Toshikazu Tanaka
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View article: Delirium in Nonagenarians with Acute Coronary Syndrome Following Percutaneous Coronary Intervention
Delirium in Nonagenarians with Acute Coronary Syndrome Following Percutaneous Coronary Intervention Open
The aging population has led to an increase in nonagenarians undergoing percutaneous coronary intervention (PCI). Nonagenarian patients are at risk for geriatric complications, including delirium, which can worsen clinical outcomes. Howeve…
View article: Residual pulmonary hypertension and clinical outcomes in acute decompensated heart failure patients stratified by left ventricular ejection fraction
Residual pulmonary hypertension and clinical outcomes in acute decompensated heart failure patients stratified by left ventricular ejection fraction Open
Aims The precise outcomes for patients with residual pulmonary hypertension ( PH ) following the optimized treatment of acute decompensated heart failure ( ADHF ) remain poorly understood. This study aimed to investigate the prognostic ass…
View article: Reduced peak pressure gradient in patients with aortic stenosis and type 2 diabetes
Reduced peak pressure gradient in patients with aortic stenosis and type 2 diabetes Open
Diabetes may impair left ventricular (LV) contractility, but clear human evidence remains limited. This study investigated its impact in patients with aortic stenosis (AS), demonstrating that diabetes significantly reduces LV function. Cli…
View article: Real-world trends in the use and outcomes of novel androgen receptor signaling inhibitor therapy in patients with non-metastatic castration-resistant prostate cancer: A multicenter retrospective study
Real-world trends in the use and outcomes of novel androgen receptor signaling inhibitor therapy in patients with non-metastatic castration-resistant prostate cancer: A multicenter retrospective study Open
Background: Although three phase III trials demonstrated significant oncological benefits of novel androgen receptor signaling inhibitors (ARSIs) in patients with non-metastatic castration-resistant prostate cancer (nmCRPC), trends in nove…
View article: Association between mixed venous oxygen saturation and serum uric acid levels in patients with heart failure
Association between mixed venous oxygen saturation and serum uric acid levels in patients with heart failure Open
Hypoxia leads to increased purine metabolism in tissues, resulting in increased serum uric acid levels, and may also cause impaired uric acid excretion in the kidneys and intestinal tract. However, the relationship between hypoxia and seru…
View article: Familial restrictive cardiomyopathy with novel missense variant of uncertain significance in the <i>FLNC</i> gene
Familial restrictive cardiomyopathy with novel missense variant of uncertain significance in the <i>FLNC</i> gene Open
View article: The relationship between mixed venous blood oxygen saturation and pulmonary arterial and venous pressures in patients with heart failure
The relationship between mixed venous blood oxygen saturation and pulmonary arterial and venous pressures in patients with heart failure Open
Recent discoveries have identified intrapulmonary bronchopulmonary anastomoses (IBAs) as a relatively common phenomenon forming intrapulmonary right‐to‐left shunts. This study hypothesizes that IBAs play a significant role in the pathophys…
View article: Blunted increase in plasma BNP during acute coronary syndrome attacks in obese patients
Blunted increase in plasma BNP during acute coronary syndrome attacks in obese patients Open
Blunted increase in plasma BNP in response to cardiac hemodynamic stress during ACS attacks was observed in obese individuals. In addition to the relatively low plasma BNP levels at baseline in obese individuals, the blunted response of BN…
View article: Effects of platelet-to-lymphocyte ratio on renal function following acute myocardial infarction: A retrospective observational study
Effects of platelet-to-lymphocyte ratio on renal function following acute myocardial infarction: A retrospective observational study Open
Increased platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in acute myocardial infarction (AMI), which indicate accelerated thrombus formation and inflammatory response, potentially have prognostic implications. …
View article: Treatment trends in patients with de novo metastatic prostate cancer in the era of upfront combination therapy
Treatment trends in patients with de novo metastatic prostate cancer in the era of upfront combination therapy Open
Objectives The objective of this study is to assess the trends in treatment selection for patients with de novo metastatic castration‐sensitive prostate cancer in the era of upfront combination therapy. Methods This multicenter retrospecti…
View article: Association between mixed venous oxygen saturation and serum uric acid levels in patients with heart failure
Association between mixed venous oxygen saturation and serum uric acid levels in patients with heart failure Open
Hypoxia leads to increased purine metabolism in tissues, resulting in increased serum uric acid (UA) levels, and may also cause impaired UA excretion in the kidneys and intestinal tract. However, the relationship between hypoxia and serum …
View article: Rationale and protocol of the LAQUA-HF trial: a factorial randomised controlled trial evaluating the effects of neurohormonal and diuretic agents on health-status reported outcomes in heart failure patients
Rationale and protocol of the LAQUA-HF trial: a factorial randomised controlled trial evaluating the effects of neurohormonal and diuretic agents on health-status reported outcomes in heart failure patients Open
Introduction The current guidelines strongly recommend early initiation of multiple classes of cardioprotective drugs for patients with heart failure with reduced ejection fraction to improve prognosis and health status. However, evidence …
View article: Real-world effects of novel androgen receptor axis-targeted agents on oncological outcomes in non-metastatic castration-resistant prostate cancer: A multi-institutional retrospective study
Real-world effects of novel androgen receptor axis-targeted agents on oncological outcomes in non-metastatic castration-resistant prostate cancer: A multi-institutional retrospective study Open
View article: URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease
URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease Open
View article: Trends of incidence and age in adults with testicular germ cell tumors: a two-decade multicenter retrospective study
Trends of incidence and age in adults with testicular germ cell tumors: a two-decade multicenter retrospective study Open
The number of patients with GCTs aged ≥40 years was significantly higher in 2011-2021, even in a population-adjusted analysis. Treatment strategies need to be adapted to older testicular germ cell tumor patients.
