Torsten Möhlmann
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View article: Uracil phosphoribosyltransferase is required to establish a functional cytochrome <i>b</i><sub>6</sub><i>f</i> complex
Uracil phosphoribosyltransferase is required to establish a functional cytochrome <i>b</i><sub>6</sub><i>f</i> complex Open
SUMMARY Arabidopsis uracil phosphoribosyltransferase (UPP) is an essential enzyme and plants lacking this enzyme are strongly compromised in chloroplast function. Our analysis of UPP amiRNA mutants has confirmed that this vital function is…
View article: UPP affects chloroplast development by interfering with chloroplast proteostasis
UPP affects chloroplast development by interfering with chloroplast proteostasis Open
Arabidopsis uracil phosphoribosyltransferase (UPP) has been identified as an essential protein with a previously unknown moonlighting activity. By analysis of UPP amiRNA mutants, we first confirmed a vital function of UPP in chloroplast de…
View article: Nucleotide Imbalance, Provoked by Downregulation of Aspartate Transcarbamoylase Impairs Cold Acclimation in Arabidopsis
Nucleotide Imbalance, Provoked by Downregulation of Aspartate Transcarbamoylase Impairs Cold Acclimation in Arabidopsis Open
Aspartate transcarbamoylase (ATC) catalyzes the first committed step in pyrimidine de novo synthesis. As shown before, mutants with 80% reduced transcript and protein levels exhibit reduced levels of pyrimidine metabolites and thus nucleot…
View article: Cytidine Triphosphate Synthase Four From Arabidopsis thaliana Attenuates Drought Stress Effects
Cytidine Triphosphate Synthase Four From Arabidopsis thaliana Attenuates Drought Stress Effects Open
Cytidine triphosphate synthase (CTPS) catalyzes the final step in pyrimidine de novo synthesis. In Arabidopsis, this protein family consists of five members (CTPS1–5), and all of them localize to the cytosol. Specifically, CTPS4 showed a m…
View article: Cytosolic CTP Production Limits the Establishment of Photosynthesis in Arabidopsis
Cytosolic CTP Production Limits the Establishment of Photosynthesis in Arabidopsis Open
CTP synthases (CTPS) comprise a protein family of the five members CTPS1-CTPS5 in Arabidopsis, all located in the cytosol. Specifically, downregulation of CTPS2 by amiRNA technology results in plants with defects in chlorophyll accumulatio…
Differential degradation of RNA species by autophagy-related pathways in Arabidopsis Open
The plant vacuole recycles proteins and RNA delivered to it by autophagy. In this study, by isolating intact vacuoles from Arabidopsis plants, followed by subsequent RNA purification, and deep sequencing, we provide a comprehensive charact…
CTP Synthase 2 From Arabidopsis thaliana Is Required for Complete Embryo Development Open
Pyrimidine de novo synthesis is an essential pathway in all organisms. The final and rate-limiting step in the synthesis of the nucleotide cytidine triphosphate (CTP) is catalyzed by CTP synthase (CTPS), and Arabidopsis harbors five isofor…
Limitation of Cytokinin Export to the Shoots by Nucleoside Transporter ENT3 and Its Linkage with Root Elongation in Arabidopsis Open
The trans-membrane carrier AtENT3 is known to transport externally supplied cytokinin ribosides and thus promote uptake by cells. However, its role in distributing either exogenous or endogenous cytokinins within the intact plant has not h…
View article: Nucleotide limitation results in impaired photosynthesis, reduced growth and seed yield together with massively altered gene expression
Nucleotide limitation results in impaired photosynthesis, reduced growth and seed yield together with massively altered gene expression Open
Nucleotide limitation and imbalance is a well described phenomenon in animal research but understudied in the plant field. A peculiarity of pyrimidine de novo synthesis in plants is the complex subcellular organization. Here, we studied tw…
CTP-Synthase 2 from<i>Arabidopsis thaliana</i>is required for complete embryo development Open
Pyrimidine de novo synthesis is an essential pathway in all organisms. The final and rate limiting step in the synthesis of the nucleotide CTP is catalyzed by CTP-Synthase (CTPS) and Arabidopsis harbors five isoforms. Single knockouts of e…
Acclimation in plants – the Green Hub consortium Open
Summary Acclimation is the capacity to adapt to environmental changes within the lifetime of an individual. This ability allows plants to cope with the continuous variation in ambient conditions to which they are exposed as sessile organis…
View article: UMP inhibition and sequential firing in aspartate transcarbamoylase open ways to regulate plant growth
UMP inhibition and sequential firing in aspartate transcarbamoylase open ways to regulate plant growth Open
Pyrimidine nucleotides are essential to plant development. We proved that Arabidopsis growth can be inhibited or enhanced by down- or upregulating aspartate transcarbamoylase (ATC), the first committed enzyme for de novo biosynthesis of py…
Differential degradation of RNA species by autophagy related pathways in plants Open
An important function of the plant vacuole is the recycling of the delivered proteins and RNA by autophagy. We provide the first plant vacuolar small RNome by isolation of intact vacuoles from Barley and Arabidopsis, subsequent RNA purific…
The Role of Plastidic Trigger Factor Serving Protein Biogenesis in Green Algae and Land Plants Open
Biochemical processes in chloroplasts are important for virtually all life forms. Tight regulation of protein homeostasis and the coordinated assembly of protein complexes, composed of both imported and locally synthesized subunits, are vi…
PUMPKIN, the Sole Plastid UMP Kinase, Associates with Group II Introns and Alters Their Metabolism Open
The chloroplast hosts photosynthesis and a variety of metabolic pathways that are essential for plant viability and acclimation processes. In this study, we show that the sole plastid UMP kinase (PUMPKIN) in Arabidopsis (Arabidopsis thalia…
Characterization of filament‐forming <span>CTP</span> synthases from <i>Arabidopsis thaliana</i> Open
Summary Cytidine triphosphate ( CTP ) is essential for DNA , RNA and phospholipid biosynthesis. De novo synthesis is catalyzed by CTP synthases ( CTPS ). Arabidopsis encodes five CTPS isoforms that unanimously share conserved motifs found …