Torbjörn Tomson
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View article: Therapeutic Reference Ranges for ADHD Drugs in Blood of Children and Adolescents: A Systematic Review by the AGNP TDM-Task Force
Therapeutic Reference Ranges for ADHD Drugs in Blood of Children and Adolescents: A Systematic Review by the AGNP TDM-Task Force Open
Attention deficit-/hyperactivity disorder (ADHD) medications are commonly prescribed to children and adolescents, but therapeutic reference ranges have not been systematically evaluated yet. This study aimed to establish preliminary therap…
View article: Neurologists' perspectives on <scp>SUDEP</scp> communication: A comparative study across five European countries
Neurologists' perspectives on <span>SUDEP</span> communication: A comparative study across five European countries Open
Objectives The leading cause of epilepsy mortality is Sudden unexpected death in epilepsy (SUDEP). National and international guidelines recommend that people with epilepsy are counseled on SUDEP risk at the point of diagnosis or at the ea…
View article: Treatment of epilepsy using newer antiseizure medications: A retrospective cohort study of prescription patterns in Sweden 2013–2022
Treatment of epilepsy using newer antiseizure medications: A retrospective cohort study of prescription patterns in Sweden 2013–2022 Open
Objective This study aimed to analyze the choice of newly introduced antiseizure medications (ASMs; brivaracetam, cannabidiol, cenobamate, fenfluramine, and perampanel) by age and sex, and the use of these ASMs in relation to regulatory ap…
View article: Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication
Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication Open
This practice guideline provides updated evidence-based conclusions and recommendations regarding the effects of antiseizure medications (ASMs) and folic acid supplementation on the prevalence of major congenital malformations (MCMs), adve…
View article: Antiseizure medication use during pregnancy and children’s neurodevelopmental outcomes
Antiseizure medication use during pregnancy and children’s neurodevelopmental outcomes Open
The teratogenic potential of valproate in pregnancy is well established; however, evidence regarding the long-term safety of other antiseizure medications (ASMs) during pregnancy remains limited. Using routinely collected primary care data…
View article: High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study Open
Objective This study was undertaken to study whether high‐dose folic acid ( > 1 mg daily) use is associated with an increased risk of cancer in all women who have given birth and in women with epilepsy. High‐dose folic acid supplementation…
View article: Incidence, methods and circumstances of suicide in epilepsy: A population-based study in Sweden
Incidence, methods and circumstances of suicide in epilepsy: A population-based study in Sweden Open
View article: Cognitive outcomes after fetal exposure to carbamazepine, lamotrigine, valproate or levetiracetam monotherapy: Data from the EURAP neurocognitive extension protocol
Cognitive outcomes after fetal exposure to carbamazepine, lamotrigine, valproate or levetiracetam monotherapy: Data from the EURAP neurocognitive extension protocol Open
Consistent with previous reports, our results provide evidence for an adverse effect of prenatal exposure to valproate on verbal development. Our finding of relatively weaker performance of VPA-exposed children compared to other ASM exposu…
View article: Progress report on new medications for seizures and epilepsy: A summary of the 17th Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVII). II. Drugs in more advanced clinical development
Progress report on new medications for seizures and epilepsy: A summary of the 17th Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVII). II. Drugs in more advanced clinical development Open
The 17th Eilat Conference on New Antiepileptic Drugs and Devices took place in Madrid, Spain on May 5–8, 2024. As usual, the core part of the conference consisted of presentations on investigational drugs at various stages of development f…
View article: Risk of Perinatal and Maternal Morbidity and Mortality Among Pregnant Women With Epilepsy
Risk of Perinatal and Maternal Morbidity and Mortality Among Pregnant Women With Epilepsy Open
Importance Maternal epilepsy is associated with adverse pregnancy and neonatal outcomes. A better understanding of this condition and the associated risk of mortality and morbidity at the time of delivery could help reduce adverse outcomes…
View article: Socioeconomic differences in use of antiseizure medication in pregnancies with maternal epilepsy: A population‐based study from Nordic universal health care systems
Socioeconomic differences in use of antiseizure medication in pregnancies with maternal epilepsy: A population‐based study from Nordic universal health care systems Open
Objective Research points to disparities in disease burden and access to medical care in epilepsy. We studied the association between socioeconomic status (SES) and antiseizure medication (ASM) use in pregnancies with maternal epilepsy. Me…
View article: First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort study
First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort study Open
Background Antiseizure medications (ASMs) during the first trimester of pregnancy have been associated with an increased risk of miscarriage. Methods We carried out a population-based cohort study using routinely collected healthcare data …
View article: The impact of pregnancy on the pharmacokinetics of antiseizure medications: A systematic review and meta-analysis of data from 674 pregnancies
The impact of pregnancy on the pharmacokinetics of antiseizure medications: A systematic review and meta-analysis of data from 674 pregnancies Open
Data for lamotrigine, oxcarbazepine (and monohydroxycarbazepine) and levetiracetam demonstrate major changes in pharmacokinetics during pregnancy, suggesting the importance of therapeutic drug monitoring to assist clinicians in optimizing …
View article: Prescribing patterns for higher dose folic acid in pregnant women with epilepsy treated with antiseizure medication
Prescribing patterns for higher dose folic acid in pregnant women with epilepsy treated with antiseizure medication Open
Objective This study was undertaken to characterize the use of higher doses of folic acid (≥1 mg daily) in relation to pregnancy in Denmark, Norway, and Sweden in women with epilepsy treated with antiseizure medication (ASM). Methods In th…
