Toni Weinhage
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View article: Patient parameters and response after administration of rituximab in pediatric mature B‐cell non‐Hodgkin lymphoma
Patient parameters and response after administration of rituximab in pediatric mature B‐cell non‐Hodgkin lymphoma Open
Background Mature aggressive B‐cell lymphomas are heterogenous malignancies that make up more than half of all diagnosed non‐Hodgkin lymphoma in children and adolescents. The overall survival rate increased over the last decades to 80%–90%…
View article: Characterization of tumor response after administration of rituximab in pediatric B-NHL
Characterization of tumor response after administration of rituximab in pediatric B-NHL Open
Background Mature aggressive B-cell lymphoma are heterogenous malignancies that make up more than half of all diagnosed Non-Hodgkin lymphoma in children and adolescents. The overall survival rate increased over the last decades to 80–90%, …
View article: The Receptor for Advanced Glycation Endproducts (RAGE) Contributes to Severe Inflammatory Liver Injury in Mice
The Receptor for Advanced Glycation Endproducts (RAGE) Contributes to Severe Inflammatory Liver Injury in Mice Open
Background: The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in a number of processes and disorders. While it is known that RAGE-signaling can contribute to toxic liver damage and fibrosis, its rol…
View article: Spontaneous onset of TNFα‐triggered colonic inflammation depends on functional T lymphocytes, <scp>S100A8</scp>/<scp>A9</scp> alarmins, and <scp>MHC</scp> H‐2 haplotype
Spontaneous onset of TNFα‐triggered colonic inflammation depends on functional T lymphocytes, <span>S100A8</span>/<span>A9</span> alarmins, and <span>MHC</span> H‐2 haplotype Open
Recently, we established a doxycycline‐inducible human tumor necrosis factor alpha (TNFα)‐transgenic mouse line, ihTNFtg. Non‐induced young and elderly mice showed low but constitutive expression of hTNFα due to promoter leakiness. The per…
View article: Synergistic Signaling of TLR and IFNα/β Facilitates Escape of IL-18 Expression from Endotoxin Tolerance
Synergistic Signaling of TLR and IFNα/β Facilitates Escape of IL-18 Expression from Endotoxin Tolerance Open
Rationale: IL-18 is a member of the IL-1 cytokine family, and elevated blood IL-18 concentrations associate with disease activity in macrophage activation syndrome (MAS) and poor clinical outcomes in severe inflammatory and septic conditio…
View article: Tofacitinib Reprograms Human Monocytes of IBD Patients and Healthy Controls Toward a More Regulatory Phenotype
Tofacitinib Reprograms Human Monocytes of IBD Patients and Healthy Controls Toward a More Regulatory Phenotype Open
Background The inhibition of Janus kinases (JAKs) and subsequent signal transducers and activators of transcription (STATs) by tofacitinib represents a new therapeutic strategy in inflammatory bowel diseases (IBD) as clinical trials have l…
View article: Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study
Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study Open
Purpose: To characterize peripheral blood T cells in juvenile idiopathic arthritis-associated uveitis (JIAU). Methods: Blood samples were taken from children with JIAU (n = 18), JIA without ocular involvement (n = 11), idiopathic anterior …
View article: Long-Term Clinical Outcomes after Early Initiation of RRT in Critically Ill Patients with AKI
Long-Term Clinical Outcomes after Early Initiation of RRT in Critically Ill Patients with AKI Open
Whether earlier initiation of RRT in critically ill patients with AKI can improve outcomes remains debated. We examined follow-up data from a large clinical trial to prospectively investigate the long-term outcomes associated with the timi…
View article: P118 Balancing JAK/STAT-signaling with Tofacitinib in monocytes of healthy controls and IBD patients
P118 Balancing JAK/STAT-signaling with Tofacitinib in monocytes of healthy controls and IBD patients Open
Background: Monocytes are bridging natural and acquired immunity. Information about JAK signaling in monocytes is scarce. JAK-inhibition is a promising new anti-inflammatory treatment option. However, JAK/STAT activation may be involved bo…
View article: Effect of Adalimumab on Peripheral Blood Mononuclear Cells in Non-Infectious Uveitis
Effect of Adalimumab on Peripheral Blood Mononuclear Cells in Non-Infectious Uveitis Open
Purpose: This study analyzed the effect of adalimumab on peripheral blood mononuclear cells (PBMCs) in uveitis. Methods: PBMCs and serum S100A12 levels from 14 uveitis patients and 28 healthy controls were analyzed. Patient samples were ta…
View article: Activation‐dependent cell death of human monocytes is a novel mechanism of fine‐tuning inflammation and autoimmunity
Activation‐dependent cell death of human monocytes is a novel mechanism of fine‐tuning inflammation and autoimmunity Open
In patients with juvenile idiopathic arthritis (JIA), increased release of IFN‐γ and GM‐CSF in cells infiltrating synovial tissue can be a potent driver of monocyte activation. Given the fundamental role of monocyte activation in remodelin…
View article: Granulocyte Macrophage Colony-Stimulating Factor–Activated CD39+/CD73+ Murine Monocytes Modulate Intestinal Inflammation via Induction of Regulatory T Cells
Granulocyte Macrophage Colony-Stimulating Factor–Activated CD39+/CD73+ Murine Monocytes Modulate Intestinal Inflammation via Induction of Regulatory T Cells Open
GM-CSF leads to specific monocyte activation that modulates experimental colitis via mechanisms that include the induction of Treg. We demonstrate a possible mechanism of Treg induction through CD39 and CD73 expression on monocytes.
View article: Myeloid regulatory cells: cross talk of innate and adaptive immunity to maintain the intestinal immune homeostasis in inflammatory bowel disease
Myeloid regulatory cells: cross talk of innate and adaptive immunity to maintain the intestinal immune homeostasis in inflammatory bowel disease Open
Meeting abstractIntestinal monocytes/macrophages sustain the intestinal immune homeostasis and might be an attractive therapeutic target for the management of inflammatory bowel disease (IBD). Granulocyte macrophage colony-stimulating fact…