Toshio Kuwai
YOU?
Author Swipe
View article: Single-dose DSS-induced inflammation enhances colorectal tumorigenesis in APC and KRAS mutant mice
Single-dose DSS-induced inflammation enhances colorectal tumorigenesis in APC and KRAS mutant mice Open
Colorectal cancer (CRC) arises through interactions between driver mutations, such as in APC and KRAS , and the tumor microenvironment (TME), including inflammatory factors. While chronic inflammation is a known risk factor, the role of tr…
View article: Safety and efficacy of scissor-type knives in colorectal endoscopic submucosal dissection: International multicenter observational study
Safety and efficacy of scissor-type knives in colorectal endoscopic submucosal dissection: International multicenter observational study Open
Scissor-type knives have shown safety and efficacy in endoscopic submucosal dissection (ESD) procedures, particularly in studies from Japan. However, the safety and efficacy of these devices in international settings, particularly outside …
View article: A Three‐Way Comparison of Nodular Lesions in <i>H. pylori</i> ‐Induced Gastritis, Non‐ <i>Helicobacter pylori Helicobacter</i> ( <scp>NHPH</scp> )‐Induced Gastritis, and <scp>NHPH</scp> ‐Induced <scp>MALT</scp> Lymphoma Reveals Their Distinct Endoscopic Predictors: Distribution for Bacterial Etiology and Morphology for Malignancy
A Three‐Way Comparison of Nodular Lesions in <i>H. pylori</i> ‐Induced Gastritis, Non‐ <i>Helicobacter pylori Helicobacter</i> ( <span>NHPH</span> )‐Induced Gastritis, and <span>NHPH</span> ‐Induced <span>MALT</span> Lymphoma Reveals Their Distinct Endoscopic Predictors: Distribution for Bacterial Etiology and Morphology for Malignancy Open
Background Nodular gastritis associated with Helicobacter pylori infection (HPi‐NG) has long been recognized. Recently, similar mucosal changes have been reported with non‐ H. pylori Helicobacter (NHPH), including NHPH‐induced gastric muco…
View article: Clinical utility of repeated IgH gene rearrangement testing for the diagnosis and surveillance of gastric MALT lymphoma
Clinical utility of repeated IgH gene rearrangement testing for the diagnosis and surveillance of gastric MALT lymphoma Open
Gastric MALT lymphoma diagnosis relies on histopathological findings and immunoglobulin H gene (IgHr) rearrangement testing, which reflects monoclonal immunoglobulin proliferation. This study aimed to clarify the role of IgHr in the diagno…
View article: Investigating tumor-infiltrating lymphocytes as predictors of lymph node metastasis in deep submucosal invasive esophageal squamous cell carcinoma: a retrospective cross-sectional study
Investigating tumor-infiltrating lymphocytes as predictors of lymph node metastasis in deep submucosal invasive esophageal squamous cell carcinoma: a retrospective cross-sectional study Open
View article: Efficacy of Hybrid Endoscopic Submucosal Dissection to Ensure Adequate Submucosal Layer for T1b Colorectal Carcinomas of 20-30 mm in Diameter
Efficacy of Hybrid Endoscopic Submucosal Dissection to Ensure Adequate Submucosal Layer for T1b Colorectal Carcinomas of 20-30 mm in Diameter Open
PH-ESD for 20-30-mm T1b CRCs may be more useful than C-ESD in terms of procedure time, especially for superficial lesions, ensuring a longer resected SM distance and VM ≥500 μm.
