Explanipedia

Clinical and molecular findings in actin-related inborn errors of immunity: the middle East and North Africa registry Open

Zahra Chavoshzadeh, Shahrzad Fallah, Vahide Zeinali, Samin Sharafian, Samaneh Delavari , et al. · 2025

Background The majority of monogenic inborn errors of immunity presenting as actinopathies were reported originally from the Middle East and North Africa (MENA) countries indicating a high prevalence of these entities in the region. Howeve…

Disseminated Bacille Calmette-Guérin Vaccine-Induced Disease in a Sample of Iranian Children: A Longitudinal Case-Series Study Open

Hamid Rahimi, Gelareh Kiani, Sayed Nassereddin Mostafavi Esfahani, Monir Sadat Emadoleslami, Tooba Momen , et al. · 2024

Background: Approximately a quarter-million Iranian newborns receive the Bacille Calmette-Guérin (BCG) vaccine annually. However, in immunodeficient infants, this vaccine can lead to disseminated BCG disease (DBD). Objectives: This study a…

Genomic testing identifies monogenic causes in patients with very early-onset inflammatory bowel disease: a multicenter survey in an Iranian cohort Open

Golnaz Eslamian, Mahnaz Jamee, Tooba Momen, Pejman Rohani, Sarehossadat Ebrahimi , et al. · 2024

Patients with very early-onset inflammatory bowel disease (VEO-IBD) may present because of underlying monogenic inborn errors of immunity (IEI). Strong differences have been observed in the causes of monogenic IBD among ethnic populations.…

Antiepileptic Medication-induced Severe Cutaneous Adverse Reactions in Hospitalized Children: A Retrospective Study Open

Bahareh Abtahi‐Naeini, reza makhmali, Niloufar Amini, Mohammad Reza Maracy, Nikta Nouri , et al. · 2024

There are limited data on severe cutaneous adverse reactions (SCARs) associated with antiepileptic medications. The current study aims to investigate the clinical and epidemiological characteristics of antiepileptic medication-induced SCAR…

Clinical heterogeneity in families with multiple cases of inborn errors of immunity Open

Samaneh Delavari, Seyed Erfan Rasouli, Saba Fekrvand, Zahra Chavoshzade, Seyed Alireza Mahdaviani , et al. · 2024

Autoimmune versus Non-autoimmune Cutaneous Features in Monogenic Patients with Inborn Errors of Immunity Open

Niusha Sharifinejad, Gholamreza Azizi, Seyed Erfan Rasouli, Zahra Chavoshzadeh, Seyed Alireza Mahdaviani , et al. · 2023

Cutaneous manifestations are one of the most common presentations among patients with inborn errors of immunity (IEI). These skin manifestations are often among the first presenting features in the majority of patients preceding the IEI di…

Clinical, immunological, and genetic findings in Iranian patients with MHC-II deficiency: confirmation of c.121delG RFXANK founder mutation in the Iranian population Open

Mohadese-sadat Musavi Khorshidi, Yoann Seeleuthner, Zahra Chavoshzadeh, Maryam Behfar, Amir Ali Hamidieh , et al. · 2023

Purpose: Major histocompatibility complex class II (MHC-II) deficiency is a rare inborn error of immunity (IEI). Impaired antigen presentation to CD4+ T-cells results in combined immunodeficiency. Patients typically present with severe res…

Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review Open

Bahareh Abtahi‐Naeini, Tooba Momen, Rezvan Amiri, Parvin Rajabi, Fereshte Rastegarnasab · 2023

Metformin is a commonly used medication in diabetic patients. It can cause different complications including cutaneous adverse reactions. Metformin-induced fixed-drug eruption (FDE) has been reported in limited cases. Due to the popularity…

Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry Open

Mahnaz Jamee, Gholamreza Azizi, Safa Barış, Elif Karakoç‐Aydiner, Ahmet Özen , et al. · 2022

Epidemiology, Sociodemographic Factors and Comorbidity for Allergic Rhinitis, Asthma, and Rhinosinusitis Among 15 to 65-year-Old Iranian Patients Open

Seyed Hesamedin Nabavizadeh, Mozhgan Moghtaderi, Soheila Alyasin, Hossein Esmaeilzadeh, Saeed Hosseini Teshnizi , et al. · 2022

