important mediators of cell–cell communication, including immune regulation. Despite the recent development of several EV‐based cancer immunotherapies, their clinical efficacy remains limited. Here, we crea…
View article: Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers
Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers Open
Precision medicine has drastically changed cancer treatment strategies including KRAS -mutant cancers which have been undruggable for decades. While intrinsic or acquired treatment resistance remains unresolved in many cases, epigenome-tar…
View article: Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage
Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage Open
Background KRAS mutations frequently occur in cancers, particularly pancreatic ductal adenocarcinoma, colorectal cancer, and non-small cell lung cancer. Although KRAS G12C inhibitors have recently been approved, effective precision therapi…
View article: Surface-engineered extracellular vesicles to modulate antigen-specific T cell expansion for cancer immunotherapy
Surface-engineered extracellular vesicles to modulate antigen-specific T cell expansion for cancer immunotherapy Open
Extracellular vesicles (EVs), including exosomes, are emerging as novel mediators of cell-cell communications, involved in various processes such as immune activation and immunosuppression. Despite the recent development of several EVs-bas…
View article: TurboID-EV: Proteomic Mapping of Recipient Cellular Proteins Proximal to Small Extracellular Vesicles
TurboID-EV: Proteomic Mapping of Recipient Cellular Proteins Proximal to Small Extracellular Vesicles Open
Extracellular vesicles (EVs), including exosomes, have been recognized as key mediators of intercellular communications through donor EV and recipient cell interaction. Until now, most studies have focused on the development of analytical …
View article: Nanoscopic Assessment of Anti-SARS-CoV-2 Spike Neutralizing Antibody Using High-Speed AFM
Nanoscopic Assessment of Anti-SARS-CoV-2 Spike Neutralizing Antibody Using High-Speed AFM Open
Anti-spike neutralizing antibodies (S NAbs) have been developed for prevention and treatment against COVID-19. The nanoscopic characterization of the dynamic interaction between spike proteins and S NAbs remains difficult. By using high-sp…
View article: Spatiotemporal tracking of small extracellular vesicle nanotopology in response to physicochemical stresses revealed by HS‐AFM
Spatiotemporal tracking of small extracellular vesicle nanotopology in response to physicochemical stresses revealed by HS‐AFM Open
Small extracellular vesicles (sEVs) play a crucial role in local and distant cell communication. The intrinsic properties of sEVs make them compatible biomaterials for drug delivery, vaccines, and theranostic nanoparticles. Although sEV pr…
View article: 714 Selective expansion of antigen-specific CD8 T cells with engineered antigen presenting exosome
714 Selective expansion of antigen-specific CD8 T cells with engineered antigen presenting exosome Open
Background Exosomes are vesicular granules of about 100 nm and are secreted by many types of cells. Exosomes contain various proteins, lipids, and RNAs that are transported to target cells which induce functional and physiological changes.…
View article: Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer
Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer Open
Drug tolerance is the basis for acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) including osimertinib, through mechanisms that still remain unclear. Here, we show that while AXL-low expressing…
View article: Aire-expressing ILC3-like cells in the lymph node display potent APC features
Aire-expressing ILC3-like cells in the lymph node display potent APC features Open
The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the “promiscuous” expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, b…
View article: B cells latently infected with murine gammaherpesvirus 68 (MHV‐68) are present in the mouse thymus–A step toward immune evasion?
B cells latently infected with murine gammaherpesvirus 68 (MHV‐68) are present in the mouse thymus–A step toward immune evasion? Open
We show that latently gammaherpesvirus-infected B cells are present in the thymus. This could result in a functional T-cell tolerance against certain viral epitopes. It is conceivable that also antigens from other viruses or pathogens may …