Tonghao Zhang
YOU?
Author Swipe
View article: Pharmacokinetic and mass balance characterization of [ <sup>14</sup> C] RAY1216, a SARS-CoV-2 M <sup>pro</sup> inhibitor, in healthy Chinese male subjects
Pharmacokinetic and mass balance characterization of [ <sup>14</sup> C] RAY1216, a SARS-CoV-2 M <sup>pro</sup> inhibitor, in healthy Chinese male subjects Open
Background RAY1216 is an alpha-ketoamide-based peptide inhibitor of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) major protease (M pro ). This study evaluated the absorption, distribution, metabolism and excretion of […
View article: Acute kidney injury: pathogenesis and therapeutic interventions
Acute kidney injury: pathogenesis and therapeutic interventions Open
Acute kidney injury (AKI) is a prevalent clinical condition that is associated with unacceptably high morbidity and mortality, as well as the development of chronic kidney disease (CKD). The pathogenesis of AKI is highly complex and hetero…
View article: State of the art review on inorganic powders modified asphalt materials: Reducing the temperature of asphalt pavement
State of the art review on inorganic powders modified asphalt materials: Reducing the temperature of asphalt pavement Open
To reduce the temperature diseases of asphalt pavement, improve the service quality of road and extend service life, the research of inorganic powders that reduce the temperature of asphalt pavements was systematically sorted out. The comm…
View article: Clinical study of the pharmacokinetics and pharmacodynamics of Xininurad tablets in patients with renal impairment
Clinical study of the pharmacokinetics and pharmacodynamics of Xininurad tablets in patients with renal impairment Open
Background and Aims: Xininurad is an inhibitor of URAT1 that inhibits URAT1 reabsorption of uric acid in the kidneys and thus serves as a treatment for hyperuricaemia and gout. The purpose of this trial was to evaluate the pharmacokinetics…
View article: Increased ferritin, serum lactate dehydrogenase, and aspartate aminotransferase levels predict macrophage activation syndrome complicating systemic lupus erythematosus: a retrospective study
Increased ferritin, serum lactate dehydrogenase, and aspartate aminotransferase levels predict macrophage activation syndrome complicating systemic lupus erythematosus: a retrospective study Open
Background This study aimed to assess the diagnosis of macrophage activation syndrome (MAS) at the onset of active childhood-onset systemic lupus erythematosus (cSLE), which is under-researched, and to compare the characteristics of cSLE w…
View article: The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer
The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer Open
Background Chronic infections by pathogenic microorganisms play a significant role in cancer development, disrupting the body's immune system and microenvironment. This interference impairs the body's ability to eliminate these microorgani…
View article: Single center clinical analysis of macrophage activation syndrome complicating juvenile rheumatic diseases
Single center clinical analysis of macrophage activation syndrome complicating juvenile rheumatic diseases Open
Background Macrophage activation syndrome (MAS), an example of secondary hemophagocytic lymphohistiocytosis, is a potentially fatal complication of rheumatic diseases. We aimed to study the clinical and laboratory characteristics, treatmen…
View article: Recent advances in microfluidic technology of arterial thrombosis investigations
Recent advances in microfluidic technology of arterial thrombosis investigations Open
Microfluidic technology has emerged as a powerful tool in studying arterial thrombosis, allowing researchers to construct artificial blood vessels and replicate the hemodynamics of blood flow. This technology has led to significant advance…
View article: Innovative Self-Recovery Tristable Metastructural Damper with Super-Elastic Properties
Innovative Self-Recovery Tristable Metastructural Damper with Super-Elastic Properties Open
View article: The Silent Erosion: Mechanisms of Bone Damage in Non-Bone Metastatic Tumors
The Silent Erosion: Mechanisms of Bone Damage in Non-Bone Metastatic Tumors Open
View article: Imaging of Inclusions in Concrete with Enhanced Low-Frequency Ultrasound Tomography
Imaging of Inclusions in Concrete with Enhanced Low-Frequency Ultrasound Tomography Open
View article: The Multi-Scale Measurement of Internal Defect by Low Frequency Ultrasonics in the Half-Grouted Sleeve
The Multi-Scale Measurement of Internal Defect by Low Frequency Ultrasonics in the Half-Grouted Sleeve Open
View article: The Development and Mechanical Analysis of Bistable Element for a Novel Self-Centering Tri-Stable Meta-Structural Metal Damper
The Development and Mechanical Analysis of Bistable Element for a Novel Self-Centering Tri-Stable Meta-Structural Metal Damper Open
View article: Imaging of Inclusions in Concrete with Enhanced Low-Frequency Ultrasound Tomography
Imaging of Inclusions in Concrete with Enhanced Low-Frequency Ultrasound Tomography Open
