Tōru Kimura
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View article: Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath
Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath Open
Purpose Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP)…
View article: Surgical Management of Destructive Thyroiditis Triggered by Neoadjuvant Immune Checkpoint Inhibitor Therapy in Locally Advanced Non-Small Cell Lung Cancer: A Case Report
Surgical Management of Destructive Thyroiditis Triggered by Neoadjuvant Immune Checkpoint Inhibitor Therapy in Locally Advanced Non-Small Cell Lung Cancer: A Case Report Open
This report highlights a case of preoperative destructive thyroiditis secondary to irAEs. In patients receiving preoperative ICIs therapy, routine blood tests, including thyroid function tests, are recommended as part of preoperative asses…
View article: AB010. Surgical treatment strategy for thymic cancer invading the aorta: a case report
AB010. Surgical treatment strategy for thymic cancer invading the aorta: a case report Open
BACKGROUND: Thymic carcinoma is a rare but aggressive tumor, and multidisciplinary treatment is necessary to improve prognosis. Although complete surgical resection is a prognostic factor, it is not always an option for advanced tumors bec…
View article: AB024. Evaluation of surgical treatment of myasthenia gravis complicated thymoma
AB024. Evaluation of surgical treatment of myasthenia gravis complicated thymoma Open
BACKGROUND: Thymoma-associated myasthenia gravis (TAMG) differs from nonthymomatous myasthenia gravis (MG) in its pathogenesis, and the therapeutic effect of extended thymectomy on MG is also different. The purpose of this study is to clar…
View article: Percutaneous laryngeal elevation technique to achieve excellent hypopharyngeal exposure in transoral surgery
Percutaneous laryngeal elevation technique to achieve excellent hypopharyngeal exposure in transoral surgery Open
Endoscopic laryngopharyngeal surgery (ELPS) is a transoral surgery performed for the treatment of early-stage pharyngeal and supralaryngeal cancer. In Japan, ELPS is often chosen for transoral resection of hypopharyngeal cancer. However, i…
View article: <scp>ACTN4</scp> is associated with the malignant potential of thymic epithelial tumors through the β‐catenin/Slug pathway
<span>ACTN4</span> is associated with the malignant potential of thymic epithelial tumors through the β‐catenin/Slug pathway Open
Thymic epithelial tumors (TETs) are rare tumors arising from the mediastinum. Among TETs, thymoma type B2, B3 and thymic carcinoma are highly malignant and often present invasion and dissemination. However, the biological characteristics o…
View article: Endothelial cell–specific LAT1 ablation normalizes tumor vasculature
Endothelial cell–specific LAT1 ablation normalizes tumor vasculature Open
Some endothelial cells in the tumor vasculature express a system L amino acid transporter, LAT1. To elucidate the role of LAT1 in tumor-related endothelial cells, tumor cells were injected into endothelial cell-specific LAT1 conditional kn…
View article: Expression of fibroblast activation protein in intrathoracic solitary fibrous tumor
Expression of fibroblast activation protein in intrathoracic solitary fibrous tumor Open
SFTPs expressed FAP to varying degrees in different patients and the [18F]FAPI-74 PET results in one patient reflected FAP expression in the tumor tissue.
