Tomoyuki Hishida
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View article: Clinical utility of comprehensive genomic profiling versus Oncomine Dx target test in pathological stage II–III non-small cell lung cancer
Clinical utility of comprehensive genomic profiling versus Oncomine Dx target test in pathological stage II–III non-small cell lung cancer Open
View article: Real-World Outcomes of Limited Resection for Tumours Greater Than 20 mm in Non-Small Cell Lung Cancer
Real-World Outcomes of Limited Resection for Tumours Greater Than 20 mm in Non-Small Cell Lung Cancer Open
OBJECTIVES Sublobar resection is an established surgical option for early-stage non-small cell lung cancer. However, evidence remains limited regarding its use for tumours >20 mm in real-world settings. We evaluated characteristics and …
View article: Clinical Characteristics and Indicators of Spontaneous Hemopneumothorax Comparing With Primary Spontaneous Pneumothorax
Clinical Characteristics and Indicators of Spontaneous Hemopneumothorax Comparing With Primary Spontaneous Pneumothorax Open
SHP had distinct clinical characteristics compared to PSP. Older age (>30 years), left-side laterality, smoking status, and a first episode of pneumothorax were feasible indicators of SHP.
View article: A Novel Strategy to Optimize Surgical Outcomes in Thymoma-Associated Myasthenia Gravis: Perioperative Use of Efgartigimod
A Novel Strategy to Optimize Surgical Outcomes in Thymoma-Associated Myasthenia Gravis: Perioperative Use of Efgartigimod Open
View article: Th7R Cells: CD4⁺ T-Cell Partners That Drive Tpex-Mediated Antitumor Immunity in the Tumor Microenvironment
Th7R Cells: CD4⁺ T-Cell Partners That Drive Tpex-Mediated Antitumor Immunity in the Tumor Microenvironment Open
The priming, expansion, and function of CD8⁺ T cells depend on CD4⁺ T-cell help via dendritic cells. Precursor exhausted T cells (Tpex) maintain self-renewal and supply cytotoxic CD8⁺ T cells in the tumor microenvironment (TME), but their …
View article: Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma
Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma Open
View article: Resection of a Giant Middle Mediastinal Tumor Using a Transaortopulmonary Arterial Approach
Resection of a Giant Middle Mediastinal Tumor Using a Transaortopulmonary Arterial Approach Open
View article: Initial single-institutional experience with salvage surgery for stage IV non-small-cell lung cancer
Initial single-institutional experience with salvage surgery for stage IV non-small-cell lung cancer Open
The purpose of this study was to assess surgical outcomes of salvage surgery for clinical stage IV non-small-cell lung cancer. A total of 14 patients who underwent lung resection following systemic therapy between 2010 and 2022 were includ…
View article: Development of prediction model for zone-specific lymph node metastasis in clinical stage I–II non-small cell lung cancer: a supplementary analysis of Japan Clinical Oncology Group study 1413
Development of prediction model for zone-specific lymph node metastasis in clinical stage I–II non-small cell lung cancer: a supplementary analysis of Japan Clinical Oncology Group study 1413 Open
View article: Thoracic posture-related morphological changes in patients with pectus excavatum versus healthy controls
Thoracic posture-related morphological changes in patients with pectus excavatum versus healthy controls Open
OBJECTIVES Cases of severe pectus excavatum presenting with worsening cardiopulmonary symptoms in the upright position have been reported. However, the underlying mechanism remains unclear. We evaluated posture-related morphological change…
View article: Protocol summary of a randomized phase III study: comparing systemic therapy with and without debulking surgery (primary tumour resection) for clinical stage IVA (cT1-2bN0-1M1a) non-small cell lung cancer with radiologically undetermined pleural dissemination JCOG2103 (DEBULK-LUNG)
Protocol summary of a randomized phase III study: comparing systemic therapy with and without debulking surgery (primary tumour resection) for clinical stage IVA (cT1-2bN0-1M1a) non-small cell lung cancer with radiologically undetermined pleural dissemination JCOG2103 (DEBULK-LUNG) Open
In patients with non-small cell lung cancer (NSCLC) who present with radiologically undetermined malignant pleural dissemination or incidental surgical diagnosis of the same, surgery is generally not the preferred option; systemic therapy …
View article: Clinical impact of multiple pectus bars on surgical outcomes following pectus excavatum repair
Clinical impact of multiple pectus bars on surgical outcomes following pectus excavatum repair Open
OBJECTIVES The Nuss procedure, a minimally invasive surgery for pectus excavatum, has undergone various improvements. However, the impact of using multiple bars on thoracic shape changes and surgical outcomes remains unclear. METHODS We re…
View article: Loeys-Dietz syndrome associated with scoliosis progression after combined Ravitch and Nuss procedure for severe pectus excavatum: A case report
Loeys-Dietz syndrome associated with scoliosis progression after combined Ravitch and Nuss procedure for severe pectus excavatum: A case report Open
Loeys-Diez症候群(LDS)はMarfan症候群類縁の先天性結合織疾患で,骨格系の異常として漏斗胸を併存することが知られている.我々は漏斗胸手術後に側弯の進行を認めたLDSの一例を経験した.患者は9歳,男児.5歳時に遺伝子検査でLDSと診断された.Haller index 9.81の高度漏斗胸とCobb角8.5度の軽度側弯があり,漏斗胸に対してRavitch法とNuss法を組み合わせた術式(Combined Ravitch and Nuss Procedure:CR…
View article: Glomus Tumor of Intrathoracic Chest Wall: a Case Report
Glomus Tumor of Intrathoracic Chest Wall: a Case Report Open
40歳女性.左肺尖部に5.9 cm大の腫瘤影を認め,経皮的生検を行った所,カルチノイド腫瘍が疑われ,画像上は肺尖部胸壁浸潤癌を考え,手術の方針とした.胸腔内を観察すると腫瘍は胸壁から発生しており,胸壁腫瘍を切除した.病理では類円形核と好酸性の胞体を有する異型の弱い腫瘍細胞が増生し,形態像と免疫染色所見から胸壁発生のグロムス腫瘍と診断した.胸壁発生のグロムス腫瘍の報告は極めて少なく,文献的考察を加えて報告する.
