Tony Avril
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View article: Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface
Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface Open
While locating in different microenvironments, glioblastoma stem-like cells (GSCs) receive maintenance signals and information to exploit neurovascular tracts. Although the cell adhesion mechanisms to blood vessels have been explored, the …
View article: IRE1-dependent GOLIM4 expression controls protein secretion to modulate glioblastoma cell adhesion and migration
IRE1-dependent GOLIM4 expression controls protein secretion to modulate glioblastoma cell adhesion and migration Open
One of the main glioblastoma (GB) features is the diffuse migration of the tumor cells within the surrounding brain parenchyma, rendering almost impossible the complete tumor resection and irradiation, leading to inexorable lethal relapse …
View article: Protocol to generate two distinct standard-of-care murine glioblastoma models for evaluating novel combination therapies
Protocol to generate two distinct standard-of-care murine glioblastoma models for evaluating novel combination therapies Open
View article: IRE1 RNase controls CD95-mediated cell death
IRE1 RNase controls CD95-mediated cell death Open
Signalling by the Unfolded Protein Response (UPR) or by the Death Receptors (DR) are frequently activated towards pro-tumoral outputs in cancer. Herein, we demonstrate that the UPR sensor IRE1 controls the expression of the DR CD95/Fas, an…
View article: IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma
IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma Open
Background Intrinsic or environmental stresses trigger the accumulation of improperly folded proteins in the endoplasmic reticulum (ER), leading to ER stress. To cope with this, cells have evolved an adaptive mechanism named the unfolded p…
View article: Endoplasmic reticulum homeostasis—From molecules to organisms: Report on the 14th International Calreticulin Workshop, Saint Malo, France
Endoplasmic reticulum homeostasis—From molecules to organisms: Report on the 14th International Calreticulin Workshop, Saint Malo, France Open
The Calreticulin Workshop, initiated in 1994 by Marek Michalak in Banff (Alberta, Canada), was first organized to be an informal scientific meeting attended by researchers working on diverse biological questions related to functions associ…
View article: A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment
A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment Open
View article: Supplementary Materials and Methods, Supplementary Figures 1-7, Supplementary Tables 1-2 from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
Supplementary Materials and Methods, Supplementary Figures 1-7, Supplementary Tables 1-2 from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma Open
Figure S1: CD90 mRNA expression on NCI and glioma cell lines, glioma and GBM specimens; Figure S2: CD90 mRNA and protein are expressed on all GBM cells; Figure S3: Expression of adhesion/migration genes in CD90low and CD90high RNS cell lin…
View article: Data from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
Data from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma Open
Purpose: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells, including glioblastoma (GBM) stem cells (GSC). However, the molecular and cellular functions of…
View article: Supplementary Materials and Methods, Supplementary Figures 1-7, Supplementary Tables 1-2 from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
Supplementary Materials and Methods, Supplementary Figures 1-7, Supplementary Tables 1-2 from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma Open
Figure S1: CD90 mRNA expression on NCI and glioma cell lines, glioma and GBM specimens; Figure S2: CD90 mRNA and protein are expressed on all GBM cells; Figure S3: Expression of adhesion/migration genes in CD90low and CD90high RNS cell lin…
View article: Data from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
Data from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma Open
Purpose: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells, including glioblastoma (GBM) stem cells (GSC). However, the molecular and cellular functions of…
View article: A novel optin<i>E</i>u<i>R</i>in stress connection in glaucoma
A novel optin<i>E</i>u<i>R</i>in stress connection in glaucoma Open
The endoplasmic reticulum (ER) is the organelle where the production and shaping of most secreted and transmembrane proteins happens. ER function is finely regulated to prevent accumulation of misfolded proteins generating ER stress. ER st…
View article: Dual <scp>IRE1 RNase</scp> functions dictate glioblastoma development
Dual <span>IRE1 RNase</span> functions dictate glioblastoma development Open
View article: A novel blood brain barrier-permeable IRE1 kinase inhibitor for adjuvant glioblastoma treatment in mice.
A novel blood brain barrier-permeable IRE1 kinase inhibitor for adjuvant glioblastoma treatment in mice. Open
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease. It is a major mediator of the Unfolded Protein Response (UPR), which is activated upon endoplasmic reticulum (ER) stress. Tumor cells experi…
View article: Challenges in glioblastoma research: focus on the tumor microenvironment
Challenges in glioblastoma research: focus on the tumor microenvironment Open
View article: A novel blood brain barrier-permeable IRE1 kinase inhibitor for adjuvant glioblastoma treatment in mice.