View article: Surgical resection of advanced intrathoracic tumors through a combination of the hemiclamshell and transmanubrial approaches
Surgical resection of advanced intrathoracic tumors through a combination of the hemiclamshell and transmanubrial approaches Open
Purpose The hemiclamshell (HCS) approach provides a comprehensive view of the anterior mediastinum, whereas the transmanubrial osteomuscular sparing approach (TMA) allows sufficient exposure of the cervico-thoracic transition. We assessed …
View article: Acute mediastinal mass syndrome after surgical biopsy of a massive anterior mediastinal tumor: a case report
Acute mediastinal mass syndrome after surgical biopsy of a massive anterior mediastinal tumor: a case report Open
Background Mediastinal lymphatic tumors are relatively rare. The prognosis is poor but has improved due to recent advances in treatment strategies. Herein, we report a case of mediastinal lymphoma diagnosed using surgical biopsy, which was…
View article: Japanese Patient Engagement Promotion Training (<scp>J‐PEPT</scp>): Learning course on the implementation strategy of patient engagement
Japanese Patient Engagement Promotion Training (<span>J‐PEPT</span>): Learning course on the implementation strategy of patient engagement Open
Patient engagement for patient safety is emphasized in recent years. Therefore, the Committee on Quality and Patient Safety of the Japan Primary Care Association developed a Japanese Patient Engagement Promotion Training (J‐PEPT) course. J…
View article: Combination Biologic Therapy with Mepolizumab and Dupilumab for Severe Eosinophilic Granulomatosis with Polyangiitis and Chronic Rhinosinusitis with Nasal Polyp
Combination Biologic Therapy with Mepolizumab and Dupilumab for Severe Eosinophilic Granulomatosis with Polyangiitis and Chronic Rhinosinusitis with Nasal Polyp Open
We report the case of a 55-year-old female with eosinophilic granulomatosis with polyangiitis and chronic rhinosinusitis with nasal polyp. Rhinosinusitis recurred 6 months after full-house endoscopic sinus surgery. Although conventional tr…
View article: Progressive Changes in the Protein Expression Profile of Alveolar Septa in Early-Stage Lung Adenocarcinoma
Progressive Changes in the Protein Expression Profile of Alveolar Septa in Early-Stage Lung Adenocarcinoma Open
Background Adenocarcinomas show a stepwise progression from atypical adenomatous hyperplasia (AAH) through adenocarcinoma in situ (AIS) to invasive adenocarcinoma (IA). Immunoglobulin superfamily containing leucine-rich repeat (ISLR) is a …
View article: Integrated cardiothoracic team approach for complex lung transplantation procedures in Japan—current status and future direction
Integrated cardiothoracic team approach for complex lung transplantation procedures in Japan—current status and future direction Open
The first lung transplant procedure in the world was performed in 1983, while in Japan that was first accomplished in 1998. Over the following 25 years, lung transplantation has become a viable treatment option for Japanese patients with a…
View article: Evaluation of LAT1 Expression in Patients With Lung Cancer and Mediastinal Tumors
Evaluation of LAT1 Expression in Patients With Lung Cancer and Mediastinal Tumors Open
Purpose of the Report L-type amino acid transporter-1 (LAT1) is a tumor-specific transporter expressed in various tumor types, with minimal expression in normal organs. We previously demonstrated 18 F-fluoro-borono-phenylalanine ( 18 F-FBP…
View article: Progressive Changes in Protein Expression Profile of Alveolar Septa in Early-Stage Lung Adenocarcinoma
Progressive Changes in Protein Expression Profile of Alveolar Septa in Early-Stage Lung Adenocarcinoma Open
Background Adenocarcinomas show a stepwise progression from atypical adenomatous hyperplasia (AAH) to adenocarcinoma in situ (AIS) and finally to invasive adenocarcinoma (IA). The expression of immunoglobulin superfamily containing leucine…
View article: Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation
Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation Open
Pituitary organoids are promising graft sources for transplantation in treatment of hypopituitarism. Building on development of self-organizing culture to generate pituitary-hypothalamic organoids (PHOs) using human pluripotent stem cells …
View article: Initial Evaluation of [<sup>18</sup>F]FAPI-74 PET for Various Histopathologically Confirmed Cancers and Benign Lesions
Initial Evaluation of [<sup>18</sup>F]FAPI-74 PET for Various Histopathologically Confirmed Cancers and Benign Lesions Open
The 18F-labeled fibroblast activation protein inhibitor (FAPI) [18F]FAPI-74 has the benefit of a higher synthetic yield and better image resolution than 68Ga-labeled FAPI. We preliminarily evaluated the diagnostic performance of [18F]FAPI-…
View article: Significance of the Surgical Treatment with Lymph Node Dissection for Neuroendocrine Tumors of Thymus
Significance of the Surgical Treatment with Lymph Node Dissection for Neuroendocrine Tumors of Thymus Open
Background: Neuroendocrine tumors of a thymus (NETTs) are rare, accounting for approximately 2–5% of all thymic epithelial tumors, and have a poor prognosis due to frequent lymph nodes or distant metastasis. Methods: We retrospectively rev…
View article: Self-organization, quality control, and preclinical studies of human iPSC-derived retinal sheets for tissue-transplantation therapy
Self-organization, quality control, and preclinical studies of human iPSC-derived retinal sheets for tissue-transplantation therapy Open
Three-dimensional retinal organoids (3D-retinas) are a promising graft source for transplantation therapy. We previously developed self-organizing culture for 3D-retina generation from human pluripotent stem cells (hPSCs). Here we present …