Tony Durand
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View article: Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability
Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability Open
Some recent studies suggest that gastrointestinal inflammation could play a role in the development of Parkinson’s disease (PD) by increasing intestinal permeability and triggering early neuropathological changes in the gut. Therefore, we …
View article: Enteric glia promotes the survival of CD4 and CD8 T cells in plexitis: a new player in Crohn’s disease recurrence?
Enteric glia promotes the survival of CD4 and CD8 T cells in plexitis: a new player in Crohn’s disease recurrence? Open
Both CD4 and CD8 T cells adhere to enteric glial cells in patients with Crohn’s disease, contributing to the development of plexitis associated with postoperative recurrence. The adhesion of CD4 and CD8 T cells to enteric glial cells is de…
View article: Confocal laser endomicroscopy as predictive biomarker of clinical and endoscopic efficacy of vedolizumab in ulcerative colitis: The DETECT study
Confocal laser endomicroscopy as predictive biomarker of clinical and endoscopic efficacy of vedolizumab in ulcerative colitis: The DETECT study Open
Aims In patients with ulcerative colitis (UC), no biomarker is available to help the physician to choose the most suitable biotherapy. The primary objective of this pilot study was to assess the feasibility of identification of α4β7- and T…
View article: P027 Involvement of PD-L1 in myenteric plexitis associated with postoperative recurrence of Crohn's disease
P027 Involvement of PD-L1 in myenteric plexitis associated with postoperative recurrence of Crohn's disease Open
Background Despite a growing therapeutic armamentarium, post-operative recurrence (POR) in Crohn’s disease (CD) remains frequent. The presence of myenteric plexitis at the proximal margin of ileocolonic resection has been recognized as a r…
View article: Role of ICAM-1 in the Adhesion of T Cells to Enteric Glia: Perspectives in the Formation of Plexitis in Crohn’s Disease
Role of ICAM-1 in the Adhesion of T Cells to Enteric Glia: Perspectives in the Formation of Plexitis in Crohn’s Disease Open
Our present work argues for a role of glia-T-cell interaction in the development of myenteric plexitis through the adhesion molecules ICAM-1/LFA-1 and suggests that deciphering the functional consequences of glia-T-cell interaction is impo…
View article: Visualizing enteric nervous system activity through dye-free dynamic full-field optical coherence tomography
Visualizing enteric nervous system activity through dye-free dynamic full-field optical coherence tomography Open
Major advances have been achieved in imaging technologies but most methodological approaches currently used to study the enteric neuronal functions rely on exogenous contrast dyes that can interfere with cellular functions or survival. In …
View article: Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors
Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors Open
Introduction Repeated acute stress (RASt) is known to be associated with gastrointestinal dysfunctions. However, the mechanisms underlying these effects have not yet been fully understood. While glucocorticoids are clearly identified as st…
View article: P320 Confocal Laser Endomicroscopy to predict the efficacy of vedolizumab as first-line biotherapy in ulcerative colitis
P320 Confocal Laser Endomicroscopy to predict the efficacy of vedolizumab as first-line biotherapy in ulcerative colitis Open
Background There is no biomarker to guide first-line of biotherapy in ulcerative colitis (UC). The main objective of this multicenter pilot study was to demonstrate the feasibility of identifying a4b7 and/or TNF-a expressing cells by dual-…
View article: Could the Microbiota Be a Predictive Factor for the Clinical Response to Probiotic Supplementation in IBS-D? A Cohort Study
Could the Microbiota Be a Predictive Factor for the Clinical Response to Probiotic Supplementation in IBS-D? A Cohort Study Open
Background: Increasing evidence suggests the beneficial effects of probiotics in irritable bowel syndrome (IBS), but little is known about how they can impact the gut microbiota. Our objective was to evaluate the effects of a multistrain p…
View article: Maternal prebiotic supplementation impacts colitis development in offspring mice
Maternal prebiotic supplementation impacts colitis development in offspring mice Open
Background and aims Maternal diet plays a key role in preventing or contributing to the development of chronic diseases, such as obesity, allergy, and brain disorders. Supplementation of maternal diet with prebiotics has been shown to redu…
