Toru Yamashita
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View article: Current updates on latest basic research of scientific relevance in hypertensive dementia
Current updates on latest basic research of scientific relevance in hypertensive dementia Open
View article: <i>INF2</i>‐Related Charcot–Marie–Tooth Disease in a Japanese Cohort: Genetic and Clinical Insights
<i>INF2</i>‐Related Charcot–Marie–Tooth Disease in a Japanese Cohort: Genetic and Clinical Insights Open
Background INF2 mutations cause focal segmental glomerulosclerosis (FSGS) and Charcot–Marie–Tooth disease (CMT). Accurate genetic diagnosis is critical, as INF2 ‐related FSGS is typically resistant to immunotherapy yet rarely recurs after …
View article: Biallelic variants in DNAJC7 cause familial amyotrophic lateral sclerosis with the TDP-43 pathology
Biallelic variants in DNAJC7 cause familial amyotrophic lateral sclerosis with the TDP-43 pathology Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of motor neurons. ALS pathology primarily involves the failure of protein quality control mechanisms, leading to the ac…
View article: The potential mechanism maintaining transactive response DNA binding protein 43 kDa in the mouse stroke model
The potential mechanism maintaining transactive response DNA binding protein 43 kDa in the mouse stroke model Open
The disruption of transactive response DNA binding protein 43 kDa (TDP-43) shuttling leads to the depletion of nuclear localization and the cytoplasmic accumulation of TDP-43. We aimed to evaluate the mechanism underlying the behavior of T…
View article: Two Cases of Autosomal Recessive Spinocerebellar Ataxia-8 Showing Two Novel Variants of <i>SYNE1</i> in Japanese Families
Two Cases of Autosomal Recessive Spinocerebellar Ataxia-8 Showing Two Novel Variants of <i>SYNE1</i> in Japanese Families Open
Autosomal recessive spinocerebellar ataxia-8 (SCAR8) is a neurodegenerative disorder caused by the biallelic pathogenic variants of SYNE1. It is characterized by slowly progressive cerebellar ataxia and atrophy. We identified two SCAR8 fam…
View article: Lyme neuroborreliosis in Japan: <i>Borrelia burgdorferi</i> sensu lato as a cause of meningitis of previously undetermined etiology in hospitalized patients outside of the island of Hokkaido, 2010–2021
Lyme neuroborreliosis in Japan: <i>Borrelia burgdorferi</i> sensu lato as a cause of meningitis of previously undetermined etiology in hospitalized patients outside of the island of Hokkaido, 2010–2021 Open
Background and Purpose Clinical manifestations of Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl), include erythema migrans, Lyme neuroborreliosis (LNB), carditis, and arthritis. LB is a notifiable disease in Japan …
View article: Frequency of FGF14 intronic GAA repeat expansion in patients with multiple system atrophy and undiagnosed ataxia in the Japanese population
Frequency of FGF14 intronic GAA repeat expansion in patients with multiple system atrophy and undiagnosed ataxia in the Japanese population Open
Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic nervous system dysfunction and cerebellar ataxia or parkinsonism. Recently, expanded GAA repeats (≥250 repeat units) in intron 1 of FGF14 have been sh…
View article: Suppression of PTBP1 in hippocampal astrocytes promotes neurogenesis and ameliorates recognition memory in mice with cerebral ischemia
Suppression of PTBP1 in hippocampal astrocytes promotes neurogenesis and ameliorates recognition memory in mice with cerebral ischemia Open
The therapeutic potential of suppressing polypyrimidine tract-binding protein 1 (Ptbp1) messenger RNA by viral transduction in a post-stroke dementia mouse model has not yet been examined. In this study, 3 days after cerebral ischemia, we …
View article: CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis
CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis Open
CHCHD2 and CHCHD10, linked to Parkinson's disease and amyotrophic lateral sclerosis-frontotemporal dementia (ALS), respectively, are mitochondrial intermembrane proteins that form a heterodimer. This study aimed to investigate the impact o…
