Toshiki Ikawa
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View article: Secondary Lower‐Body Sarcomas in Cervical Cancer Survivors Following Surgery, Radiotherapy, or Both: A Population‐Based Study
Secondary Lower‐Body Sarcomas in Cervical Cancer Survivors Following Surgery, Radiotherapy, or Both: A Population‐Based Study Open
Secondary sarcomas in cervical cancer survivors are understudied. We investigated the incidence and subtypes of secondary sarcomas by treatment modalities, the prognosis of secondary sarcomas, and whether surgery plus radiotherapy increase…
View article: Correction: Temporal changes in regional variations in cancer survival rates in Osaka, Japan (1997–2015)
Correction: Temporal changes in regional variations in cancer survival rates in Osaka, Japan (1997–2015) Open
View article: Prognostic factors after salvage resection for local progression of brain metastases after radiotherapy
Prognostic factors after salvage resection for local progression of brain metastases after radiotherapy Open
This study highlights a relatively prolonged survival period following salvage surgery for local progression of BM after irradiation. Salvage surgery is a treatment option in patients with good extracranial control and performance status. …
View article: Temporal changes in regional variations in cancer survival rates in Osaka, Japan (1997–2015)
Temporal changes in regional variations in cancer survival rates in Osaka, Japan (1997–2015) Open
The variation in survival rates among patients with cancer based on residential areas has become a significant concern globally. Japan's Basic Plan to Promote Cancer Control Programs (BPPCCP), implemented in 2007, aimed to reduce this vari…
View article: Effects of Institutional Experience on Plan Quality in Stereotactic Radiotherapy Using HyperArc for Brain Metastases
Effects of Institutional Experience on Plan Quality in Stereotactic Radiotherapy Using HyperArc for Brain Metastases Open
Enhanced dosimetric outcomes in the later group suggested that accumulated experience contributed to improve GTV and brain dose in HA SRT. Institutional experience is important to improve the plan quality for SRT even with automatic planni…
View article: Association of increasing gross tumor volume dose with tumor volume reduction and local control in fractionated stereotactic radiosurgery for unresected brain metastases
Association of increasing gross tumor volume dose with tumor volume reduction and local control in fractionated stereotactic radiosurgery for unresected brain metastases Open
Background Fractionated stereotactic radiosurgery (fSRS) is an important treatment strategy for unresected brain metastases. We previously reported that a good volumetric response 6 months after fSRS can be the first step for local control…
View article: Multifraction stereotactic radiotherapy utilizing inhomogeneous dose distribution for brainstem metastases: a single-center retrospective analysis
Multifraction stereotactic radiotherapy utilizing inhomogeneous dose distribution for brainstem metastases: a single-center retrospective analysis Open
Brainstem metastases are challenging to manage owing to the critical neurological structures involved. Although stereotactic radiotherapy (SRT) offers targeted high doses while minimizing damage to adjacent normal tissues, the optimal dose…
View article: What is the optimal isodose line for stereotactic radiotherapy for single brain metastases using HyperArc?
What is the optimal isodose line for stereotactic radiotherapy for single brain metastases using HyperArc? Open
Purpose The study aimed to investigate the optimal isodose line (IDL) in linear accelerator‐based stereotactic radiotherapy for single brain metastasis, using HyperArc. We compared the dosimetric parameters for target and normal brain tiss…
View article: Risk of thoracic soft tissue sarcoma after breast cancer radiotherapy: a population-based cohort study in Osaka, Japan
Risk of thoracic soft tissue sarcoma after breast cancer radiotherapy: a population-based cohort study in Osaka, Japan Open
Postoperative radiotherapy for breast cancer reportedly increases the risk of thoracic soft tissue sarcomas, particularly angiosarcomas; however, the risk in the Japanese population remains unknown. Therefore, this study aimed to investiga…
View article: Safety and Feasibility of Combining On-Demand Selective Locoregional Treatment with First-Line Atezolizumab Plus Bevacizumab for Patients with Unresectable Hepatocellular Carcinoma
Safety and Feasibility of Combining On-Demand Selective Locoregional Treatment with First-Line Atezolizumab Plus Bevacizumab for Patients with Unresectable Hepatocellular Carcinoma Open
Various locoregional treatments for localized hepatocellular carcinoma (HCC) have been developed. This retrospective study investigated the safety and feasibility of combining on-demand selective locoregional treatment for residual lesions…
View article: Dual-energy computed tomography-based iodine concentration as a predictor of histopathological response to preoperative chemoradiotherapy for pancreatic cancer
Dual-energy computed tomography-based iodine concentration as a predictor of histopathological response to preoperative chemoradiotherapy for pancreatic cancer Open
To explore predictors of the histopathological response to preoperative chemoradiotherapy (CRT) in patients with pancreatic cancer (PC) using dual-energy computed tomography-reconstructed images. This retrospective study divided 40 patient…
View article: Combined surgery and radiotherapy for synchronous multiple primary lung cancers: a clinical retrospective study
Combined surgery and radiotherapy for synchronous multiple primary lung cancers: a clinical retrospective study Open
Background The recommended treatment strategy for early-stage synchronous multiple primary lung cancers (sMPLC) involves multiple resections of all lesions, if possible. However, some patients with sMPLC cannot tolerate multiple surgeries …
View article: Effect of topical agents on skin surface dose in volumetric modulated arc therapy for head and neck cancer
Effect of topical agents on skin surface dose in volumetric modulated arc therapy for head and neck cancer Open
In volumetric modulated arc therapy (VMAT), the effect of an increase in skin surface dose due to topical agents might be negligible. We investigated the bolus effects of three types of topical agents in VMAT for head and neck cancer (HNC)…
View article: Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis
Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis Open
Background Data on acute toxicities after stereotactic radiotherapy (SRT) for brain metastases, including multiple and large lesions, are lacking. We aimed to evaluate the incidence and nature of toxicities immediately after SRT using a li…
View article: Improved Patients’ Satisfaction Level of Radiation Therapy: The Effect of “Explainer Videos about Radiation Therapy”, “Treatment of Breast Cancer Patients by Female Radiation Therapists” and “Treating Male Patients While Wearing Underwear in Pelvic Radiation Therapy”
Improved Patients’ Satisfaction Level of Radiation Therapy: The Effect of “Explainer Videos about Radiation Therapy”, “Treatment of Breast Cancer Patients by Female Radiation Therapists” and “Treating Male Patients While Wearing Underwear in Pelvic Radiation Therapy” Open
RT-Video, F-RTT and M-RTT treatments improved patients' satisfaction.
