Torben E. Lund
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View article: A Review of AI-Powered Controls in the Field of Magnetic Resonance Imaging
A Review of AI-Powered Controls in the Field of Magnetic Resonance Imaging Open
Artificial intelligence (AI) is increasingly reshaping the control mechanisms that govern magnetic resonance imaging (MRI), enabling faster, safer, and more adaptive operation of the scanner’s physical subsystems. This review provides a co…
View article: Sex-specific cortical brain differences in children at familial high risk for schizophrenia or bipolar disorder
Sex-specific cortical brain differences in children at familial high risk for schizophrenia or bipolar disorder Open
Background Schizophrenia (SZ) and bipolar disorder (BP) are severe psychiatric disorders with neurodevelopmental underpinnings. Familial high risk (FHR) is the strongest predictor of developing SZ and BP. Children at FHR offer a unique opp…
View article: The laminar pattern of proprioceptive activation in human primary motor cortex
The laminar pattern of proprioceptive activation in human primary motor cortex Open
The primary motor cortex (M1) is increasingly being recognized for its vital role in proprioceptive somatosensation. However, our current understanding of proprioceptive processing at the laminar scale is limited. Empirical findings in pri…
View article: Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single‐Center Experience
Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single‐Center Experience Open
Background Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging–guided focused ultrasound (MRgFUS) has emerged as second‐line therapy. Objective The aim was to obtain the results of the first 108 p…
View article: Improving B1+$$ {B}_1^{+} $$‐inhomogeneity tolerance by resolving non‐bijection in <scp> MP2RAGE <i>R</i> <sub>1</sub> </scp> mapping: A <scp>2D</scp> look‐up table approach demonstrated at <scp>3 T</scp>
Improving B1+$$ {B}_1^{+} $$‐inhomogeneity tolerance by resolving non‐bijection in <span> MP2RAGE <i>R</i> <sub>1</sub> </span> mapping: A <span>2D</span> look‐up table approach demonstrated at <span>3 T</span> Open
Purpose Regarding in vivo, robust longitudinal relaxation rate ( R 1 ) mapping, the goal of the present paper is two‐fold. First, to verify that non‐bijective mapping in magnetization‐prepared 2 rapid gradient echo (MP2RAGE) imaging can be…
View article: Laminar fMRI in the locked-in stage of amyotrophic lateral sclerosis shows preserved activity in layer Vb of primary motor cortex
Laminar fMRI in the locked-in stage of amyotrophic lateral sclerosis shows preserved activity in layer Vb of primary motor cortex Open
Amyotrophic lateral sclerosis (ALS) affects the cerebral cortex layer-dependently, most notably by the foremost targeting of upper motor neurons (UMNs) sited in layer Vb. Previous studies have shown a retained ability of paralysed patients…
View article: Cerebral microvascular changes in healthy carriers of the APOE-ɛ4 Alzheimer's disease risk gene
Cerebral microvascular changes in healthy carriers of the APOE-ɛ4 Alzheimer's disease risk gene Open
APOE-ɛ4 is a genetic risk factor for Alzheimer's disease (AD). AD is associated with reduced cerebral blood flow (CBF) and with microvascular changes that limit the transport of oxygen from blood into brain tissue: reduced microvascular ce…
View article: Laminar fMRI in the locked-in stage of amyotrophic lateral sclerosis shows preserved activity in layer Vb of primary motor cortex
Laminar fMRI in the locked-in stage of amyotrophic lateral sclerosis shows preserved activity in layer Vb of primary motor cortex Open
Amyotrophic lateral sclerosis (ALS) affects the cerebral cortex layer-dependently, most notably by the foremost targeting of upper motor neurons (UMNs) sited in layer Vb. Previous studies have shown a retained ability of paralysed patients…
View article: A 3T investigation of<i>B</i><sub>1</sub><sup>+</sup>-inhomogeneity tolerance in MP2RAGE-based<i>R</i><sub>1</sub>-mapping by calculating second contrast that permits previously problematic sequence parameters
A 3T investigation of<i>B</i><sub>1</sub><sup>+</sup>-inhomogeneity tolerance in MP2RAGE-based<i>R</i><sub>1</sub>-mapping by calculating second contrast that permits previously problematic sequence parameters Open
Purpose Regarding in vivo, robust R 1 -mapping, the goal of the present paper is twofold. First, to verify that non-bijective mapping in MP2RAGE imaging can be resolved through a 2D look-up-table approach. Second, that the expanded paramet…
View article: The laminar pattern of proprioceptive activation in human primary motor cortex
The laminar pattern of proprioceptive activation in human primary motor cortex Open
The primary motor cortex (M1) has traditionally been viewed as a motor output generator. However, its vital role in proprioceptive somatosensation is increasingly being recognized. Yet, our understanding of proprioceptive somatosensation i…
View article: Executive Control and Associated Brain Activity in Children With Familial High-Risk of Schizophrenia or Bipolar Disorder: A Danish Register-based Study
Executive Control and Associated Brain Activity in Children With Familial High-Risk of Schizophrenia or Bipolar Disorder: A Danish Register-based Study Open
Background and Hypotheses Impaired executive control is a potential prognostic and endophenotypic marker of schizophrenia (SZ) and bipolar disorder (BP). Assessing children with familial high-risk (FHR) of SZ or BP enables characterization…
View article: Interference control and associated brain activity in children with familial high-risk of schizophrenia or bipolar disorder – A Danish register-based study
Interference control and associated brain activity in children with familial high-risk of schizophrenia or bipolar disorder – A Danish register-based study Open
