Toshifumi Doi
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View article: Combination chemotherapy for older patients with unresectable biliary tract cancer: a prospective observational study using propensity-score matched analysis (JON2104-B)
Combination chemotherapy for older patients with unresectable biliary tract cancer: a prospective observational study using propensity-score matched analysis (JON2104-B) Open
Background Systemic chemotherapy with gemcitabine plus S-1 (GEM + S-1), GEM + CDDP plus S-1 (GEM + CDDP + S-1), or gemcitabine plus cisplatin (GEM + CDDP) is standard treatment for advanced biliary tract cancer (aBTC). We aimed to evaluate…
View article: Correction: Efficacy of liposomal irinotecan + 5-FU/LV vs. S-1 in gemcitabine-refractory metastatic pancreatic cancer: a real-world study using inverse probability of treatment weighting
Correction: Efficacy of liposomal irinotecan + 5-FU/LV vs. S-1 in gemcitabine-refractory metastatic pancreatic cancer: a real-world study using inverse probability of treatment weighting Open
View article: Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer
Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer Open
Cancer cachexia is a complex disorder characterized by skeletal muscle loss, which may influence the prognosis of patients with cancer. The cachexia index (CXI) is a new index for cachexia. The present study aimed to assess whether the CXI…
View article: Efficacy of liposomal irinotecan + 5-FU/LV vs. S-1 in gemcitabine-refractory metastatic pancreatic cancer: a real-world study using inverse probability of treatment weighting
Efficacy of liposomal irinotecan + 5-FU/LV vs. S-1 in gemcitabine-refractory metastatic pancreatic cancer: a real-world study using inverse probability of treatment weighting Open
View article: Real‐world genome profiling in Japanese patients with pancreatic ductal adenocarcinoma focusing on <scp>HRD</scp> implications
Real‐world genome profiling in Japanese patients with pancreatic ductal adenocarcinoma focusing on <span>HRD</span> implications Open
Pancreatic ductal adenocarcinoma (PDAC) poses significant challenges due to its high mortality, making it a critical area of research. This retrospective observational study aimed to analyze real‐world data from comprehensive genome profil…
View article: Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis
Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis Open
View article: Nationwide data from comprehensive genomic profiling assays for detecting driver oncogenes in non‐small cell lung cancer
Nationwide data from comprehensive genomic profiling assays for detecting driver oncogenes in non‐small cell lung cancer Open
Driver oncogenes are investigated upfront at diagnosis using multi‐CDx systems with next‐generation sequencing techniques or multiplex reverse‐transcriptase polymerase chain reaction assays. Additionally, from 2019, comprehensive genomic p…
View article: Diagnostic ability of magnifying endoscopy compared to biopsy examination for early gastric cancer prior to endoscopic submucosal dissection
Diagnostic ability of magnifying endoscopy compared to biopsy examination for early gastric cancer prior to endoscopic submucosal dissection Open
Background Biopsy-specimen examination is the gold standard for the preoperative histological diagnosis of early gastric cancer (EGC). However, few studies have compared the diagnostic accuracies of biopsy and magnifying endoscopy with nar…
View article: Efficacy of Glycicumarin and Isoliquiritigenin in Suppressing Colonic Peristalsis in Both an Animal Model and a Clinical Trial
Efficacy of Glycicumarin and Isoliquiritigenin in Suppressing Colonic Peristalsis in Both an Animal Model and a Clinical Trial Open
Patients with diarrhea-predominant irritable bowel syndrome (IBS-D) show excessive peristalsis, and antispasmodic agents may be useful therapeutic agents. There are few reports on the use of Kampo medicines for the treatment of IBS-D. Shak…
View article: Prognostic value of moderate or massive ascites in patients with advanced gastric cancer
Prognostic value of moderate or massive ascites in patients with advanced gastric cancer Open
Advanced gastric cancer is a highly aggressive malignancy. The available literature does not provide the prognostic value of ascites based on their degree, because most clinical trials exclude patients who present with massive ascites. The…
View article: Conventional versus underwater endoscopic resection for superficial non-ampullary duodenal epithelial tumours
Conventional versus underwater endoscopic resection for superficial non-ampullary duodenal epithelial tumours Open
Background and objective Several endoscopic resection methods have been developed as less invasive treatments for superficial non-ampullary duodenal epithelial tumours. This study aimed to compare outcomes of conventional endoscopic mucosa…
View article: 1426P Real-world data on next-generation sequencing using comprehensive genomic profiling assays for detecting driver oncogenes in advanced non-small cell lung cancer: Analysis with the National Database of Japan
1426P Real-world data on next-generation sequencing using comprehensive genomic profiling assays for detecting driver oncogenes in advanced non-small cell lung cancer: Analysis with the National Database of Japan Open
View article: Prognostic value of moderate or massive ascites in patients with advanced gastric cancer
Prognostic value of moderate or massive ascites in patients with advanced gastric cancer Open
Background Advanced gastric cancer is one of highly aggressive malignancies. The available literature does not provide the prognostic value of ascites based on its degree because most clinical trials exclude patients who present with massi…
View article: Author Correction: Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production
Author Correction: Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production Open
View article: Genomic landscape and clinical features of rare subtypes of pancreatic cancer: analysis with the national database of Japan
Genomic landscape and clinical features of rare subtypes of pancreatic cancer: analysis with the national database of Japan Open