View article: Dose reduction of hippocampus using HyperArc planning in postoperative radiotherapy for primary brain tumors
Dose reduction of hippocampus using HyperArc planning in postoperative radiotherapy for primary brain tumors Open
View article: Additional file 2 of Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis
Additional file 2 of Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis Open
Additional file 2: Table S1. Characteristics of all patients who experienced immediate side effects.
View article: Volumetric reduction of brain metastases after stereotactic radiotherapy: Prognostic factors and effect on local control
Volumetric reduction of brain metastases after stereotactic radiotherapy: Prognostic factors and effect on local control Open
Background and Purpose Few reports include volumetric measurements as endpoints after stereotactic radiotherapy (SRT) despite the importance of such measurements. This study aimed to (1) investigate the impact of the volumetric response (s…
View article: Influence of radiation dose and predicted tumor invasion depth on local recurrence after definitive chemoradiotherapy for stage 0–I esophageal squamous cell carcinoma: a propensity score-weighted, retrospective, observational study
Influence of radiation dose and predicted tumor invasion depth on local recurrence after definitive chemoradiotherapy for stage 0–I esophageal squamous cell carcinoma: a propensity score-weighted, retrospective, observational study Open
Background The optimal radiation dose for treating non-metastatic superficial esophageal squamous cell carcinoma is unknown. In this retrospective observational study, we investigated the influence of radiation dose and pretreatment endosc…
View article: Additional file 4 of Influence of radiation dose and predicted tumor invasion depth on local recurrence after definitive chemoradiotherapy for stage 0–I esophageal squamous cell carcinoma: a propensity score-weighted, retrospective, observational study
Additional file 4 of Influence of radiation dose and predicted tumor invasion depth on local recurrence after definitive chemoradiotherapy for stage 0–I esophageal squamous cell carcinoma: a propensity score-weighted, retrospective, observational study Open
Additional file 4. Dataset used in this study.
View article: Prolonged overall treatment time negatively affects the outcomes of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: A propensity score-weighted, single-center analysis
Prolonged overall treatment time negatively affects the outcomes of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: A propensity score-weighted, single-center analysis Open
Previous studies have reported conflicting results for the effect of overall treatment time with stereotactic body radiotherapy on tumor control in early-stage non-small-cell lung cancer. To examine this effect, we conducted a propensity s…
View article: Improvement of image quality and assessment of respiratory motion for hepatocellular carcinoma with portal vein tumor thrombosis using contrast-enhanced four-dimensional dual-energy computed tomography
Improvement of image quality and assessment of respiratory motion for hepatocellular carcinoma with portal vein tumor thrombosis using contrast-enhanced four-dimensional dual-energy computed tomography Open
To assess the objective and subjective image quality, and respiratory motion of hepatocellular carcinoma with portal vein tumor thrombosis (PVTT) using the contrast-enhanced four-dimensional dual-energy computed tomography (CE-4D-DECT). Fo…
View article: Prolonged Overall Treatment Time Negatively Affects the Outcomes of Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer: A Propensity Score-Weighted, Single-Center Analysis
Prolonged Overall Treatment Time Negatively Affects the Outcomes of Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer: A Propensity Score-Weighted, Single-Center Analysis Open
BackgroundPrevious studies have reported conflicting results for the effect of overall treatment time (OTT) on tumor control with stereotactic body radiotherapy (SBRT) for early-stage non-small cell lung cancer (NSCLC). To examine this eff…
View article: Intra-fractional patient setup error during fractionated intracranial stereotactic irradiation treatment of patients wearing medical masks: comparison with and without bite block during COVID-19 pandemic
Intra-fractional patient setup error during fractionated intracranial stereotactic irradiation treatment of patients wearing medical masks: comparison with and without bite block during COVID-19 pandemic Open
The immobilization of patients with a bite block (BB) carries the risk of interpersonal infection, particularly in the context of pandemics such as COVID-19. Here, we compared the intra-fractional patient setup error (intra-SE) with and wi…
View article: Death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy for head and neck cancer
Death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy for head and neck cancer Open
View article: Determination of optimal virtual monochromatic energy level for target delineation of brain metastases in radiosurgery using dual-energy CT
Determination of optimal virtual monochromatic energy level for target delineation of brain metastases in radiosurgery using dual-energy CT Open
Objective: Determination of the optimal energy level of virtual monochromatic image (VMI) for brain metastases in contrast-enhanced dual-energy CT (DECT) for radiosurgery and assessment of the subjective and objective image quality of VMI …
View article: Failure patterns after adjuvant chemoradiotherapy following endoscopic resection for superficial esophageal squamous cell carcinoma
Failure patterns after adjuvant chemoradiotherapy following endoscopic resection for superficial esophageal squamous cell carcinoma Open
Background This study evaluated the locations of lymph node recurrence and their association with irradiation fields used for radiotherapy after adjuvant chemoradiotherapy following endoscopic resection for superficial esophageal squamous …