Toshiki Watanabe
YOU?
Author Swipe
View article: Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention
Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention Open
View article: A viral clonality evenness score to predict progression to adult T-cell leukaemia in asymptomatic carriers of human T-lymphotropic virus type 1 in Japan: a retrospective longitudinal cohort study
A viral clonality evenness score to predict progression to adult T-cell leukaemia in asymptomatic carriers of human T-lymphotropic virus type 1 in Japan: a retrospective longitudinal cohort study Open
Association Jules Bordet, FNRS-Télévie, FCC, WALInnov, FLF, JSPS-KAKENHI, and CoBiA.
View article: An Open‐Label, Multicenter, Phase <scp>II</scp> Study of Bexarotene in Patients with Adult T‐Cell Leukemia/Lymphoma
An Open‐Label, Multicenter, Phase <span>II</span> Study of Bexarotene in Patients with Adult T‐Cell Leukemia/Lymphoma Open
A multicenter, open‐label, historically controlled, 2‐arm phase II study was conducted to evaluate the safety, efficacy, and pharmacokinetics of bexarotene in Japanese patients with adult T‐cell lymphoma/leukemia (ATL). The study enrolled …
View article: Machine learning based characterization of high risk carriers of HTLV-1-associated myelopathy (HAM)
Machine learning based characterization of high risk carriers of HTLV-1-associated myelopathy (HAM) Open
HTLV-1-associated myelopathy (HAM) develops in a part of HTLV-1-infected individuals while most of the individuals remain asymptomatic. This complicates the identification of HTLV-1 carriers at elevated risk. In this study, we integrated H…
View article: Seismic tomography for subsurface structures imaging beneath Hachijojima Volcanic Island, Izu-Bonin Arc, Japan
Seismic tomography for subsurface structures imaging beneath Hachijojima Volcanic Island, Izu-Bonin Arc, Japan Open
We present a seismic tomography study of the subsurface structure beneath Hachijojima Island, one of the volcanic fronts in the Izu-Bonin Arc, Japan. Seismic observations were conducted over two 7-month periods in 2019 and 2021, utilizing …
View article: Clonality analysis of HTLV-1-infected cells enhances prognostic precision in smoldering adult T-cell leukemia/lymphoma
Clonality analysis of HTLV-1-infected cells enhances prognostic precision in smoldering adult T-cell leukemia/lymphoma Open
Not available.
View article: Seismic Tomography for Subsurface Structures Imaging beneath Hachijojima Volcanic Island, Izu-Bonin Arc, Japan
Seismic Tomography for Subsurface Structures Imaging beneath Hachijojima Volcanic Island, Izu-Bonin Arc, Japan Open
We present a seismic tomography study of the subsurface structure beneath Hachijojima Island, one of the volcanic fronts in the Izu-Bonin Arc, Japan. Seismic observations were conducted over two 7-month periods in 2019 and 2021, utilizing …
View article: Machine Learning-based Identification and Characterization of High-risk Carriers of HTLV-1-Associated Myelopathy (HAM)
Machine Learning-based Identification and Characterization of High-risk Carriers of HTLV-1-Associated Myelopathy (HAM) Open
HTLV-1-associated myelopathy (HAM) develops in a part of HTLV-1-infected individuals while most of the individuals remain asymptomatic. This complicates the identification of HTLV-1 carriers at elevated risk. In this study, we integrated H…
View article: OB3D: A New Dataset for Benchmarking Omnidirectional 3D Reconstruction Using Blender
OB3D: A New Dataset for Benchmarking Omnidirectional 3D Reconstruction Using Blender Open
View article: Two Origins for Bell-Shaped Velocity-Dependent Friction Coefficient: Kelvin-Voigt or Standard Linear Solid Viscoelasticity
Two Origins for Bell-Shaped Velocity-Dependent Friction Coefficient: Kelvin-Voigt or Standard Linear Solid Viscoelasticity Open
It is well known that the friction coefficient of viscoelastic solids against the drive speed exhibits a bell shape. In previous theoretical studies on viscoelastic friction, we can find two origins for the bell shape. One is due to the ma…
View article: Three-dimensional Structure of the Omiya and the Iriyamase Faults and Its Formation Process, the Eastern Margin of the Fujikawa-kako Fault Zone, the Northwestern Border of the Izu Collision Zone, Central Japan: Outcomes of the Multi-line Integrated Seismic Exploration in the Hoshiyama Hills
