Explanipedia

Fatigue on Waking, Insomnia, and Workplace Relationship Problems May Help to Detect Suicidal Ideation among New Middle-Aged Primary Care Patients: A 6-Month Prospective Study in Japan Open

Megumi Fujieda, Katsuhisa Uchida, Shin-ichiro Ikebe, Akihiko Kimura, Masashi Kimura , et al. · 2023

Signs of suicidal depression often go undetected in primary care settings. This study explored predictive factors for depression with suicidal ideation (DSI) among middle-aged primary care patients at 6 months after an initial clinic visit…

Dietary High-Dose Biotin Intake Activates Fat Oxidation and Hepatic Carnitine Palmitoyltransferase in Rat Open

Masahiro Yuasa, Koji Kawabeta, Momoe UEMURA, Kazunori Koba, Hiromi Sawamura , et al. · 2022

This study investigated the effects of dietary high-dose biotin intake on fat oxidation in rats using respiratory gas analysis, and evaluated fatty-acid oxidation-related enzyme activities and gene expressions in the liver. Five-week-old m…

Cumulative risk of developing a new symptom in patients with primary biliary cholangitis and its impact on prognosis Open

Naruhiro Kimura, Toru Setsu, Yoshihisa Arao, Norihiro Sakai, Yusuke Watanabe , et al. · 2022

Background and Aim Symptoms of primary biliary cholangitis (PBC) frequently impair one's quality of life (QOL). Nonetheless, with improved treatment, the prognosis of PBC also improves. QOL plays an important role in patients with PBC. In …

Broadband excitation of spin wave using microstrip line antennas for integrated magnonic devices Open

Kanta Mori, Taichi Goto, Toshiaki Watanabe, Takumi Koguchi, Y. Nakamura , et al. · 2021

Strong- and broadband-spin wave (SW) excitation/detection structures are useful for magnonic devices. In particular, such structures are essential for observing magnonic bandgaps of magnonic crystals (MCs). Therefore, this study proposes a…

Effects of Inadequate Folate Intake on the Onset and Progression of Hypertensive Vascular Injury Open

Kumiko Takemori, Takuya Matsuo, Toshiaki Watanabe, Shuhei Ebara, Takaaki Chikugo , et al. · 2021

We investigated the effects of inadequate folate intake on the onset and progression of hypertensive organ injury. In the present study, 5-wk-old male stroke-prone spontaneously hypertensive rats (SHRSP) were fed with a normal-folate (cont…

Sigmoid Volvulus in Pregnancy Assessed by Contrast-Enhanced Computed Tomography Scanning Open

Toshiaki Watanabe, Tadatsugu Kinjo, Yoshino Kinjyo, Hayase Nitta, Hitoshi Masamoto , et al. · 2021

Sigmoid volvulus requires urgent treatment, and it is particularly rare among pregnant women without a history of laparotomy. A delay in diagnosis may lead to serious consequences for the mother and fetus, and a rapid diagnosis and treatme…

Association of Dietary Fatty Acid Intake With the Development of Ulcerative Colitis: A Multicenter Case-Control Study in Japan Open

Y. Kobayashi, Satoko Ohfuji, Kyoko Kondo, Wakaba Fukushima, Satoshi Sasaki , et al. · 2020

Background Dietary fatty acids can affect chronic intestinal inflammation and have been reported to be associated with the development of ulcerative colitis (UC), mainly in Europe and the United States. The association of dietary intake of…

Gene Expression Signature in Surgical Tissues and Endoscopic Biopsies Identifies High-Risk T1 Colorectal Cancers Open

Raju Kandimalla, Tsuyoshi Ozawa, Feng Gao, Xin Wang, Ajay Goel , et al. · 2019

Expand+In Vivoiv.iiarjournals.orgIn Vivo September-October 2017 vol. 31 no. 5 1011-1017 Lymph Node Size on Computed Tomography Images Is a Predictive Indicator for Lymph Node Metastasis in Patients with Colorectal Neuroendocrine Tumors Open

Toshiaki Tanaka, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu , et al. · 2018

CT images provide predictive information for lymph node metastasis with a high rate of accuracy.

