Tong Zhao
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View article: Effects of Maternal Iodine Deficiency in Women with Mild Thyroid Dysfunction During Early Pregnancy on Mental and Motor Growth of Their Offspring During Levothyroxine Treatment
Effects of Maternal Iodine Deficiency in Women with Mild Thyroid Dysfunction During Early Pregnancy on Mental and Motor Growth of Their Offspring During Levothyroxine Treatment Open
The relationship between maternal thyroid function and intellectual development of offspring is controversial. Iodine may be an important confounding factor. This study investigated whether maternal iodine status could affect the efficacy …
View article: Intelligent Optimization of Single-Stand Control in Directional Drilling with Single-Bent-Housing Motors
Intelligent Optimization of Single-Stand Control in Directional Drilling with Single-Bent-Housing Motors Open
Borehole trajectory control is a fundamental task for directional well engineers. Now that there are inevitable errors about single-stand control in the field situation, it is difficult to deal with the complex underground problems in real…
View article: Digital clinical teaching of cardiovascular surgery supported by precision imaging and 3D printing technology: a randomized parallel-controlled trial
Digital clinical teaching of cardiovascular surgery supported by precision imaging and 3D printing technology: a randomized parallel-controlled trial Open
The integration of digital technologies, exemplified by precision imaging and 3D printing, with CBL, PBL, and TBL methodologies, has been shown to significantly enhance the spatial visualization skills of medical students. This approach no…
View article: Latent profile analysis of social participation among adults with cardiovascular disease based on the CHARLS
Latent profile analysis of social participation among adults with cardiovascular disease based on the CHARLS Open
Social participation is recognized as a critical factor in reducing mortality and promoting healthy aging in middle-aged and older adults with cardiovascular disease (CVD). However, the determinants influencing social participation within …
View article: Sex-Specific effects of vitamin D on autistic behavior and gastrointestinal symptoms in rats via the regulation of serotonin metabolism
Sex-Specific effects of vitamin D on autistic behavior and gastrointestinal symptoms in rats via the regulation of serotonin metabolism Open
Vitamin D (VitD) deficiency (VDD) during prenatal and early brain development may be an environmental risk factor for autism spectrum disorder (ASD). While supplementation with high-dose VitD can improve core ASD symptoms, its mechanism is…
View article: TGF-β induces EMT in thyroid cancer cells by regulating transcription factors
TGF-β induces EMT in thyroid cancer cells by regulating transcription factors Open
Background Transforming growth factor-β (TGF-β) plays well-established roles in cancer cell invasion and epithelial–mesenchymal transition (EMT); however, its role in thyroid carcinoma (TC) remains unclear. This study aimed to evaluate the…
View article: Mechanism of Curcumol Targeting the OTUB1/TGFBI Ubiquitination Pathway in the Inhibition of Angiogenesis in Colon Cancer
Mechanism of Curcumol Targeting the OTUB1/TGFBI Ubiquitination Pathway in the Inhibition of Angiogenesis in Colon Cancer Open
Tumor angiogenesis and metastasis are critical processes in the progression of colon carcinoma. Curcumol, a bioactive sesquiterpenoid derived from curcuma, exhibits anti-angiogenic properties, though its underlying mechanisms remain unclea…
View article: Advancements in Cell Membrane-Derived Biomimetic Nanotherapeutics for Breast Cancer
Advancements in Cell Membrane-Derived Biomimetic Nanotherapeutics for Breast Cancer Open
Breast cancer remains the leading cause of female mortality worldwide, necessitating innovative and multifaceted approaches to address its various subtypes. Nanotechnology has attracted considerable attention due to its nanoscale dimension…
View article: Research Progress in the Treatment of Bronchiectasis by Traditional Chinese Medicine
Research Progress in the Treatment of Bronchiectasis by Traditional Chinese Medicine Open
The incidence of bronchiectasis is associated with infection, immunodeficiency, heredity and so on. Because of its persistent and irreversible expansion, it often recurs and persists, which seriously affects the quality of life of patients…
View article: Nanocarrier-encapsulated SGLT-2 inhibitor (dapagliflozin) protects against diabetic cardiomyopathy by reducing myocardial fibrosis
