Explanipedia

Ex Vivo Optical Coherence Tomography Analysis of Resected Human Bladder with a Forward-Looking Microelectromechanical Systems Mirror-Based Catheter Open

Marinka J. Remmelink, Paul R. Bloemen, Patrick van der Voorn, Xavier Attendu, Richard M. van den Elzen , et al. · 2025

A technique that enables real-time diagnosis of bladder cancer is needed. Optical coherence tomography (OCT) is a promising technique, but a forward-looking OCT catheter is necessary for OCT to enable bladder cancer diagnosis. This study a…

Nerve Fibres in Psoriatic Skin and Their Relation to Vasculature and Clinical Parameters Open

Meagan Doppegieter, N. van der Beek, Maurice C. G. Aalders, Erik N.T.P. Bakker, Martino Neumann , et al. · 2025

Emerging evidence supports the neurogenic origin of psoriasis, yet the morphology and distribution of nerve fibres in psoriatic skin remain poorly characterised due to methodological inconsistencies and limited 3D data. The aim of this stu…

Identification of Ischemic Stroke Patients Based on Plasma Concentrations of Extracellular Vesicles Open

N Buntsma, Chi M. Hau, Mandy Los, Vivien Chen, Ton G. van Leeuwen , et al. · 2025

Patients presenting with stroke symptoms suffer from either ischemic stroke, hemorrhagic stroke, transient ischemic attacks (TIA), or “stroke mimics,” which include benign headaches, epilepsy, and vestibular disorders. As ischemic and hemo…

Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour‐Derived Extracellular Vesicles Open

Agustin Enciso‐Martinez, Caroline Løppke, Joyce J. Koene, Jade Ebbelaar, Marleen van Geest , et al. · 2025

Tumour‐derived extracellular vesicles (tdEVs) are widely studied for their contribution to tumour progression and metastasis. These studies are hampered by the lack of specific markers to identify the tdEVs. Here, we show that oncofoetal c…

Perspective on the use of optics in bladder cancer detection and diagnosis Open

Marinka J. Remmelink, Dylan J. Peterson, Jakko A. Nieuwenhuijzen, Ton G. van Leeuwen, Joseph C. Liao , et al. · 2025

Optical techniques could accelerate BC diagnosis, reduce costs, and enable alternative treatments. However, overcoming technical and practical challenges is essential for their successful integration.

Achieving High‐Precision Attenuation Coefficient Measurement in Optical Coherence Tomography Open

Linda B. Neubrand, Xavier Attendu, Ton G. van Leeuwen · 2025

In this study, we aim to validate the analytical Cramer‐Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the v…

Pulse Oximetry: 50 Years of Inventions & Discoveries in Biomedical Optics Open

Jana M. Kainerstorfer, Kenneth M. Tichauer, Arjun G. Yodh, Ton G. van Leeuwen, Brian W. Pogue · 2025

The editorial introduces the JBO Special Issue on Pulse Oximetry.

Contrast-enhanced Ultrasound Imaging Following Transperineal Laser Ablation for Lower Urinary Tract Symptoms Open

Rob A. A. van Kollenburg, L.A.M.J.G. van Riel, Jorg R. Oddens, Theo M. de Reijke, Ton G. van Leeuwen , et al. · 2024

This study described ablation zone shape and measured the ablation volume following TPLA by various fiber configurations using CEUS, and compared these to functional outcomes. Prostate volume reduced significantly during follow-up. Segment…

All-reflective tethered capsule endoscope for multimodal optical coherence tomography in the esophagus Open

Xavier Attendu, Paul R. Bloemen, Niels H. Kind, Dirk J. Faber, Daniël M. de Bruin , et al. · 2024

An all-reflective TCE is feasible and allows for achromatic high-quality imaging. Such a device could be utilized as a platform for testing various combinations of modalities to identify the optimal candidates without requiring design iter…

Model for the diffuse reflectance in spatial frequency domain imaging (Erratum) Open

Anouk L. Post, Dirk J. Faber, Ton G. van Leeuwen · 2024

[This corrects the article DOI: 10.1117/1.JBO.28.4.046002.].

