Toshifumi YOKOYAMA
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View article: Morphological Sex Reversal in the Sexually Dimorphic Nucleus of the Preoptic Area in the Hypothalamus Delineated by Calbindin D28k-Immunoreactive Cell Clusters in Y<i><sup>POS</sup></i> mice
Morphological Sex Reversal in the Sexually Dimorphic Nucleus of the Preoptic Area in the Hypothalamus Delineated by Calbindin D28k-Immunoreactive Cell Clusters in Y<i><sup>POS</sup></i> mice Open
Sex-determining region Y (Sry) triggers testis development in mammals, and the presence or absence of testicular secretion determines their sex-specific brain phenotype. Mice with Y chromosome replaced by that of Mus domesticus p…
View article: Colonizing bacteria around aggregated lymphoid tissue of the rat ascending colon change diurnally and affect the host local transcriptome
Colonizing bacteria around aggregated lymphoid tissue of the rat ascending colon change diurnally and affect the host local transcriptome Open
The settlement levels of indigenous bacteria show circadian rhythms in various regions of the rat alimentary tract. Numerous bacteria colonize between the mucosal folds of the ascending colon in rodents; however, the rhythm of bacteria col…
View article: Histological study on the postnatal development of the nerve network in the rat ileal mucosa and submucosa
Histological study on the postnatal development of the nerve network in the rat ileal mucosa and submucosa Open
View article: Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm Mirna Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring
Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm Mirna Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring Open
View article: Effects of low-dose subchronic exposure to the phenylpyrazole insecticide fipronil in juvenile mice
Effects of low-dose subchronic exposure to the phenylpyrazole insecticide fipronil in juvenile mice Open
Fipronil (FPN) inhibits gamma-aminobutyric acid type A receptors and exhibits strong insecticidal effects. Although FPN's adverse effects on mammals have been reported recently, few studies have examined subchronic exposure to low doses. W…
View article: Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring
Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring Open
Our previous reports showed that exposure to the neonicotinoid pesticide clothianidin (CLO) at a no-observed-adverse-effect-level (NOAEL) dose during fetal development and lactation in mice led to higher rates of maternal neglect and infan…
View article: Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis
Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis Open
The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO ma…
View article: Establishment of an organ culture system to maintain the structure of mouse Müllerian ducts during development
Establishment of an organ culture system to maintain the structure of mouse Müllerian ducts during development Open
We previously showed that the anti-Müllerian hormone (AMH), infiltrating from the testis to the mesonephros reaches the cranial and middle regions of the Müllerian duct (MD) and induces their regression using an organ culture in mice. Howe…
View article: Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice
Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice Open
The mechanism by which the neonicotinoid pesticide clothianidin (CLO) disrupts the intestinal microbiota of experimental animals is unknown. We focused on α-defensins, which are regulators of the intestinal microbiota. Subchronic exposure …
View article: No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum
No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum Open
Neonicotinoid pesticides (NNs) have been associated with numerous neurobehavioral effects in rodents, raising concerns about their impact on cognitive function. Clothianidin (CLO), a type of NN, was orally administered to male mice (10 wee…
View article: Direct diffusion of anti‐<scp>Müllerian</scp> hormone from both the cranial and caudal regions of the testis during early gonadal development in mice
Direct diffusion of anti‐<span>Müllerian</span> hormone from both the cranial and caudal regions of the testis during early gonadal development in mice Open
Background The Müllerian duct (MD), the primordium of the female reproductive tract, is also formed in males during the early stage of development, then regresses due to the anti‐Müllerian hormone (AMH) secreted from the testes. However, t…
View article: Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota
Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota Open
Recently, the effects of exposure to clothianidin (CLO) on the thymus and gut microbiota have become clear, but no report has examined its next-generation impacts. Pregnant C57BL/6N mice were administered a no-observed-adverse-effect-level…
View article: Histological study on the reginal difference in the localization of mucosal enteric glial cells and their sheath structure in the rat intestine
Histological study on the reginal difference in the localization of mucosal enteric glial cells and their sheath structure in the rat intestine Open
The present study aimed to histologically clarify the regional specificity of the mucosal enteric glial cells (mEGCs) in the rat intestine with serial block-face scanning electron microscopy (SBF-SEM). SBF-SEM analysis with the ileum, the …
View article: Neurotoxicity and behavioral disorders induced in mice by acute exposure to the diamide insecticide chlorantraniliprole
Neurotoxicity and behavioral disorders induced in mice by acute exposure to the diamide insecticide chlorantraniliprole Open
Diamide insecticides activate ryanodine receptors expressed in lepidopteran skeletal muscle and promote Ca2+ release in the sarcoplasmic reticulum, causing abnormal contractions and paralysis, leading to death of the pest. Altho…