View article: Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study
Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study Open
In the pathophysiology of acute coronary syndrome (ACS), platelet (PLT) and neutrophil (Neu) crosstalk may be important for activating coagulation and inflammation. It has been speculated that PLTs and Neu may affect each other’s cell coun…
View article: Utility of the Age Discrepancy between Frailty-Based Biological Age and Expected Life Age in Patients with Urological Cancers
Utility of the Age Discrepancy between Frailty-Based Biological Age and Expected Life Age in Patients with Urological Cancers Open
Background: The estimation of biological age is challenging in patients with cancers. We aimed to investigate frailty-based biological ages using frailty-discriminant scores (FDS) and examined the effect of biological-expected life age dis…
View article: Exogenous ANP Treatment Ameliorates Myocardial Insulin Resistance and Protects against Ischemia–Reperfusion Injury in Diet-Induced Obesity
Exogenous ANP Treatment Ameliorates Myocardial Insulin Resistance and Protects against Ischemia–Reperfusion Injury in Diet-Induced Obesity Open
Increasing evidence suggests natriuretic peptides (NPs) coordinate interorgan metabolic crosstalk. We recently reported exogenous ANP treatment ameliorated systemic insulin resistance by inducing adipose tissue browning and attenuating hep…
View article: Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes
Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes Open
View article: A case of cardiac strangulation following epicardial pacemaker implantation in an adult: a case report
A case of cardiac strangulation following epicardial pacemaker implantation in an adult: a case report Open
Background Cardiac strangulation (CS) is a rare but potentially devastating complication caused by the leads of an epicardial pacemaker (EP). Most cases have been reported in paediatric patients, and there has been no report wherein the di…
View article: URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice
URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice Open
View article: ＜Editors' Choice＞ Prevalence of acute coronary syndrome during the pandemic of COVID-19 in the Tokai Region of Japan.
＜Editors' Choice＞ Prevalence of acute coronary syndrome during the pandemic of COVID-19 in the Tokai Region of Japan. Open
The outbreak of coronavirus disease 19 (COVID-19) has had a great impact on medical care. During the COVID-19 pandemic, the rate of hospital admissions has been lower and the rate of in-hospital mortality has been higher in patients with a…
View article: The impact of eligibility for maintenance immunotherapy on prognosis in patients with unresectable or metastatic urothelial carcinoma
The impact of eligibility for maintenance immunotherapy on prognosis in patients with unresectable or metastatic urothelial carcinoma Open
Objectives To investigate the eligibility for maintenance immunotherapy and its impact on the prognosis of advanced urothelial carcinoma treated with first‐line chemotherapy, as the selection biases of the eligible population in the JAVELI…
View article: Prognostic impact of proton pump inhibitors for immunotherapy in advanced urothelial carcinoma
Prognostic impact of proton pump inhibitors for immunotherapy in advanced urothelial carcinoma Open
Objective To evaluate the effects of the concomitant use of proton pump inhibitors (PPIs) and/or antibiotics (Abs) on oncological outcomes in patients with advanced urothelial carcinoma. Patients and methods We retrospectively evaluated 15…
View article: Prognostic impact of eligibility for adjuvant immunotherapy in locally advanced urothelial cancer
Prognostic impact of eligibility for adjuvant immunotherapy in locally advanced urothelial cancer Open
Objective To evaluate the effect of postoperative pathological findings related to the eligibility of adjuvant immunotherapy on oncologic outcomes in patients with localized and locally advanced muscle‐invasive bladder carcinoma (MIBC) and…
View article: URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and BAT whitening in mice
URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and BAT whitening in mice Open
Background Accumulating evidence suggests that high uric acid is strongly associated with obesity and metabolic syndrome and drives the development of non-alcoholic fatty liver disease (NAFLD) and insulin resistance. Although urate transpo…
View article: Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo
Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo Open
View article: The Effect of Upfront Intensive Therapy on Primary Resistance in Metastatic Castration-sensitive Prostate Cancer: A Multicenter Retrospective Study
The Effect of Upfront Intensive Therapy on Primary Resistance in Metastatic Castration-sensitive Prostate Cancer: A Multicenter Retrospective Study Open
We investigated the effect of upfront intensive therapy on primary resistance in patients with metastatic castration-sensitive prostate cancer (mCSPC) in real-world practice. We retrospectively evaluated the medical records of 348 patients…
View article: A pilot cohort study assessing the feasibility of complete revascularization with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
A pilot cohort study assessing the feasibility of complete revascularization with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension Open
Balloon pulmonary angioplasty improves prognosis by alleviating pulmonary hypertension in patients with chronic thromboembolic pulmonary hypertension, even with incomplete revascularization. However, hypoxia or the requirement for pulmonar…
View article: Treatment With Atrial Natriuretic Peptide Induces Adipose Tissue Browning and Exerts Thermogenic Actions in Vivo.
Treatment With Atrial Natriuretic Peptide Induces Adipose Tissue Browning and Exerts Thermogenic Actions in Vivo. Open
Background: Although natriuretic peptides (NPs) classically act on the renal and cardiovascular systems, increasing evidence suggests that NPs also largely coordinate inter-organ metabolic crosstalk with adipose tissues and play a critical…