Subminute thermal damage to cell types present in the skin Open

Meagan Doppegieter, Ton G. van Leeuwen, Angela van Weert, Maurice C. G. Aalders, Erik N.T.P. Bakker · 2024

The results imply that there is a cell-type-dependent sensitivity to thermal damage which suggests that neuronal cells and keratinocytes are particularly susceptible to diffusing heat from laser treatment. Damage to these cells may aid in …

Towards non‐invasive tissue hydration measurements with optical coherence tomography Open

Linda B. Neubrand, Ton G. van Leeuwen, Dirk J. Faber · 2024

The attenuation coefficient () measured by optical coherence tomography (OCT) has been used to determine tissue hydration. Previous dual‐wavelength OCT systems could not attain the needed precision, which we attribute to the absence of wav…

The impact of temperature on vascular function in connection with vascular laser treatment Open

Meagan Doppegieter, Ton G. van Leeuwen, Maurice C. G. Aalders, Judith de Vos, Ed VanBavel , et al. · 2024

Pulsed dye lasers are used effectively in the treatment of psoriasis with long remission time and limited side effects. It is, however, not completely understood which biological processes underlie its favorable outcome. Pulsed dye laser t…

Poloxamer-188 as a wetting agent for microfluidic resistive pulse sensing measurements of extracellular vesicles Open

Mona Shahsavari, Rienk Nieuwland, Ton G. van Leeuwen, Edwin van der Pol · 2024

Introduction Microfluidic resistive pulse sensing (MRPS) can determine the concentration and size distribution of extracellular vesicles (EVs) by measuring the electrical resistance of single EVs passing through a pore. To ensure that the …

Modeling pulsed dye laser treatment of psoriatic plaques by combining numerical methods and image‐derived lesion morphologies Open

Leah S. Wilk, Meagan Doppegieter, N. van der Beek, Ton G. van Leeuwen, Maurice C. G. Aalders · 2024

Objectives Knowledge of the physical effects of pulsed dye laser (PDL) treatment of psoriatic lesions is essential in unraveling the remedial mechanisms of this treatment and hence also in maximizing in its disease‐modifying potential. The…

Optical feedback for real-time monitoring during transperineal laser ablation: Towards accurate treatment planning Open

Mitra Almasian, P.B. Bloemen, R. van den Elzen, Ton G. van Leeuwen, Theo M. de Reijke , et al. · 2024

Accuracy and precision of depth-resolved estimation of attenuation coefficients in optical coherence tomography Open

Linda B. Neubrand, Ton G. van Leeuwen, Dirk J. Faber · 2023

We derived and validated expressions for the accuracy and precision of DRE of . A commonly used simplification of this method is not recommended as being used for OCT-attenuation reconstruction. We give a rule of thumb providing guidance i…

Preventing swarm detection in extracellular vesicle flow cytometry: a clinically applicable procedure Open

N Buntsma, Mona Shahsavari, Aleksandra Gąsecka, Rienk Nieuwland, Ton G. van Leeuwen , et al. · 2023

To prevent swarm detection in a series of clinical samples, the measurement count rate of a single diluted plasma sample can be used to determine the optimal dilution factor. For our samples, flow cytometer, and settings, the optimal dilut…

Model for the diffuse reflectance in spatial frequency domain imaging Open

Anouk L. Post, Dirk J. Faber, Ton G. van Leeuwen · 2023

For the diffuse reflectance in SFDI, the model based on the PCBC provides more accurate results than the currently used model by Cuccia et al.

A compendium of single extracellular vesicle flow cytometry Open

Joshua A Welsh, Ger J. A. Arkesteijn, Michel Bremer, Michael Cimorelli, Françoise Dignat‐George , et al. · 2023

Flow cytometry (FCM) offers a multiparametric technology capable of characterizing single extracellular vesicles (EVs). However, most flow cytometers are designed to detect cells, which are larger than EVs. Whereas cells exceed the backgro…

Calibration procedure for enhanced mirror artifact removal in full-range optical coherence tomography using passive quadrature demultiplexing Open

Xavier Attendu, Dirk J. Faber, Guy Lamouche, Ton G. van Leeuwen, Caroline Boudoux , et al. · 2022

The proposed method is simple to implement and produces high mirror artifact extinction. This may encourage the adoption of FR-OCT in clinical and industrial systems or loosen the performance requirements on the optical demodulation circui…

