Toshi Shioda
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View article: Brown Adipose Tissue Dysfunction Links Obesogen Exposure to Reduced Energy Expenditure and Transgenerational Obesity
Brown Adipose Tissue Dysfunction Links Obesogen Exposure to Reduced Energy Expenditure and Transgenerational Obesity Open
Obesity has become a global health challenge, and increasing evidence suggests that environmental obesogens contribute to its prevalence. Tributyltin (TBT) is a model obesogen known to activate PPARγ and RXR and to promote transgenerationa…
View article: SUN-651 Transgenerational Obesity Induced By Prenatal Tributyltin Exposure Is Exacerbated By Diet And Associated With Reduced Thermogenic Activity
SUN-651 Transgenerational Obesity Induced By Prenatal Tributyltin Exposure Is Exacerbated By Diet And Associated With Reduced Thermogenic Activity Open
Disclosure: Y. Huang: None. R. Chang: None. K. To: None. R.S. Whitlock: None. K.U. Nguyen: None. M.C. Joemon: None. M.C. Joemon: None. M. Lopez: None. K.G. Deeprompt: None. B. Blumberg: None. T. Shioda: None. Obesity is a critical public h…
View article: Initiation of meiosis from human iPSCs under defined conditions through identification of regulatory factors
Initiation of meiosis from human iPSCs under defined conditions through identification of regulatory factors Open
Meiotic failure is a major cause of infertility, but the lack of an in vitro model of human meiosis is a barrier to understanding its mechanism. Here, we establish a method to initiate meiosis directly from male or female human-induced plu…
View article: Transgenerational Effects of the Obesogen Tributyltin on Metabolic Health in Mice: Interactions With a Western Diet
Transgenerational Effects of the Obesogen Tributyltin on Metabolic Health in Mice: Interactions With a Western Diet Open
Obesity is a global health crisis, with increasing evidence linking environmental factors such as exposure to endocrine-disrupting chemicals (EDCs) to its development. This study examines the transgenerational effects of exposure to the mo…
View article: Rapid human oogonia-like cell specification via transcription factor-directed differentiation
Rapid human oogonia-like cell specification via transcription factor-directed differentiation Open
View article: Association Between Activated Loci of HML-2 Primate-Specific Endogenous Retrovirus and Newly Formed Chromatin Contacts in Human Primordial Germ Cell-like Cells
Association Between Activated Loci of HML-2 Primate-Specific Endogenous Retrovirus and Newly Formed Chromatin Contacts in Human Primordial Germ Cell-like Cells Open
The pluripotent stem cell (PSC)-derived human primordial germ cell-like cells (PGCLCs) are a cell culture-derived surrogate model of embryonic primordial germ cells. Upon differentiation of PSCs to PGCLCs, multiple loci of HML-2, the homin…
View article: Induction of Meiosis from Human Pluripotent Stem Cells
Induction of Meiosis from Human Pluripotent Stem Cells Open
An in vitro model of human meiosis would accelerate research into this important reproductive process and development of therapies for infertility. We have developed a method to induce meiosis starting from male or female human pluripotent…
View article: Comment on “Comment on ‘A Nested Case–Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen’”
Comment on “Comment on ‘A Nested Case–Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen’” Open
View article: Heritable changes in chromatin contacts linked to transgenerational obesity
Heritable changes in chromatin contacts linked to transgenerational obesity Open
Burgeoning evidence demonstrates that effects of environmental exposures can be transmitted to subsequent generations through the germline without DNA mutations1,2. This phenomenon remains controversial because underlying mechan…
View article: Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally
Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally Open
People are widely exposed to polycyclic aromatic hydrocarbons, like benzo[a]pyrene (BaP). Prior studies showed that prenatal exposure to BaP depletes germ cells in ovaries, causing earlier onset of ovarian senescence post-natally; developi…
View article: Exploration multi-omique et in silico des effets transgénérationels et sexe-spécifiques induits par le TBT, un composé obésogène, sur le métabolisme hépatique de la souris
Exploration multi-omique et in silico des effets transgénérationels et sexe-spécifiques induits par le TBT, un composé obésogène, sur le métabolisme hépatique de la souris Open
International audience
View article: Figure S2 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S2 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S2. Scatter-plots showing a linear relationship between expression of housekeeping genes.