View article: Clinicopathological Features and Survival Outcomes of Resected Lung Adenosquamous Carcinoma: Results From a Nationwide Japanese Registry Data
Clinicopathological Features and Survival Outcomes of Resected Lung Adenosquamous Carcinoma: Results From a Nationwide Japanese Registry Data Open
In this nationwide registry study, lung ASC was more aggressive than both AC and SC. No apparent survival impact of conventional adjuvant chemotherapy prompted us to investigate novel adjuvant strategies to optimize survival outcomes.
View article: Quality of life, psychological states, and personality traits in patients with pectus excavatum
Quality of life, psychological states, and personality traits in patients with pectus excavatum Open
View article: Prognostic significance of ground-glass areas within tumours in non-small-cell lung cancer
Prognostic significance of ground-glass areas within tumours in non-small-cell lung cancer Open
OBJECTIVES To validate or refute the hypothesis that non-small-cell lung cancers (NSCLC) with ground-glass areas (GGA+) within the tumour on high-resolution computed tomography are associated with a more favourable prognosis than those wit…
View article: Nuss procedure for the treatment of pectus excavatum with dyspnea following oropharyngeal cancer surgery: a case report
Nuss procedure for the treatment of pectus excavatum with dyspnea following oropharyngeal cancer surgery: a case report Open
Pectus excavatum (PE) causes cardiopulmonary dysfunction depending on the degree and form of the depression. The patient was a 74-year-old woman with a history of PE. Fourteen years ago, a total glossolaryngectomy was performed for orophar…
View article: Combined Ravitch and Nuss procedure for pectus excavatum with dyspnea following scoliosis repair
Combined Ravitch and Nuss procedure for pectus excavatum with dyspnea following scoliosis repair Open
Pectus excavatum (PE) is often associated with scoliosis and can elicit cardiovascular disturbances under rare conditions. Here we report a patient who was treated with a combined Ravitch and Nuss procedure for PE with dyspnea following sc…
View article: EP09.01-01 Feasibility and Survival Outcomes of “Salvage Surgery” for Initially Clinical Stage IV Non-small Cell Lung Cancer
EP09.01-01 Feasibility and Survival Outcomes of “Salvage Surgery” for Initially Clinical Stage IV Non-small Cell Lung Cancer Open
View article: EP08.02-10 Clinicopathological Analyses for Predicting Survival After Salvage Surgery for Initially Unresectable Lung Cancer
EP08.02-10 Clinicopathological Analyses for Predicting Survival After Salvage Surgery for Initially Unresectable Lung Cancer Open
View article: Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses Open
View article: Survival impact of pathologic features after salvage lung resection following definitive chemoradiotherapy or systemic therapy for initially unresectable lung cancer
Survival impact of pathologic features after salvage lung resection following definitive chemoradiotherapy or systemic therapy for initially unresectable lung cancer Open
Purpose Salvage surgery for non-small cell lung cancer (NSCLC) is expected to become increasingly more common; however, the association between pathologic features and the postoperative prognosis remains unclear. This study aimed to clarif…
View article: Combined Ravitch and Nuss procedure for patients with severe pectus excavatum: technique and initial results
Combined Ravitch and Nuss procedure for patients with severe pectus excavatum: technique and initial results Open
The Nuss procedure for pectus excavatum (PE) is both less invasive and very simple compared to the Ravitch procedure. However, it may be difficult to perform the Nuss procedure in cases of severe PE. Therefore, we developed a Combined Ravi…
View article: Prognostic factors affecting survival in patients with non-small cell lung cancer treated with salvage surgery after drug therapy: a multi-institutional retrospective study
Prognostic factors affecting survival in patients with non-small cell lung cancer treated with salvage surgery after drug therapy: a multi-institutional retrospective study Open
Background The prevalence of salvage surgeries after drug therapy for non-small cell lung cancer (NSCLC) has risen, mainly due to recent progress in molecular-targeted drugs and immune checkpoint inhibitors for NSCLC. While the safety and …
View article: Supplementary Tables from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung
Supplementary Tables from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung Open
Supplementary Table 1- List of the 244 cancer related genes of the target capturing panel Supplementary Table 2 - The coverage statistics for each sample of large cell neuroendocrine carcinoma (LCNEC) Supplementary Table 3 - The coverage s…
View article: Supplementary Methods from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung
Supplementary Methods from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung Open
Supplementary methods for Sanger sequencing, copy number analysis with quantitative PCR, and Immunohistochemical staining
View article: Supplementary Figures from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung
Supplementary Figures from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung Open
Supplementary Figure 1: Representative example of tissue microarray (TMA) punched out from a combined large-cell neuroendocrine carcinoma (LCNEC) with adenocarcinoma. Supplementary Figure 2: Validation of five mutations on the PI3K/AKT/mTO…
View article: Supplementary Methods from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung
Supplementary Methods from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung Open
Supplementary methods for Sanger sequencing, copy number analysis with quantitative PCR, and Immunohistochemical staining
View article: Data from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung
Data from Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung Open
Purpose: Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small-cell lung cancer (SCLC), little is known about its molecular features. We analyzed lung LCNECs to identify bio…