Toru Imamura
YOU?
Author Swipe
View article: Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells
Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells Open
Cancer therapy is often hampered by the disease’s development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene ( FGF13 ; also known as FGF homologous fact…
View article: Tissue‐specific analysis of <i>Fgf18</i> gene function in palate development
Tissue‐specific analysis of <i>Fgf18</i> gene function in palate development Open
Background Previous studies showed that mice lacking Fgf18 function had cleft palate defects and that the FGF18 locus was associated with cleft lip and palate in humans, but what specific roles Fgf18 plays during palatogenesis are unclear.…
View article: Assessment of Memory Impairment
Assessment of Memory Impairment Open
心理学と臨床医学ではさまざまな種類の記憶が提唱・定義されている。本稿では, それらのなかで, 臨床で脳損傷患者の記憶障害をみる上で有用な概念, 図式について述べる。次に, 近時記憶課題を用いたテストにおける質的観察のポイントを, 単語列再生課題を例に挙げて紹介する。最後に日常記憶の評価法について述べ, 話題提供を行う。
View article: Vegetable Freshness Perception in Dementia with Lewy Bodies and Alzheimer’s Disease
Vegetable Freshness Perception in Dementia with Lewy Bodies and Alzheimer’s Disease Open
Introduction: Although various visual function deficits have been reported in patients with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), vegetable freshness perception has not been thoroughly examined. Objective: To invest…
View article: Comprehensive histological investigation of age‐related changes in dermal extracellular matrix and muscle fibers in the upper lip vermilion
Comprehensive histological investigation of age‐related changes in dermal extracellular matrix and muscle fibers in the upper lip vermilion Open
Objective Few histological studies have directly examined age‐related changes within the lips, although non‐invasive investigations of such changes are increasing. Therefore, this study aimed to provide histological and molecular data on a…
View article: Combination of Pure and Constructional Agraphias in A Right Hemisphere Damage
Combination of Pure and Constructional Agraphias in A Right Hemisphere Damage Open
症例は 57 歳, 右利き男性。兄には左利きの矯正歴がみられた。右頭頂後頭葉皮質下出血発症 4 週時点で左半側空間無視, 構成障害, 着衣失行を認めた。音声言語の理解, 表出および読字には問題なかったが, 漢字書字に障害がみられ, 無反応, 部分反応, 存在字近似反応などの純粋失書と思われる反応に加えて, 文字の構成要素はすべて書き出されているが空間配置が乱れた構成失書がみられた。小学校 1, 2, 3 年生の教育漢字から無作為に選択した 51 文字の書取と写字では, 純粋…
View article: Age-related changes in the vasculature of the dermis of the upper lip vermilion
Age-related changes in the vasculature of the dermis of the upper lip vermilion Open
Lip redness is unique to humans and creates an important facial impression, but this redness decreases with age. Here, using histological and immunohistological staining of human upper lip vermilion from donors of different ages, we invest…
View article: Environmental dependency syndrome (Lhermitte) after left frontal subcortical hemorrhage
Environmental dependency syndrome (Lhermitte) after left frontal subcortical hemorrhage Open
症例は 80 歳, 女性, 右利き。左前頭葉の脳内出血発症 60 日で当施設転入居。四肢に粗大な運動麻痺なし。自発話は乏しく, 話し掛けられると単語~短文レベルで発話がみられることがある程度。問いかけへの肯定 / 否定の意思表示は曖昧だが, 表情や行動, 態度から非言語的な状況理解は基本的に悪くないと思われた。施設内での生活場面で, 窓の鍵やドアが見えると開けようとするといった使用行動がみられた。さらに, 複数の職員がテーブルを囲んでミーティングをしていると, 近づいてきて…
View article: Strong radioprotective FGF1 signaling down-regulates proliferative and metastatic capabilities of the angiosarcoma cell line, ISOS-1, through the dual inhibition of EGFR and VEGFR pathways
Strong radioprotective FGF1 signaling down-regulates proliferative and metastatic capabilities of the angiosarcoma cell line, ISOS-1, through the dual inhibition of EGFR and VEGFR pathways Open
These results suggest that strong FGF1 signaling exerts not only radioprotective effects, but also inhibitory effects on proliferative and metastatic capacities of angiosarcoma through the dual inhibition of EGFR and VEGFR pathways.
View article: A case of fluent aphasia with monemic paraphasia following left putaminal hemorrhage
A case of fluent aphasia with monemic paraphasia following left putaminal hemorrhage Open
左被殻出血後に慢性期まで記号素性錯語を呈した流暢性失語例において, 記号素性錯語の特徴について検討した。症例は 64 歳右利き女性で, 意識障害はなく, 非言語的な認知機能は保たれていた。自発話や呼称において豊富な錯語を示し, 特に呼称における記号素性錯語が特徴的だった。記号素性錯語は発症 1 年後にも認められ, 保続型と非保続型に分類できた。保続型はすでに表出された記号素やその意味的関連語を含む記号素性錯語で, 目標語を含まないものが多かった。一方, 非保続型は目標語や目…
View article: FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling
FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling Open
These results suggest that FGF18 signaling mediates radioresistance in telogen HFs by arresting the cell cycle, and that FGF18 has potential as a radioprotector for radiation-induced alopecia.
View article: Relationship between Dementia Severity and Behavioral and Psychological Symptoms of Dementia in Dementia with Lewy Bodies and Alzheimer's Disease Patients
Relationship between Dementia Severity and Behavioral and Psychological Symptoms of Dementia in Dementia with Lewy Bodies and Alzheimer's Disease Patients Open
Background/Aims: Behavioral and psychological symptoms of dementia (BPSD) are common in the clinical manifestation of dementia. Although most patients with dementia exhibit some BPSD during the course of the illness, the association of BPS…
View article: A Stable Chimeric Fibroblast Growth Factor (FGF) Can Successfully Replace Basic FGF in Human Pluripotent Stem Cell Culture
A Stable Chimeric Fibroblast Growth Factor (FGF) Can Successfully Replace Basic FGF in Human Pluripotent Stem Cell Culture Open
Fibroblast growth factors (FGFs) are essential for maintaining self-renewal in human embryonic stem cells and induced pluripotent stem cells. Recombinant basic FGF (bFGF or FGF2) is conventionally used to culture pluripotent stem cells; ho…
View article: Automatic Detection of Good/Bad Colonies of iPS Cells Using Local Features
Automatic Detection of Good/Bad Colonies of iPS Cells Using Local Features Open
In this paper we propose a method able to automatically detect good/bad colonies of iPS cells using local patches based on densely extracted SIFT features. Different options for local patch classification based on a kernelized novelty dete…