Torsten Dahlén
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View article: Empirical and projected economic burden of chronic myeloid leukaemia in Sweden from 2015 to 2030: A population‐based study
Empirical and projected economic burden of chronic myeloid leukaemia in Sweden from 2015 to 2030: A population‐based study Open
Summary Despite therapeutic advances and improved survival, the long‐term economic burden of chronic myeloid leukaemia (CML) remains under‐recognised given evolving treatment practices and fluctuating drug costs. We aimed to estimate and p…
View article: An agnostic study of donor and component factors associated with transfusion‐related changes in laboratory markers
An agnostic study of donor and component factors associated with transfusion‐related changes in laboratory markers Open
Background Donor and red blood cell (RBC) component factors may affect patient outcomes after RBC transfusions, but data on the magnitude and consequences of these associations are limited. Study Design and Methods In this retrospective co…
View article: Loss in Overall and Quality‐Adjusted Life Expectancy for Patients With Chronic‐Phase Chronic Myeloid Leukemia
Loss in Overall and Quality‐Adjusted Life Expectancy for Patients With Chronic‐Phase Chronic Myeloid Leukemia Open
The introduction of tyrosine kinase inhibitors has considerably improved the life expectancy (LE) for patients with chronic myeloid leukemia (CML). Evaluating health‐related quality of life within the treatment pathway remains crucial. Usi…
View article: Using routine health-care data to search for unknown transfusion-transmitted disease: a nationwide, agnostic retrospective cohort study
Using routine health-care data to search for unknown transfusion-transmitted disease: a nationwide, agnostic retrospective cohort study Open
Department of Health and Human Services, US National Heart, Lung, and Blood Institute, US National Institutes of Health, Swedish Research Council and Region Stockholm.
View article: Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients
Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients Open
Importance Recent reports have suggested that cerebral amyloid angiopathy, a common cause of multiple spontaneous intracerebral hemorrhages (ICHs), may be transmissible through parenteral injection of contaminated cadaveric pituitary hormo…
View article: A population‐based, retrospective cohort study of the association between ABO blood group and risk of COVID‐19
A population‐based, retrospective cohort study of the association between ABO blood group and risk of COVID‐19 Open
Background Several studies have investigated associations between ABO blood group and risk of COVID‐19, with inconsistent results. Objective To study associations between ABO blood group and risk of different stages of COVID‐19. Methods Th…
View article: Neutrophil‐to‐Lymphocyte Ratios in Patients Undergoing Aortic Valve Replacement: The PARTNER Trials and Registries
Neutrophil‐to‐Lymphocyte Ratios in Patients Undergoing Aortic Valve Replacement: The PARTNER Trials and Registries Open
Background The neutrophil‐to‐lymphocyte ratio (NLR) as a marker of systemic inflammation has been associated with worse prognosis in several chronic disease states, including heart failure. However, few data exist on the prognostic impact …
View article: Adverse outcomes in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Follow‐up of patients diagnosed 2002–2017 in a complete coverage and nationwide agnostic register study
Adverse outcomes in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Follow‐up of patients diagnosed 2002–2017 in a complete coverage and nationwide agnostic register study Open
Tyrosine kinase inhibitors (TKIs) have profoundly improved the clinical outcome for patients with chronic myeloid leukemia (CML), but their overall survival is still subnormal and the treatment is associated with adverse events. In a large…
View article: The frequency of misattributed paternity in Sweden is low and decreasing: A nationwide cohort study
The frequency of misattributed paternity in Sweden is low and decreasing: A nationwide cohort study Open
Background The occurrence of misattributed paternity has consequences throughout society with implications ranging from inheritance and royal succession to transplantation. However, its frequency in Sweden is unknown. Objective To estimate…
View article: An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk
An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk Open
Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been cond…
View article: Author response: An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk
Author response: An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk Open
Article Figures and data Executable code Abstract eLife digest Introduction Materials and methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Background: T…
View article: Successful tyrosine kinase inhibitor discontinuation outside clinical trials — data from the population‐based Swedish chronic myeloid leukaemia registry
Successful tyrosine kinase inhibitor discontinuation outside clinical trials — data from the population‐based Swedish chronic myeloid leukaemia registry Open
Summary Clinical trials show that tyrosine kinase inhibitor (TKI) treatment can be discontinued in selected patients with chronic myeloid leukaemia (CML). Although updated CML guidelines support such procedure in clinical routine, data on …
View article: An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk
An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk Open
There are multiple known associations between the ABO and RhD blood groups and disease. However, no systematic population-based studies elucidating associations between a large number of disease states and blood group have been conducted. …
View article: Costs associated with transfusion therapy in patients with myelodysplastic syndromes in Sweden: a nationwide retrospective cohort study
Costs associated with transfusion therapy in patients with myelodysplastic syndromes in Sweden: a nationwide retrospective cohort study Open
Background and objectives Blood transfusion is a cornerstone therapy for many patients with myelodysplastic syndromes (MDS), but ranges from few to no transfusions to intensive transfusion therapy. To date, no large studies have described …
View article: Risk of hematological malignancy in blood donors: A nationwide cohort study
Risk of hematological malignancy in blood donors: A nationwide cohort study Open
Background There has been a concern that blood donations can increase the risk of hematological malignancies. We investigated if blood donations increase the risk of developing hematological malignancies, specifically acute lymphoblastic l…
View article: Measurable health effects associated with the daylight saving time shift
Measurable health effects associated with the daylight saving time shift Open
The transition to daylight saving time (DST) is beneficial for energy conservation but at the same time it has been reported to increase the risk of cerebrovascular and cardiovascular problems. Here, we evaluate the effect of the DST shift…
View article: Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
Estimating heritability and genetic correlations from large health datasets in the absence of genetic data Open
Typically, estimating genetic parameters, such as disease heritability and between-disease genetic correlations, demands large datasets containing all relevant phenotypic measures and detailed knowledge of family relationships or, alternat…