Torsten Bauer
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View article: Methylomes of human CD4 and CD8 memory T lymphocytes reveal tissue-specific epigenetic signatures for maintenance and recall function
Methylomes of human CD4 and CD8 memory T lymphocytes reveal tissue-specific epigenetic signatures for maintenance and recall function Open
Adaptive immunity relies on antibodies and memory B and T cells, with memory T cells providing "reactive memory". These cells either circulate in the blood or remain as tissue-resident memory T cells, yet the epigenetic mechanisms underlyi…
View article: Evaluation of three novel antigens and costimulatory agents for improvement of M. Tuberculosis specific interferon gamma release assays
Evaluation of three novel antigens and costimulatory agents for improvement of M. Tuberculosis specific interferon gamma release assays Open
View article: Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus
Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus Open
Streptococcus pneumoniae is the most common causative agent of community-acquired pneumonia worldwide. A key pathogenic mechanism that exacerbates severity of disease is the disruption of the alveolar–capillary barrier. However, the specif…
View article: Trends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021
Trends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021 Open
Breast cancer is the most frequently diagnosed cancer in females globally. However, we know relatively little about trends in males. This study describes United Kingdom (UK) secular trends in breast cancer from 2000 to 2021 for both sexes.…
View article: Tuberkulose bei ukrainischen Geflüchteten in Deutschland – ein Vergleich von Screening- und Meldedaten
Tuberkulose bei ukrainischen Geflüchteten in Deutschland – ein Vergleich von Screening- und Meldedaten Open
Zusammenfassung Seit Beginn des Krieges in der Ukraine bis November 2022 haben fast 1 Million Menschen Zuflucht in Deutschland gefunden. Trotz der Bemühungen, die Tuberkulose (TB)-Fallzahlen zu senken, verzeichnete die Ukraine im Jahr 2020…
View article: Therapie bei MDR-, prä-XDR-, XDR-Tuberkulose und Rifampicin-Resistenz oder bei Medikamentenunverträglichkeit gegenüber mindestens Rifampicin
Therapie bei MDR-, prä-XDR-, XDR-Tuberkulose und Rifampicin-Resistenz oder bei Medikamentenunverträglichkeit gegenüber mindestens Rifampicin Open
Zusammenfassung Im Dezember 2022 hat die Weltgesundheitsorganisation (WHO) die Empfehlungen für die Behandlung der medikamentenresistenten Tuberkulose (TB) aktualisiert. Die Bewertung dieser Empfehlungen und der neuen Studiendaten macht au…
View article: Infektionsprävention & Hygiene bei Tuberkulose – Empfehlungen des DZK
Infektionsprävention & Hygiene bei Tuberkulose – Empfehlungen des DZK Open
Zusammenfassung Die Vermeidung der Weiterverbreitung der Erkrankung ist ein wesentliches Ziel in der Betreuung und Behandlung von Tuberkulose. Für die Infektionsprävention von besonderer Bedeutung sind neben der frühzeitigen Diagnose und e…
View article: Axenic Long-Term Cultivation of Pneumocystis jirovecii
Axenic Long-Term Cultivation of Pneumocystis jirovecii Open
Pneumocystis jirovecii, a fungus causing severe Pneumocystis pneumonia (PCP) in humans, has long been described as non-culturable. Only isolated short-term experiments with P. jirovecii and a small number of experiments involving animal-de…
View article: TB screening of Ukrainian refugees in Germany
TB screening of Ukrainian refugees in Germany Open
View article: Integrated Clinical, Molecular and Immunological Characterization of Pulmonary Sarcomatoid Carcinomas Reveals an Immune Escape Mechanism That May Influence Therapeutic Strategies
Integrated Clinical, Molecular and Immunological Characterization of Pulmonary Sarcomatoid Carcinomas Reveals an Immune Escape Mechanism That May Influence Therapeutic Strategies Open
