Torben Moos
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View article: Deep brain stimulation is beneficial for treatment-resistant depression: A systematic review and meta–analysis of clinical trials and long-term follow-ups
Deep brain stimulation is beneficial for treatment-resistant depression: A systematic review and meta–analysis of clinical trials and long-term follow-ups Open
Background Most conventional treatments for MDD (major depressive disorder) fail to demonstrate significant results, which highlights an urgent need for novel treatments. DBS (deep brain stimulation) has shown great promise in several clin…
View article: Deep Brain Stimulation Is Beneficial for Treatment-Resistant Depression: A Systematic Review and Meta-Analysis of Clinical Trials and Long-Term Follow-Ups
Deep Brain Stimulation Is Beneficial for Treatment-Resistant Depression: A Systematic Review and Meta-Analysis of Clinical Trials and Long-Term Follow-Ups Open
BACKGROUND: Most conventional treatments for MDD (major depressive disorder) fail to demonstrate significant results, which highlights an urgent need for novel treatments. DBS (deep brain stimulation) has shown great promise in several cli…
View article: Systematic Review of glucose transporter alterations in human Alzheimer’s disease and rodent Alzheimer’s disease models
Systematic Review of glucose transporter alterations in human Alzheimer’s disease and rodent Alzheimer’s disease models Open
The brain requires a constant glucose supply to fuel energy production for numerous cellular functions. Glucose is transported into the brain by means of specialized glucose transporter proteins (GLUTs), which ensure transport across the b…
View article: Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2
Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 Open
Background: Patients with the genetic disorder Niemann-Pick type C2 disease (NP-C2) suffer from lysosomal accumulation of cholesterol causing both systemic and severe neurological symptoms. In a murine NP-C2 model, otherwise successful int…
View article: Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration
Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration Open
Chronic neurodegenerative diseases are characterized by substantial inflammation with putative impairment of the brain vasculature also commonly observed. To address effects of chronic neurodegeneration on the regional vasculature under ex…
View article: Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells
Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells Open
Purpose The blood-brain barrier (BBB), formed by brain endothelial cells (BECs) ensures a stable microenvironment inside the brain by regulating transport of blood-borne molecules to the brain. However, neurodegenerative diseases are often…
View article: Viral gene therapeutic strategies to obtain abluminal protein secretion from brain endothelial cells denoting the blood-brain barrier
Viral gene therapeutic strategies to obtain abluminal protein secretion from brain endothelial cells denoting the blood-brain barrier Open
The blood-brain barrier (BBB) formed by brain endothelial cells (BECs) limits the passage of biopharmaceuticals from the circulation into the brain parenchyma. An emerging strategy suggests that viral vectors may specifically target and pr…
View article: Normalization of Fetal Cerebral and Hepatic Iron by Parental Iron Therapy to Pregnant Rats with Systemic Iron Deficiency without Anemia
Normalization of Fetal Cerebral and Hepatic Iron by Parental Iron Therapy to Pregnant Rats with Systemic Iron Deficiency without Anemia Open
Background/Objectives: Iron (Fe) is a co-factor for enzymes of the developing brain necessitating sufficient supply. We investigated the effects of administering ferric derisomaltose/Fe isomaltoside (FDI) subcutaneously to Fe-deficient (ID…
View article: Normalization of Fetal Cerebral and Hepatic Iron by Parental Iron Therapy to Pregnant Rats with Systemic Iron Deficiency without Anemia
Normalization of Fetal Cerebral and Hepatic Iron by Parental Iron Therapy to Pregnant Rats with Systemic Iron Deficiency without Anemia Open
Iron (Fe) is co-factor for enzymes of the developing brain necessitating sufficient supply. We investigated the effects of administering ferric derisomaltose/Fe isomaltoside (FDI) subcutaneously to Fe deficient (ID) pregnant rats on cerebr…
View article: Upregulation of Transferrin Receptor 1 (TfR1) but Not Glucose Transporter 1 (GLUT1) or CD98hc at the Blood–Brain Barrier in Response to Valproic Acid
Upregulation of Transferrin Receptor 1 (TfR1) but Not Glucose Transporter 1 (GLUT1) or CD98hc at the Blood–Brain Barrier in Response to Valproic Acid Open
Background: Transferrin receptor 1 (TfR1), glucose transporter 1 (GLUT1), and CD98hc are candidates for targeted therapy at the blood–brain barrier (BBB). Our objective was to challenge the expression of TfR1, GLUT1, and CD98hc in brain ca…
View article: Calmodulin variants in schizophrenia patients display gain-of-function or loss-of-function effects
Calmodulin variants in schizophrenia patients display gain-of-function or loss-of-function effects Open
