Tonya J. Webb YOU? Author Swipe

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Developing CAR-T cells to target immunosuppressive ganglioside GD3 in ovarian cancer 4664 Open

Yuyi Zhu, Tonya J. Webb · 2025

Description Ovarian cancer (OC) is the fifth leading cause of death in women in the US and the most lethal gynecological malignancy worldwide. Previous studies from our lab have shown that OC cells shed high concentrations of the immunosup…

Identification of Functional Immune Biomarkers in Breast Cancer Patients Open

Roshanak Derakhshandeh, Yuyi Zhu, Junxin Li, Danubia Hester, Rania H. Younis , et al. · 2024

Cancer immunotherapy has emerged as an effective, personalized treatment for certain patients, particularly for those with hematological malignancies. However, its efficacy in breast cancer has been marginal—perhaps due to cold, immune-exc…

Novel lipid antigens for NKT cells in cancer Open

Michael S. Lee, Tonya J. Webb · 2023

Cancer immunotherapy aims to unleash the power of the immune system against tumors without the side effects of traditional chemotherapy. Immunotherapeutic methods vary widely, but all follow the same basic principle: overcome the barriers …

Supplemental Figure 1. from VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells Open

Irina V. Tiper, Sarah M. Temkin, Sarah Spiegel, Simeon E. Goldblum, Robert Giuntoli , et al. · 2023

Ovarian cancer associated ascites contains soluble inhibitory factors. The ascites was cleared of cellular debris by centrifugation as previously described (18). (A, B) The ascites was filtered 0.2 micron filter and fractionated- f1: <5KDa…

Data from VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells Open

Irina V. Tiper, Sarah M. Temkin, Sarah Spiegel, Simeon E. Goldblum, Robert Giuntoli , et al. · 2023

Purpose: Natural killer T (NKT) cells are important mediators of antitumor immune responses. We have previously shown that ovarian cancers shed the ganglioside GD3, which inhibits NKT-cell activation. Ovarian cancers also secrete hi…

Supplemental Figure 2. from VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells Open

Irina V. Tiper, Sarah M. Temkin, Sarah Spiegel, Simeon E. Goldblum, Robert Giuntoli , et al. · 2023

The source of GD3 impacts CD1d-mediated antigen presentation.(A) LCD1d cells were treated with GD3 from different sources for 4 hours, then washed extensively and cocultured with NKT cell hybridomas. IL-2 was measured, as an indication of …

Supplemental Figure 2. from VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells Open

Irina V. Tiper, Sarah M. Temkin, Sarah Spiegel, Simeon E. Goldblum, Robert Giuntoli , et al. · 2023

The source of GD3 impacts CD1d-mediated antigen presentation.(A) LCD1d cells were treated with GD3 from different sources for 4 hours, then washed extensively and cocultured with NKT cell hybridomas. IL-2 was measured, as an indication of …

Supplemental Figure 1. from VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells Open

Irina V. Tiper, Sarah M. Temkin, Sarah Spiegel, Simeon E. Goldblum, Robert Giuntoli , et al. · 2023

Ovarian cancer associated ascites contains soluble inhibitory factors. The ascites was cleared of cellular debris by centrifugation as previously described (18). (A, B) The ascites was filtered 0.2 micron filter and fractionated- f1: <5KDa…

Data from VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells Open

Irina V. Tiper, Sarah M. Temkin, Sarah Spiegel, Simeon E. Goldblum, Robert Giuntoli , et al. · 2023

Purpose: Natural killer T (NKT) cells are important mediators of antitumor immune responses. We have previously shown that ovarian cancers shed the ganglioside GD3, which inhibits NKT-cell activation. Ovarian cancers also secrete hi…

Data from Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer Open

Tonya J. Webb, Xiangming Li, Robert Giuntoli, Pablo H.H. López, Christoph Heuser , et al. · 2023

Tumors often display mechanisms to avoid or suppress immune recognition. One such mechanism is the shedding of gangliosides into the local tumor microenvironment, and a high concentration of circulating gangliosides is associated with poor…

Supplementary Figure 1 from Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer Open

Tonya J. Webb, Xiangming Li, Robert Giuntoli, Pablo H.H. López, Christoph Heuser , et al. · 2023

PDF file - 225K, Schematic of Ganglioside GD3 and other glycolipids used or referred to in this paper

Supplementary Figure Legend from Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer Open

Tonya J. Webb, Xiangming Li, Robert Giuntoli, Pablo H.H. López, Christoph Heuser , et al. · 2023

PDF file - 53K

Supplementary Figure 1 from Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer Open

Tonya J. Webb, Xiangming Li, Robert Giuntoli, Pablo H.H. López, Christoph Heuser , et al. · 2023

PDF file - 225K, Schematic of Ganglioside GD3 and other glycolipids used or referred to in this paper

Supplementary Figure Legend from Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer Open

Tonya J. Webb, Xiangming Li, Robert Giuntoli, Pablo H.H. López, Christoph Heuser , et al. · 2023

PDF file - 53K

Data from Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer Open

Tonya J. Webb, Xiangming Li, Robert Giuntoli, Pablo H.H. López, Christoph Heuser , et al. · 2023

Tumors often display mechanisms to avoid or suppress immune recognition. One such mechanism is the shedding of gangliosides into the local tumor microenvironment, and a high concentration of circulating gangliosides is associated with poor…