Pulmonary sarcomatoid carcinoma (PSC) has highly aggressive biological behaviour and poor clinical outcomes, raising expectations for new therapeutic strategies. We characterized 179 PSC by immunohistochemistry, next-generation sequencing …
View article: Diffuse Alveolar Hemorrhage Associated with Epithelioid Angiosarcoma of the Lung: A Challenging Diagnosis
Diffuse Alveolar Hemorrhage Associated with Epithelioid Angiosarcoma of the Lung: A Challenging Diagnosis Open
A 68-year-old patient presented with persistent hemoptysis and weight loss. A CT scan showing diffuse bilateral ground-glass opacities and nodules was followed by bronchoscopy. While diffuse alveolar hemorrhage (DAH) could be seen, specime…
View article: Tuberkulose
Tuberkulose Open
Tuberkulose (TB) wird durch Bakterien des Mycobacterium-tuberculosis-Komplexes ausgelöst und zählt weltweit zu den häufigsten Infektionserkrankungen. Die Übertragung erfolgt von Mensch zu Mensch durch erregerhaltige Aerosole. Häufigster Ma…
View article: Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus
Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus Open
View article: Tuberkulose im Erwachsenenalter
Tuberkulose im Erwachsenenalter Open
Zusammenfassung Die Tuberkulose ist in Deutschland eine seltene, überwiegend gut behandelbare Erkrankung. Weltweit ist sie eine der häufigsten Infektionserkrankungen mit ca. 10 Millionen Neuerkrankungen/Jahr. Auch bei einer niedrigen Inzid…
View article: Landscape of Genomic Alterations and PD-L1 Expression in Early-Stage Non-Small-Cell Lung Cancer (NSCLC)—A Single Center, Retrospective Observational Study
Landscape of Genomic Alterations and PD-L1 Expression in Early-Stage Non-Small-Cell Lung Cancer (NSCLC)—A Single Center, Retrospective Observational Study Open
Precision oncology and immunotherapy have revolutionized the treatment of advanced non-small-cell lung cancer (NSCLC). Emerging studies show that targeted therapies are also beneficial for patients with driver alterations such as epidermal…
View article: Human alveolar progenitors generate dual lineage bronchioalveolar organoids
Human alveolar progenitors generate dual lineage bronchioalveolar organoids Open
View article: Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilises the angiotensin-converting enzyme 2 (ACE2) transmembrane peptidase as cellular entry receptor. However, whether SARS-CoV-2 in the alveolar compartment is stri…
View article: Mortality in cancer patients with SARS-CoV-2 or seasonal influenza: an observational cohort study from a German-wide hospital network
Mortality in cancer patients with SARS-CoV-2 or seasonal influenza: an observational cohort study from a German-wide hospital network Open
Purpose At the beginning of the COVID-19 pandemic, SARS-CoV-2 was often compared to seasonal influenza. We aimed to compare the outcome of hospitalized patients with cancer infected by SARS-CoV-2 or seasonal influenza including intensive c…
View article: <i>M</i><i>ycobacterium tuberculosis</i>-specific CD4 T-cell scoring discriminates tuberculosis infection from disease
<i>M</i><i>ycobacterium tuberculosis</i>-specific CD4 T-cell scoring discriminates tuberculosis infection from disease Open
Background Rapid and reliable diagnostic work-up of tuberculosis (TB) remains a major healthcare goal. In particular, discrimination of TB infection from TB disease with currently available diagnostic tools is challenging and time consumin…
View article: Digital gene expression analysis of NSCLC-patients reveals strong immune pressure, resulting in an immune escape under immunotherapy
Digital gene expression analysis of NSCLC-patients reveals strong immune pressure, resulting in an immune escape under immunotherapy Open
View article: Risk Assessment for Patients with Chronic Respiratory Conditions in the Context of the SARS-CoV-2 Pandemic Statement of the German Respiratory Society with the Support of the German Association of Chest Physicians