Three-dimensional Structure of the Omiya and the Iriyamase Faults and Its Formation Process, the Eastern Margin of the Fujikawa-kako Fault Zone, the Northwestern Border of the Izu Collision Zone, Central Japan: Outcomes of the Multi-line Integrated Seismic Exploration in the Hoshiyama Hills Open
The Fujikawa-kako fault zone (FKFZ) is one of the most active fault zones constituting the northwest border of the Izu collision zone between the Honshu and Izu arcs. Its vertical slip rate is estimated to reach 6 to 7 m/ky along the easte…
View article: Crustal Structure of the Northwestern Border of the Izu Collision Zone from the Fujikawa-kako Fault Zone to the Itoigawa–Shizuoka Tectonic Line, Central Japan: Outcomes of Integrated Seismic Exploration FIST2012
Crustal Structure of the Northwestern Border of the Izu Collision Zone from the Fujikawa-kako Fault Zone to the Itoigawa–Shizuoka Tectonic Line, Central Japan: Outcomes of Integrated Seismic Exploration FIST2012 Open
The Fujikawa-kako fault zone (FKFZ) is one of the most active fault zones constituting the northwest border of the Izu collision zone between the Honshu and Izu arcs. Although FKFZ has the highest vertical slip-rate in Japan, its structure…
View article: Mechanisms of action and resistance in histone methylation-targeted therapy
Mechanisms of action and resistance in histone methylation-targeted therapy Open
View article: Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations
Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations Open
Antibody screening tests for human T-cell leukemia virus type 1 (HTLV-1) are performed based on methods such as chemiluminescent enzyme immunoassay (CLEIA), chemiluminescence immunoassay (CLIA), electrochemiluminescence immunoassay, and pa…
View article: Anti‐HTLV‐1 immunity combined with proviral load as predictive biomarkers for adult T‐cell leukemia‐lymphoma
Anti‐HTLV‐1 immunity combined with proviral load as predictive biomarkers for adult T‐cell leukemia‐lymphoma Open
Human T‐cell leukemia virus type 1 (HTLV‐1) establishes chronic infection in humans and induces a T‐cell malignancy called adult T‐cell leukemia‐lymphoma (ATL) and several inflammatory diseases such as HTLV‐1‐associated myelopathy/tropical…
View article: Dimensionless Numbers and Master Curves for Sliding Friction from the Kelvin-Voigt Viscoelasticity of Solids
Dimensionless Numbers and Master Curves for Sliding Friction from the Kelvin-Voigt Viscoelasticity of Solids Open
Recent advances in computational methods have enabled realistic numerical simulations for the sliding friction of viscoelastic solids (e.g., rubber friction by the finite element method in the macroscale and soft matter friction by the mol…
View article: Solidified magma reservoir derived from active source seismic experiments in the Aira caldera, southern Kyushu, Japan
Solidified magma reservoir derived from active source seismic experiments in the Aira caldera, southern Kyushu, Japan Open
The Aira caldera, located in southern Kyushu, Japan, originally formed 100 ka, and its current shape reflects the more recent 30 ka caldera-forming eruptions (hereafter, called the AT eruptions). This study aimed to delineate the detailed …
View article: Study on the Intent-based System Design Automation Method for Fault Detection and Fault Tolerance
Study on the Intent-based System Design Automation Method for Fault Detection and Fault Tolerance Open
ICT systems are becoming an important infrastructure indispensable for business operations in various industries. While the requirements are becoming more diverse and complex, stable service provision is required. As a result, the burden o…
View article: Seismic structure and its implication on the hydrothermal system beneath Mt. Ontake, central Japan
Seismic structure and its implication on the hydrothermal system beneath Mt. Ontake, central Japan Open
Mt. Ontake is an active volcano in central Japan where phreatic eruption activity is prominent. A shallow subsurface structure in the summit region of this volcano has been scarcely studied despite its importance. Our study examines the st…
View article: HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma
HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma Open
Viral cell‐free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus‐associated tumors. We investigated whether the amount of cfDNA of human T‐cell leukemia virus type 1 (HTLV‐1) correlates w…