Current Developments in the Preclinical and Clinical use of Natural Killer T cells Open

Christina Kratzmeier, Sasha A. Singh, Emmanuel B. Asiedu, Tonya J. Webb · 2022

Microtentacle Formation in Ovarian Carcinoma Open

Jocelyn Reader, Cong Fan, Eleanor C. Ory, Julia A. Ju, Rachel Lee , et al. · 2022

Background: The development of chemoresistance to paclitaxel and carboplatin represents a major therapeutic challenge in ovarian cancer, a disease frequently characterized by malignant ascites and extrapelvic metastasis. Microtentacles (Mc…

The Minority Scientists’ Experience: Challenging and Overcoming Barriers to Enhancing Diversity and Career Advancement Open

Tonya J. Webb, Mireia Guerau‐de‐Arellano, Harlan P. Jones, Cherié Butts, Luis Sanchez-Perez , et al. · 2022

Minority groups face barriers in accessing quality health care, professional advancement, and representation in immunology research efforts as a result of institutional racism that if unaddressed can perpetuate a lack of diversity. In 2021…

Effective Barriers: The Role of NKT Cells and Innate Lymphoid Cells in the Gut Open

Cristiana Cairo, Tonya J. Webb · 2022

The critical role of commensal microbiota in regulating the host immune response has been established. In addition, it is known that host–microbial interactions are bidirectional, and this interplay is tightly regulated to prevent chronic …

Inclusion criteria: how NK cells gain access to T cells Open

Tonya J. Webb · 2021

Natural killer (NK) cells play an important role in host defense against viral infections and malignancy, and their role for regulating other components of the antiviral response is being investigated. In this issue of the JCI, Ali et al. …

Deletion Mutants of Francisella Phagosomal Transporters FptA and FptF Are Highly Attenuated for Virulence and Are Protective Against Lethal Intranasal Francisella LVS Challenge in a Murine Model of Respiratory Tularemia Open

Brandi E. Hobbs, Courtney Alexandra Matson, Vasileios Ionas Theofilou, Tonya J. Webb, Rania H. Younis , et al. · 2021

Francisella tularensis (Ft) is a Gram-negative, facultative intracellular bacterium that is a Tier 1 Select Agent of concern for biodefense for which there is no licensed vaccine. A subfamily of 9 Francisella phagosomal transporter (fpt) g…

Targeting Natural Killer T Cells in Solid Malignancies Open

Zewde Ingram, Shriya Madan, Jenoy Merchant, Zakiya Carter, Zen Gordon , et al. · 2021

Natural killer T (NKT) cells are a unique subset of lymphocytes that recognize lipid antigens in the context of the non-classical class I MHC molecule, CD1d, and serve as a link between the innate and adaptive immune system through their e…

Soluble Sema4D in Plasma of Head and Neck Squamous Cell Carcinoma Patients Is Associated With Underlying Non-Inflamed Tumor Profile Open

Rania H. Younis, Ioana Ghita, Manar Elnaggar, Risa Chaisuparat, Vasileios Ionas Theofilou , et al. · 2021

Semaphorin 4D (Sema4D) is a glycoprotein that is expressed by several tumors and immune cells. It can function as a membrane bound protein or as a cleaved soluble protein (sSema4D). We sought to investigate the translational potential of p…

Inbred Strain Characteristics Impact the NKT Cell Repertoire Open

Susannah C. Shissler, Joshua P. Bates, Danubia Hester, Laundette P. Jones, Tonya J. Webb · 2021

NKT cells are primed lymphocytes that rapidly secrete cytokines and can directly kill cancerous cells. Given the critical role NKT cells play in cancer immune surveillance, we sought to investigate the effect of mutations in Brca1, specifi…

Editorial: NKT Cells in Cancer Immunotherapy Open

Tonya J. Webb, Weiming Yuan, Everett Meyer, Paolo Dellabona · 2020

EDITORIAL article Front. Immunol., 23 June 2020Sec. Cancer Immunity and Immunotherapy Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.01314

Thymic resident NKT cell subsets show differential requirements for CD28 co-stimulation during antigenic activation Open

Susannah C. Shissler, Nevil J. Singh, Tonya J. Webb · 2020

Natural killer T (NKT) cells rapidly respond to antigenic stimulation with cytokine production and direct cytotoxicity. These innate-like characteristics arise from their differentiation into mature effector cells during thymic development…

Sphingosine Kinase Blockade Leads to Increased Natural Killer T Cell Responses to Mantle Cell Lymphoma Open

Michael S. Lee, Wenji Sun, Tonya J. Webb · 2020

Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin’s lymphoma. Despite being responsive to combination chemotherapy, median survival remains around 5 years due to high rates of relapse. Sphingolipid metabolism regulates MCL…

Publisher Correction: Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor Open

Piotr Humeniuk, Sabine Geiselhart, Claire Battin, Tonya J. Webb, Peter Steinberger , et al. · 2019

Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor Open

Piotr Humeniuk, Sabine Geiselhart, Claire Battin, Tonya J. Webb, Peter Steinberger , et al. · 2019

Invariant natural killer T (iNKT) cells are a specialized subset of T cells contributing to both, the innate and adaptive immune responses. In contrast to conventional T lymphocytes they recognize lipid antigens. The aim of the project is …

Defining Barriers that Impede Choices Open

Tonya J. Webb, Amy S. Weinmann · 2019

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