View article: Clinical Outcomes of Endoscopic Submucosal Dissection for Early Gastric Cancer Patients With Concurrent Advanced Malignancies With Expected Poor Prognosis
Clinical Outcomes of Endoscopic Submucosal Dissection for Early Gastric Cancer Patients With Concurrent Advanced Malignancies With Expected Poor Prognosis Open
Aims Despite improved outcomes for malignant tumors, evidence regarding the management of patients with multiple malignancies remains limited. We aimed to evaluate the clinical outcomes and prognosis of patients undergoing endoscopic submu…
View article: Effectiveness of endoscopic submucosal dissection in the management of internal hemorrhoids: a retrospective cohort study
Effectiveness of endoscopic submucosal dissection in the management of internal hemorrhoids: a retrospective cohort study Open
Background: Improvement in internal hemorrhoids is frequently observed after endoscopic submucosal dissection (ESD) for rectal intraepithelial neoplasia. This study investigated the effectiveness of rectal ESD in the management of internal…
View article: Endoscopic drainage for the treatment of intramural colonic abscess
Endoscopic drainage for the treatment of intramural colonic abscess Open
View article: Prophylactic clip closure after endoscopic submucosal dissection of large flat and sessile colorectal polyps: a multicentre randomised controlled trial (EPOC trial)
Prophylactic clip closure after endoscopic submucosal dissection of large flat and sessile colorectal polyps: a multicentre randomised controlled trial (EPOC trial) Open
Background Prophylactic clip closure after endoscopic mucosal resection reduces delayed bleeding in large and proximal colon lesions; however, evidence regarding its effectiveness in colorectal endoscopic submucosal dissection (ESD) is lac…
View article: Endoscopic features differentiating non‐<i>Helicobacter pylori Helicobacter</i>‐induced gastric mucosa‐associated lymphoid tissue lymphoma with a nodular gastritis‐like appearance and <i>H. pylori</i>‐induced conventional nodular gastritis
Endoscopic features differentiating non‐<i>Helicobacter pylori Helicobacter</i>‐induced gastric mucosa‐associated lymphoid tissue lymphoma with a nodular gastritis‐like appearance and <i>H. pylori</i>‐induced conventional nodular gastritis Open
Objectives Conventional nodular gastritis has been known to be caused by Helicobacter pylori infection. Several cases of gastric mucosa‐associated lymphoid tissue (MALT) lymphoma with non‐ H. pylori Helicobacters (NHPH) exhibit endoscopic …
View article: Long‐term results of palliative placement of very low‐axial force self‐expandable metallic stents for malignant colorectal obstruction
Long‐term results of palliative placement of very low‐axial force self‐expandable metallic stents for malignant colorectal obstruction Open
Objectives Stent placement is a standard option for palliative decompression in patients with malignant colorectal obstruction. Long‐term stent placement is associated with perforation, migration, and stent occlusion. Perforation is associ…
View article: <i>Helicobacter pylori</i>-positive Colorectal MALT Lymphoma with Repeated Metachronous Recurrence after a Complete Response to Eradication Therapy and Regression after a Watch-and-wait Strategy
<i>Helicobacter pylori</i>-positive Colorectal MALT Lymphoma with Repeated Metachronous Recurrence after a Complete Response to Eradication Therapy and Regression after a Watch-and-wait Strategy Open
A 77-year-old man underwent a colonoscopy. A submucosal cecal tumor was found, and localized colorectal MALT lymphoma (Lugano stage I) was diagnosed with a Helicobacter pylori infection. The first-line eradication therapy was successful, a…
View article: Efficiency of Real-time Computer-aided Polyp Detection during Surveillance Colonoscopy: A Pilot Study
Efficiency of Real-time Computer-aided Polyp Detection during Surveillance Colonoscopy: A Pilot Study Open
Computer-aided detection may help identify adenomas during surveillance colonoscopy for patients with untreated diminutive adenomas and those with a history of endoscopic resection.
View article: A Proton Pump Inhibitor Independently Elevates Gastrin Levels as a Marker for Metachronous Gastric Cancer After Endoscopic Submucosal Dissection
A Proton Pump Inhibitor Independently Elevates Gastrin Levels as a Marker for Metachronous Gastric Cancer After Endoscopic Submucosal Dissection Open
Background and Objective: Serum markers such as gastrin and pepsinogen are useful for stratifying gastric cancer risk. However, their utility in predicting metachronous gastric cancer after endoscopic submucosal dissection (ESD) in patient…
View article: Comparative prediction of lymph node metastasis in pT1 colorectal cancer among Western and Japanese guidelines
Comparative prediction of lymph node metastasis in pT1 colorectal cancer among Western and Japanese guidelines Open
Background Additional surgery with lymph node (LN) dissection is recommended for pT1 colorectal carcinoma (CRC) resected by endoscopy, based on pathological risk factors for LN metastasis (LNM), according to guidelines by the Japanese Soci…
View article: Clinical usefulness of hybrid endoscopic submucosal dissection for T1b colorectal carcinomas ≤20 mm to ensure adequate vertical margins
Clinical usefulness of hybrid endoscopic submucosal dissection for T1b colorectal carcinomas ≤20 mm to ensure adequate vertical margins Open
Objective To evaluate endoscopic resection strategies for cT1b colorectal carcinomas (CRCs) ≤20 mm to determine strategies that enable adequate vertical margins (VMs). Methods We enrolled 128 consecutive patients with cT1b colorectal carci…
View article: A case of esophageal squamous cell carcinoma with epidermization showing a unique morphology