View article: Solidified magma reservoir derived from seismic exploration in the Aira caldera, southern Kyushu, Japan
Solidified magma reservoir derived from seismic exploration in the Aira caldera, southern Kyushu, Japan Open
Seismic exploration was conducted along a profile running through the Aira caldera located in southern Kyushu, Japan. The caldera was formed by an ignimbrite eruption approximately 30 ka BP, namely, the “AT eruption,” which produced the It…
View article: Supplementary Methods, Table 1, Figures 1-3 from Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation
Supplementary Methods, Table 1, Figures 1-3 from Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation Open
PDF file - 292K, hyperactivation of 4E-BP1 in UPR inhibition
View article: Data from Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation
Data from Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation Open
Biguanides, including metformin, buformin, and phenformin, are potential antitumorigenic agents and induce cell death during glucose deprivation, a cell condition that occurs in the tumor microenvironment. Here, we show that this selective…
View article: Supplementary Figures S1~S7, Tables S1 and S2 from Functional Analysis of Aberrantly Spliced Caspase8 Variants in Adult T-Cell Leukemia Cells
Supplementary Figures S1~S7, Tables S1 and S2 from Functional Analysis of Aberrantly Spliced Caspase8 Variants in Adult T-Cell Leukemia Cells Open
Figure S1. Primary structures of Casp8 isoforms. Figure S2. Replicated results in the CASP8 mRNA alternative splicing reporter assay. Figure S3. Apoptosis assays in EGFP-Casp8 expressing cells. Figure S4. Condensed structures and death eff…
View article: Data from Functional Analysis of Aberrantly Spliced Caspase8 Variants in Adult T-Cell Leukemia Cells
Data from Functional Analysis of Aberrantly Spliced Caspase8 Variants in Adult T-Cell Leukemia Cells Open
The genetic and molecular alterations responsible for leukemogenesis and progression of HTLV-infected adult T-cell leukemia (ATL) have not been fully clarified. Previously, we reported that various genes are not only overexpressed but also…
View article: Data from Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation
Data from Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation Open
Biguanides, including metformin, buformin, and phenformin, are potential antitumorigenic agents and induce cell death during glucose deprivation, a cell condition that occurs in the tumor microenvironment. Here, we show that this selective…
View article: Data from Functional Analysis of Aberrantly Spliced Caspase8 Variants in Adult T-Cell Leukemia Cells
Data from Functional Analysis of Aberrantly Spliced Caspase8 Variants in Adult T-Cell Leukemia Cells Open
The genetic and molecular alterations responsible for leukemogenesis and progression of HTLV-infected adult T-cell leukemia (ATL) have not been fully clarified. Previously, we reported that various genes are not only overexpressed but also…
View article: Supplementary Methods, Table 1, Figures 1-3 from Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation
Supplementary Methods, Table 1, Figures 1-3 from Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation Open
PDF file - 292K, hyperactivation of 4E-BP1 in UPR inhibition
View article: Supplementary Figures S1~S7, Tables S1 and S2 from Functional Analysis of Aberrantly Spliced Caspase8 Variants in Adult T-Cell Leukemia Cells
Supplementary Figures S1~S7, Tables S1 and S2 from Functional Analysis of Aberrantly Spliced Caspase8 Variants in Adult T-Cell Leukemia Cells Open
Figure S1. Primary structures of Casp8 isoforms. Figure S2. Replicated results in the CASP8 mRNA alternative splicing reporter assay. Figure S3. Apoptosis assays in EGFP-Casp8 expressing cells. Figure S4. Condensed structures and death eff…
View article: Supplementary Figure 2 from CADM1 Expression and Stepwise Downregulation of CD7 Are Closely Associated with Clonal Expansion of HTLV-I–Infected Cells in Adult T-cell Leukemia/Lymphoma
Supplementary Figure 2 from CADM1 Expression and Stepwise Downregulation of CD7 Are Closely Associated with Clonal Expansion of HTLV-I–Infected Cells in Adult T-cell Leukemia/Lymphoma Open
PDF file - 67KB, FISH analysis of HTLV-1-infected cells.