Background Special subtypes of pancreatic cancer, such as acinar cell carcinoma (ACC), adenosquamous carcinoma (ASC), and anaplastic carcinoma of the pancreas (ACP), are rare, and so data on them are limited. Using the C-CAT database, we a…
View article: Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production
Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production Open
Colonic mucus layers protect intestinal tissues against intestinal bacteria. We investigated the effects of dietary fiber and its metabolites on mucus production in the colonic mucosa. Mice were fed a partially hydrolyzed guar gum (PHGG)-c…
View article: Evaluation of Environmental Stability and Disinfectant Effectiveness for Human Coronavirus OC43 on Human Skin Surface
Evaluation of Environmental Stability and Disinfectant Effectiveness for Human Coronavirus OC43 on Human Skin Surface Open
This study revealed the environmental stability of HCoV-OC43 and disinfectant effectiveness against HCoV-OC43, which had not been demonstrated in previous studies. HCoV-OC43 is highly stable on the surface of human skin, with a survival ti…
View article: Gastrointestinal Angiodysplasia in Patients with Severe Aortic Stenosis: The Endoscopic Features of Heyde’s Syndrome
Gastrointestinal Angiodysplasia in Patients with Severe Aortic Stenosis: The Endoscopic Features of Heyde’s Syndrome Open
Introduction: Aortic stenosis (AS) is sometimes associated with gastrointestinal bleeding, and this phenomenon is known as Heyde’s syndrome. Such bleeding is most often considered to originate from gastrointestinal angiodysplasias, but the…
View article: Supplementary Material for: The Effects of Mucopolysaccharide Polysulfate on Steroid-Induced Tight Junction Barrier Dysfunction in Human Epidermal Keratinocytes and a 3D Skin Model
Supplementary Material for: The Effects of Mucopolysaccharide Polysulfate on Steroid-Induced Tight Junction Barrier Dysfunction in Human Epidermal Keratinocytes and a 3D Skin Model Open
Introduction: The long-term use of topical corticosteroids (TCS) is associated with side effects such as skin atrophy and barrier deterioration. Moisturizers, such as mucopolysaccharide polysulfate (MPS), have been reported to prevent rela…
View article: Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model
Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model Open
For the first time, this study demonstrates that cool temperature-dependent suppression of colonic peristalsis may be associated with TRPM8 activation.
View article: Gut Microbiota Associated with Clinical Relapse in Patients with Quiescent Ulcerative Colitis
Gut Microbiota Associated with Clinical Relapse in Patients with Quiescent Ulcerative Colitis Open
The microbiota associated with relapse in patients with quiescent ulcerative colitis (qUC) remains unclear. Our objective was to analyze the fecal microbiota of Japanese patients with qUC and identify the relapse-associated microbiota. In …
View article: Proton Pump Inhibitors Enhance the Antitumor Effect of Chemotherapy for Esophageal Squamous Cell Carcinoma
Proton Pump Inhibitors Enhance the Antitumor Effect of Chemotherapy for Esophageal Squamous Cell Carcinoma Open
Background: Vacuolar ATPase (V-ATPase) is involved in cancer development. The use of proton pump inhibitors (PPIs) as V-ATPase inhibitors has been reported to enhance the effectiveness of chemotherapy in certain cancers. This study aimed t…
View article: Water‐soluble dietary fiber alleviates cancer‐induced muscle wasting through changes in gut microenvironment in mice
Water‐soluble dietary fiber alleviates cancer‐induced muscle wasting through changes in gut microenvironment in mice Open
Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that the pathogenesis of skeletal muscle loss may i…
View article: Endoscopic submucosal dissection for a laterally spreading ampullary carcinoma
Endoscopic submucosal dissection for a laterally spreading ampullary carcinoma Open
View article: Improved Visibility of Early Gastric Cancer after Successful Helicobacter pylori Eradication with Image-Enhanced Endoscopy: A Multi-Institutional Study Using Video Clips
Improved Visibility of Early Gastric Cancer after Successful Helicobacter pylori Eradication with Image-Enhanced Endoscopy: A Multi-Institutional Study Using Video Clips Open
The visibility and diagnostic accuracy of early gastric cancer (EGC) after Helicobacter pylori (HP) eradication have been reported to improve using image-enhanced endoscopy (IEE) compared with white light imaging (WLI). The present study c…
View article: Treatment with broad-spectrum antibiotics upregulates Sglt1 and induces small intestinal villous hyperplasia in mice
Treatment with broad-spectrum antibiotics upregulates Sglt1 and induces small intestinal villous hyperplasia in mice Open
Although extensive evidence indicates that the gut microbiota plays a crucial role in regulating glucose homeostasis, the exact regulatory mechanism remains unclear. This study aimed to investigate the effect of broad-spectrum antibiotics …
View article: Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study
Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study Open
View article: Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study
Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study Open
Background Nonalcoholic fatty liver disease is characterized by excessive hepatic fat accumulation. Some individuals frequently present elevated gamma-glutamyl transferase (GGT) levels without fatty liver ultrasound images and other abnorm…
View article: Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study
Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study Open
Background Nonalcoholic fatty liver disease is characterized by excessive hepatic fat accumulation. Some individuals frequently present elevated gamma-glutamyl transferase (GGT) levels without fatty liver ultrasound images and other abnorm…
View article: A Bile Duct Stone Formation around a Fish Bone as a Nidus after Pancreatoduodenectomy
A Bile Duct Stone Formation around a Fish Bone as a Nidus after Pancreatoduodenectomy Open
We report a rare case of bile duct stone formation around an ingested fish bone as a nidus after pancreatoduodenectomy. A 78-year-old woman was admitted to our department for fever and epigastric pain. Abdominal computed tomography reveale…