Duration of Adjuvant Chemotherapy for Stage III Colon Cancer Open

Axel Grothey, Alberto Sobrero, Anthony F. Shields, Takayuki Yoshino, James Paul , et al. · 2018

Among patients with stage III colon cancer receiving adjuvant therapy with FOLFOX or CAPOX, noninferiority of 3 months of therapy, as compared with 6 months, was not confirmed in the overall population. However, in patients treated with CA…

Association between institutional procedural preference and in-hospital outcomes in laparoscopic surgeries; Insights from a retrospective cohort analysis of a nationwide surgical database in Japan Open

Hiroaki Miyata, Masaki Mori, Norihiro Kokudo, Mitsukazu Gotoh, Hiroyuki Konno , et al. · 2018

LS use widely increased during 2011-2013 in Japan. Facilities with higher than expected LS use had higher mortality compared to other hospitals, suggesting a need for careful patient selection and dissemination of the procedure.

Protrusion on the Depressed Surface of Non-polypoid T1 Colorectal Cancer Is Associated with Venous Invasion Open

Takahide Shinagawa, Keisuke Hata, Teppei Morikawa, Hirotoshi Takiyama, Kensuke Otani , et al. · 2018

The endoscopic finding of protrusion on a depressed surface may be a sign indicating venous invasion in non-polypoid T1 CRC.

Multivisceral resections for locally advanced colorectal cancer after preoperative treatment Open

Takeshi Nishikawa, Soichiro Ishihara, Shigenobu Emoto, Manabu Kaneko, Koji Murono , et al. · 2018

Multivisceral resection for colorectal cancer invading into the adjacent organs may often be difficult and may involve serious complications. Preoperative therapy may facilitate resection with safe margins. Between August 2007 and July 201…

Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report Open

K Arakawa, Keisuke Hata, Yoko Yamamoto, Takeshi Nishikawa, Toshiaki Tanaka , et al. · 2018

Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (Translated Version) Open

Hideyuki Ishida, Tatsuro Yamaguchi, Kohji Tanakaya, Kiwamu Akagi, Yasuhiro Inoue , et al. · 2018

Hereditary colorectal cancer accounts for less than 5% of all colorectal cancer cases. Some of the unique characteristics that are commonly encountered in cases of hereditary colorectal cancer include early age at onset, synchronous/metach…

Supplementary Material for: Gankyrin Contributes to Tumorigenesis and Chemoresistance in Sporadic Colorectal Cancer Open

Toshiharu Sakurai, Yoriaki Komeda, Tomoyuki Nagai, Ken Kamata, Kosuke Minaga , et al. · 2018

Background: Although Gankyrin is overexpressed in many malignancies, the role of Gankyrin for tumorigenesis and chemoresistance remains to be elucidated in sporadic colorectal cancer (CRC). Aims: We investigate …

Comparison of the guidelines for colorectal cancer in Japan, the USA and Europe Open

Takahide Shinagawa, Toshiaki Tanaka, Hiroaki Nozawa, Shigenobu Emoto, Koji Murono , et al. · 2017

Colorectal cancer ( CRC ) is one of the most common cancers globally as well as in Japan and has shown a pattern of increasing incidence and mortality rates. Therefore, guidelines for CRC are considered to be crucial for establishing stand…

A MicroRNA Signature Associated With Metastasis of T1 Colorectal Cancers to Lymph Nodes Open

Tsuyoshi Ozawa, Raju Kandimalla, Feng Gao, Hiroaki Nozawa, Keisuke Hata , et al. · 2017

Leucine‑rich repeat‑containing G protein‑coupled receptor 5 and CD133 expression is associated with tumor progression and resistance to preoperative chemoradiotherapy in low rectal cancer Open

Yuzo Harada, Shinsuke Kazama, Teppei Morikawa, Koji Murono, Koji Yasuda , et al. · 2017

Preoperative chemoradiotherapy has been performed as a standard therapy for advanced low rectal cancer. Cancer stem cells (CSCs) have been reported to contribute to resistance to treatment and patient prognosis. Leucine-rich repeat-contain…

Colonoscopy reduces colorectal cancer mortality: A multicenter, long-term, colonoscopy-based cohort study Open

Ryota Niikura, Yoshihiro Hirata, Nobumi Suzuki, Atsuo Yamada, Yoku Hayakawa , et al. · 2017

The colorectal cancer mortality of patients who received colonoscopy without colorectal cancer diagnosis decreased significantly compared with that of individuals in the general population. These results were compatible even in patients wi…

Comparison of volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with conventional radiotherapy in preoperative chemoradiation for rectal cancers: a propensity score case-matched analysis Open

Hideomi Yamashita, Soichiro Ishihara, Hiroaki Nozawa, Kazushige Kawai, Tomomichi Kiyomatsu , et al. · 2017

The SIB-VMAT may be a promising method for preoperative CRT of rectal cancer.