Comparison of preprocessing techniques to reduce nontissue-related variations in hyperspectral reflectance imaging Open

Mark Witteveen, Henricus J. C. M. Sterenborg, Ton G. van Leeuwen, Maurice C. G. Aalders, Theo J. M. Ruers , et al. · 2022

Preprocessing reduces the overlap due to glare and distance variations. In general, the algorithms standard normal variate, min-max, area under the curve, and single wavelength normalization are the most suitable to preprocess data used to…

Opportunities and pitfalls in (sub)diffuse reflectance spectroscopy Open

Mark Witteveen, Dirk J. Faber, Henricus J. C. M. Sterenborg, Theo J. M. Ruers, Ton G. van Leeuwen , et al. · 2022

For a long time, steady-state reflectance spectroscopy measurements have been performed so that diffusion theory could be used to extract tissue optical properties from the reflectance. The development of subdiffuse techniques, such as Sin…

Precision of attenuation coefficient measurements by optical coherence tomography Open

Linda B. Neubrand, Ton G. van Leeuwen, Dirk J. Faber · 2022

Our analytical solution provides a fast, rigorous, and easy-to-use measure for OCT-derived attenuation coefficients for signals above 20 dB. The effect of uncertainties in the focal point position on the precision in the attenuation coeffi…

Quantitative Fluorescence Imaging of Perfusion—An Algorithm to Predict Anastomotic Leakage Open

Sanne Jansen, Daniël M. de Bruin, Leah S. Wilk, Mark I. van Berge Henegouwen, Simon D. Strackee , et al. · 2022

This study tests fluorescence imaging-derived quantitative parameters for perfusion evaluation of the gastric tube during surgery and correlates these parameters with patient outcomes in terms of anastomotic leakage. Poor fundus perfusion …

Misinterpretation of solid sphere equivalent refractive index measurements and smallest detectable diameters of extracellular vesicles by flow cytometry Open

Edwin van der Pol, Ton G. van Leeuwen, Xiaomei Yan · 2021

Flow cytometers are utilized to characterize single submicrometer particles in biofluids, such as extracellular vesicles (EVs) and viruses.However, because calibration of the optical signals measured by flow cytometers requires optical mod…

EDTA stabilizes the concentration of platelet-derived extracellular vesicles during blood collection and handling Open

N Buntsma, Aleksandra Gąsecka, Yvo B.W.E.M. Roos, Ton G. van Leeuwen, Edwin van der Pol , et al. · 2021

Citrate is the recommended anticoagulant for studies on plasma extracellular vesicles (EVs). Because citrate incompletely blocks platelet activation and the release of platelet-derived EVs, we compared EDTA and citrate in that regard. Bloo…

Correction to: A literature review and novel theoretical approach on the optical properties of whole blood Open

Nienke Bosschaart, Gerda J. Edelman, Maurice C. G. Aalders, Ton G. van Leeuwen, Dirk J. Faber · 2021

MP46-07 PRELIMINARY RESULTS OF IN VIVO FOCAL TRANSPERINEAL LASER ABLATION TREATMENT OF THE PROSTATE: CORRELATION OF mpMRI AND CEUS IMAGING TO HISTOLOGY IN RADICAL PROSTATECTOMY SPECIMEN Open

Luigi A.M.J.G. van Riel, Rob van Kollenburg, Theo de Reijke, Dilara C. Savci-Heijink, Marc Engelbrecht , et al. · 2021

You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy (MP46)1 Sep 2021MP46-07 PRELIMINARY RESULTS OF IN VIVO FOCAL TRANSPERINEAL LASER ABLATION TREATMENT OF THE PROSTATE: CORRELATION OF mpMRI AND CEUS IMAGING TO HIS…

Bronchoscopic needle-based confocal laser endomicroscopy (nCLE) as a real-time detection tool for peripheral lung cancer Open

Tess Kramer, Lizzy Wijmans, Daniël M. de Bruin, Ton G. van Leeuwen, Teodora Radonic , et al. · 2021

Introduction Diagnosing peripheral lung cancer with the bronchoscope is challenging with near miss of the target lesion as major obstacle. Needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic tumour visualisation…

Ton G. van Leeuwen YOU? Author Swipe