Nanocarrier-encapsulated SGLT-2 inhibitor (dapagliflozin) protects against diabetic cardiomyopathy by reducing myocardial fibrosis Open
Background: Diabetic cardiomyopathy (DCM) is a common complication in diabetic patients and often leads to the onset of heart failure (HF). Nanoparticle (NP) drug delivery systems are a therapeutic approach that have a potential therapeuti…
View article: Multi-omics approaches for biomarker discovery and precision diagnosis of prediabetes
Multi-omics approaches for biomarker discovery and precision diagnosis of prediabetes Open
Recent advancements in multi-omics technologies have provided unprecedented opportunities to identify biomarkers associated with prediabetes, offering novel insights into its diagnosis and management. This review synthesizes the latest fin…
View article: Genome-Wide Scans for Selection Signatures in Ningxia Angus Cattle Reveal Genetic Variants Associated with Economic and Adaptive Traits
Genome-Wide Scans for Selection Signatures in Ningxia Angus Cattle Reveal Genetic Variants Associated with Economic and Adaptive Traits Open
The genetic improvement of beef cattle breeds is crucial for the advancement of the beef cattle industry. Whole-genome resequencing technology has been widely applied in genetic breeding as well as research on selection signatures in beef …
View article: Prevalence of <i>Helicobacter pylori</i> infection in China from 2014-2023: A systematic review and meta-analysis
Prevalence of <i>Helicobacter pylori</i> infection in China from 2014-2023: A systematic review and meta-analysis Open
BACKGROUND Helicobacter pylori (H. pylori) stands as the predominant infectious agent linked to the onset of gastritis, peptic ulcer diseases, and gastric cancer (GC). Identified as the exclusive bacterial factor associated with the onset …
View article: ALKBH5 deficiency attenuates oxygen-glucose deprivation-induced injury in mouse brain microvascular endothelial cells in an m6A dependent manner
ALKBH5 deficiency attenuates oxygen-glucose deprivation-induced injury in mouse brain microvascular endothelial cells in an m6A dependent manner Open
Structural and functional alterations in brain microvascular endothelial cells (BMECs) caused by oxygen-glucose deprivation (OGD) are involved in the pathogenesis of various brain disorders. AlkB homolog 5 (ALKBH5) is a primary m6A demethy…
View article: Global profiling of protein lactylation in microglia in experimental high-altitude cerebral edema
Global profiling of protein lactylation in microglia in experimental high-altitude cerebral edema Open
Background High-altitude cerebral edema (HACE) is considered an end-stage acute mountain sickness (AMS) that typically occurs in people after rapid ascent to 2500 m or more. While hypoxia is a fundamental feature of the pathophysiological …
View article: Integrated Metabolome and Transcriptome Analyses Reveal That the Flavonoid Metabolic Pathway Is Associated with Pigment Differential Accumulation in Two Colors of Petaloid Staminodes in Canna glauca
Integrated Metabolome and Transcriptome Analyses Reveal That the Flavonoid Metabolic Pathway Is Associated with Pigment Differential Accumulation in Two Colors of Petaloid Staminodes in Canna glauca Open
Canna glauca, an ornamental plant widely cultivated in aquatic habitats, is notable for its long florescence and showy flowers. The flower of this species is distinguished by its petaloid staminodes, which comprise the majority of the over…
View article: GhCTSF1, a short PPR protein with a conserved role in chloroplast development and photosynthesis, participates in intron splicing of rpoC1 and ycf3-2 transcripts in cotton
GhCTSF1, a short PPR protein with a conserved role in chloroplast development and photosynthesis, participates in intron splicing of rpoC1 and ycf3-2 transcripts in cotton Open
Cotton is one of the most important textile fibers worldwide. As crucial agronomic traits, leaves play an essential role in the growth, disease resistance, fiber quality, and yield of cotton plants. Pentatricopeptide repeat (PPR) proteins …
View article: Prolyl hydroxylase inhibitor FG-4592 alleviates neuroinflammation via HIF-1/BNIP3 signaling in microglia
Prolyl hydroxylase inhibitor FG-4592 alleviates neuroinflammation via HIF-1/BNIP3 signaling in microglia Open
FG-4592 alleviates neuroinflammation through facilitating microglial HIF-1/BNIP3 signaling pathway in mice. Targeting HIF-PHD/HIF-1/BNIP3 axis is a promising strategy for the development of anti-neuroinflammation drugs.
