Toshiya Endo
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View article: Future population dynamics of two temperate mosquito species under various precipitation scenarios
Future population dynamics of two temperate mosquito species under various precipitation scenarios Open
To evaluate the risk of disease spread by vectors, future mosquito population dynamics, which are strongly affected by climate change, must be predicted. Despite the importance of precipitation to mosquito development, predictions of mosqu…
View article: Msp1 and Pex19‐Pex3 cooperate to achieve correct localization of Pex15 to peroxisomes
Msp1 and Pex19‐Pex3 cooperate to achieve correct localization of Pex15 to peroxisomes Open
Yeast Msp1 is a dual‐localized AAA‐ATPase on the mitochondrial outer membrane (OM) and peroxisomal membrane. We previously showed that Msp1 transfers mistargeted tail‐anchored (TA) proteins from mitochondria to the endoplasmic reticulum (E…
View article: Msp1 and Pex19-Pex3 cooperate to achieve correct localization of Pex15 to peroxisomes
Msp1 and Pex19-Pex3 cooperate to achieve correct localization of Pex15 to peroxisomes Open
Yeast Msp1 is a dual-localized AAA-ATPase on the mitochondrial outer membrane (OM) and peroxisomal membrane. We previously showed that Msp1 transfers mistargeted tail-anchored (TA) proteins from mitochondria to the endoplasmic reticulum (E…
View article: Compositional Flexibility of the ER-Mitochondria Encounter Structure
Compositional Flexibility of the ER-Mitochondria Encounter Structure Open
Yeast mitochondria receive the majority of their lipids from the endoplasmic reticulum (ER) via the heterotetrameric ERMES lipid transport complex. This complex is thought to establish a lipid transporting tube of fixed composition spannin…
View article: Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes
Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes Open
Hundreds of mitochondrial proteins with N-terminal presequences are translocated across the outer and inner mitochondrial membranes via the TOM and TIM23 complexes, respectively. How translocation of proteins across two mitochondrial membr…
View article: TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria Open
PINK1 is activated by autophosphorylation and forms a high-molecular-weight complex, thereby initiating the selective removal of damaged mitochondria by autophagy. Other than translocase of the outer mitochondrial membrane complexes, membe…
View article: Dissociation of ERMES clusters plays a key role in attenuating the endoplasmic reticulum stress
Dissociation of ERMES clusters plays a key role in attenuating the endoplasmic reticulum stress Open
In yeast, ERMES, which mediates phospholipid transport between the ER and mitochondria, forms a limited number of oligomeric clusters at ER-mitochondria contact sites in a cell. Although the number of the ERMES clusters appears to be regul…
View article: GET pathway mediates transfer of mislocalized tail-anchored proteins from mitochondria to the ER
GET pathway mediates transfer of mislocalized tail-anchored proteins from mitochondria to the ER Open
Tail-anchored (TA) membrane proteins have a potential risk to be mistargeted to the mitochondrial outer membrane (OM). Such mislocalized TA proteins can be extracted by the mitochondrial AAA-ATPase Msp1 from the OM and transferred to the E…
View article: Role of the TOM Complex in Protein Import into Mitochondria: Structural Views
Role of the TOM Complex in Protein Import into Mitochondria: Structural Views Open
Mitochondria are central to energy production, metabolism and signaling, and apoptosis. To make new mitochondria from preexisting mitochondria, the cell needs to import mitochondrial proteins from the cytosol into the mitochondria with the…
View article: Structural overview of the translocase of the mitochondrial outer membrane complex
Structural overview of the translocase of the mitochondrial outer membrane complex Open
Most mitochondrial proteins are synthesized as precursor proteins (preproteins) in the cytosol and imported into mitochondria. The translocator of the outer membrane (TOM) complex functions as a main entry gate for the import of mitochondr…
View article: Phosphatidylserine flux into mitochondria unveiled by organelle‐targeted <i>Escherichia coli</i> phosphatidylserine synthase PssA
Phosphatidylserine flux into mitochondria unveiled by organelle‐targeted <i>Escherichia coli</i> phosphatidylserine synthase PssA Open
Most phospholipids are synthesised in the endoplasmic reticulum and distributed to other cellular membranes. Although the vesicle transport contributes to the phospholipid distribution among the endomembrane system, exactly how phospholipi…
View article: Lipid homeostasis in mitochondria
Lipid homeostasis in mitochondria Open
Mitochondria are surrounded by the two membranes, the outer and inner membranes, whose lipid compositions are optimized for proper functions and structural organizations of mitochondria. Although a part of mitochondrial lipids including th…
View article: Structural basis for interorganelle phospholipid transport mediated by VAT-1
Structural basis for interorganelle phospholipid transport mediated by VAT-1 Open
Eukaryotic cells are compartmentalized to form organelles, whose functions rely on proper phospholipid and protein transport. Here we determined the crystal structure of human VAT-1, a cytosolic soluble protein that was suggested to transf…
View article: ERdj3B-Mediated Quality Control Maintains Anther Development at High Temperatures
ERdj3B-Mediated Quality Control Maintains Anther Development at High Temperatures Open
Pollen development is highly sensitive to heat stress, which impairs cellular proteostasis by causing misfolded proteins to accumulate. Therefore, each cellular compartment possesses a dedicated protein quality control system. An elaborate…
View article: A non-canonical unfolded protein response pathway and mitochondrial dynamics control the number of ER-mitochondria contact sites
A non-canonical unfolded protein response pathway and mitochondrial dynamics control the number of ER-mitochondria contact sites Open
Mitochondria maintain their morphology and functions through the optimized balance between the mitochondrial fusion and division. Here we report a novel role of mitochondrial dynamics in controlling the number of ER-mitochondria encounter …
View article: Role of the membrane potential in mitochondrial protein unfolding and import
Role of the membrane potential in mitochondrial protein unfolding and import Open
Newly synthesized mitochondrial precursor proteins have to become unfolded to cross the mitochondrial membranes. This unfolding is achieved primarily by mitochondrial Hsp70 (mtHsp70) for presequence-containing precursor proteins. However, …
View article: Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport
Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport Open
Mitochondria are dynamic organelles that constantly fuse and divide to maintain their proper morphology, which is essential for their normal functions. Energy production, a central role of mitochondria, demands highly folded structures of …
View article: Organelle contact zones as sites for lipid transfer
Organelle contact zones as sites for lipid transfer Open
Since the 1950s, electron microscopic observations have suggested the existence of special regions where the distinct organelle membranes are closely apposed to each other, yet their molecular basis and functions have not been examined for…
View article: Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins
Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins Open
Mitochondrial β-barrel proteins are encoded in the nucleus, translated by cytosolic ribosomes, and then imported into the organelle. Recently, a detailed understanding of the intramitochondrial import pathway of β-barrel proteins was obtai…