View article: Multi-scale ultrasonic imaging of sub-surface concrete defects
Multi-scale ultrasonic imaging of sub-surface concrete defects Open
This paper introduces a new method for creating the ultrasonic image of concrete that utilizes both linear and nonlinear wave properties in a single measurement. Linear ultrasonic imaging relies on wave velocity. The resolution of linear u…
View article: Experimental Study on Monitoring Damage Progression of Basalt-FRP Reinforced Concrete Slabs Using Acoustic Emission and Machine Learning
Experimental Study on Monitoring Damage Progression of Basalt-FRP Reinforced Concrete Slabs Using Acoustic Emission and Machine Learning Open
Basalt fiber-reinforced polymer (BFRP) reinforced concrete is a new alternative to conventional steel-reinforced concrete due to its high tensile strength and corrosion resistance characteristics. However, as BFRP is a brittle material, un…
View article: Effectiveness of tumor necrosis factor inhibitors in children with enthesitis-related arthritis: a single-center retrospective analysis
Effectiveness of tumor necrosis factor inhibitors in children with enthesitis-related arthritis: a single-center retrospective analysis Open
Objective In children with enthesitis-related arthritis (ERA), the hip and sacroiliac joint function might be impaired if not properly treated. We sought to evaluate the effectiveness of anti-tumor necrosis factor-α (TNF-α) therapy using t…
View article: Axial involvement in enthesitis-related arthritis: results from a single-center cohort
Axial involvement in enthesitis-related arthritis: results from a single-center cohort Open
Background Axial involvement in children with enthesitis-related arthritis (ERA) has characteristics that differ from those of peripheral involvement. This study characterized their clinical characteristics and treatment. Methods Patients …
View article: Experimental Investigation on Coal Desorption Characteristics and Spontaneous Combustion Properties Evolution Under Pressure-Temperature Coupling
Experimental Investigation on Coal Desorption Characteristics and Spontaneous Combustion Properties Evolution Under Pressure-Temperature Coupling Open
View article: Multi-Frequency Mems Acoustic Emission Sensor
Multi-Frequency Mems Acoustic Emission Sensor Open
View article: Physicochemical Characteristics and Flavor Properties of Texturized Dual-Proteins Extrudates: Effect of Surimi to Soybean Flour Ratio
Physicochemical Characteristics and Flavor Properties of Texturized Dual-Proteins Extrudates: Effect of Surimi to Soybean Flour Ratio Open
This study investigated the effects of surimi to soybean flour ratio (0:10, 1:9, 2:8, 3:7, 4:6) on the physicochemical characteristics and flavor properties of dual-proteins extrudates. The increasing ratio of surimi improved the color of …
View article: Experimental Study of the Pore Structure and Gas Desorption Characteristics of a Low-Rank Coal: Impact of Moisture
Experimental Study of the Pore Structure and Gas Desorption Characteristics of a Low-Rank Coal: Impact of Moisture Open
Coal-water interactions have a prominent impact on the prediction of coal mine gas disasters and coalbed methane extraction. The change of characteristics in the microscopic pores of coal caused by the existence of water is an important fa…
View article: Axial Involvement in Enthesitis-Related Arthritis: Results from a Single-Center Cohort
Axial Involvement in Enthesitis-Related Arthritis: Results from a Single-Center Cohort Open
Background: Axial involvement in children with enthesitis-related arthritis (ERA) has characteristics that differ from those of peripheral involvement. This study characterized their clinical characteristics and treatment. Methods: Patient…
View article: Disentangling the Influence of Data Contamination in Growth Curve Modeling: A Median Based Bayesian Approach
Disentangling the Influence of Data Contamination in Growth Curve Modeling: A Median Based Bayesian Approach Open
Growth curve models (GCMs), with their ability to directly investigate within-subject change over time and between-subject differences in change for longitudinal data, are widely used in social and behavioral sciences. While GCMs are typic…
View article: A multiscale indentation-based technique to correlate acoustic emission with deformation mechanisms in complex alloys
A multiscale indentation-based technique to correlate acoustic emission with deformation mechanisms in complex alloys Open
View article: Effect of Commercialization on Tourists’ Perceived Authenticity and Satisfaction in the Cultural Heritage Tourism Context: Case Study of Langzhong Ancient City
Effect of Commercialization on Tourists’ Perceived Authenticity and Satisfaction in the Cultural Heritage Tourism Context: Case Study of Langzhong Ancient City Open
Although some studies claim that tourism commercialization can promote the authentic experience and behaviour of tourists, there is a lack of empirical support. The main purpose of this study is to identify whether tourism commercializatio…