Risk Assessment for Patients with Chronic Respiratory Conditions in the Context of the SARS-CoV-2 Pandemic Statement of the German Respiratory Society with the Support of the German Association of Chest Physicians Open
Assessing the risk for specific patient groups to suffer from severe courses of COVID-19 is of major importance in the current SARS-CoV-2 pandemic. This review focusses on the risk for specific patient groups with chronic respiratory condi…
View article: Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ)
Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ) Open
View article: Tuberkuloseversorgung in Deutschland unter Pandemiebedingungen – eine Online-Umfrage des DZK im Öffentlichen Gesundheitsdienst
Tuberkuloseversorgung in Deutschland unter Pandemiebedingungen – eine Online-Umfrage des DZK im Öffentlichen Gesundheitsdienst Open
Seit Beginn der COVID-19-Pandemie kommt es in vielen Ländern zu einem Rückgang der gemeldeten Tuberkulosefälle. In Ländern mit geringem oder mitt¬lerem Einkommen werden vor allem Einschränkungen der allgemeinen Gesundheitsversorgung als Ur…
View article: Purple urine bag syndrome: When the urine turns purple – An under diagnosed spot diagnosis
Purple urine bag syndrome: When the urine turns purple – An under diagnosed spot diagnosis Open
The Purple Urine Bag Syndrome (PUBS) is a rare condition in which the urine turns purple. It may occur in Urinary Tract Infections (UTIs) when bacteria metabolize dietary tryptophan to indole resulting in indigo (blue) and indirubin (red).…
View article: Welttuberkulosetag 2021: Infektionskontrolle gestern und heute – 125 Jahre Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose (DZK
Welttuberkulosetag 2021: Infektionskontrolle gestern und heute – 125 Jahre Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose (DZK Open
Die COVID-19-Pandemie gefährdet weltweit die bisher erreichten Erfolge im Kampf gegen die Tuberkulose. Wie das Epidemiologische Bulletin 11/2021 anlässlich des Welttuberkulosetages ausführt, bleibt die Infektionskontrolle angesichts global…
View article: Autoimmune disorders and paraneoplastic syndromes in thymoma
Autoimmune disorders and paraneoplastic syndromes in thymoma Open
Thymomas are counted among the rare tumour entities which are associated with autoimmune disorders (AIDs) and paraneoplastic syndromes (PNS) far more often than other malignancies. Through its complex immunological function in the context …
View article: Risikoabschätzung bei Patienten mit chronischen Atemwegs- und Lungenerkrankungen im Rahmen der SARS-CoV-2-Pandemie
Risikoabschätzung bei Patienten mit chronischen Atemwegs- und Lungenerkrankungen im Rahmen der SARS-CoV-2-Pandemie Open
Im Rahmen der aktuellen SARS-CoV-2-Pandemie gibt es eine Verunsicherung bezüglich der Frage des individuellen Schutzes bestimmter Patientengruppen mit chronischen Atemwegs- und Lungenerkrankungen, sowohl bei den Ärzten, die in der Pflicht …
View article: Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure Open
The plasma of COVID-19 patients induces pulmonary microvascular barrier failure, which increases with disease severity. Here, a screening platform to test for plasma mediators and the therapeutic potential of barrier stabilising compounds …
View article: Die neuen WHO-Empfehlungen für schnelle Diagnostik und Therapie resistenter Tuberkulose in Deutschland, Österreich und der Schweiz
Die neuen WHO-Empfehlungen für schnelle Diagnostik und Therapie resistenter Tuberkulose in Deutschland, Österreich und der Schweiz Open
Zusammenfassung Die erfreulicherweise zunehmende Evidenz hat in den letzten Jahren mehrfache Änderungen der internationalen Empfehlungen für die Diagnostik und Therapie der resistenten Tuberkulose notwendig gemacht. In diesem Jahr hat die …
View article: Clinical course and factors associated with outcomes among 1904 patients hospitalized with COVID-19 in Germany: an observational study
Clinical course and factors associated with outcomes among 1904 patients hospitalized with COVID-19 in Germany: an observational study Open