A case of esophageal squamous cell carcinoma with epidermization showing a unique morphology Open
View article: Radiation Exposure with Self-Expandable Metallic Stent versus Transanal Decompression Tube for Malignant Colorectal Obstruction: A Post Hoc Propensity Score Matched Analysis
Radiation Exposure with Self-Expandable Metallic Stent versus Transanal Decompression Tube for Malignant Colorectal Obstruction: A Post Hoc Propensity Score Matched Analysis Open
Background: Although several reports have compared the outcomes of self-expandable metallic stent (SEMSs) and transanal decompression tube (TDT) placement for malignant colorectal obstruction (MCO), few studies have compared the radiation …
View article: Genetic Analysis of Biopsy Tissues from Colorectal Tumors in Patients with Ulcerative Colitis
Genetic Analysis of Biopsy Tissues from Colorectal Tumors in Patients with Ulcerative Colitis Open
Background/Objectives: Colorectal neoplasia developing from ulcerative colitis mucosa (CRNUC) can be divided into ulcerative colitis-associated neoplasia (UCAN) and non-UCAN; however, it is often difficult to distinguish UCAN from non-UCAN…
View article: Clinicopathologic Features of Early Gastric Cancer after Helicobacter pylori Eradication in Japanese Patients: Comparative Study between Early (<10 Years) and Late (>10 Years) Onset
Clinicopathologic Features of Early Gastric Cancer after Helicobacter pylori Eradication in Japanese Patients: Comparative Study between Early (10 Years) Onset Open
Background/Objectives: Eradication therapy for Helicobacter pylori gastritis was approved for insurance coverage by the Japanese government in 2013. Since then, the incidence of gastric cancer discovered after eradication (GCAE) has increa…
View article: A New Self-Expandable Metallic Stent with Low Axial Force and a High Axial Force Zero-Border Shows a Very Low Perforation Rate in Malignant Colorectal Obstruction: A Japanese Multicenter Prospective Study
A New Self-Expandable Metallic Stent with Low Axial Force and a High Axial Force Zero-Border Shows a Very Low Perforation Rate in Malignant Colorectal Obstruction: A Japanese Multicenter Prospective Study Open
Background: Recently, there has been a significant increase in the utilization of self-expandable metallic stents (SEMSs) for treating malignant colorectal obstructions through colorectal stenting. The mechanical properties of SEMSs are us…
View article: Vertical margin distance in T1 colorectal carcinoma resected by endoscopic submucosal dissection affects prognosis after additional surgery
Vertical margin distance in T1 colorectal carcinoma resected by endoscopic submucosal dissection affects prognosis after additional surgery Open
View article: Long-Term Outcomes of Additional Surgery After Endoscopic Resection Versus Primary Surgery for T1 Colorectal Cancer
Long-Term Outcomes of Additional Surgery After Endoscopic Resection Versus Primary Surgery for T1 Colorectal Cancer Open
INTRODUCTION: There is considerable concern about whether endoscopic resection (ER) before additional surgery (AS) for T1 colorectal cancer (CRC) has oncologically potential adverse effects. Therefore, the aim of this study was to compare …
View article: High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings: A case report
High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings: A case report Open
BACKGROUND High-grade pancreatic intraepithelial neoplasia (PanIN) exhibits no mass and is not detected by any examination modalities. However, it can be diagnosed by pancreatic juice cytology from indirect findings. Most previous cases we…
View article: Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan
Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan Open
Background The clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, remain undetermined due to its rarity in Japan. Methods We analyzed 354 patients with 358 PSBAs, between Jan…
View article: Treatment Decision for Locally Resected T1 Colorectal Carcinoma–Verification of the Japanese Guideline Criteria for Additional Surgery Based on Long-Term Clinical Outcomes
Treatment Decision for Locally Resected T1 Colorectal Carcinoma–Verification of the Japanese Guideline Criteria for Additional Surgery Based on Long-Term Clinical Outcomes Open
INTRODUCTION: To verify the value of the pathological criteria for additional treatment in locally resected pT1 colorectal carcinoma (CRC) which have been used in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines s…
View article: Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study
Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study Open
PURPOSE Limited information is available regarding the characteristics and outcomes of stage IV small bowel adenocarcinoma (SBA) in Japan. This study examined the clinical and pathological characteristics and outcomes according to the trea…
View article: Vertical margin distance in T1 colorectal carcinoma resected by endoscopic submucosal dissection affects prognosis after additional surgery
Vertical margin distance in T1 colorectal carcinoma resected by endoscopic submucosal dissection affects prognosis after additional surgery Open
Purpose A vertical margin (VM) distance of < 500 µm is a risk factor for recurrence in patients with T1 colorectal carcinoma (CRC) resected by endoscopy. We aimed to determine the effects of the VM distance on the recurrence and prognosis …
View article: High comorbidity indexes predict 30-day mortality after percutaneous endoscopic gastrostomy
High comorbidity indexes predict 30-day mortality after percutaneous endoscopic gastrostomy Open
Background High postoperative mortality rates have been reported for percutaneous endoscopic gastrostomy (PEG), although guidelines recommend PEG for patients anticipated inability of oral intake for more than 4 weeks. Conversely, comorbid…