View article: Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy
Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy Open
Importance Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring. Objective To investiga…
View article: Prenatal Exposure to Antiseizure Medications and Risk of Epilepsy in Children of Mothers With Epilepsy
Prenatal Exposure to Antiseizure Medications and Risk of Epilepsy in Children of Mothers With Epilepsy Open
Importance Use of valproate and certain other antiseizure medications (ASMs) in pregnancy is associated with abnormal fetal brain development with potential long-term implications for the child. Objective To examine whether use of valproat…
View article: Prenatal exposure to antiseizure medications and fetal growth: a population-based cohort study from the Nordic countries
Prenatal exposure to antiseizure medications and fetal growth: a population-based cohort study from the Nordic countries Open
The NordForsk Nordic Program on Health and Welfare (83539), the Independent Research Fund Denmark (1133-00026B), the Danish Epilepsy Association, the Central Denmark Region, the Novo Nordisk Foundation (NNF16OC0019126 and NNF22OC0075033), …
View article: Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects
Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects Open
Background Psychiatric comorbidities are common in patients with epilepsy. Reasons for the co-occurrence of psychiatric conditions and epilepsy remain poorly understood. Aim We aimed to triangulate the relationship between epilepsy and psy…
View article: Comparative Risk of Major Congenital Malformations With Antiseizure Medication Combinations vs Valproate Monotherapy in Pregnancy
Comparative Risk of Major Congenital Malformations With Antiseizure Medication Combinations vs Valproate Monotherapy in Pregnancy Open
This study provides Class II evidence that in people with epilepsy treated in the first trimester of pregnancy, the risk of major congenital malformations is lower with lamotrigine-levetiracetam duotherapy than with valproate alone, but si…
View article: Type, Etiology, and Duration of Epilepsy as Risk Factors for SUDEP
Type, Etiology, and Duration of Epilepsy as Risk Factors for SUDEP Open
Although certain etiologies, such as post-traumatic epilepsy, seem to entail a higher SUDEP risk, our data indicate that frequent and nocturnal TCS carry a similar level of risk whether focal or generalized from onset. The tonic-clonic par…
View article: Report of the ILAE SUDEP Task Force on national recommendations and practices around the world regarding the use of wearable seizure detection devices: A global survey
Report of the ILAE SUDEP Task Force on national recommendations and practices around the world regarding the use of wearable seizure detection devices: A global survey Open
Wearable seizure detection devices have the potential to address unmet needs of people with epilepsy. A recently published evidence‐based international guideline recommends using such devices for safety indications in patients with tonic–c…
View article: High‐dose folic acid and cancer risk; unjustified concerns by von Wrede and colleagues regarding our paper
High‐dose folic acid and cancer risk; unjustified concerns by von Wrede and colleagues regarding our paper Open
Women using antiseizure medication in pregnancy are often advised to use high doses of folic acid supplements (1mg to 5 mg) to reduce the risk of teratogenicity. Recently, we published a report showing an association between maternal presc…
View article: The pharmacological treatment of epilepsy in adults
The pharmacological treatment of epilepsy in adults Open
The pharmacological treatment of epilepsy entails several critical decisions that need to be based on an individual careful risk–benefit analysis. These include when to initiate treatment and with which antiseizure medication (ASM). With m…
View article: Trends and patterns of antiseizure medication prescribing during pregnancy between 1995 and 2018 in the United Kingdom: A cohort study
Trends and patterns of antiseizure medication prescribing during pregnancy between 1995 and 2018 in the United Kingdom: A cohort study Open
Objective To examine antiseizure medication (ASM) prescription during pregnancy. Design Population‐based drug utilisation study. Setting UK primary and secondary care data, 1995–2018, from the Clinical Practice Research Datalink GOLD versi…
View article: The importance of pregnancy registries for the management of women with epilepsy and childbearing potential: Emphasis on EURAP
The importance of pregnancy registries for the management of women with epilepsy and childbearing potential: Emphasis on EURAP Open
In light of the increased awareness of the teratogenic risks with older-generation antiseizure medications (ASMs) and the introduction of many new drugs, prospective antiepileptic drugs and pregnancy registries were introduced some 25 year…
View article: Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders
Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders Open
Importance Prenatal antiseizure medication (ASM) exposure has been associated with adverse early neurodevelopment, but associations with a wider range of psychiatric end points have not been studied. Objective To examine the association be…
View article: Updates to Table 1, the Institutional Review Board Statement, the Additional Information Section, and References
Updates to Table 1, the Institutional Review Board Statement, the Additional Information Section, and References Open
Cameron Miller-Patterson, MD, MS; Jesse Y. Hsu, PhD, MS; Allison W. Willis, MD, MS; Ali G. Hamedani, MD, MHS
View article: Error in Methods Section
Error in Methods Section Open
Deborah A. Levine, MD, MPH; Alden L. Gross, PhD; Emily M. Briceño, PhD; Nicholas Tilton, PhD; Mohammed U. Kabeto, MS; Stephanie M. Hingtgen, MPP; Bruno J. Giordani, PhD; Jeremy B. Sussman, MD, MS; Rodney A. Hayward, MD; James F. Burke, MD,…
View article: Proposal for reference values for the developmental effects of valproate based on human data using a benchmark dose approach
Proposal for reference values for the developmental effects of valproate based on human data using a benchmark dose approach Open
Following accidental release of valproate into ambient air during manufacture at a French production site in 2018, concerns were raised for inhabitants of the surrounding area. As no toxicological reference value (TRV) was available, the r…
View article: Error in Byline, Affiliations, and Table 1
Error in Byline, Affiliations, and Table 1 Open
Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants