Toni S. Taylor
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View article: Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity
Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity Open
Visceral pain is a leading cause of morbidity in gastrointestinal diseases, which is exacerbated by the gut‐related side‐effects of many analgesics. New treatments are needed and further understanding of the mediators and mechanisms underp…
View article: Sensitisation of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity
Sensitisation of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity Open
Visceral pain is a leading cause of morbidity in gastrointestinal diseases, which is exacerbated by the gut related side-effects of many analgesics. New treatments are needed and further understanding of the mediators and mechanisms underp…
View article: Data to support: Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli
Data to support: Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli Open
View article: Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli.
Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli. Open
Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent signaling within the upper GI tract, and the goal of this study was to determine the…
View article: Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli
Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli Open
Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent signaling within the upper GI tract, and the goal of this study was to determine the…
View article: Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves
Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves Open
Acid sensing in the gastrointestinal tract is required for gut homeostasis and the detection of tissue acidosis caused by ischaemia, inflammation and infection. In the colorectum, activation of colonic afferents by low pH contributes to vi…
View article: Expression and Function of Galanin in Colonic Sensory Neurones
Expression and Function of Galanin in Colonic Sensory Neurones Open
The gastrointestinal (GI) tract is innervated by both the enteric nervous system and the sensory nervous system, and it is the latter that is responsible for giving rise to conscious sensations arising from the GI tract, such as pain. In p…
View article: Galanin inhibits visceral afferent responses to noxious mechanical and inflammatory stimuli
Galanin inhibits visceral afferent responses to noxious mechanical and inflammatory stimuli Open
Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent signalling within the upper GI tract, and the goal of this study was to determine th…
View article: Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves
Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves Open
Acid sensing in the gastrointestinal tract is required for gut homeostasis and the detection of tissue acidosis caused by ischaemia, inflammation and infection. In the colorectum, activation of colonic afferents by low pH contributes to vi…
View article: Chromosomal over-replication in Escherichia coli recG cells is triggered by replication fork fusion and amplified if replichore symmetry is disturbed
Chromosomal over-replication in Escherichia coli recG cells is triggered by replication fork fusion and amplified if replichore symmetry is disturbed Open
Chromosome duplication initiates via the assembly of replication forks at defined origins. Forks proceed in opposite directions until they fuse with a converging fork. Recent work highlights that fork fusions are highly choreographed both …
View article: Single-cell RNAseq reveals seven classes of colonic sensory neuron
Single-cell RNAseq reveals seven classes of colonic sensory neuron Open
Objective Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and give rise to conscious sensation, but …
View article: Shaping the landscape of the<i>Escherichia coli</i>chromosome: replication-transcription encounters in cells with an ectopic replication origin
Shaping the landscape of the<i>Escherichia coli</i>chromosome: replication-transcription encounters in cells with an ectopic replication origin Open
Each cell division requires the unwinding of millions of DNA base pairs to allow chromosome duplication and gene transcription. As DNA replication and transcription share the same template, conflicts between both processes are unavoidable …