Toru Kawakami
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View article: Application of cysteinyl prolyl ester for the synthesis of cyclic peptides containing an RGD sequence and their biological activity measurement
Application of cysteinyl prolyl ester for the synthesis of cyclic peptides containing an RGD sequence and their biological activity measurement Open
Cysteinyl RGD-peptidyl cysteinyl prolyl esters, which have different configurations at the cysteine and proline residues, were synthesized by the solid-phase method and cyclized by the native chemical ligation reaction. Cyclization efficie…
View article: The Molecular Basis of Heat-Stable Enterotoxin for Vaccine Development and Cancer Cell Detection
The Molecular Basis of Heat-Stable Enterotoxin for Vaccine Development and Cancer Cell Detection Open
Heat-stable enterotoxin (STa) produced by Enterotoxigenic E. coli is responsible for causing acute diarrhea in infants in developing countries. However, the chemical synthesis of STa peptides with the native conformation and the correct in…
View article: Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant
Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant Open
View article: Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation Open
View article: Enhanced processivity of Dnmt1 by monoubiquitinated histone H3
Enhanced processivity of Dnmt1 by monoubiquitinated histone H3 Open
DNA methylation controls gene expression, and once established, DNA methylation patterns are faithfully copied during DNA replication by the maintenance DNA methyltransferase Dnmt1. In vivo , Dnmt1 interacts with Uhrf1, which recognizes he…
View article: Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance
Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance Open
View article: <scp>RFTS</scp>‐dependent negative regulation of Dnmt1 by nucleosome structure and histone tails
<span>RFTS</span>‐dependent negative regulation of Dnmt1 by nucleosome structure and histone tails Open
DNA methylation in promoter regions represses gene expression and is copied over mitotic divisions by Dnmt1. Dnmt1 activity is regulated by its replication foci targeting sequence ( RFTS ) domain which masks the catalytic pocket. It has be…
View article: Glycosaminoglycan Binding and Non-Endocytic Membrane Translocation of Cell-Permeable Octaarginine Monitored by Real-Time In-Cell NMR Spectroscopy
Glycosaminoglycan Binding and Non-Endocytic Membrane Translocation of Cell-Permeable Octaarginine Monitored by Real-Time In-Cell NMR Spectroscopy Open
Glycosaminoglycans (GAGs), which are covalently-linked membrane proteins at the cell surface have recently been suggested to involve in not only endocytic cellular uptake but also non-endocytic direct cell membrane translocation of arginin…
View article: Synthesis and Structural Analysis of Ruthenium-bound Norvaline Peptides
Synthesis and Structural Analysis of Ruthenium-bound Norvaline Peptides Open
A series of norvaline (Nva) peptides possessing ONO-pincer ruthenium complexes, Boc-{l-[Ru(pydc)(t-Bu-terpy)]Nva}n-OMe (n = 2–6), were synthesized successfully by solution-phase peptide synthesis. Efficient coupling of equimolar amounts of…
View article: RP S19 C-terminal peptide trimer acts as a C5a receptor antagonist
RP S19 C-terminal peptide trimer acts as a C5a receptor antagonist Open
View article: Nucleosome compaction facilitates HP1γ binding to methylated H3K9
Nucleosome compaction facilitates HP1γ binding to methylated H3K9 Open
The α, β and γ isoforms of mammalian heterochromatin protein 1 (HP1) selectively bind to methylated lysine 9 of histone H3 via their chromodomains. Although the phenotypes of HP1-knockout mice are distinct for each isoform, the molecular m…
View article: Arginine-Glycosaminoglycan Interaction Regulates Penetration Efficiency of Arginine-Rich Cell-Penetrating Peptides in Biological Membrane
Arginine-Glycosaminoglycan Interaction Regulates Penetration Efficiency of Arginine-Rich Cell-Penetrating Peptides in Biological Membrane Open