View article: Linking LRP12 CGG repeat expansion to inherited peripheral neuropathy
Linking LRP12 CGG repeat expansion to inherited peripheral neuropathy Open
Background The causative genes for over 60% of inherited peripheral neuropathy (IPN) remain unidentified. This study endeavours to enhance the genetic diagnostic rate in IPN cases by conducting screenings focused on non-coding repeat expan…
View article: Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment
Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment Open
The strength of stem cell therapy is the regeneration of tissues by synergistic pleiotropic effects. Among many stem cell types, mesenchymal stem cells (MSCs) that are comprised of heterogenous population are widely used for clinical appli…
View article: The Japan <scp>MSA</scp> registry: A multicenter cohort study of multiple system atrophy
The Japan <span>MSA</span> registry: A multicenter cohort study of multiple system atrophy Open
Background Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure and various motor symptoms. While MSA‐C (cerebellar type) predominates in East Asia, MSA‐P (parkinsonian type) predominates in Euro…
View article: Update on Antioxidant Therapy with Edaravone: Expanding Applications in Neurodegenerative Diseases
Update on Antioxidant Therapy with Edaravone: Expanding Applications in Neurodegenerative Diseases Open
The brain is susceptible to oxidative stress, which is associated with various neurological diseases. Edaravone (MCI-186, 3-methyl-1 pheny-2-pyrazolin-5-one), a free radical scavenger, has promising effects by quenching hydroxyl radicals (…
View article: SOCIAL SURVEY ON COMMUNITY RESPONSE TO RAILWAY NOISE - COMPARISON OF RESPONSES OBTAINED WITH DIFFERENT ANNOYANCE SCALES
SOCIAL SURVEY ON COMMUNITY RESPONSE TO RAILWAY NOISE - COMPARISON OF RESPONSES OBTAINED WITH DIFFERENT ANNOYANCE SCALES Open
View article: EFFECTS OF A BELT OF TREES ON ROAD TRAFFIC NOISE ANNOYANCE
EFFECTS OF A BELT OF TREES ON ROAD TRAFFIC NOISE ANNOYANCE Open
View article: First evidence of tick-borne encephalitis (TBE) outside of Hokkaido Island in Japan
First evidence of tick-borne encephalitis (TBE) outside of Hokkaido Island in Japan Open
Tick-borne encephalitis (TBE) is an infection of the central nervous system caused by the tick-borne encephalitis virus (TBEV). TBE is endemic in parts of Europe and Asia. TBEV is transmitted to humans primarily by Ixodes ticks. The…
View article: A Unique Case of Sarcoid-associated Myelopathy Accompanied by Lung Cancer
A Unique Case of Sarcoid-associated Myelopathy Accompanied by Lung Cancer Open
The differential diagnosis of myelopathy in patients with malignancies may be challenging, as a spinal biopsy is not always applicable. A 66-year-old woman who had shown transient double vision and nausea developed spasticity and impaired …
View article: Direct reprogramming of hippocampal astrocytes ameliorates recognition memory in mice with cerebral ischemia
Direct reprogramming of hippocampal astrocytes ameliorates recognition memory in mice with cerebral ischemia Open
The therapeutic potential of suppressing polypyrimidine tract-binding protein 1 (Ptbp1) messenger ribonucleic acid (RNA) by viral transduction in a post-stroke dementia mouse model has not yet been examined. In this study, 3 days after cer…
View article: Human Cord Blood–Endothelial Progenitor Cells Alleviate Intimal Hyperplasia of Arterial Damage in a Rat Stroke Model
Human Cord Blood–Endothelial Progenitor Cells Alleviate Intimal Hyperplasia of Arterial Damage in a Rat Stroke Model Open
Human cord blood–endothelial progenitor cells (hCB-EPCs) isolated from the human umbilical cord can be used to repair damaged arteries. In this study, we used an animal model with pathological changes that mimics artery wall damage caused …
View article: Safety and Clinical Effects of a Muse Cell-Based Product in Patients With Amyotrophic Lateral Sclerosis: Results of a Phase 2 Clinical Trial
Safety and Clinical Effects of a Muse Cell-Based Product in Patients With Amyotrophic Lateral Sclerosis: Results of a Phase 2 Clinical Trial Open
Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of motor neurons. Multilineage-differentiating stress-enduring (Muse) cells are unique endogenous stem cells that show therapeutic effects on motor function in ALS mo…
View article: Actual Telemedicine Needs of Japanese Patients with Neurological Disorders in the COVID-19 Pandemic
Actual Telemedicine Needs of Japanese Patients with Neurological Disorders in the COVID-19 Pandemic Open
Objective During the coronavirus disease 2019 (COVID-19) pandemic, many social activities have moved online using applications for digital devices (e.g. computers, smartphones). We investigated the needs of telemedicine and trends in medic…
View article: Efficacy and safety of spot heating and ultrasound irradiation on in vitro and in vivo thrombolysis models
Efficacy and safety of spot heating and ultrasound irradiation on in vitro and in vivo thrombolysis models Open
The feasibility of transcranial sonothrombolysis has been demonstrated, although little is known about the relationships between thermal or mechanical mechanisms and thrombolytic outcomes. Therefore, the present study aims to reveal the ef…
View article: Supplementary Material for: Neuroprotective and therapeutic effects of Tocovid and Twendee-X on Aβ oligomers-induced damage in the SH-SY5Y cell line
Supplementary Material for: Neuroprotective and therapeutic effects of Tocovid and Twendee-X on Aβ oligomers-induced damage in the SH-SY5Y cell line Open
Background: Alzheimer’s disease (AD) is the most frequent cause of dementia among the elderly. The accumulation of amyloid beta (Aβ) and its downstream pathological events such as oxidative stress play central roles in AD. Recent studies r…
View article: Author Correction: Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis
Author Correction: Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Non-Tumorigenic Pluripotent Reparative Muse Cells Provide a New Therapeutic Approach for Neurologic Diseases
Non-Tumorigenic Pluripotent Reparative Muse Cells Provide a New Therapeutic Approach for Neurologic Diseases Open
Muse cells are non-tumorigenic endogenous reparative pluripotent cells with high therapeutic potential. They are identified as cells positive for the pluripotent surface marker SSEA-3 in the bone marrow, peripheral blood, and connective ti…
View article: Effect of edaravone on pregnant mice and their developing fetuses subjected to placental ischemia
Effect of edaravone on pregnant mice and their developing fetuses subjected to placental ischemia Open
View article: A Unique Case of Encephalopathy with an Elevated IgG-4 and Extremely High Interleukin-6 Level and Delayed Myelodysplastic Syndrome
A Unique Case of Encephalopathy with an Elevated IgG-4 and Extremely High Interleukin-6 Level and Delayed Myelodysplastic Syndrome Open
We herein report a 75-year-old man who developed disturbed consciousness with polynuclear cell dominant pleocytosis and low glucose and extremely high interleukin (IL)-6 levels in his cerebrospinal fluid. The biopsy specimen from his right…
View article: Protective effects of edaravone on white matter pathology in a novel mouse model of Alzheimer’s disease with chronic cerebral hypoperfusion
Protective effects of edaravone on white matter pathology in a novel mouse model of Alzheimer’s disease with chronic cerebral hypoperfusion Open
White matter lesions (WMLs) caused by cerebral chronic hypoperfusion (CCH) may contribute to the pathophysiology of Alzheimer’s disease (AD). However, the underlying mechanisms and therapeutic approaches have yet to be totally identified. …
View article: Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis
Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss. Muse cells are endogenous reparative pluripotent-like stem cells distributed in various tissues. They can selectively …
View article: Tocilizumab-induced Leukoencephalopathy with a Reversible Clinical Course
Tocilizumab-induced Leukoencephalopathy with a Reversible Clinical Course Open
Tocilizumab (TCZ; Actemra/RoActemra) is an anti-interleukin (IL)-6 receptor antibody for the treatment of rheumatoid arthritis (RA) and other autoimmune diseases and cytokine storms. The present case is a 63-year-old female well-controlled…