Tomoyuki Minowa
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View article: Bhlhe40 Coordinates T Cell Programs with Distinct CD4 and CD8 T Cell Requirements for Anti-PD-1 Versus Anti-CTLA-4
Bhlhe40 Coordinates T Cell Programs with Distinct CD4 and CD8 T Cell Requirements for Anti-PD-1 Versus Anti-CTLA-4 Open
The transcriptional programs that enable CD4 and CD8 T cells to mediate effective anti-tumor immunity remain incompletely defined. Here, we identify distinct, therapy-specific roles for the transcriptional regulator Bhlhe40 in CD4 and CD8 …
View article: An SNP-dependent cancer-testis antigenic epitope serves as a promising immunotherapeutic target for cancer
An SNP-dependent cancer-testis antigenic epitope serves as a promising immunotherapeutic target for cancer Open
T cells recognize peptides presented by human leukocyte antigen molecules on the cell surface, enabling the immune surveillance of pathological conditions such as cancer. Cancer-testis (CT) antigens are promising targets for cancer immunot…
View article: Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment
Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment Open
Acral lentiginous melanoma (ALM) is the most common melanoma subtype in non-Caucasians. Despite advances in cancer immunotherapy, current immune checkpoint inhibitors remain unsatisfactory for ALM. Hence, we conducted comprehensive immune …
View article: 569 Cell-specific deletion of Bhlhe40 reveals distinct mechanisms underlying anti-PD-1 and anti-CTLA-4
569 Cell-specific deletion of Bhlhe40 reveals distinct mechanisms underlying anti-PD-1 and anti-CTLA-4 Open
View article: 926 Comprehensive single-cell immune profiling of tumor-infiltrating lymphocytes in acral melanoma
926 Comprehensive single-cell immune profiling of tumor-infiltrating lymphocytes in acral melanoma Open
View article: 862 Analysis of antigen specificity of tumor infiltrating B lymphocytes in tertiary lymphoid structures positive melanoma
862 Analysis of antigen specificity of tumor infiltrating B lymphocytes in tertiary lymphoid structures positive melanoma Open
View article: Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy
Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy Open
The goal of therapeutic cancer vaccines and immune checkpoint therapy (ICT) is to promote T cells with anti-tumor capabilities. Here, we compared mutant neoantigen (neoAg) peptide-based vaccines with ICT in preclinical models. NeoAg vaccin…
View article: Targeting Mhc Class 1 Vesicle Improve Induction of Cytotoxic T Lymphocyte Using Artificial Antigen Presenting Cells
Targeting Mhc Class 1 Vesicle Improve Induction of Cytotoxic T Lymphocyte Using Artificial Antigen Presenting Cells Open
View article: Effects of temozolomide on tumor mutation burden and microsatellite instability in melanoma cells
Effects of temozolomide on tumor mutation burden and microsatellite instability in melanoma cells Open
Background: The efficacy of combination therapy with an immune checkpoint inhibitor (ICI) and cytotoxic chemotherapeutic agents has been investigated in cancer including melanoma. Before ICIs were introduced, dacarbazine or temozolomide (T…
View article: Cisplatin resistance driver claspin is a target for immunotherapy in urothelial carcinoma
Cisplatin resistance driver claspin is a target for immunotherapy in urothelial carcinoma Open
Bladder cancer is a major and fatal urological disease. Cisplatin is a key drug for the treatment of bladder cancer, especially in muscle-invasive cases. In most cases of bladder cancer, cisplatin is effective; however, resistance to cispl…
View article: Two cases of angioedema without wheals induced by exercising or bathing
Two cases of angioedema without wheals induced by exercising or bathing Open
View article: Dermoscopy of Melanoma and Non-melanoma Skin Cancers
Dermoscopy of Melanoma and Non-melanoma Skin Cancers Open
Dermoscopy is a widely used non-invasive technique for diagnosing skin tumors. In melanocytic tumors, e.g., melanoma and basal cell carcinoma (BCC), the effectiveness of dermoscopic examination has been fully established over the past two …
View article: Transient hypogammaglobulinemia of infancy with no evidence of immunodeficiency other than atopic dermatitis: A case report and review of literature
Transient hypogammaglobulinemia of infancy with no evidence of immunodeficiency other than atopic dermatitis: A case report and review of literature Open
We report an infant with transient hypogammaglobulinemia of infancy (THI) who had severe atopic dermatitis (AD), but showed no history of infections. The lack of history of infections poses a risk that the underlying THI may be overlooked …
View article: A Case of Cutaneous Manifestation of Angioimmunoblastic T-cell Lymphoma
A Case of Cutaneous Manifestation of Angioimmunoblastic T-cell Lymphoma Open
75 歳，男性。初診 2 週間前より全身のリンパ節腫脹を伴う発熱と共に体幹・四肢に自覚症状を欠く播種状の紅色丘疹・紅斑が出現した。背部紅斑の皮膚生検では，真皮深層の血管および付属器周囲に異型リンパ球を含む単核球の集簇を認め，異型リンパ球は CD3，CD4，CD10，bcl-6，PD-1が陽性であり，angioimmunoblastic T-cell lymphoma(以下 AITL)が疑われ，その後の右鼠径リンパ節生検により AITL と確定診断された。AITL は約半数で…
View article: Retrospective study of 48 cases of metastatic skin tumors, including 4 cases with Sister Mary Joseph nodules
Retrospective study of 48 cases of metastatic skin tumors, including 4 cases with Sister Mary Joseph nodules Open
過去17年間に当科でSister Mary Joseph’s nodule（以下SMJN）と診断した4例を経験した。さらに同時期に臨床的および病理組織学的に診断した転移性皮膚腫瘍44例を経験した。SMJNを含めた転移性皮膚腫瘍48例に対し原発巣，皮膚転移出現部位および時期などについて検討した。転移性皮膚腫瘍48例の原発巣の内訳は肺癌（11例）が最も多く，次いで膵臓癌（5例）であり，膵臓癌の5例中3例がSMJNであった。また，原発巣より先行して皮膚転移が発見された症例は，SM…