Toshiomi Katsuki
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View article: Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC–CXCL1–CXCR2 axis
Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC–CXCL1–CXCR2 axis Open
Heart failure (HF) is a growing global health issue. While most studies focus on cardiomyocytes, here we highlight the role of cardiac fibroblasts (CFs) in HF. Single-cell RNA sequencing of mouse hearts under pressure overload identified s…
View article: Inhibition of Scarb1 on Endothelial Cells Attenuates Pressure Overload-Induced Heart Failure Progression
Inhibition of Scarb1 on Endothelial Cells Attenuates Pressure Overload-Induced Heart Failure Progression Open
Inappropriate endothelial cell (EC) interactions contribute to heart failure; however, their precise mechanisms remain poorly understood. This study investigated EC-fibroblast interactions mediated by Scarb1 using single-cell RNA-sequencin…
View article: Refractory Vasospastic Angina Complicated by Bronchial Asthma with Eosinophilia
Refractory Vasospastic Angina Complicated by Bronchial Asthma with Eosinophilia Open
A 48-year-old woman with a history of bronchial asthma and allergic rhinitis presented with cardiac arrest due to ventricular fibrillation and was resuscitated by defibrillation. Coronary angiography revealed coronary vasospasm. Various an…
View article: A deep learning-based automated diagnosis system for SPECT myocardial perfusion imaging
A deep learning-based automated diagnosis system for SPECT myocardial perfusion imaging Open
View article: Clinical outcome for heart failure hospitalizations in patients with leadless pacemaker
Clinical outcome for heart failure hospitalizations in patients with leadless pacemaker Open
Background Leadless pacemaker has a low risk of complications such as infection, pneumothorax, and skin erosion, and it is good adaptation for elderly patients. While ventricular pacing induces ventricular desynchronization, and that is ca…
View article: The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure
The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure Open
Failure of the right ventricle plays a critical role in any type of heart failure. However, the mechanism remains unclear, and there is no specific therapy. Here, we show that the right ventricle predominantly expresses alternative complem…
View article: Anti-senescent drug screening by deep learning-based morphology senescence scoring
Anti-senescent drug screening by deep learning-based morphology senescence scoring Open
View article: Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial
Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial Open
Background Drug-eluting stent-induced vasospastic angina (DES-VSA) has emerged as a novel complication in the modern era of percutaneous coronary intervention (PCI). Although beta blockers (BBs) are generally recommended for coronary heart…
View article: Impact of tacrolimus versus cyclosporin A on renal function during the first year after heart transplant
Impact of tacrolimus versus cyclosporin A on renal function during the first year after heart transplant Open
Aims Nephrotoxicity of calcineurin inhibitors (CNIs) is associated with adverse events in patients undergoing heart transplant (HTx), although studies directly comparing tacrolimus (TAC) versus cyclosporin A (CsA), especially in combinatio…
View article: Benefit and harm of intravenous vasodilators across the clinical profile spectrum in acute cardiogenic pulmonary oedema patients
Benefit and harm of intravenous vasodilators across the clinical profile spectrum in acute cardiogenic pulmonary oedema patients Open
Background: The absence of high quality, large-scale data that indicates definitive mortality benefits does not allow for firm conclusions on the role of intravenous vasodilators in acute heart failure. We aimed to investigate the associat…
View article: Effects of body habitus on contrast-induced acute kidney injury after percutaneous coronary intervention
Effects of body habitus on contrast-induced acute kidney injury after percutaneous coronary intervention Open
A V/CrCl ratio > 3 was strongly associated with the occurrence of CI-AKI. Importantly, we also identified a tendency for physicians to use higher V/CrCl ratios in lean patients. Thus, recognizing this trend may provide a therapeutic target…
View article: Automated Deep Learning-Based System to Identify Endothelial Cells Derived from Induced Pluripotent Stem Cells
Automated Deep Learning-Based System to Identify Endothelial Cells Derived from Induced Pluripotent Stem Cells Open
Deep learning technology is rapidly advancing and is now used to solve complex problems. Here, we used deep learning in convolutional neural networks to establish an automated method to identify endothelial cells derived from induced pluri…
View article: 2033Incidence and predictors of stroke after percutaneous coronary intervention in the era of transradial intervention
2033Incidence and predictors of stroke after percutaneous coronary intervention in the era of transradial intervention Open
View article: Reverse Takotsubo Cardiomyopathy and Shock Supported by Continuous Hemodiafiltration in a Patient with Anorexia Nervosa
Reverse Takotsubo Cardiomyopathy and Shock Supported by Continuous Hemodiafiltration in a Patient with Anorexia Nervosa Open
Background: Takotsubo cardiomyopathy (TC) is known as stress-induced cardiomyopathy. It is characterized by relatively benign transient systolic dysfunction of the apical segments of the left ventricle. Reverse Takotsubo cardiomyopathy (RT…