Colitic Cancer Develops Through Mutational Alteration Distinct from that in Sporadic Colorectal Cancer: A Comparative Analysis of Mutational Rates at Each Step Open

Toshiaki Tanaka, Takashi Kobunai, Yoko Yamamoto, Shigenobu Emoto, Koji Murono , et al. · 2017

We demonstrated that mutational rates for APC and KRAS differ between colitic cancer and sporadic CRC. Furthermore, we revealed that CDH1 and FGFR2 become mutated at an earlier stage in colitic carcinogenesis than in sporadic CRC.

Neoadjuvant Imatinib Therapy Followed by Intersphincteric Resection for Low Rectal Gastrointestinal Stromal Tumors Open

Manabu Kaneko, Hiroaki Nozawa, Shigenobu Emoto, Koji Murono, Kazuhito Sasaki , et al. · 2017

Neoadjuvant imatinib therapy and ISR for low rectal GISTs is a challenging, but promising, alternative to achieve complete resection margins and preserve anal function.

Neural tube defects and folic acid in Japan: Prologue introduction ‐ Understanding of the current status of Japan and the proposal from Japanese Teratology Society Open

Toshiaki Watanabe · 2017

The 56th Annual Meeting of the Japanese Teratology Society (President: Watanabe T) was held in Himeji, Hyogo Prefecture, Japan, from July 29–31, 2016. The highlight of the academic meeting this year was "New Developments and Future Perspec…

Intestinal perforation after nivolumab immunotherapy for a malignant melanoma: a case report Open

Koji Yasuda, Toshiaki Tanaka, Soichiro Ishihara, Kensuke Otani, Takeshi Nishikawa , et al. · 2017

Morphological Changes and Device Migration After Stent Graft Insertion　― Clinical Application of an Image-Based Modeling System and Analysis With Geometric Parameters ― Open

Youkou Nemoto, Katsuyuki Hoshina, Masaharu Kobayashi, Mutsumi Kimura, Sota YAMAMOTO , et al. · 2017

The present study demonstrates SG behavior after implantation with numerical values for SG length and curvature.

Giant gastrointestinal stromal tumor of the vermiform appendix: A case report Open

Manabu Kaneko, Kazushige Kawai, Koji Murono, Takeshi Nishikawa, Kazuhito Sasaki , et al. · 2017

Gastrointestinal stromal tumors (GISTs) of the vermiform appendix are rare, measuring <3 cm in 82.4% of the reported cases. Neoadjuvant therapy with the receptor tyrosine kinase inhibitor imatinib mesylate has the potential to improve rese…

Theoretical mechanism of temporary renal function improvement after abdominal aortic aneurysm surgery Open

Katsuyuki Hoshina, Takafumi Akai, Marie Ohshima, Toshiaki Watanabe, Sota YAMAMOTO · 2017

We evaluated the effects of changes in blood flow due to abdominal aortic aneurysm (AAA) surgery by using a simple zero-dimension model and applied theoretical values to clinical data.The zero-dimension electronic circuit model and diagram…

Laparoscopic surgery for colorectal cancers complicated by Leriche syndrome: A report of three cases Open

Koji Murono, Soichiro Ishihara, Kazushige Kawai, Hiroshi Nagata, Manabu Kaneko , et al. · 2017

Leriche syndrome is a disease of aortoiliac occlusion, which causes diminished femoral pulses, impotence and claudication. As blood flow to the rectum is also decreased in Leriche syndrome, reconstruction with anastomosis may be complicate…

Optimization of a novel series of potent and orally bioavailable GPR119 agonists Open

Tomoaki Koshizawa, Toshiharu Morimoto, Gen Watanabe, Toshiaki Watanabe, Nao Yamasaki , et al. · 2017

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