Background: It is well established that upper and lower airways are often clumped together when diagnosing and treating a disease. This study was designed to determine the prevalence of upper and lower airway diseases and to assess …

An unusual cause of facial wound in a child: Hyper <span>IgE</span> syndrome‐associated Noma neonatorum Open

Bahareh Abtahi‐Naeini, Tooba Momen, Shakiba Dehghani, Fereshte Rastegarnasab · 2022

A 4-month-old failure to thrive (FTT) infant presented with large ulcerative ecthyma-like lesions on the face. Five days before the well-developed facial wound, a small area of erythematous papule and plaque was appeared on the right cheek…

The Effectiveness of Synbiotic on the Improvement of Clinical Symptoms in Children with Eosinophilic Esophagitis Open

Niloufar Amini, Majid Khademian, Tooba Momen, Hossein Saneian, Peiman Nasri , et al. · 2022

Background. Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder of the esophagus. Today, probiotics are included as adjuvant therapy in the treatment of allergic diseases. The aim of this study was to assess the effect of s…

Clinical and Epidemiological Features of Patients with Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Iran: Different Points of Children from Adults Open

Bahareh Abtahi‐Naeini, Masoumeh Dehghan, Fatemeh Paknazar, Zabihollah Shahmoradi, Gita Faghihi , et al. · 2022

Background. Different epidemiologic aspects of drug-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children are scarce. Aim. To compare the clinical and epidemiological features of patients with drug-induced…

The Association between Celiac Disease and Eosinophilic Esophagitis among Children, in Isfahan, Iran Open

Niloufar Amini, Tooba Momen, Maryam Ghaderian, Hossein Saneian, Mohammad Hassan Emami · 2022

Background: The prevalence of eosinophilic esophagitis (EoE) has increased in recent decades. Recent studies have found that the prevalence of EoE in patients with celiac disease (CD) is much higher compared with the general population. In…

Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency Open

Asena Pınar Sefer, Hassan Abolhassani, Franziska Ober, Başak Kayaoğlu, Sevgi Bilgiç Eltan , et al. · 2022

This cohort provides the largest analysis for clinical and immunological features of MALT1 deficiency. HSCT should be offered as a curative therapeutic option for all patients at the early stage of life.

Prevalence of nephrocalcinosis in children with congenital adrenal hyperplasia Open

Yahya Madihi, Neda Mostofizadeh, Hossein Shamsipour Dehkordi, Maryam Riahinezhad, Silva Hovsepian , et al. · 2022

Background: We aimed to investigate the prevalence of nephrocalcinosis (NC) among children with diagnosed congenital adrenal hyperplasia (CAH). Our findings would be helpful for earlier diagnosis, management, and prevention of NC-related c…

Consensus Middle East and North Africa Registry on Inborn Errors of Immunity Open

Asghar Aghamohammadi, Nima Rezaei, Reza Yazdani, Samaneh Delavari, Necil Kütükçüler , et al. · 2021

Background Inborn errors of immunity (IEIs) are a heterogeneous group of genetic defects of immunity, which cause high rates of morbidity and mortality mainly among children due to infectious and non-infectious complications. The IEI burde…

Author response for "Autoimmune Manifestations among Patients with Monogenic Inborn Errors of Immunity" Open

Gholamreza Azizi, Marzieh Tavakol, Reza Yazdani, Samaneh Delavari, Tannaz Moeini Shad , et al. · 2021

Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency Open

Samaneh Delavari, Hassan Abolhassani, Farhad Abolnezhadian, Fateme Babaha, Sara Iranparast , et al. · 2020

Global systematic review of primary immunodeficiency registries Open

Hassan Abolhassani, Gholamreza Azizi, Laleh Sharifi, Reza Yazdani, Monireh Mohsenzadegan , et al. · 2020

Although these data suggest some progress in the identification and documentation of PID patients worldwide, achieving the basic requirement for the global PID burden estimation and registration of undiagnosed patients will require more re…

Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency Open

Sujal Ghosh, Sevgi Köstel Bal, Emily S.J. Edwards, Bethany Pillay, Raúl Jiménez Heredia , et al. · 2020