View article: Transgenerational effects of developmental neurotoxicity induced by exposure to a no-observed-adverse-effect level (NOAEL) of neonicotinoid pesticide clothianidin
Transgenerational effects of developmental neurotoxicity induced by exposure to a no-observed-adverse-effect level (NOAEL) of neonicotinoid pesticide clothianidin Open
Neonicotinoid pesticides (NNs) transfer rapidly from mother to offspring, which exhibit neurobehavioral effects. However, no studies have investigated NNs' transgenerational effects. We exposed F0 generation mice (mothers) to a no-observed…
View article: Developmental stage-specific exposure and neurotoxicity evaluation of low-dose clothianidin during neuronal circuit formation
Developmental stage-specific exposure and neurotoxicity evaluation of low-dose clothianidin during neuronal circuit formation Open
Neonicotinoid pesticides (NN) were recently reported to exhibit adverse effects in higher vertebrates. Moreover, NNs are routinely transferred from mother to offspring, raising concerns about their effects on future generations. The fetal …
View article: Substrain differences in Sry expression at the stage of sex determination in C57BL/6 mouse strains
Substrain differences in Sry expression at the stage of sex determination in C57BL/6 mouse strains Open
The expression of sex determining region of the Y chromosome (Sry) in the fetal gonads is important for male development. In a mouse model of disorders of sex development (C57BL/6 (B6)-XYPOS), the gonadal phenotype and the timin…
View article: Histological study on regional specificity of the mucosal nerve network in the rat large intestine
Histological study on regional specificity of the mucosal nerve network in the rat large intestine Open
Our previous studies and others have revealed detailed characteristics of the mucosal nerve network in the small intestine, but much remains unknown about the corresponding network in the large intestine. We herein investigated regional di…
View article: Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice
Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice Open
View article: Sex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice
Sex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice Open
View article: Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy <i>in vivo</i> imaging
Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy <i>in vivo</i> imaging Open
Neonicotinoid pesticides (NNs) cause behavioral abnormalities in mammals, raising concerns about their effects on neural circuit activity. We herein examined the neurological effects of the NN clothianidin (CLO) by in vivo Ca2+ …
View article: Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice
Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice Open
Recently, it has been reported that neonicotinoid pesticides (NNs) are transferred from mother to child and are assumed to affect the next generation, but the behavioral effects of NN exposure at different developmental stages have not bee…
View article: Effects of <i>in utero</i> and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice
Effects of <i>in utero</i> and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice Open
Recently, developmental exposure to clothianidin (CLO) has been shown to cause reproductive toxicity in male mice, but the effects in female mice remain to be clarified. Pregnant C57BL/6N mice were given a no-observed-adverse-effect-level …
View article: Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice
Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice Open
Fipronil (FPN) is a systemic insecticide that antagonizes the gamma-aminobutyric acid type A (GABAA) receptors in insects. Recently, adverse effects of FPN on mammals have been reported, but most of those were caused by high dos…
View article: Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice
Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice Open
View article: Three-dimensional analysis of neural connectivity with cells in rat ileal mucosa by serial block-face scanning electron microscopy
Three-dimensional analysis of neural connectivity with cells in rat ileal mucosa by serial block-face scanning electron microscopy Open
The comprehensive targets of innervation in the intestinal mucosa are unknown, partly because of the diversity of cell types and the complexity of the neural circuits. Herein, we investigated the comprehensive targets of neural connectivit…
View article: Immunotoxicity evaluation by subchronic oral administration of clothianidin in Sprague-Dawley rats
Immunotoxicity evaluation by subchronic oral administration of clothianidin in Sprague-Dawley rats Open
Neonicotinoid pesticides (NNs) act as agonists on nicotinic acetylcholine receptors (nAChRs) of insects, and there have been concerns about the effects of NNs on the health of mammals. Since nAChRs are expressed in immune cells, it is poss…
View article: Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice
Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice Open
Dinotefuran (DIN) belongs to the neonicotinoids (NNs), a class of globally applied pesticides originally developed to exhibit selective toxicity in insects. However, several reports have suggested that NNs also exert neurotoxic effects in …
View article: Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads
Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads Open
Organ culture systems are useful for elucidating the process of testicular differentiation from mammalian undifferentiated genetically male gonads, as they permit various experiments, including experiments involving the control of gene exp…
View article: Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells
Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells Open
In murine fetal germ cells, retinoic acid (RA) is an extrinsic cue for meiotic initiation that stimulates transcriptional activation of the Stimulated by retinoic acid gene 8 (Stra8), which is required for entry of germ cells into meiotic …