View article: Altered epithelial barrier functions in the colon of patients with spina bifida
Altered epithelial barrier functions in the colon of patients with spina bifida Open
Our objectives were to better characterize the colorectal function of patients with Spina Bifida (SB). Patients with SB and healthy volunteers (HVs) completed prospectively a standardized questionnaire, clinical evaluation, rectal barostat…
View article: Psychological Stress Induces an Increase in Cholinergic Enteric Neuromuscular Pathways Mediated by Glucocorticoid Receptors
Psychological Stress Induces an Increase in Cholinergic Enteric Neuromuscular Pathways Mediated by Glucocorticoid Receptors Open
Repeated acute stress (RASt) is known to be associated with gastrointestinal dysfunctions. However, mechanisms underlying these effects are not fully understood. While glucocorticoids are clearly identified as hormones of stress, their imp…
View article: The ephrin receptor EphB2 regulates the connectivity and activity of enteric neurons
The ephrin receptor EphB2 regulates the connectivity and activity of enteric neurons Open
View article: Analysis of enteric nervous system and intestinal epithelial barrier to predict complications in Hirschsprung’s disease
Analysis of enteric nervous system and intestinal epithelial barrier to predict complications in Hirschsprung’s disease Open
View article: T cells show preferential adhesion to enteric neural cells in culture and are close to neural cells in the myenteric ganglia of Crohn's patients
T cells show preferential adhesion to enteric neural cells in culture and are close to neural cells in the myenteric ganglia of Crohn's patients Open
View article: Hepatitis C Virus Regulates its Replication by Maturing miR-122 Through Akt-Dependent Phosphorylation of KSRP
Hepatitis C Virus Regulates its Replication by Maturing miR-122 Through Akt-Dependent Phosphorylation of KSRP Open
The liver-specific micro-RNA-122 (miR-122) is required for the replication of hepatitis C virus (HCV). The direct interaction between miR-122 and the 5’ untranslated region of the HCV genome promotes viral replication and protects HCV RNA …
View article: IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease
IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease Open
It remains unknown what causes inflammatory bowel disease (IBD), including signaling networks perpetuating chronic gastrointestinal inflammation in Crohn's disease (CD) and ulcerative colitis (UC), in humans. According to an analysis of up…
View article: Acute inflammation down‐regulates alpha‐synuclein expression in enteric neurons
Acute inflammation down‐regulates alpha‐synuclein expression in enteric neurons Open
The protein alpha‐synuclein whose expression is strongly implicated in Parkinson's disease ( PD ) is not only expressed in the CNS but also in the enteric nervous system ( ENS ). The growing body of evidence suggesting that gastrointestina…
View article: Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type
Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type Open
Gastric cancer is the third leading cause of cancer-related death worldwide, but the mechanisms of gastric carcinogenesis are not completely understood. Recently, the role of cholinergic neuronal pathways in promoting this process has been…
View article: Glioplasticity in irritable bowel syndrome
Glioplasticity in irritable bowel syndrome Open
Background Growing evidence indicates a wide array of cellular remodeling in the mucosal microenvironment during irritable bowel syndrome ( IBS ), which possibly contributes to pathophysiology and symptom generation. Here, we investigated …
View article: Anti‐inflammatory Effects of Enhanced Recovery Programs on Early‐Stage Colorectal Cancer Surgery
Anti‐inflammatory Effects of Enhanced Recovery Programs on Early‐Stage Colorectal Cancer Surgery Open
Background Postoperative ileus (POI) is observed in 20–30% of patients undergoing colorectal cancer surgery, despite enhanced recovery programs (ERPs). Cyclooxygenase (COX)‐2 is identified as a key enzyme in POI, but other arachidonic acid…
View article: Enteric glial cells have specific immunosuppressive properties
Enteric glial cells have specific immunosuppressive properties Open
View article: Specialization of Hepatitis C Virus Envelope Glycoproteins for B Lymphocytes in Chronically Infected Patients
Specialization of Hepatitis C Virus Envelope Glycoproteins for B Lymphocytes in Chronically Infected Patients Open
Hepatitis C virus (HCV) productively infects hepatocytes. Virion surface glycoproteins E1 and E2 play a major role in this restricted cell tropism by mediating virus entry into particular cell types. However, several pieces of evidence hav…