Torrey Baines
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View article: Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes
Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes Open
View article: Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock
Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock Open
OBJECTIVES: Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. We sought to the determine reproducibility of the data-driven “persistent hypoxemia, en…
View article: Revisiting Post-ICU Admission Fluid Balance Across Pediatric Sepsis Mortality Risk Strata: A Secondary Analysis of a Prospective Observational Cohort Study
Revisiting Post-ICU Admission Fluid Balance Across Pediatric Sepsis Mortality Risk Strata: A Secondary Analysis of a Prospective Observational Cohort Study Open
OBJECTIVES: Post-ICU admission cumulative positive fluid balance (PFB) is associated with increased mortality among critically ill patients. We sought to test whether this risk varied across biomarker-based risk strata upon adjusting for i…
View article: Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness
Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness Open
View article: Derivation, validation, and transcriptomic assessment of pediatric septic shock phenotypes identified through latent profile analyses: Results from a prospective multi-center observational cohort
Derivation, validation, and transcriptomic assessment of pediatric septic shock phenotypes identified through latent profile analyses: Results from a prospective multi-center observational cohort Open
Background Sepsis poses a grave threat, especially among children, but treatments are limited due to clinical and biological heterogeneity among patients. Thus, there is an urgent need for precise subclassification of patients to guide the…
View article: External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock
External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock Open
View article: SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK–ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME
SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK–ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME Open
Background: Multiple-organ dysfunction syndrome disproportionately contributes to pediatric sepsis morbidity. Humanin (HN) is a small peptide encoded by mitochondrial DNA and thought to exert cytoprotective effects in endothelial cells and…
View article: External validation and biomarker assessment of a high-risk, data-driven pediatric sepsis phenotype characterized by persistent hypoxemia, encephalopathy, and shock.
External validation and biomarker assessment of a high-risk, data-driven pediatric sepsis phenotype characterized by persistent hypoxemia, encephalopathy, and shock. Open
Objective Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. Data-driven phenotyping approaches that leverage electronic health record (EHR) data hold…
View article: SERUM SOLUBLE ENDOGLIN IN PEDIATRIC SEPTIC SHOCK–ASSOCIATED MULTIPLE ORGAN DYSFUNCTION SYNDROME
SERUM SOLUBLE ENDOGLIN IN PEDIATRIC SEPTIC SHOCK–ASSOCIATED MULTIPLE ORGAN DYSFUNCTION SYNDROME Open
Background: Endothelial activation is a key driver of multiple organ dysfunction syndrome (MODS). Soluble endoglin (sENG) is expressed by mature and progenitor endothelial cells and thought to have angiogenic properties. We sought to deter…
View article: Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock
Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock Open
View article: Revisiting post-ICU admission fluid balance across pediatric sepsis mortality risk strata: A secondary analyses from a prospective observational cohort study.
Revisiting post-ICU admission fluid balance across pediatric sepsis mortality risk strata: A secondary analyses from a prospective observational cohort study. Open
View article: Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1
Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1 Open
View article: Serum Humanin in Pediatric Septic Shock Associated Multiple Organ Dysfunction Syndrome
Serum Humanin in Pediatric Septic Shock Associated Multiple Organ Dysfunction Syndrome Open
Background Multiple organ dysfunction syndrome (MODS) disproportionately contributes to pediatric sepsis morbidity. Humanin (HN) is a small peptide encoded by mitochondrial DNA and thought to exert cytoprotective effects in endothelial cel…
View article: Cerebral venous sinus thrombosis and skull base osteomyelitis as manifestations of cat‐scratch disease in a pediatric patient: A case report and literature review
Cerebral venous sinus thrombosis and skull base osteomyelitis as manifestations of cat‐scratch disease in a pediatric patient: A case report and literature review Open
Key Clinical Message Cat‐scratch disease (CSD) is caused by Bartonella henselae and usually presents with regional lymphadenopathy. Skull base osteomyelitis and cerebral venous sinus thrombosis are rarely reported, particularly in immunoco…
View article: Prognostic and Predictive Value of Endothelial Dysfunction Biomarkers in Sepsis-Associated Acute Kidney Injury: Risk Stratified Analysis from a Prospective Observational Cohort of Pediatric Septic Shock
Prognostic and Predictive Value of Endothelial Dysfunction Biomarkers in Sepsis-Associated Acute Kidney Injury: Risk Stratified Analysis from a Prospective Observational Cohort of Pediatric Septic Shock Open
Background Sepsis Associated Acute Kidney Injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement therapy (CRRT). Systemic inflammation and endothelial dysfunction are key …
View article: Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1
Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1 Open
Background: Sepsis is associated with significant mortality, yet there are no efficacious therapies beyond antibiotics and supportive care. In adult sepsis studies, PCSK9 loss-of-function (LOF) and inhibition has shown therapeutic promise,…
View article: Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study
Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study Open
View article: Integrated PERSEVERE and endothelial biomarker risk model predicts MODS in pediatric septic shock: A retrospective observational study
Integrated PERSEVERE and endothelial biomarker risk model predicts MODS in pediatric septic shock: A retrospective observational study Open
Background: Multiple organ dysfunction syndrome (MODS) is a critical driver of sepsis morbidity and mortality in children. Early identification of those at risk of persistent organ dysfunctions is necessary to enrich patients for future tr…
View article: High-Frequency Oscillatory Ventilation as a Rescue Mode for Refractory Hypercarbia in Children
High-Frequency Oscillatory Ventilation as a Rescue Mode for Refractory Hypercarbia in Children Open
High-frequency oscillatory ventilation (HFOV) use in the airway obstructive status can be relatively contraindicated by the risk of air trapping leading to hemodynamic compromise. We experienced three young patients, a 7-month preterm male…
View article: A Continuous Metric to Measure Endotype and Corticosteroid Interaction in Septic Shock
A Continuous Metric to Measure Endotype and Corticosteroid Interaction in Septic Shock Open
The benefit of corticosteroids for septic shock remains unclear, reflecting heterogeneity of treatment effect. We previously reported a binary septic shock endotype classification based on expression of 100 genes. This binary classificatio…
View article: PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock
PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock Open
Rationale: Acute kidney injury (AKI), a common complication of sepsis, is associated with substantial morbidity and mortality and lacks definitive disease-modifying therapy. Early, reliable identification of at-risk patients is impo…
View article: Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model
Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model Open
Prognostic biomarkers for pediatric septic shock are conserved in a murine model of sepsis and accelerate testing of precision medicine strategies.