Background and hypotheses Impaired interference control is a potential prognostic and endophenotypic marker of schizophrenia (SZ) and bipolar disorder (BP). Assessing children with familial high-risk (FHR) of SZ or BP enables characterizat…
View article: Feasibility of 3T layer-dependent fMRI with GE-BOLD using NORDIC and phase regression
Feasibility of 3T layer-dependent fMRI with GE-BOLD using NORDIC and phase regression Open
Introduction Functional MRI with spatial resolution in the submillimeter domain enables measurements of activation across cortical layers in humans. This is valuable as different types of cortical computations, e.g., feedforward versus fee…
View article: The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls
The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls Open
Background Children born to parents with severe mental illness have gained more attention during the last decades because of increasing evidence documenting that these children constitute a population with an increased risk of developing m…
View article: Clipped DeepControl: deep neural network two-dimensional pulse design with an amplitude constraint layer
Clipped DeepControl: deep neural network two-dimensional pulse design with an amplitude constraint layer Open
Advanced radio-frequency pulse design used in magnetic resonance imaging has recently been demonstrated with deep learning of (convolutional) neural networks and reinforcement learning. For two-dimensionally selective radio-frequency pulse…
View article: Optimal control gradient precision trade-offs: application to fast generation of DeepControl libraries for MRI
Optimal control gradient precision trade-offs: application to fast generation of DeepControl libraries for MRI Open
We have recently demonstrated supervised deep learning methods for rapid generation of radiofrequency pulses in magnetic resonance imaging (https://doi.org/10.1002/mrm.27740, https://doi.org/10.1002/mrm.28667). Unlike the previous iterativ…
View article: Rapid microstructural plasticity in the cortical semantic network following a short language learning session
Rapid microstructural plasticity in the cortical semantic network following a short language learning session Open
Despite the clear importance of language in our life, our vital ability to quickly and effectively learn new words and meanings is neurobiologically poorly understood. Conventional knowledge maintains that language learning—especially in a…
View article: DeepControl: 2D RF pulses facilitating $B_1^+$ inhomogeneity and $B_0$\n off-resonance compensation in vivo at 7T
DeepControl: 2D RF pulses facilitating $B_1^+$ inhomogeneity and $B_0$\n off-resonance compensation in vivo at 7T Open
Purpose: Rapid 2D RF pulse design with subject specific $B_1^+$ inhomogeneity\nand $B_0$ off-resonance compensation at 7 T predicted from convolutional neural\nnetworks is presented.\n Methods: The convolution neural network was trained on…
View article: DeepControl: 2D RF pulses facilitating $B_1^+$ inhomogeneity and $B_0$ off-resonance compensation in vivo at 7T
DeepControl: 2D RF pulses facilitating $B_1^+$ inhomogeneity and $B_0$ off-resonance compensation in vivo at 7T Open
Purpose: Rapid 2D RF pulse design with subject specific $B_1^+$ inhomogeneity and $B_0$ off-resonance compensation at 7 T predicted from convolutional neural networks is presented. Methods: The convolution neural network was trained on hal…
View article: The sensation of groove engages motor and reward networks
The sensation of groove engages motor and reward networks Open
The sensation of groove has been defined as the pleasurable desire to move to music, suggesting that both motor timing and reward processes are involved in this experience. Although many studies have investigated rhythmic timing and musica…
View article: Language beyond the language system: Dorsal visuospatial pathways support processing of demonstratives and spatial language during naturalistic fast fMRI
Language beyond the language system: Dorsal visuospatial pathways support processing of demonstratives and spatial language during naturalistic fast fMRI Open
Spatial demonstratives are powerful linguistic tools used to establish joint attention. Identifying the meaning of semantically underspecified expressions like "this one" hinges on the integration of linguistic and visual cues, attentional…
View article: Language beyond the language system: dorsal visuospatial pathways support processing of demonstratives and spatial language during naturalistic fast fMRI
Language beyond the language system: dorsal visuospatial pathways support processing of demonstratives and spatial language during naturalistic fast fMRI Open
Spatial demonstratives are powerful linguistic tools used to establish joint attention. Identifying the meaning of semantically underspecified expressions like “this one” hinges on the integration of linguistic and visual cues, attentional…
View article: Ultrafast (milliseconds), multidimensional RF pulse design with deep learning
Ultrafast (milliseconds), multidimensional RF pulse design with deep learning Open
Purpose Some advanced RF pulses, like multidimensional RF pulses, are often long and require substantial computation time because of a number of constraints and requirements, sometimes hampering clinical use. However, the pulses offer oppo…
View article: APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan
APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan Open
Age and apolipoprotein E (APOE) e4 genotype are two of the strongest known risk factors for sporadic Alzheimer's disease (AD). Neuroimaging has shown hemodynamic response changes with age, in asymptomatic carriers of the APOE e4 allele, an…