Calmodulin acts as a vital calcium sensor in cells, crucial for relaying calcium signals to different protein partners. While rare missense variants in calmodulin are linked to cardiac arrhythmia, particularly long QT syndrome (LQTS), thei…
View article: Upregulation of Transferrin Receptor 1 (TfR1) at the Blood‐Brain Barrier by Valproic Acid, but Not of Glucose Transporter 1 (GLUT1) or CD98hc
Upregulation of Transferrin Receptor 1 (TfR1) at the Blood‐Brain Barrier by Valproic Acid, but Not of Glucose Transporter 1 (GLUT1) or CD98hc Open
Background. Transferrin receptor 1 (TfR1), glucose transporter 1 (GLUT1), and CD98hc are candidates for targeted therapy at the blood-brain barrier (BBB). Our objective was to challenge the expression of TfR1, GLUT1, and CD98hc in brain ca…
View article: Endothelial and neuronal engagement by AAV-BR1 alleviates neurological symptoms and cholesterol deposition in a mouse model of Niemann-Pick type C2
Endothelial and neuronal engagement by AAV-BR1 alleviates neurological symptoms and cholesterol deposition in a mouse model of Niemann-Pick type C2 Open
Background Patients with the genetic disorder Niemann-Pick type C2 disease (NP-C2) suffer from lysosomal accumulation of cholesterol causing both systemic and severe neurological symptoms. In a murine NP-C2 model, otherwise successful intr…
View article: Endothelial and neuronal engagement by AAV-BR1 alleviates cholesterol deposition in a mouse model of Niemann-Pick type C2
Endothelial and neuronal engagement by AAV-BR1 alleviates cholesterol deposition in a mouse model of Niemann-Pick type C2 Open
Background Patients with the genetic disorder Niemann-Pick type C2 disease (NP-C2) suffer from lysosomal accumulation of cholesterol causing both systemic and severe neurological symptoms. In a murine NP-C2 model, otherwise successful intr…
View article: Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration
Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration Open
Background Chronic neurodegenerative diseases are characterized by substantial neuroinflammation with accumulation of macrophages, reactive microglia, and reactive astrocytes. Impairment of the brain vasculature is also commonly seen in ch…
View article: CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration
CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration Open
Since the delivery of biologic drugs to the brain is greatly hampered by the existence of the blood–brain barrier (BBB), brain shuttles are being developed to enhance therapeutic efficacy. As we have previously shown, efficient and selecti…
View article: Significant change in biometal distribution in brains of Alzheimer´s Disease (TgSwDI) mice
Significant change in biometal distribution in brains of Alzheimer´s Disease (TgSwDI) mice Open
AimsNeuronal demise in Alzheimer’s disease (AD) occurs years later than the accumulation of amyloid-beta plaquesand neurofibrillary tangles, but the mechanisms underlying neuronal death remain unresolved. Increasingaccumulation of biometal…
View article: Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation
Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation Open
Overexpression of α-synuclein with tyrosine mutated to phenylalanine at position 125 leads to a severe phenotype with motor impairment and neuropathology in Drosophila. Here, we hypothesized that tyrosine mutations would similarly lead to …
View article: Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles
Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles Open
The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for the delivery of biologics across the BECs, as they can encapsulate numerous mole…
View article: Blood-Brain Barrier Transport of Transferrin-Receptor Targeted Nanoparticles
Blood-Brain Barrier Transport of Transferrin-Receptor Targeted Nanoparticles Open
The blood-brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for delivery of biologics across the BECs, as they can encapsulate numerous molecule…
View article: Intravenous ferric derisomaltose versus oral iron for persistent iron deficient pregnant women: a randomised controlled trial
Intravenous ferric derisomaltose versus oral iron for persistent iron deficient pregnant women: a randomised controlled trial Open
Purpose To compare the efficacy of intravenous (IV) iron (ferric derisomaltose) with oral iron (ferrous fumarate) in women 14–21 weeks pregnant with persistent iron deficiency (ferritin < 30 µg/L). Methods In a single-centre, open-label, r…
View article: A novel strategy for delivering<scp>N</scp>iemann‐<scp>P</scp>ick type<scp>C2</scp>proteins across the blood–brain barrier using the brain endothelial‐specific<scp>AAV‐BR1</scp>virus
A novel strategy for delivering<span>N</span>iemann‐<span>P</span>ick type<span>C2</span>proteins across the blood–brain barrier using the brain endothelial‐specific<span>AAV‐BR1</span>virus Open
Treating central nervous system (CNS) diseases is complicated by the incapability of numerous therapeutics to cross the blood–brain barrier (BBB), mainly composed of brain endothelial cells (BECs). Genetically modifying BECs into protein f…