A novel blood brain barrier-permeable IRE1 kinase inhibitor for adjuvant glioblastoma treatment in mice. Open
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease. It is a major mediator of the Unfolded Protein Response (UPR), which is activated during endoplasmic reticulum (ER) stress. Tumor cells expe…
View article: IRE1 RNase controls CD95-mediated cell death
IRE1 RNase controls CD95-mediated cell death Open
Signalling by the Unfolded Protein Response (UPR) or by the Death Receptors (DR) represents cellular stress pathways frequently activated towards pro-tumoral outputs in cancer. Experimental evidence has highlighted functional links between…
View article: A cell-based system combined with flow cytometry to evaluate antibody responses against SARS-CoV-2 transmembrane proteins in patients with COVID-19
A cell-based system combined with flow cytometry to evaluate antibody responses against SARS-CoV-2 transmembrane proteins in patients with COVID-19 Open
This protocol describes a flow cytometry approach to evaluate antibody responses against SARS-CoV-2 transmembrane proteins in COVID-19-positive patient sera samples without the need of specific laboratory facilities for viral infection. We…
View article: A novel blood brain barrier-permeable IRE1 kinase inhibitor sensitizes glioblastoma to chemotherapy in mice.
A novel blood brain barrier-permeable IRE1 kinase inhibitor sensitizes glioblastoma to chemotherapy in mice. Open
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease. It is a major mediator of the Unfolded Protein Response (UPR), which is activated during endoplasmic reticulum (ER) stress. Tumor cells expe…
View article: Dual IRE1 RNase functions dictate glioblastoma development
Dual IRE1 RNase functions dictate glioblastoma development Open
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View article: SARS-CoV-2 integral membrane proteins shape the serological responses of patients with COVID-19
SARS-CoV-2 integral membrane proteins shape the serological responses of patients with COVID-19 Open
View article: SARS-CoV-2 integral membrane proteins shape the serological responses of COVID-19 patients_Martin et al.
SARS-CoV-2 integral membrane proteins shape the serological responses of COVID-19 patients_Martin et al. Open
This Excel-format table includes clinical data (i.e. socio-demographic information, underlying medical conditions, history of symptoms back to January 2020, and history of COVID-19 diagnosis) and raw data concerning our serological assay.
View article: The unfolded protein response as regulator of cancer stemness and differentiation: Mechanisms and implications for cancer therapy
The unfolded protein response as regulator of cancer stemness and differentiation: Mechanisms and implications for cancer therapy Open
The unfolded protein response (UPR) is an adaptive mechanism that regulates protein and cellular homeostasis. Three endoplasmic reticulum (ER) membrane localized stress sensors, IRE1, PERK and ATF6, coordinate the UPR in order to maintain …
View article: Death sentence: The tale of a fallen endoplasmic reticulum
Death sentence: The tale of a fallen endoplasmic reticulum Open
View article: SARS-CoV2 Envelop Proteins Reshape the Serological Responses of COVID-19 Patients
SARS-CoV2 Envelop Proteins Reshape the Serological Responses of COVID-19 Patients Open
View article: IRE1‐mediated miRNA maturation in macrophage phosphoinositide signaling
IRE1‐mediated miRNA maturation in macrophage phosphoinositide signaling Open
View article: Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo
Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo Open
View article: The integrated stress response promotes B7H6 expression
The integrated stress response promotes B7H6 expression Open
View article: Extracellular AGR3 regulates breast cancer cells migration via Src signaling
Extracellular AGR3 regulates breast cancer cells migration via Src signaling Open
Human anterior gradient proteins AGR2 and AGR3 are overexpressed in a variety of adenocarcinomas and are often secreted in cancer patients' specimens, which suggests a role for AGR proteins in intra and extracellular compartments. Although…
View article: P11.61 Development of a novel preclinical GBM model and therapeutic impact of IRE1 inhibition
P11.61 Development of a novel preclinical GBM model and therapeutic impact of IRE1 inhibition Open
Glioblastoma Multiforme (GBM) is the most severe primary brain tumor and represents more than 15% of all brain tumors. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient’s survival post diagnosis …