View article: Figure S3 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S3 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S3. Illustration of modeling and correcting for dependence of each marker through the expression level of housekeeping genes.
View article: Data from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Data from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Epithelial-to-mesenchymal transition (EMT) has been implicated in models of tumor cell migration, invasion, and metastasis. In a search for candidate therapeutic targets to reverse this process, nontumorigenic MCF10A breast epithelial cell…
View article: Supplementary Figures S1 - S10 from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Supplementary Figures S1 - S10 from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Supplementary Figure S1: RNA sequencing and pathway analysis of CTCs from Bone(+) versus Visceral(+) breast cancer patients. Supplementary Figure S2: Correlation between AR expression and AR signatures. Supplementary Figure S3: ER and PR e…
View article: Supplemental Methods, Tables S1-2, Table Legends and Figure Legends from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Supplemental Methods, Tables S1-2, Table Legends and Figure Legends from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Supplemental Methods, Tables S1-2, Table Legends and Figure Legends Table S1.List of qRT-PCR primers used for epithelial, mesenchymal, inducer and housekeeping genes. Table S2. RNA-ISH quantitation of expression scores used in Figure 5.
View article: Figure S4 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S4 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S4. Heat map analysis of the kinome screen generated by the Wilcoxon method.
View article: Supplementary Tables from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Supplementary Tables from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Supplementary Table S1: Patients and clinical information. Supplementary Table S2: Genes used to determine the AR signature.
View article: Figure S1 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S1 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S1. Summary of kinome screen.
View article: Figure S2 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S2 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S2. Scatter-plots showing a linear relationship between expression of housekeeping genes.
View article: Figure S1 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S1 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S1. Summary of kinome screen.
View article: Figure S3 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S3 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S3. Illustration of modeling and correcting for dependence of each marker through the expression level of housekeeping genes.
View article: Data from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Data from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Epithelial-to-mesenchymal transition (EMT) has been implicated in models of tumor cell migration, invasion, and metastasis. In a search for candidate therapeutic targets to reverse this process, nontumorigenic MCF10A breast epithelial cell…
View article: Figure S4 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S4 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S4. Heat map analysis of the kinome screen generated by the Wilcoxon method.
View article: Figure S5 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S5 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S5. Knockdown of MAPK7, CDC7, CDC2L5 and CSNKID induces Mesenchymal-Epithelial Transition (MET).
View article: Supplementary Figures S1 - S10 from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Supplementary Figures S1 - S10 from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Supplementary Figure S1: RNA sequencing and pathway analysis of CTCs from Bone(+) versus Visceral(+) breast cancer patients. Supplementary Figure S2: Correlation between AR expression and AR signatures. Supplementary Figure S3: ER and PR e…
View article: Supplementary Tables from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Supplementary Tables from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Supplementary Table S1: Patients and clinical information. Supplementary Table S2: Genes used to determine the AR signature.
View article: Supplemental Methods, Tables S1-2, Table Legends and Figure Legends from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Supplemental Methods, Tables S1-2, Table Legends and Figure Legends from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Supplemental Methods, Tables S1-2, Table Legends and Figure Legends Table S1.List of qRT-PCR primers used for epithelial, mesenchymal, inducer and housekeeping genes. Table S2. RNA-ISH quantitation of expression scores used in Figure 5.
View article: Figure S6 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S6 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S6. Knockdown of MAPK7 does not increase proliferation rate in primary tumor or lung metastasis.
View article: Figure S5 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Figure S5 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs Open
Figure S5. Knockdown of MAPK7, CDC7, CDC2L5 and CSNKID induces Mesenchymal-Epithelial Transition (MET).