View article: Effects of exercise, metformin, and their combination on glucose metabolism in individuals with impaired glycemic control: A systematic review and network meta-analysis
Effects of exercise, metformin, and their combination on glucose metabolism in individuals with impaired glycemic control: A systematic review and network meta-analysis Open
Objective To compare the efficacy of exercise, metformin, and their combination on glucose metabolism in individuals with prediabetes and type 2 diabetes mellitus (T2DM), and rank these treatments by exercise modality and metformin dosage.…
View article: Risk Factor Analysis in Patients Exhibiting Cerebral Microbleeds and the Correlation with Cognitive Impairment
Risk Factor Analysis in Patients Exhibiting Cerebral Microbleeds and the Correlation with Cognitive Impairment Open
Objective: To identify the risk factors contributing to cerebral microbleeds (CMBs), analyze the correlation between the quantity and distribution of CMBs and overall cognitive performance, including specific cognitive domains in patients,…
View article: <scp>PHB3</scp> interacts with <scp>BRI1</scp> and <scp>BAK1</scp> to mediate brassinosteroid signal transduction in <i>Arabidopsis</i> and tomato
<span>PHB3</span> interacts with <span>BRI1</span> and <span>BAK1</span> to mediate brassinosteroid signal transduction in <i>Arabidopsis</i> and tomato Open
Summary Brassinosteroids (BRs) are plant hormones that are essential in plant growth and development. BRASSINOSTEROID‐INSENSITIVE 1 (BRI1) and BRI1 ASSOCIATED RECEPTOR KINASE 1 (BAK1), which are located on the plasma membrane, function as …
View article: Analyzing Morphology, Metabolomics, and Transcriptomics Offers Invaluable Insights into the Mechanisms of Pigment Accumulation in the Diverse-Colored Labellum Tissues of Alpinia
Analyzing Morphology, Metabolomics, and Transcriptomics Offers Invaluable Insights into the Mechanisms of Pigment Accumulation in the Diverse-Colored Labellum Tissues of Alpinia Open
Alpinia plants are widely cherished for their vibrant and captivating flowers. The unique feature of this genus lies in their labellum, a specialized floral structure resulting from the fusion of two non-fertile staminodes. However, the in…
View article: Study of the Preparation and Quality of Gastrodia elata with Different Drying Processes
Study of the Preparation and Quality of Gastrodia elata with Different Drying Processes Open
The objective of this study was to evaluate the effects of different drying methods on the quality of fresh Gastrodia elata after drying and processing. Four drying methods, including natural air drying, hot air drying, vacuum freeze dryin…
View article: Research Advances in the High-Value Utilization of Peanut Meal Resources and Its Hydrolysates: A Review
Research Advances in the High-Value Utilization of Peanut Meal Resources and Its Hydrolysates: A Review Open
Peanut meal (PM) is a by-product of extracting oil from peanut kernels. Although peanut meal contains protein, carbohydrates, minerals, vitamins, and small amounts of polyphenols and fiber, it has long been used as a feed in the poultry an…
View article: Association of Plasma Vitamins and Carotenoids, DNA Methylation of LCAT, and Risk of Age-Related Macular Degeneration
Association of Plasma Vitamins and Carotenoids, DNA Methylation of LCAT, and Risk of Age-Related Macular Degeneration Open
Dysregulation of lipid metabolism has been implicated in age-related macular degeneration (AMD), the leading cause of blindness among the elderly. Lecithin cholesterol acyltransferase (LCAT) is an important enzyme responsible for lipid met…
View article: Efficacy and safety of CalliSpheres drug-eluting beads for bronchial arterial chemoembolization for refractory non-small-cell lung cancer and its impact on quality of life: A multicenter prospective study
Efficacy and safety of CalliSpheres drug-eluting beads for bronchial arterial chemoembolization for refractory non-small-cell lung cancer and its impact on quality of life: A multicenter prospective study Open
Objective This study aimed to prospectively observe the efficacy and safety of CalliSpheres drug-eluting beads bronchial arterial chemoembolization (DEB-BACE) for refractory non-small-cell lung cancer (NSCLC). Methods The interventional th…
View article: Prediction of Axillary Lymph Node Metastatic Load of Breast Cancer Based on Ultrasound Deep Learning Radiomics Nomogram
Prediction of Axillary Lymph Node Metastatic Load of Breast Cancer Based on Ultrasound Deep Learning Radiomics Nomogram Open
Background: Axillary lymph node (ALN) metastatic load is very important in the diagnosis and treatment of breast cancer (BC). We aimed to construct a model for predicting ALN metastatic load using deep learning radiomics (DLR) techniques b…
View article: The modified shrinkage classification modes could help to guide breast conserving surgery after neoadjuvant therapy in breast cancer
The modified shrinkage classification modes could help to guide breast conserving surgery after neoadjuvant therapy in breast cancer Open
Purpose The traditional shrinkage classification modes might not suitable for guiding breast conserving surgery (BCS) after neoadjuvant therapy (NAT). Aim was to explore the modified shrinkage classification modes to guide BCS after NAT. M…
View article: Genetic Diversity Analysis Reveals Potential of the Green Peach Aphid (Myzus persicae) Resistance in Ethiopian Mustard
Genetic Diversity Analysis Reveals Potential of the Green Peach Aphid (Myzus persicae) Resistance in Ethiopian Mustard Open
Brassica carinata (BBCC, 2n = 34) is commonly known as Ethiopian mustard, Abyssinian mustard, or carinata. Its excellent agronomic traits, including resistance to biotic and abiotic stresses, make it a potential genetic donor for interspec…