Biallelic mutations in the genes encoding CD27 or its ligand CD70 underlie inborn errors of immunity (IEIs) characterized predominantly by Epstein-Barr virus (EBV)-associated immune dysregulation, such as chronic viremia, severe infectious…

Exome-first Approach Identified Novel Homozygous Dedicator of Cytokinesis 8 (DOCK8) Mutations in Three Unrelated Iranian Pedigrees Suspected with Hyper-IgE Syndrome Open

Ali Aghebati‐Maleki, Tina Shahani, Tooba Momen, Soheila Alyasin, Majid Changi‐Ashtiani , et al. · 2020

The prevalence of primary immunodeficiency (PID) is rather high in Iran compared to the world average, mainly due to the high rate of consanguineous marriage. Despite that, little genetic information is available about primary immunodefici…

Demographic, Clinical, and Allergic Characteristics of Children with Eosinophilic Esophagitis in Isfahan, Iran Open

Tooba Momen, Hossein Saneian, Niloufar Amini · 2019

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease isolated to the esophagus Food allergy is thought to play an important role in the pathophysiology of EOE. The aim of this study is to evaluate demographic features and se…

Effect of Fish Oil on the Level of Interferon Gamma on the Breast Milk of Atopic Mothers: A Randomized Clinical Trial Open

Tooba Momen, Sara Saraeian, Nafiseh Esmaeil, Roya Kelishadi · 2019

Background: The prevalence of allergic diseases is increasing worldwide. The effective role of omega-3 fatty acids in the maturation of immune system and protection against atopic diseases has been well discussed. However, previous studies…

Survey on the Prevalence of Allergic Rhinitis in Junior High School Students in Isfahan, Iran Open

Tooba Momen, Mahdie Saffari, Mohsen Jari, Kamyab Karimpour, Armindokht Shahsanai , et al. · 2018

Background Allergic rhinitis (AR) is a common form of nose inflammatory disease that occurs when the mucosal immune system overreacts to environmental allergens especially in the air. It’s absolutely clear that the prevalence of AR varies …

Seroprevalence of Toxocara Canis In Asthmatic Children and its Relation to the Severity of Diseases Open

Tooba Momen, Nafiseh Esmaeil, Mohsen Reisi · 2018

In this study, we found a significantly positive serology of T. canis in asthmatic children especially in more severe disease. To verify the etiologic role of Toxocara in asthma, more advanced studies are needed.

Prevalence and Risk Factors of Allergic Rhinitis in Primary School Students of Isfahan, Iran Open

Tooba Momen, Sahar Salarnia, Mohsen Jari · 2018

Background: Allergic rhinitis (AR) is one of the most common chronic diseases of childhood. Different studies have indicated an increasing prevalence of AR worldwide. The most common complaints of the patients are itching, tearing eyes, an…

Comparison of Interleukin-33 Serum Levels in Asthmatic Patients with a Control Group and Relation with the Severity of the Disease Open

Seyedeh Azra Shamsdin, Tooba Momen, Hamid Ahanchian, Mohsen Reisi, Armindokht Shahsanai , et al. · 2017

Background: The relation between interleukin-33 (IL-33) and asthma is not precisely known yet. The present study set to compare the serum level of IL-33 in patients with asthma and controls and study the relation with the severity of disea…

Evaluation of Right Ventricular Function by Tissue Doppler Echocardiography in Asthmatic Children Open

Mehdi Ghaderian, Seyed Javad Sayedi, Tooba Momen, Zahra Zadi, Mohsen Reisi · 2016

BackgroundAsthma is the most chronic inflammatory disorder of the airways in children and asthmatic patients can experience cardiac dysfunction, pulmonary hypertension and finally cor pulmonale later in life. We aimed to investigate Right …

Bullous Systemic Lupus Erythematosus and Lupus Nephritis in a Young Girl Open

Tooba Momen, Yahya Madihi · 2016

Bullous systemic lupus erythematosus (BSLE) is an autoimmune blistering disease occurring in patients with systemic lupus erythematosus (SLE). It is a rare disease, especially in children. A 14-year-old girl initially presented with fatigu…

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