Torsten Fauth
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View article: The Volume-Regulated Anion Channel LRRC8 is Involved in the Initiation of Epidermal Differentiation and is Deregulated in Psoriasis
The Volume-Regulated Anion Channel LRRC8 is Involved in the Initiation of Epidermal Differentiation and is Deregulated in Psoriasis Open
Recent studies have shown that LRRC8A, the essential subunit of the volume-regulated anion channel LRRC8, which is responsible for mediating cell volume regulation during hypotonic stress, is predominantly localized in the basal layer of t…
View article: Different immortalized keratinocyte cell lines display distinct capabilities to differentiate and reconstitute an epidermis in vitro
Different immortalized keratinocyte cell lines display distinct capabilities to differentiate and reconstitute an epidermis in vitro Open
Dermatological research relies on the availability of suitable models that most accurately reflect the in vivo situation. Primary keratinocytes obtained from skin reduction surgeries are not only limited by availability but have a short li…
View article: Targeting Cancer Chemotherapy Resistance by Precision Medicine-Driven Nanoparticle-Formulated Cisplatin
Targeting Cancer Chemotherapy Resistance by Precision Medicine-Driven Nanoparticle-Formulated Cisplatin Open
Therapy resistance is the major cause of cancer death. As patients respond heterogeneously, precision/personalized medicine needs to be considered, including the application of nanoparticles (NPs). The success of therapeutic NPs requires t…
View article: 3D live cell imaging: study of inter- and intracellular signalling induced by bitter molecules in tongue cell spheroids
3D live cell imaging: study of inter- and intracellular signalling induced by bitter molecules in tongue cell spheroids Open
Tissue complexity is not well represented in a flat 2D environment. In particular, proliferation rates and cellular phenotypes are altered, intercellular communication is lost or severely affected and signalling molecules do not have to di…
View article: Profiling Cisplatin Resistance in Head and Neck Cancer: A Critical Role of the VRAC Ion Channel for Chemoresistance
Profiling Cisplatin Resistance in Head and Neck Cancer: A Critical Role of the VRAC Ion Channel for Chemoresistance Open
Treatment success of head and neck cancers (HNSCC) is often hindered by tumor relapses due to therapy resistances. This study aimed at profiling cisplatin resistance mechanisms and identifying biomarkers potentially suitable as drug target…
View article: Cell Volume Regulation in the Epidermis
Cell Volume Regulation in the Epidermis Open
In order to cope with external stressors such as changes in humidity and temperature or irritating substances, the epidermis as the outermost skin layer forms a continuously renewing and ideally intact protective barrier. Under certain cir…
View article: Routine Optical Clearing of 3D-Cell Cultures: Simplicity Forward
Routine Optical Clearing of 3D-Cell Cultures: Simplicity Forward Open
Three-dimensional cell cultures, such as spheroids and organoids, serve as increasingly important models in fundamental and applied research and start to be used for drug screening purposes. Optical tissue clearing procedures are employed …
View article: Identification of new molecular targets and small molecule compounds to modulate saliva secretion for experimental treatment of salivary gland pathologies
Identification of new molecular targets and small molecule compounds to modulate saliva secretion for experimental treatment of salivary gland pathologies Open
Hypo- and hypersalivation and resulting symptoms like xerostomia, dysphagia and aspiration hazard lead to a significant decrease in quality of life. Undernutrition and worsening of overall prognosis are common and, due to very limited trea…
View article: In vitro skin three-dimensional models and their applications
In vitro skin three-dimensional models and their applications Open
Skin fulfils a plethora of eminent physiological functions ranging from physical barrier over immunity shield to the interface mediating social interaction.Prone to several acquired and inherited diseases, skin is therefore a major target …