Tongxuan Wei
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View article: Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope
Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope Open
Metastasis is the leading cause of death from cutaneous melanoma. Identifying metastasis-related targets and developing corresponding therapeutic strategies are major areas of focus. While functional genomics strategies provide powerful to…
View article: Cancer cell target discovery: comparing laboratory evolution of expanded DNA six-nucleotide alphabets with standard four-nucleotide alphabets
Cancer cell target discovery: comparing laboratory evolution of expanded DNA six-nucleotide alphabets with standard four-nucleotide alphabets Open
Anthropogenic evolvable genetic information systems (AEGIS) are DNA-like molecules that can be copied, support laboratory in vitro evolution (LIVE), and evolve to give AegisBodies, analogs of antibodies. However, unlike DNA aptamers built …
View article: Functional Aptamers in vitro Evolution for Protein-protein Interaction Blockage
Functional Aptamers in vitro Evolution for Protein-protein Interaction Blockage Open
As aptamer development progresses, their applications have expanded significantly beyond high affinity to include functional capabilities. Currently, identifying functional aptamers relies on traditional SELEX techniques, followed by funct…